CN101595212B - 肾源细胞及在组织修复和再生中的使用方法 - Google Patents

肾源细胞及在组织修复和再生中的使用方法 Download PDF

Info

Publication number
CN101595212B
CN101595212B CN200780045631.3A CN200780045631A CN101595212B CN 101595212 B CN101595212 B CN 101595212B CN 200780045631 A CN200780045631 A CN 200780045631A CN 101595212 B CN101595212 B CN 101595212B
Authority
CN
China
Prior art keywords
cells
kidney
cell
derived
renal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200780045631.3A
Other languages
English (en)
Chinese (zh)
Other versions
CN101595212A (zh
Inventor
D·C·科尔特
A·西达
C·S·比恩苏西索
A·戈西夫斯卡
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johnson and Johnson Medical SAS
Original Assignee
Ethicon SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethicon SAS filed Critical Ethicon SAS
Publication of CN101595212A publication Critical patent/CN101595212A/zh
Application granted granted Critical
Publication of CN101595212B publication Critical patent/CN101595212B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0687—Renal stem cells; Renal progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
CN200780045631.3A 2006-10-12 2007-10-11 肾源细胞及在组织修复和再生中的使用方法 Expired - Fee Related CN101595212B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82923806P 2006-10-12 2006-10-12
US60/829,238 2006-10-12
PCT/US2007/021708 WO2008045498A1 (en) 2006-10-12 2007-10-11 Kidney-derived cells and methods of use in tissue repair and regeneration

Publications (2)

Publication Number Publication Date
CN101595212A CN101595212A (zh) 2009-12-02
CN101595212B true CN101595212B (zh) 2014-04-30

Family

ID=39116540

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200780045631.3A Expired - Fee Related CN101595212B (zh) 2006-10-12 2007-10-11 肾源细胞及在组织修复和再生中的使用方法

Country Status (12)

