CA2673521C - Kidney-derived cells and methods of use in tissue repair and regeneration - Google Patents

Kidney-derived cells and methods of use in tissue repair and regeneration Download PDF

Info

Publication number
CA2673521C
CA2673521C CA2673521A CA2673521A CA2673521C CA 2673521 C CA2673521 C CA 2673521C CA 2673521 A CA2673521 A CA 2673521A CA 2673521 A CA2673521 A CA 2673521A CA 2673521 C CA2673521 C CA 2673521C
Authority
CA
Canada
Prior art keywords
kidney
cells
cell
cell population
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2673521A
Other languages
English (en)
French (fr)
Other versions
CA2673521A1 (en
Inventor
David C. Colter
Agnieszka Seyda
Charito S. Buensuceso
Anna Gosiewska
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DePuy Synthes Products Inc
Original Assignee
DePuy Synthes Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DePuy Synthes Products Inc filed Critical DePuy Synthes Products Inc
Publication of CA2673521A1 publication Critical patent/CA2673521A1/en
Application granted granted Critical
Publication of CA2673521C publication Critical patent/CA2673521C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0687—Renal stem cells; Renal progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
CA2673521A 2006-10-12 2007-10-11 Kidney-derived cells and methods of use in tissue repair and regeneration Expired - Fee Related CA2673521C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82923806P 2006-10-12 2006-10-12
US60/829,238 2006-10-12
PCT/US2007/021708 WO2008045498A1 (en) 2006-10-12 2007-10-11 Kidney-derived cells and methods of use in tissue repair and regeneration

Publications (2)

Publication Number Publication Date
CA2673521A1 CA2673521A1 (en) 2008-04-17
CA2673521C true CA2673521C (en) 2017-01-17

Family

ID=39116540

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2673521A Expired - Fee Related CA2673521C (en) 2006-10-12 2007-10-11 Kidney-derived cells and methods of use in tissue repair and regeneration

Country Status (12)

