ES2392073T3 - Formulación farmacéutica líquida estable de anticuerpos IGG - Google Patents
Formulación farmacéutica líquida estable de anticuerpos IGG Download PDFInfo
- Publication number
- ES2392073T3 ES2392073T3 ES02802895T ES02802895T ES2392073T3 ES 2392073 T3 ES2392073 T3 ES 2392073T3 ES 02802895 T ES02802895 T ES 02802895T ES 02802895 T ES02802895 T ES 02802895T ES 2392073 T3 ES2392073 T3 ES 2392073T3
- Authority
- ES
- Spain
- Prior art keywords
- clear
- antibody
- formulation
- buffer
- succinate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Landscapes
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| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7588766B1 (en) | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| ATE442862T2 (de) * | 2000-10-12 | 2009-10-15 | Genentech Inc | Niederviskose konzentrierte proteinformulierungen |
| US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| TWI255272B (en) | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| CN1292655C (zh) * | 2001-11-08 | 2007-01-03 | 蛋白质设计实验室股份有限公司 | IgG抗体稳定的液态药物制剂 |
| US20070148171A1 (en) * | 2002-09-27 | 2007-06-28 | Xencor, Inc. | Optimized anti-CD30 antibodies |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| US20040002451A1 (en) * | 2002-06-20 | 2004-01-01 | Bruce Kerwin | Compositions of pegylated soluble tumor necrosis factor receptors and methods of preparing |
| EP1551875A4 (en) * | 2002-06-21 | 2006-06-28 | Biogen Idec Inc | TAMPON PREPARATIONS FOR CONCENTRATING ANTIBODIES AND METHODS FOR USE THEREOF |
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| MY150740A (en) * | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
| AU2003293543A1 (en) * | 2002-12-13 | 2004-07-09 | Abgenix, Inc. | System and method for stabilizing antibodies with histidine |
| US20040208869A1 (en) * | 2003-01-30 | 2004-10-21 | Medimmune, Inc. | Uses of anti-integrin alphanubeta3 antibody formulations |
| US20040208870A1 (en) * | 2003-01-30 | 2004-10-21 | Medimmune, Inc. | Stabilized high concentration anti-integrin alphanubeta3 antibody formulations |
| CA2517310C (en) | 2003-02-28 | 2015-11-24 | Chugai Seiyaku Kabushiki Kaisha | Stabilized protein-containing formulations comprising a poloxamer |
| US20050158303A1 (en) * | 2003-04-04 | 2005-07-21 | Genentech, Inc. | Methods of treating IgE-mediated disorders comprising the administration of high concentration anti-IgE antibody formulations |
| RU2332986C2 (ru) | 2003-04-04 | 2008-09-10 | Дженентек, Инк. | Высококонцентрированные композиции антител и белков |
| PE20050627A1 (es) | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
| CA2544532C (en) * | 2003-11-28 | 2015-06-16 | Micromet Ag | Compositions comprising polypeptides |
| US20050136055A1 (en) * | 2003-12-22 | 2005-06-23 | Pfizer Inc | CD40 antibody formulation and methods |
| NZ548702A (en) * | 2004-01-09 | 2009-06-26 | Pfizer | Antibodies to MAdCAM |
| US20060008415A1 (en) * | 2004-06-25 | 2006-01-12 | Protein Design Labs, Inc. | Stable liquid and lyophilized formulation of proteins |
| US20060051347A1 (en) | 2004-09-09 | 2006-03-09 | Winter Charles M | Process for concentration of antibodies and therapeutic products thereof |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| CA2590337C (en) | 2004-12-15 | 2017-07-11 | Neuralab Limited | Humanized amyloid beta antibodies for use in improving cognition |
| WO2006066049A2 (en) | 2004-12-15 | 2006-06-22 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