Country Link
US (2) US10500230B2 (enExample)
EP (1) EP2078073B1 (enExample)
JP (1) JP5450072B2 (enExample)
CN (1) CN101595212B (enExample)
AU (1) AU2007308168B2 (enExample)
CA (1) CA2673521C (enExample)
DK (1) DK2078073T3 (enExample)
ES (1) ES2432395T3 (enExample)
PL (1) PL2078073T3 (enExample)
PT (1) PT2078073E (enExample)
SI (1) SI2078073T1 (enExample)
WO (1) WO2008045498A1 (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7862810B2 (en) * 2000-07-31 2011-01-04 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
US20110091428A1 (en) * 2000-07-31 2011-04-21 New York Medical College Compositions of adult organ stem cells and uses thereof
CA2530421C (en) 2003-06-27 2015-04-21 Ethicon, Incorporated Repair and regeneration of ocular tissue using postpartum-derived cells
US8518390B2 (en) 2003-06-27 2013-08-27 Advanced Technologies And Regenerative Medicine, Llc Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells
US8491883B2 (en) * 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US7875272B2 (en) * 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US20060153815A1 (en) * 2004-12-21 2006-07-13 Agnieszka Seyda Tissue engineering devices for the repair and regeneration of tissue
US20060166361A1 (en) * 2004-12-21 2006-07-27 Agnieszka Seyda Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
WO2006101548A2 (en) * 2004-12-21 2006-09-28 Ethicon, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
JP5340599B2 (ja) 2004-12-23 2013-11-13 エシコン・インコーポレイテッド 臍帯組織由来産褥細胞ならびにその製造方法および使用方法
EP1835924B1 (en) 2004-12-23 2013-08-21 Ethicon, Incorporated Treatment of parkinson's disease and related disorders using postpartum derived cells
PL1971681T3 (pl) 2005-12-16 2018-01-31 Depuy Synthes Products Inc Kompozycje oraz sposoby do hamowania niepożądanej odpowiedzi immunologicznej w przypadku transplantacji z brakiem zgodności tkankowej
JP5179376B2 (ja) * 2005-12-19 2013-04-10 エシコン・インコーポレイテッド ローラーボトルでの分娩後取り出し細胞の体外増殖
WO2007076522A2 (en) * 2005-12-28 2007-07-05 Ethicon, Incorporated Treatment of peripheral vascular disease using postpartum-derived cells
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
JP2009525781A (ja) 2006-02-02 2009-07-16 イノベーティブ バイオ セラピーズ 細胞をベースとする体外治療装置および送達システム
AU2007308168B2 (en) 2006-10-12 2013-09-26 Ethicon, Inc. Kidney-derived cells and methods of use in tissue repair and regeneration
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
EP2162529B1 (en) 2007-06-08 2019-03-27 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
US9580688B2 (en) 2007-06-08 2017-02-28 Wake Forest University Health Sciences Kidney structures and methods of forming the same
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
JP5323832B2 (ja) 2007-08-07 2013-10-23 アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー 酸性水溶液中にｇｄｆ−５を含むタンパク質製剤
JP5323845B2 (ja) * 2007-10-05 2013-10-23 エシコン・インコーポレイテッド ヒト臍帯組織由来細胞を用いた腎組織の修復および再建
US8236538B2 (en) * 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
BRPI0911048A2 (pt) 2008-04-14 2015-12-29 Atrm Llc formulações líquidas tamponadas de gdf-5
AU2009327485A1 (en) * 2008-06-18 2010-06-24 Cytopherx, Inc. Methods for propagation of renal precursor cells
AU2009308094A1 (en) * 2008-10-24 2010-04-29 Childrens Hospital Los Angeles Amniotic fluid cells and uses thereof
EP2186883A1 (en) * 2008-11-04 2010-05-19 Fresenius Medical Care An isolated multipotent mesenchymal stem cell from human adult glomeruli (hGL-MSC), a method of preparing thereof and uses thereof in the regenerative medicine of the kidney
JP5974233B2 (ja) 2008-11-12 2016-08-24 リージェンメド（ケイマン）エルティーディー． 単離した腎細胞およびその使用
WO2010057013A1 (en) 2008-11-14 2010-05-20 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
US20100151575A1 (en) * 2008-12-15 2010-06-17 Colter David C Method of Making Conditioned Media from Kidney Derived Cells
US10179900B2 (en) * 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
CA2747794C (en) 2008-12-19 2018-10-30 Advanced Technologies And Regenerative Medicine, Llc Treatment of lung and pulmonary diseases and disorders
EP2379089B1 (en) * 2008-12-19 2019-04-17 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue following injury
CA2747757C (en) * 2008-12-19 2020-11-03 Ethicon, Incorporated Umbilical cord tissue derived cells for treating neuropathic pain and spasticity
CN102498204B (zh) 2009-03-26 2015-02-04 德普伊新特斯产品有限责任公司 人脐带组织细胞作为用于阿尔茨海默病的疗法
US20110142805A1 (en) 2009-12-15 2011-06-16 Advanced Technologies And Regenerative Medicine, Llc Method of renal repair and regeneration and the treatment of diabetic nephropathy
EP2569418B1 (en) * 2010-05-12 2016-11-02 RegenMed (Cayman) Ltd. Bioactive renal cells
KR102302069B1 (ko) 2010-11-10 2021-09-14 인리젠 장기 확대를 위한 주사가능 제제
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
US20120156780A1 (en) 2010-12-21 2012-06-21 Cooper Kevin L Polymer Substrates Having Improved Biological Response From HKDCS
US20120156433A1 (en) 2010-12-21 2012-06-21 Natarajan Sriram N Silicone polymer substrates having improved biological response from hkdcs
WO2012166668A1 (en) * 2011-05-27 2012-12-06 Christian Kazanecki Bioartificial proximal tubule systems and methods of use
US20130157368A1 (en) * 2011-12-20 2013-06-20 Advanced Technologies And Regenerative Medicine, Llc Induced pluripotent stem cells prepared from human kidney-derived cells
PL3567099T3 (pl) * 2012-10-24 2021-11-29 Prokidney Populacje komórek nerkowych i ich zastosowania
WO2016112779A1 (en) * 2015-01-17 2016-07-21 Zhejiang University Modified cells evoking reduced immunogenic responses
DE102016109067B4 (de) 2016-05-17 2018-07-19 Leibniz-Institut Für Polymerforschung Dresden E.V. Verfahren zur Bildung von Nierentubuli
US11123372B2 (en) 2016-07-29 2021-09-21 Prokidney Bioactive renal cells for the treatment of chronic kidney disease
CN106166161A (zh) * 2016-08-03 2016-11-30 中国人民解放军总医院 用于治疗系膜增生性肾小球肾炎的药物
CN106267192A (zh) * 2016-09-14 2017-01-04 中国人民解放军总医院 一种用于治疗系膜增生性肾炎的药物
US11889829B2 (en) 2016-12-14 2024-02-06 Otsuka Pharmaceutical Factory, Inc. Mammalian cell cryopreservation liquid
WO2018183625A1 (en) * 2017-03-30 2018-10-04 Wake Forest University Health Sciences Methods of treatment for kidney disease
JPWO2019045049A1 (ja) * 2017-09-01 2020-12-03 学校法人帝京大学 腎尿細管細胞特異的発現ベクター
JP7016185B2 (ja) * 2018-03-28 2022-02-04 国立大学法人大阪大学 幹細胞由来涙腺組織の作製方法
US11331333B2 (en) 2019-11-08 2022-05-17 Georg-August-Universität Göttingen Stiftung Öffentichen Rechts, Universitätsmadizin Treatment of aberrant fibroblast proliferation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1307643A (zh) * 1998-04-30 2001-08-08 赫斯特·马里恩·鲁索公司 人bmp－7启动子以及用其探测骨相关物质的方法
WO2002061053A1 (en) * 2001-01-31 2002-08-08 The General Hospital Corporation Renal stem cells and uses thereof
WO2005021738A1 (en) * 2003-08-29 2005-03-10 Regents Of The University Of Minnesota Kidney derived stem cells and methods for their isolation, differentiation and use

