ES2432395T3 - Células derivadas de riñon y metodo de uso en la reparación y regeneración tisular - Google Patents
Células derivadas de riñon y metodo de uso en la reparación y regeneración tisular Download PDFInfo
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- ES2432395T3 ES2432395T3 ES07852651T ES07852651T ES2432395T3 ES 2432395 T3 ES2432395 T3 ES 2432395T3 ES 07852651 T ES07852651 T ES 07852651T ES 07852651 T ES07852651 T ES 07852651T ES 2432395 T3 ES2432395 T3 ES 2432395T3
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/0684—Cells of the urinary tract or kidneys
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Landscapes
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| PCT/US2007/021708 WO2008045498A1 (en) | 2006-10-12 | 2007-10-11 | Kidney-derived cells and methods of use in tissue repair and regeneration |
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| US7862810B2 (en) * | 2000-07-31 | 2011-01-04 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| US20110091428A1 (en) * | 2000-07-31 | 2011-04-21 | New York Medical College | Compositions of adult organ stem cells and uses thereof |
| CA2530421C (en) | 2003-06-27 | 2015-04-21 | Ethicon, Incorporated | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US8518390B2 (en) | 2003-06-27 | 2013-08-27 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells |
| US8491883B2 (en) * | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
| US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
| US7875272B2 (en) * | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| US20060153815A1 (en) * | 2004-12-21 | 2006-07-13 | Agnieszka Seyda | Tissue engineering devices for the repair and regeneration of tissue |
| US20060166361A1 (en) * | 2004-12-21 | 2006-07-27 | Agnieszka Seyda | Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same |
| WO2006101548A2 (en) * | 2004-12-21 | 2006-09-28 | Ethicon, Inc. | Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same |
| JP5340599B2 (ja) | 2004-12-23 | 2013-11-13 | エシコン・インコーポレイテッド | 臍帯組織由来産褥細胞ならびにその製造方法および使用方法 |
| EP1835924B1 (en) | 2004-12-23 | 2013-08-21 | Ethicon, Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
| PL1971681T3 (pl) | 2005-12-16 | 2018-01-31 | Depuy Synthes Products Inc | Kompozycje oraz sposoby do hamowania niepożądanej odpowiedzi immunologicznej w przypadku transplantacji z brakiem zgodności tkankowej |
| JP5179376B2 (ja) * | 2005-12-19 | 2013-04-10 | エシコン・インコーポレイテッド | ローラーボトルでの分娩後取り出し細胞の体外増殖 |
| WO2007076522A2 (en) * | 2005-12-28 | 2007-07-05 | Ethicon, Incorporated | Treatment of peripheral vascular disease using postpartum-derived cells |
| US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
| JP2009525781A (ja) | 2006-02-02 | 2009-07-16 | イノベーティブ バイオ セラピーズ | 細胞をベースとする体外治療装置および送達システム |
| AU2007308168B2 (en) | 2006-10-12 | 2013-09-26 | Ethicon, Inc. | Kidney-derived cells and methods of use in tissue repair and regeneration |
| AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
| EP2162529B1 (en) | 2007-06-08 | 2019-03-27 | Wake Forest University Health Sciences | Selective cell therapy for the treatment of renal failure |
| US9580688B2 (en) | 2007-06-08 | 2017-02-28 | Wake Forest University Health Sciences | Kidney structures and methods of forming the same |
| US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
| JP5323832B2 (ja) | 2007-08-07 | 2013-10-23 | アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー | 酸性水溶液中にｇｄｆ−５を含むタンパク質製剤 |
| JP5323845B2 (ja) * | 2007-10-05 | 2013-10-23 | エシコン・インコーポレイテッド | ヒト臍帯組織由来細胞を用いた腎組織の修復および再建 |
| US8236538B2 (en) * | 2007-12-20 | 2012-08-07 | Advanced Technologies And Regenerative Medicine, Llc | Methods for sterilizing materials containing biologically active agents |