Country Link
US (2) US10500230B2 (enExample)
EP (1) EP2078073B1 (enExample)
JP (1) JP5450072B2 (enExample)
CN (1) CN101595212B (enExample)
AU (1) AU2007308168B2 (enExample)
CA (1) CA2673521C (enExample)
DK (1) DK2078073T3 (enExample)
ES (1) ES2432395T3 (enExample)
PL (1) PL2078073T3 (enExample)
PT (1) PT2078073E (enExample)
SI (1) SI2078073T1 (enExample)
WO (1) WO2008045498A1 (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110091428A1 (en) * 2000-07-31 2011-04-21 New York Medical College Compositions of adult organ stem cells and uses thereof
US7862810B2 (en) * 2000-07-31 2011-01-04 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
US20100158880A1 (en) * 2008-12-19 2010-06-24 Ethicon, Incorporated Regeneration and repair of neural tissue following injury
US8491883B2 (en) * 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
ES2569780T3 (es) * 2003-06-27 2016-05-12 DePuy Synthes Products, Inc. Células posparto derivadas de tejido placentario y métodos de preparación y uso de las mismas
US8518390B2 (en) 2003-06-27 2013-08-27 Advanced Technologies And Regenerative Medicine, Llc Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells
WO2006083394A2 (en) * 2004-12-21 2006-08-10 Ethicon, Inc. Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
WO2006101548A2 (en) * 2004-12-21 2006-09-28 Ethicon, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
US20060153815A1 (en) * 2004-12-21 2006-07-13 Agnieszka Seyda Tissue engineering devices for the repair and regeneration of tissue
CA2589063C (en) 2004-12-23 2016-08-09 DePuy Synthes Products, Inc. Treatment of parkinson's disease and related disorders using postpartum derived cells
ES2621847T3 (es) * 2004-12-23 2017-07-05 DePuy Synthes Products, Inc. Células posparto derivadas de tejido de cordón umbilical, y métodos de elaboración y uso de las mismas
US9175261B2 (en) 2005-12-16 2015-11-03 DePuy Synthes Products, Inc. Human umbilical cord tissue cells for inhibiting adverse immune response in histocompatibility-mismatched transplantation
ES2391034T3 (es) * 2005-12-19 2012-11-20 Ethicon, Inc. Expansión in vitro de células derivadas postparto en frascos rotatorios
CN101437576A (zh) * 2005-12-28 2009-05-20 伊西康公司 使用产后衍生细胞治疗外周血管疾病
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US8048419B2 (en) 2006-02-02 2011-11-01 Innovative Biotherapies, Inc. Extracorporeal cell-based therapeutic device and delivery system
DK2078073T3 (da) 2006-10-12 2013-10-28 Ethicon Inc Nyreafledte celler og fremgangsmåder til anvendelse deraf til vævsreparation og -regenerering
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
JP2010528658A (ja) * 2007-06-08 2010-08-26 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 腎不全の治療のための選択的細胞治療
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
CN101801405A (zh) 2007-08-07 2010-08-11 先进科技及再生医学有限责任公司 包含于酸性水溶液中的gdf-5的蛋白质配方
EP2203186B1 (en) * 2007-10-05 2014-09-24 DePuy Synthes Products, LLC Repair and regeneration of renal tissue using human umbilical cord tissue-derived cells
US8236538B2 (en) * 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
JP5599778B2 (ja) 2008-04-14 2014-10-01 デピュイ・シンセス・プロダクツ・エルエルシー 液体緩衝gdf−5製剤
CA2728215A1 (en) * 2008-06-18 2010-06-24 Innovative Biotherapies, Inc. Methods for enhanced propagation of cells
US20110256110A1 (en) * 2008-10-24 2011-10-20 Children's Hospital Los Angeles Amniotic fluid cells and uses thereof
EP2186883A1 (en) * 2008-11-04 2010-05-19 Fresenius Medical Care An isolated multipotent mesenchymal stem cell from human adult glomeruli (hGL-MSC), a method of preparing thereof and uses thereof in the regenerative medicine of the kidney
KR102428795B1 (ko) 2008-11-12 2022-08-04 인리젠 분리된 신장 세포 및 이의 용도
WO2010057013A1 (en) 2008-11-14 2010-05-20 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
WO2010057015A1 (en) * 2008-11-14 2010-05-20 Wake Forest University Health Sciences Kidney structures and methods of forming the same
US20100151575A1 (en) * 2008-12-15 2010-06-17 Colter David C Method of Making Conditioned Media from Kidney Derived Cells
WO2010071862A1 (en) * 2008-12-19 2010-06-24 Ethicon, Incorporated Umbilical cord tissue derived cells for treating neuropathic pain and spasticity
US10557116B2 (en) 2008-12-19 2020-02-11 DePuy Synthes Products, Inc. Treatment of lung and pulmonary diseases and disorders
US10179900B2 (en) * 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
PL2411504T3 (pl) 2009-03-26 2017-10-31 Depuy Synthes Products Inc Komórki ludzkiej tkanki pępowinowej jako terapia choroby Alzheimera
US20110142805A1 (en) * 2009-12-15 2011-06-16 Advanced Technologies And Regenerative Medicine, Llc Method of renal repair and regeneration and the treatment of diabetic nephropathy
ES2906750T3 (es) 2010-05-12 2022-04-20 Prokidney Células renales bioactivas
US9724367B2 (en) 2010-11-10 2017-08-08 Regenmed (Cayman) Ltd. Injectable formulations for organ augmentation
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