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| GT200600033A (es) * | 2005-01-28 | 2006-10-25 | Formulaciones liquidas estabilizadas de polipeptido | |
| AU2012200203B2 (en) * | 2005-03-08 | 2014-07-03 | Pfizer Products Inc. | Anti-CTLA-4 Antibody Compositions |
| AU2014240252B2 (en) * | 2005-03-08 | 2016-10-06 | Pfizer Products Inc | Anti-CTLA-4 Antibody Compositions |
| TW200719913A (en) * | 2005-03-08 | 2007-06-01 | Pharmacia & Upjohn Co Llc | Anti-madcam antibody compositions |
| LT2586459T (lt) | 2005-03-25 | 2017-09-25 | Regeneron Pharmaceuticals, Inc. | Vegf antagonisto kompozicijos |
| US8858935B2 (en) * | 2005-05-19 | 2014-10-14 | Amgen Inc. | Compositions and methods for increasing the stability of antibodies |
| EP3673919A1 (en) | 2005-06-14 | 2020-07-01 | Amgen Inc. | Self-buffering protein formulations |
| JP2008546805A (ja) * | 2005-06-23 | 2008-12-25 | メディミューン，エルエルシー | 最適な凝集および断片化プロフィールを有する抗体製剤 |
| MX2008001068A (es) * | 2005-07-29 | 2008-03-19 | Amgen Inc | Formulacion que inhibe la agregacion de proteina. |
| MX336033B (es) * | 2005-08-03 | 2016-01-07 | Immunogen Inc | Formulaciones de inmunoconjugado. |
| CA2625815A1 (en) * | 2005-09-12 | 2007-03-22 | Novimmune S.A. | Anti-cd3 antibody formulations |
| KR101105871B1 (ko) * | 2005-09-27 | 2012-01-16 | 주식회사 엘지생명과학 | 인 난포자극호르몬의 안정한 용액 제형 |
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| BR112022022620A2 (pt) * | 2020-05-11 | 2022-12-20 | Medimmune Ltd | Formulações de anticorpos anti-il-33 |
| CN115605185A (zh) * | 2020-05-19 | 2023-01-13 | 豪夫迈·罗氏有限公司（Ch） | 螯合剂用于防止胃肠外蛋白质溶液中形成可见颗粒的用途 |
| GB202007655D0 (en) | 2020-05-22 | 2020-07-08 | King S College London | Chimeric nkg2d protein |
| EP4171622B1 (en) | 2021-03-23 | 2024-05-01 | King's College London | Compositions comprising nkg2d, cxcr2, and dap10/dap12 fusion polypeptides and methods of use thereof |
| AU2023236910A1 (en) | 2022-03-14 | 2024-08-01 | LamKap Bio gamma AG | Bispecific gpc3xcd28 and gpc3xcd3 antibodies and their combination for targeted killing of gpc3 positive malignant cells |
| GB202214120D0 (en) | 2022-09-27 | 2022-11-09 | King S College London | Compositions comprising NKG2D, CXCR2, and DAP10/DAP12 fusion polypeptides and methods of use thereof |
| EP4389762A1 (en) | 2022-12-23 | 2024-06-26 | Ospedale San Raffaele S.r.l. | Inhibitors of dux4 activity and their use in therapy. |
| WO2025140467A1 (zh) * | 2023-12-29 | 2025-07-03 | 上海复宏汉霖生物技术股份有限公司 | 稳定的高浓度抗pd-1抗体药物制剂 |
| WO2025196207A1 (en) | 2024-03-20 | 2025-09-25 | King's College London | Compositions and methods for use in depleting senescent cells and treating aging |
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| US5091178A (en) * | 1986-02-21 | 1992-02-25 | Oncogen | Tumor therapy with biologically active anti-tumor antibodies |
| DE68908175T2 (de) | 1988-05-27 | 1994-03-03 | Centocor Inc | Gefriergetrocknete formulierung für antikörperprodukte. |
| JPH04502914A (ja) * | 1988-12-15 | 1992-05-28 | セントユール，インコーポレイテッド | 免疫グロブリンを可溶化するための塩基性アミノ酸の使用 |
| CA2049342A1 (en) | 1989-03-27 | 1990-09-28 | Sally Bolmer | Formulations for stabilizing of igm antibodies |
| US6165467A (en) * | 1991-07-20 | 2000-12-26 | Yoshihide Hagiwara | Stabilized human monoclonal antibody preparation |
| DE69620877T2 (de) * | 1995-02-06 | 2002-12-12 | Genetics Institute, Inc. | Arzneimittelformulierungen für il-12 |
| US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| DK2275119T3 (da) * | 1995-07-27 | 2013-11-11 | Genentech Inc | Stabil, isotonisk lyofiliseret proteinformulering |