| BRPI0911048A2 (pt) | 2008-04-14 | 2015-12-29 | Atrm Llc | formulações líquidas tamponadas de gdf-5 |
| AU2009327485A1 (en) * | 2008-06-18 | 2010-06-24 | Cytopherx, Inc. | Methods for propagation of renal precursor cells |
| AU2009308094A1 (en) * | 2008-10-24 | 2010-04-29 | Childrens Hospital Los Angeles | Amniotic fluid cells and uses thereof |
| EP2186883A1 (en) * | 2008-11-04 | 2010-05-19 | Fresenius Medical Care | An isolated multipotent mesenchymal stem cell from human adult glomeruli (hGL-MSC), a method of preparing thereof and uses thereof in the regenerative medicine of the kidney |
| JP5974233B2 (ja) | 2008-11-12 | 2016-08-24 | リージェンメド（ケイマン）エルティーディー． | 単離した腎細胞およびその使用 |
| WO2010057013A1 (en) | 2008-11-14 | 2010-05-20 | Wake Forest University Health Sciences | Selective cell therapy for the treatment of renal failure |
| US20100151575A1 (en) * | 2008-12-15 | 2010-06-17 | Colter David C | Method of Making Conditioned Media from Kidney Derived Cells |
| US10179900B2 (en) * | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
| CA2747794C (en) | 2008-12-19 | 2018-10-30 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of lung and pulmonary diseases and disorders |
| EP2379089B1 (en) * | 2008-12-19 | 2019-04-17 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue following injury |
| CA2747757C (en) * | 2008-12-19 | 2020-11-03 | Ethicon, Incorporated | Umbilical cord tissue derived cells for treating neuropathic pain and spasticity |
| CN102498204B (zh) | 2009-03-26 | 2015-02-04 | 德普伊新特斯产品有限责任公司 | 人脐带组织细胞作为用于阿尔茨海默病的疗法 |
| US20110142805A1 (en) | 2009-12-15 | 2011-06-16 | Advanced Technologies And Regenerative Medicine, Llc | Method of renal repair and regeneration and the treatment of diabetic nephropathy |
| EP2569418B1 (en) * | 2010-05-12 | 2016-11-02 | RegenMed (Cayman) Ltd. | Bioactive renal cells |
| KR102302069B1 (ko) | 2010-11-10 | 2021-09-14 | 인리젠 | 장기 확대를 위한 주사가능 제제 |
| US8546338B2 (en) | 2010-12-08 | 2013-10-01 | Johnson & Johnson Consumer Companies, Inc. | Self-assembling hydrogels based on dicephalic peptide amphiphiles |
| US20120156780A1 (en) | 2010-12-21 | 2012-06-21 | Cooper Kevin L | Polymer Substrates Having Improved Biological Response From HKDCS |
| US20120156433A1 (en) | 2010-12-21 | 2012-06-21 | Natarajan Sriram N | Silicone polymer substrates having improved biological response from hkdcs |
| WO2012166668A1 (en) * | 2011-05-27 | 2012-12-06 | Christian Kazanecki | Bioartificial proximal tubule systems and methods of use |
| US20130157368A1 (en) * | 2011-12-20 | 2013-06-20 | Advanced Technologies And Regenerative Medicine, Llc | Induced pluripotent stem cells prepared from human kidney-derived cells |
| PL3567099T3 (pl) * | 2012-10-24 | 2021-11-29 | Prokidney | Populacje komórek nerkowych i ich zastosowania |
| WO2016112779A1 (en) * | 2015-01-17 | 2016-07-21 | Zhejiang University | Modified cells evoking reduced immunogenic responses |
| DE102016109067B4 (de) | 2016-05-17 | 2018-07-19 | Leibniz-Institut Für Polymerforschung Dresden E.V. | Verfahren zur Bildung von Nierentubuli |
| US11123372B2 (en) | 2016-07-29 | 2021-09-21 | Prokidney | Bioactive renal cells for the treatment of chronic kidney disease |
| CN106166161A (zh) * | 2016-08-03 | 2016-11-30 | 中国人民解放军总医院 | 用于治疗系膜增生性肾小球肾炎的药物 |
| CN106267192A (zh) * | 2016-09-14 | 2017-01-04 | 中国人民解放军总医院 | 一种用于治疗系膜增生性肾炎的药物 |
| US11889829B2 (en) | 2016-12-14 | 2024-02-06 | Otsuka Pharmaceutical Factory, Inc. | Mammalian cell cryopreservation liquid |
| WO2018183625A1 (en) * | 2017-03-30 | 2018-10-04 | Wake Forest University Health Sciences | Methods of treatment for kidney disease |
| JPWO2019045049A1 (ja) * | 2017-09-01 | 2020-12-03 | 学校法人帝京大学 | 腎尿細管細胞特異的発現ベクター |
| JP7016185B2 (ja) * | 2018-03-28 | 2022-02-04 | 国立大学法人大阪大学 | 幹細胞由来涙腺組織の作製方法 |
