JP5129133B2 - 安定なｎａｄ／ｎａｄｈ誘導体 - Google Patents

安定なｎａｄ／ｎａｄｈ誘導体 Download PDF

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Publication number
JP5129133B2
JP5129133B2 JP2008523257A JP2008523257A JP5129133B2 JP 5129133 B2 JP5129133 B2 JP 5129133B2 JP 2008523257 A JP2008523257 A JP 2008523257A JP 2008523257 A JP2008523257 A JP 2008523257A JP 5129133 B2 JP5129133 B2 JP 5129133B2
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dehydrogenase
enzyme
independently
compound
coenzyme
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JP2009502844A (ja
JP2009502844A5 (enExample
Inventor
ヘーネス、ヨーアヒム
ハインドル、ディーター
ホルン、カリーナ
ゲッスラー−ディーチェ、クラウディア
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エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2008523257A 2005-07-28 2006-07-28 安定なｎａｄ／ｎａｄｈ誘導体 Expired - Fee Related JP5129133B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005035461.0 2005-07-28
DE102005035461A DE102005035461A1 (de) 2005-07-28 2005-07-28 Stabile NAD/NADH-Derivate
PCT/EP2006/007493 WO2007012494A1 (de) 2005-07-28 2006-07-28 Stabile nad/nadh-derivate

Related Child Applications (1)

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JP2012172878A Division JP5650695B2 (ja) 2005-07-28 2012-08-03 安定なｎａｄ／ｎａｄｈ誘導体

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JP2009502844A JP2009502844A (ja) 2009-01-29
JP2009502844A5 JP2009502844A5 (enExample) 2012-04-19
JP5129133B2 true JP5129133B2 (ja) 2013-01-23

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JP2008523257A Expired - Fee Related JP5129133B2 (ja) 2005-07-28 2006-07-28 安定なｎａｄ／ｎａｄｈ誘導体
JP2012172878A Expired - Fee Related JP5650695B2 (ja) 2005-07-28 2012-08-03 安定なｎａｄ／ｎａｄｈ誘導体

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US (3) US8809013B2 (enExample)
EP (3) EP2364989B1 (enExample)
JP (2) JP5129133B2 (enExample)
KR (4) KR101483829B1 (enExample)
CN (2) CN103122371B (enExample)
AU (2) AU2006274140B8 (enExample)
BR (1) BRPI0614217A2 (enExample)
CA (2) CA2737123A1 (enExample)
DE (1) DE102005035461A1 (enExample)
DK (3) DK2364988T3 (enExample)
ES (3) ES2461266T3 (enExample)
MX (1) MX2008000946A (enExample)
PL (3) PL2364989T3 (enExample)
PT (3) PT2364989E (enExample)
SG (1) SG187511A1 (enExample)
WO (1) WO2007012494A1 (enExample)

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JP2012224638A (ja) * 2005-07-28 2012-11-15 F Hoffmann-La Roche Ag 安定なｎａｄ／ｎａｄｈ誘導体