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2646438B1 (fr) 1989-03-20 2007-11-02 Pasteur Institut Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration
US5574205A (en) 1989-07-25 1996-11-12 Cell Genesys Homologous recombination for universal donor cells and chimeric mammalian hosts
JPH06506105A (ja) 1990-08-29 1994-07-14 ファーミング　ビーブイ 哺乳動物細胞における相同性組換え
US5342761A (en) 1990-10-01 1994-08-30 Research Development Foundation Oncofetal gene, gene product and uses therefor
US5286632A (en) 1991-01-09 1994-02-15 Jones Douglas H Method for in vivo recombination and mutagenesis
WO1993004169A1 (en) 1991-08-20 1993-03-04 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US5355699A (en) * 1992-04-16 1994-10-18 Tsudakoma Kogyo Kabushiki Kaisha Flat knitting machine and a method of operating the rocking sinkers of the flat knitting machine
US5320962A (en) 1992-07-22 1994-06-14 Duke University DNA encoding the human A1 adenosine receptor
US6355699B1 (en) 1999-06-30 2002-03-12 Ethicon, Inc. Process for manufacturing biomedical foams
US6759039B2 (en) 2000-06-30 2004-07-06 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
US6458588B1 (en) * 2001-01-31 2002-10-01 The General Hospital Corporation Renal stem cells and uses thereof
CA2530421C (en) 2003-06-27 2015-04-21 Ethicon, Incorporated Repair and regeneration of ocular tissue using postpartum-derived cells
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US8039258B2 (en) 2004-09-28 2011-10-18 Ethicon, Inc. Tissue-engineering scaffolds containing self-assembled-peptide hydrogels
WO2006101548A2 (en) 2004-12-21 2006-09-28 Ethicon, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
US20060166361A1 (en) 2004-12-21 2006-07-27 Agnieszka Seyda Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
US20060153815A1 (en) 2004-12-21 2006-07-13 Agnieszka Seyda Tissue engineering devices for the repair and regeneration of tissue
EP1835924B1 (en) 2004-12-23 2013-08-21 Ethicon, Incorporated Treatment of parkinson's disease and related disorders using postpartum derived cells
JP5340599B2 (ja) 2004-12-23 2013-11-13 エシコン・インコーポレイテッド 臍帯組織由来産褥細胞ならびにその製造方法および使用方法
PL1971681T3 (pl) 2005-12-16 2018-01-31 Depuy Synthes Products Inc Kompozycje oraz sposoby do hamowania niepożądanej odpowiedzi immunologicznej w przypadku transplantacji z brakiem zgodności tkankowej
JP5179376B2 (ja) 2005-12-19 2013-04-10 エシコン・インコーポレイテッド ローラーボトルでの分娩後取り出し細胞の体外増殖
WO2007076522A2 (en) 2005-12-28 2007-07-05 Ethicon, Incorporated Treatment of peripheral vascular disease using postpartum-derived cells
AU2007308168B2 (en) 2006-10-12 2013-09-26 Ethicon, Inc. Kidney-derived cells and methods of use in tissue repair and regeneration
ES2524443T3 (es) 2006-11-13 2014-12-09 DePuy Synthes Products, LLC Expansión in vitro de células postparto usando microportadores