| US6685940B2 (en) * | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| GB9610992D0 (en) * | 1996-05-24 | 1996-07-31 | Glaxo Group Ltd | Concentrated antibody preparation |
| EP0852951A1 (de) * | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
| EP0999853B1 (en) * | 1997-06-13 | 2003-01-02 | Genentech, Inc. | Stabilized antibody formulation |
| US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| US6914128B1 (en) * | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
| DK2168984T3 (da) | 1999-03-25 | 2012-12-10 | Abbott Gmbh & Co Kg | Humane antistoffer, som binder humant IL-12, og fremgangsmåder til pro-duktion heraf |
| ATE442862T2 (de) * | 2000-10-12 | 2009-10-15 | Genentech Inc | Niederviskose konzentrierte proteinformulierungen |
| GB0113179D0 (en) * | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
| CN1292655C (zh) * | 2001-11-08 | 2007-01-03 | 蛋白质设计实验室股份有限公司 | IgG抗体稳定的液态药物制剂 |
-
2002
- 2002-11-08 CN CNB028267273A patent/CN1292655C/zh not_active Expired - Fee Related
- 2002-11-08 NZ NZ532896A patent/NZ532896A/en not_active IP Right Cessation
- 2002-11-08 WO PCT/US2002/036093 patent/WO2003039485A2/en not_active Ceased
- 2002-11-08 CA CA2466034A patent/CA2466034C/en not_active Expired - Lifetime
- 2002-11-08 ES ES02802895T patent/ES2392073T3/es not_active Expired - Lifetime
- 2002-11-08 PT PT02802895T patent/PT1441589E/pt unknown
- 2002-11-08 AT AT02802895T patent/ATE556591T1/de active
- 2002-11-08 EP EP02802895A patent/EP1441589B1/en not_active Expired - Lifetime
- 2002-11-08 KR KR1020047006962A patent/KR100913714B1/ko not_active Expired - Fee Related
- 2002-11-08 DK DK02802895.9T patent/DK1441589T3/da active
- 2002-11-08 JP JP2003541777A patent/JP5290489B2/ja not_active Expired - Fee Related
- 2002-11-08 AU AU2002363339A patent/AU2002363339B2/en not_active Ceased
- 2002-11-08 US US10/291,528 patent/US20030138417A1/en not_active Abandoned
- 2002-11-08 IL IL16167702A patent/IL161677A0/xx unknown
-
2004
- 2004-04-29 IL IL161677A patent/IL161677A/en active IP Right Grant
-
2010
- 2010-11-24 US US12/954,512 patent/US20110070231A1/en not_active Abandoned
- 2010-12-10 JP JP2010276222A patent/JP2011068675A/ja active Pending
-
2011
- 2011-09-06 US US13/226,372 patent/US8465739B2/en not_active Expired - Fee Related
-
2016
- 2016-11-17 LU LU93314C patent/LU93314I2/fr unknown
- 2016-12-09 CY CY2016044C patent/CY2016044I1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1441589A4 (en) | 2007-07-04 |
| LU93314I2 (enExample) | 2019-11-20 |
| US20030138417A1 (en) | 2003-07-24 |
| DK1441589T3 (da) | 2012-08-06 |
| HK1074750A1 (en) | 2005-11-25 |
| AU2002363339B2 (en) | 2008-02-07 |
| EP1441589A2 (en) | 2004-08-04 |
| NZ532896A (en) | 2007-08-31 |
| JP5290489B2 (ja) | 2013-09-18 |
| KR20050044365A (ko) | 2005-05-12 |
| JP2005508981A (ja) | 2005-04-07 |
| KR100913714B1 (ko) | 2009-08-24 |
| US20110070231A1 (en) | 2011-03-24 |
| ATE556591T1 (de) | 2012-05-15 |
| CY2016044I2 (el) | 2017-07-12 |
| EP1441589B1 (en) | 2012-05-09 |
| CN1612689A (zh) | 2005-05-04 |
| IL161677A0 (en) | 2004-09-27 |
| CY2016044I1 (el) | 2017-07-12 |
| WO2003039485A3 (en) | 2004-02-12 |
| WO2003039485A2 (en) | 2003-05-15 |
| US20110318343A1 (en) | 2011-12-29 |
| IL161677A (en) | 2010-06-16 |
| CN1292655C (zh) | 2007-01-03 |
| JP2011068675A (ja) | 2011-04-07 |
| CA2466034C (en) | 2012-12-18 |
| PT1441589E (pt) | 2012-08-13 |
| US8465739B2 (en) | 2013-06-18 |
| CA2466034A1 (en) | 2003-05-15 |
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