US20120156433A1 (en) 2010-12-21 2012-06-21 Natarajan Sriram N Silicone polymer substrates having improved biological response from hkdcs
US20120156780A1 (en) 2010-12-21 2012-06-21 Cooper Kevin L Polymer Substrates Having Improved Biological Response From HKDCS
CN103842497A (zh) 2011-05-27 2014-06-04 德普伊新特斯产品有限责任公司 生物人工近端小管系统及使用方法
US20130157368A1 (en) * 2011-12-20 2013-06-20 Advanced Technologies And Regenerative Medicine, Llc Induced pluripotent stem cells prepared from human kidney-derived cells
AU2013334276B2 (en) * 2012-10-24 2019-07-04 ProKidney IPCo, LLC Renal cell populations and uses thereof
CN107208055B (zh) * 2015-01-17 2021-06-15 浙江大学 引起免疫原性反应降低的被修饰细胞
DE102016109067B4 (de) 2016-05-17 2018-07-19 Leibniz-Institut Für Polymerforschung Dresden E.V. Verfahren zur Bildung von Nierentubuli
US11123372B2 (en) 2016-07-29 2021-09-21 Prokidney Bioactive renal cells for the treatment of chronic kidney disease
CN106166161A (zh) * 2016-08-03 2016-11-30 中国人民解放军总医院 用于治疗系膜增生性肾小球肾炎的药物
CN106267192A (zh) * 2016-09-14 2017-01-04 中国人民解放军总医院 一种用于治疗系膜增生性肾炎的药物
WO2018110159A1 (ja) * 2016-12-14 2018-06-21 株式会社大塚製薬工場 哺乳動物細胞凍結保存液
WO2018183625A1 (en) * 2017-03-30 2018-10-04 Wake Forest University Health Sciences Methods of treatment for kidney disease
WO2019045049A1 (ja) * 2017-09-01 2019-03-07 学校法人帝京大学 腎尿細管細胞特異的発現ベクター
WO2019189640A1 (ja) 2018-03-28 2019-10-03 国立大学法人大阪大学 幹細胞由来涙腺組織の作製方法
US11331333B2 (en) 2019-11-08 2022-05-17 Georg-August-Universität Göttingen Stiftung Öffentichen Rechts, Universitätsmadizin Treatment of aberrant fibroblast proliferation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2646438B1 (fr) 1989-03-20 2007-11-02 Pasteur Institut Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration
US5574205A (en) 1989-07-25 1996-11-12 Cell Genesys Homologous recombination for universal donor cells and chimeric mammalian hosts
CA2090473A1 (en) 1990-08-29 1992-03-01 Robert M. Kay Homologous recombinatin in mammalian cells
US5342761A (en) * 1990-10-01 1994-08-30 Research Development Foundation Oncofetal gene, gene product and uses therefor
US5286632A (en) * 1991-01-09 1994-02-15 Jones Douglas H Method for in vivo recombination and mutagenesis
WO1993004169A1 (en) 1991-08-20 1993-03-04 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US5355699A (en) * 1992-04-16 1994-10-18 Tsudakoma Kogyo Kabushiki Kaisha Flat knitting machine and a method of operating the rocking sinkers of the flat knitting machine
US5320962A (en) * 1992-07-22 1994-06-14 Duke University DNA encoding the human A1 adenosine receptor
JPH11313675A (ja) * 1998-04-30 1999-11-16 Hoechst Marion Roussel Kk ヒトbmp−7プロモーターおよびこれを用いた骨関連物質の探索法
US6355699B1 (en) 1999-06-30 2002-03-12 Ethicon, Inc. Process for manufacturing biomedical foams
US6759039B2 (en) * 2000-06-30 2004-07-06 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
US6458588B1 (en) * 2001-01-31 2002-10-01 The General Hospital Corporation Renal stem cells and uses thereof
WO2002061053A1 (en) * 2001-01-31 2002-08-08 The General Hospital Corporation Renal stem cells and uses thereof
ES2569780T3 (es) 2003-06-27 2016-05-12 DePuy Synthes Products, Inc. Células posparto derivadas de tejido placentario y métodos de preparación y uso de las mismas
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
WO2005021738A1 (en) * 2003-08-29 2005-03-10 Regents Of The University Of Minnesota Kidney derived stem cells and methods for their isolation, differentiation and use
US8039258B2 (en) 2004-09-28 2011-10-18 Ethicon, Inc. Tissue-engineering scaffolds containing self-assembled-peptide hydrogels
US20060153815A1 (en) 2004-12-21 2006-07-13 Agnieszka Seyda Tissue engineering devices for the repair and regeneration of tissue
WO2006083394A2 (en) 2004-12-21 2006-08-10 Ethicon, Inc. Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
WO2006101548A2 (en) 2004-12-21 2006-09-28 Ethicon, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
CA2589063C (en) 2004-12-23 2016-08-09 DePuy Synthes Products, Inc. Treatment of parkinson's disease and related disorders using postpartum derived cells
ES2621847T3 (es) 2004-12-23 2017-07-05 DePuy Synthes Products, Inc. Células posparto derivadas de tejido de cordón umbilical, y métodos de elaboración y uso de las mismas
US9175261B2 (en) 2005-12-16 2015-11-03 DePuy Synthes Products, Inc. Human umbilical cord tissue cells for inhibiting adverse immune response in histocompatibility-mismatched transplantation
ES2391034T3 (es) 2005-12-19 2012-11-20 Ethicon, Inc. Expansión in vitro de células derivadas postparto en frascos rotatorios
CN101437576A (zh) 2005-12-28 2009-05-20 伊西康公司 使用产后衍生细胞治疗外周血管疾病
DK2078073T3 (da) 2006-10-12 2013-10-28 Ethicon Inc Nyreafledte celler og fremgangsmåder til anvendelse deraf til vævsreparation og -regenerering
ES2524443T3 (es) 2006-11-13 2014-12-09 DePuy Synthes Products, LLC Expansión in vitro de células postparto usando microportadores