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1307643A (zh) * 1998-04-30 2001-08-08 赫斯特·马里恩·鲁索公司 人bmp－7启动子以及用其探测骨相关物质的方法
WO2002061053A1 (en) * 2001-01-31 2002-08-08 The General Hospital Corporation Renal stem cells and uses thereof
WO2005021738A1 (en) * 2003-08-29 2005-03-10 Regents Of The University Of Minnesota Kidney derived stem cells and methods for their isolation, differentiation and use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Costanza Sagrinati等.Isolation and Characterization of Multipotent Progenitor Cells from the Bowman’s Capsule of Adult Human Kidneys.《Journal of the American Society of Nephrology》.2006,第17卷(第9期), *
王跃春等.人胎肾间充质样干细胞分离鉴定及其向脂肪和成骨细胞的分化.《中国临床康复》.2006,第10卷(第25期), *

Also Published As

Publication number Publication date
AU2007308168A1 (en) 2008-04-17
CA2673521C (en) 2017-01-17
CN101595212A (zh) 2009-12-02
JP2010506563A (ja) 2010-03-04
DK2078073T3 (da) 2013-10-28
EP2078073A1 (en) 2009-07-15
EP2078073B1 (en) 2013-07-24
US20080112939A1 (en) 2008-05-15
CA2673521A1 (en) 2008-04-17
AU2007308168B2 (en) 2013-09-26
JP5450072B2 (ja) 2014-03-26
ES2432395T3 (es) 2013-12-03
US20160375062A1 (en) 2016-12-29
PT2078073E (pt) 2013-11-11
SI2078073T1 (sl) 2013-11-29
US10500230B2 (en) 2019-12-10
US10413571B2 (en) 2019-09-17
WO2008045498A1 (en) 2008-04-17
PL2078073T3 (pl) 2013-12-31

Similar Documents

Publication Publication Date Title
CN101595212B (zh) 肾源细胞及在组织修复和再生中的使用方法
Liu et al. Stem cells: a potential treatment option for kidney diseases
Golpanian et al. Rebuilding the damaged heart: mesenchymal stem cells, cell-based therapy, and engineered heart tissue
RU2668389C2 (ru) МОДУЛЯЦИЯ hUTC ПРОВОСПАЛИТЕЛЬНЫХ МЕДИАТОРОВ ЛЕГОЧНЫХ И ПУЛЬМОНАЛЬНЫХ ЗАБОЛЕВАНИЙ И РАССТРОЙСТВ
KR101557256B1 (ko) 세포 증식 방법 및 세포의 용도 및 치료를 위해 그 세포에 의해 제조되는 조절된 배지
EP2422622B1 (en) Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US20030180268A1 (en) Tissue engineered construct for supplementing or replacing a damaged organ
JP5937210B2 (ja) 臍帯組織由来細胞を用いた末梢血管疾患の治療
ES2911718T3 (es) Células madre estromales derivadas de tejido adiposo para su uso en el tratamiento de fístulas perianales complejas resistentes en enfermedad de Crohn
CN102387807A (zh) 肺部疾病和病症的治疗
CN115361960A (zh) 用于治疗慢性移植物抗宿主病的方法
US20250073272A1 (en) Production of enhanced stem cell-based exosomes and uses in scar tissue prevention and treatment
CN120549981A (zh) 用于治疗肺纤维化的双干细胞协同移植组合物及其应用
ZA200507446B (en) Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
Hongbao et al. Brookdale Hospital, Brooklyn, New York 11212, USA; 2 Cambridge, MA 02138, USA ma8080@ gmail. com
Shirwan et al. New frontiers and new technologies
Hongbao et al. Bone Marrow Stem Cell

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20140430