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EP2022859A1 (de) * 2007-08-01 2009-02-11 Roche Diagnostics GmbH Verfahren und Vorrichtung zur Bestimmung der Konzentration eines Analyten mittels Fluoreszenzmessung
CN101497638B (zh) * 2008-01-30 2012-09-26 中国科学院大连化学物理研究所 一种nad+类似物及其合成和应用
EP2093284A1 (de) 2008-02-19 2009-08-26 F.Hoffmann-La Roche Ag Stabilisierung von Dehydrogenasen mit stabilen Coenzymen
EP2226007A1 (de) 2009-02-19 2010-09-08 Roche Diagnostics GmbH Testelementmagazin mit abgedeckten Testfeldern
CA2750474C (en) * 2009-02-19 2017-07-25 F. Hoffmann-La Roche Ag Fast reaction kinetics of enzymes having low activity in dry chemistry layers
CN102325496B (zh) * 2009-02-19 2015-10-07 霍夫曼-拉罗奇有限公司 分析辅助工具的节省空间的储存
EP2226008A1 (de) 2009-02-19 2010-09-08 Roche Diagnostics GmbH Verfahren zur Herstellung eines analytischen Magazins
EP2398909B1 (de) 2009-02-19 2015-07-22 F. Hoffmann-La Roche AG Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten
CN102471793B (zh) * 2009-07-27 2014-04-30 霍夫曼-拉罗奇有限公司 Carba-nad的酶促合成
WO2011012269A2 (en) 2009-07-27 2011-02-03 Roche Diagnostics Gmbh Method and substances for preparation of n-substituted pyridinium compounds
JP5544423B2 (ja) 2009-07-27 2014-07-09 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Ｎ置換ピリジニウム化合物の調製のための方法及び物質
EP2287605A1 (de) * 2009-08-20 2011-02-23 Roche Diagnostics GmbH Vereinfachte Magazinierung integrierter Systeme
EP2292751A1 (de) * 2009-08-20 2011-03-09 Roche Diagnostics GmbH Stabilisierung von Enzymen mit stabilen Coenzymen
EP2333544A1 (de) 2009-12-11 2011-06-15 F. Hoffmann-La Roche AG Sterilisierbare Chemie für Testelemente
EP2513648B1 (de) 2009-12-16 2015-05-27 F.Hoffmann-La Roche Ag Detektion der zersetzung von enzymen in einem testelement durch kontrollierte freisetzung von geschütztem analyt
KR101252351B1 (ko) * 2010-05-24 2013-04-08 동국대학교 산학협력단 전기효소적 합성 반응을 위한 ｎａｄ(ｐ) 유도체의 전기화학적 환원 방법
CN102453067B (zh) * 2010-10-29 2015-08-05 中国科学院大连化学物理研究所 一种nad+类似物的制备方法及其应用
CN103347858B (zh) 2011-01-26 2016-09-14 霍夫曼-拉罗奇有限公司 制备n-取代的吡啶鎓化合物的方法和物质
CN103458786B (zh) 2011-04-12 2015-08-19 霍夫曼-拉罗奇有限公司 分析辅件
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CN102863495A (zh) * 2011-07-06 2013-01-09 上海执诚生物科技股份有限公司 一种含有nad+或nadh的稳定的组合物
EP2760825B1 (de) 2011-09-28 2016-09-14 F.Hoffmann-La Roche Ag Azomediatoren
JP6128808B2 (ja) * 2011-11-15 2017-05-17 栄研化学株式会社 酵素活性の検出、測定方法およびこれを利用したキット
EP2620507A1 (en) 2012-01-25 2013-07-31 Roche Diagnostics GmbH Method for the evaluation of the quality of a test element
EP2636750A1 (en) 2012-03-06 2013-09-11 Roche Diagniostics GmbH Compatible solute ectoine as well as derivatives thereof for enzyme stabilization
JP6111323B2 (ja) 2012-04-19 2017-04-05 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 血液中の検体濃度を測定する方法および装置
US8921061B2 (en) * 2012-11-02 2014-12-30 Roche Diagnostics Operations, Inc. Reagent materials and associated test elements
US8920628B2 (en) 2012-11-02 2014-12-30 Roche Diagnostics Operations, Inc. Systems and methods for multiple analyte analysis
EP2936155B1 (en) 2012-12-20 2018-12-12 Roche Diabetes Care GmbH Method for analyzing a sample of a body fluid
KR101789893B1 (ko) 2012-12-20 2017-11-20 에프. 호프만-라 로슈 아게 의학적 측정 곡선들을 평가하기 위한 방법
EP2770064A1 (de) 2013-02-22 2014-08-27 F. Hoffmann-La Roche AG Hocheffiziente Herstellung von Blutglucose-Teststreifen
EP2781919A1 (en) 2013-03-19 2014-09-24 Roche Diagniostics GmbH Method / device for generating a corrected value of an analyte concentration in a sample of a body fluid
EP2994536B1 (en) 2013-05-08 2017-06-14 Roche Diabetes Care GmbH Stabilization of enzymes by nicotinic acid
EP3004372A1 (en) 2013-06-04 2016-04-13 Roche Diagnostics GmbH Novel compounds useful for fret and methods related thereto
EP2811299A1 (en) 2013-06-07 2014-12-10 Roche Diagniostics GmbH Test element for detecting at least one analyte in a body fluid
WO2015063025A1 (en) 2013-10-29 2015-05-07 F. Hoffmann-La Roche Ag Nano-enzyme containers for test elements
WO2015078899A1 (en) 2013-11-27 2015-06-04 Roche Diagnostics Gmbh Composition comprising up-converting phosphors for detecting an analyte
EP2927319A1 (en) 2014-03-31 2015-10-07 Roche Diagnostics GmbH High load enzyme immobilization by crosslinking
CN106164054B (zh) 2014-04-14 2019-05-07 豪夫迈·罗氏有限公司 吩嗪介导剂
WO2016022604A2 (en) * 2014-08-05 2016-02-11 Becton Dickinson And Company Methods and compositions for analyzing glucose-6-phosphate dehydrogenase activity in blood samples
EP3183246B1 (en) 2014-08-22 2020-09-23 Roche Diagnostics GmbH Redoxindicators
JP6639479B2 (ja) 2014-08-25 2020-02-05 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 干渉補償型の２電極テストストリップ
WO2017109003A1 (en) 2015-12-21 2017-06-29 F. Hoffmann-La Roche Ag Mutant 3-hydroxybutyrate dehydrogenase from alcaligenes faecalis as well as methods and uses involving the same
WO2017137491A1 (en) 2016-02-09 2017-08-17 Roche Diabetes Care Gmbh Mutant 3-hydroxybutyrate dehydrogenase from rhodobacter sphaeroides as well as methods and uses involving the same
JP2019529935A (ja) 2016-10-05 2019-10-17 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 多検体診断用試験エレメントのための検出試薬および電極配置、ならびにそれらを使用する方法
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Also Published As