Also Published As

Publication number Publication date
CN101595212B (zh) 2014-04-30
EP2078073A1 (en) 2009-07-15
PT2078073E (pt) 2013-11-11
JP5450072B2 (ja) 2014-03-26
ES2432395T3 (es) 2013-12-03
PL2078073T3 (pl) 2013-12-31
US10500230B2 (en) 2019-12-10
SI2078073T1 (sl) 2013-11-29
CA2673521A1 (en) 2008-04-17
AU2007308168A1 (en) 2008-04-17
US20080112939A1 (en) 2008-05-15
JP2010506563A (ja) 2010-03-04
US10413571B2 (en) 2019-09-17
DK2078073T3 (da) 2013-10-28
EP2078073B1 (en) 2013-07-24
US20160375062A1 (en) 2016-12-29
CN101595212A (zh) 2009-12-02
WO2008045498A1 (en) 2008-04-17
AU2007308168B2 (en) 2013-09-26

Similar Documents

Publication Publication Date Title
US10413571B2 (en) Kidney-derived cells and methods of use in tissue repair and regeneration
US20240360408A1 (en) Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs
KR101557256B1 (ko) 세포 증식 방법 및 세포의 용도 및 치료를 위해 그 세포에 의해 제조되는 조절된 배지
US20110171182A1 (en) Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
US20120207790A1 (en) Immunosuppressing agent comprising mesenchymal stem cell derived from adipose tissue, and use thereof
US20070249045A1 (en) Adipose derived adult stem cells in hepatic regeneration
US12291725B2 (en) Systems and methods for producing injectable enhanced stem cell exosomes, improved exosomes and methods of use
KR20180120261A (ko) 크론병의 난치성 복합 항문주위 누공 치료용 지방 조직 유래 기질 줄기 세포
Wang et al. A new scaffold containing small intestinal submucosa and mesenchymal stem cells improves pancreatic islet function and survival in vitro and in vivo
Navaei-Nigjeh et al. Reduction of marginal mass required for successful islet transplantation in a diabetic rat model using adipose tissue–derived mesenchymal stromal cells
JP2005287479A (ja) 組織幹細胞採取方法及びそれを利用した装置
JP2018035149A (ja) 臍帯血造血幹細胞支持物
CN114762697B (zh) 用于治疗糖尿病的药物及方法
US20250073272A1 (en) Production of enhanced stem cell-based exosomes and uses in scar tissue prevention and treatment
Matsumoto et al. Renal regeneration: stem cell-based therapies to battle kidney disease
EP3739040B1 (en) Sheeting method for pluripotent stem cell-derived cells
JPWO2018225703A1 (ja) 分化誘導細胞の調製方法
Ray Banerjee Some Concepts in Studies of Kidney Regeneration
HK1177759B (en) Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20221011