| US11331333B2 (en) | 2019-11-08 | 2022-05-17 | Georg-August-Universität Göttingen Stiftung Öffentichen Rechts, Universitätsmadizin | Treatment of aberrant fibroblast proliferation |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| US5574205A (en) | 1989-07-25 | 1996-11-12 | Cell Genesys | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| JPH06506105A (ja) | 1990-08-29 | 1994-07-14 | ファーミング ビーブイ | 哺乳動物細胞における相同性組換え |
| US5342761A (en) | 1990-10-01 | 1994-08-30 | Research Development Foundation | Oncofetal gene, gene product and uses therefor |
| US5286632A (en) | 1991-01-09 | 1994-02-15 | Jones Douglas H | Method for in vivo recombination and mutagenesis |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US5355699A (en) * | 1992-04-16 | 1994-10-18 | Tsudakoma Kogyo Kabushiki Kaisha | Flat knitting machine and a method of operating the rocking sinkers of the flat knitting machine |
| US5320962A (en) | 1992-07-22 | 1994-06-14 | Duke University | DNA encoding the human A1 adenosine receptor |
| JPH11313675A (ja) * | 1998-04-30 | 1999-11-16 | Hoechst Marion Roussel Kk | ヒトｂｍｐ−７プロモーターおよびこれを用いた骨関連物質の探索法 |
| US6355699B1 (en) | 1999-06-30 | 2002-03-12 | Ethicon, Inc. | Process for manufacturing biomedical foams |
| US6759039B2 (en) | 2000-06-30 | 2004-07-06 | Amcyte, Inc. | Culturing pancreatic stem cells having a specified, intermediate stage of development |
| WO2002061053A1 (en) * | 2001-01-31 | 2002-08-08 | The General Hospital Corporation | Renal stem cells and uses thereof |
| US6458588B1 (en) * | 2001-01-31 | 2002-10-01 | The General Hospital Corporation | Renal stem cells and uses thereof |
| CA2530421C (en) | 2003-06-27 | 2015-04-21 | Ethicon, Incorporated | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| CA2536909A1 (en) * | 2003-08-29 | 2005-03-10 | Regents Of The University Of Minnesota | Kidney derived stem cells and methods for their isolation, differentiation and use |
| US8039258B2 (en) | 2004-09-28 | 2011-10-18 | Ethicon, Inc. | Tissue-engineering scaffolds containing self-assembled-peptide hydrogels |
| WO2006101548A2 (en) | 2004-12-21 | 2006-09-28 | Ethicon, Inc. | Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same |
| US20060166361A1 (en) | 2004-12-21 | 2006-07-27 | Agnieszka Seyda | Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same |
| US20060153815A1 (en) | 2004-12-21 | 2006-07-13 | Agnieszka Seyda | Tissue engineering devices for the repair and regeneration of tissue |
| EP1835924B1 (en) | 2004-12-23 | 2013-08-21 | Ethicon, Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
| JP5340599B2 (ja) | 2004-12-23 | 2013-11-13 | エシコン・インコーポレイテッド | 臍帯組織由来産褥細胞ならびにその製造方法および使用方法 |
| PL1971681T3 (pl) | 2005-12-16 | 2018-01-31 | Depuy Synthes Products Inc | Kompozycje oraz sposoby do hamowania niepożądanej odpowiedzi immunologicznej w przypadku transplantacji z brakiem zgodności tkankowej |
| JP5179376B2 (ja) | 2005-12-19 | 2013-04-10 | エシコン・インコーポレイテッド | ローラーボトルでの分娩後取り出し細胞の体外増殖 |
| WO2007076522A2 (en) | 2005-12-28 | 2007-07-05 | Ethicon, Incorporated | Treatment of peripheral vascular disease using postpartum-derived cells |
| AU2007308168B2 (en) | 2006-10-12 | 2013-09-26 | Ethicon, Inc. | Kidney-derived cells and methods of use in tissue repair and regeneration |
| ES2524443T3 (es) | 2006-11-13 | 2014-12-09 | DePuy Synthes Products, LLC | Expansión in vitro de células postparto usando microportadores |
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| PT2078073E (pt) | 2013-11-11 |
| SI2078073T1 (sl) | 2013-11-29 |
| US10500230B2 (en) | 2019-12-10 |
| US10413571B2 (en) | 2019-09-17 |
| WO2008045498A1 (en) | 2008-04-17 |
| PL2078073T3 (pl) | 2013-12-31 |
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