Publication number Publication date
PT2364989E (pt) 2014-04-04
US9399790B2 (en) 2016-07-26
HK1123308A1 (en) 2009-06-12
AU2006274140B8 (en) 2011-02-03
PL2364989T3 (pl) 2014-08-29
PL1907408T3 (pl) 2014-07-31
AU2006274140B2 (en) 2010-11-11
BRPI0614217A2 (pt) 2011-03-22
AU2006274140A1 (en) 2007-02-01
CN103122371A (zh) 2013-05-29
DK2364989T3 (da) 2014-06-10
DK1907408T3 (da) 2014-06-10
US20140206024A1 (en) 2014-07-24
EP2364988B1 (de) 2014-02-26
ES2461266T3 (es) 2014-05-19
DK2364988T3 (da) 2014-05-26
AU2011200465A1 (en) 2011-02-24
CN103122371B (zh) 2016-12-28
CA2737123A1 (en) 2007-02-01
WO2007012494A1 (de) 2007-02-01
JP2009502844A (ja) 2009-01-29
CA2614792C (en) 2011-07-12
KR20110028522A (ko) 2011-03-18
CN101233144B (zh) 2013-02-06
JP2012224638A (ja) 2012-11-15
AU2011200465B2 (en) 2012-02-09
CA2614792A1 (en) 2007-02-01
ES2461624T3 (es) 2014-05-20
KR101483899B1 (ko) 2015-01-16
PT2364988E (pt) 2014-04-03
PL2364988T3 (pl) 2014-08-29
KR20120044372A (ko) 2012-05-07
US20080213809A1 (en) 2008-09-04
EP1907408A1 (de) 2008-04-09
KR20140003637A (ko) 2014-01-09
DE102005035461A1 (de) 2007-02-15
EP1907408B1 (de) 2014-03-05
JP5650695B2 (ja) 2015-01-07
EP2364989A1 (de) 2011-09-14
WO2007012494B1 (de) 2007-03-29
PT1907408E (pt) 2014-03-28
US20160326567A1 (en) 2016-11-10
MX2008000946A (es) 2008-03-27
US10167497B2 (en) 2019-01-01
SG187511A1 (en) 2013-02-28
KR101035524B1 (ko) 2011-05-23
KR20080028507A (ko) 2008-03-31
KR101483829B1 (ko) 2015-01-16
EP2364989B1 (de) 2014-03-05
US8809013B2 (en) 2014-08-19
ES2453150T3 (es) 2014-04-04
CN101233144A (zh) 2008-07-30
EP2364988A1 (de) 2011-09-14

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