ES2386782T3 - Prevención y/o tratamiento de la enfermedad cardiovascular y/o la insuficiencia cardíaca asociada - Google Patents
Prevención y/o tratamiento de la enfermedad cardiovascular y/o la insuficiencia cardíaca asociada Download PDFInfo
- Publication number
- ES2386782T3 ES2386782T3 ES03744567T ES03744567T ES2386782T3 ES 2386782 T3 ES2386782 T3 ES 2386782T3 ES 03744567 T ES03744567 T ES 03744567T ES 03744567 T ES03744567 T ES 03744567T ES 2386782 T3 ES2386782 T3 ES 2386782T3
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- Prior art keywords
- copper
- diabetic
- zinc
- agent
- trientine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000018392A1 (en) | 1998-09-25 | 2000-04-06 | Glycox Corporation Limited | Fructosamine oxidase: antagonists and inhibitors |
| EP1471931A4 (en) * | 2001-08-24 | 2006-06-14 | Maine Medical Ct Res Inst | NON-TRADITIONAL EXPORT OF COPPER-DEPENDENT PRO-INFLAMMATORY CYTOKINES AND METHODS, COMPOSITIONS, AND KITS THEREOF |
| US20040038861A1 (en) * | 2001-11-26 | 2004-02-26 | Cooper Garth J. S. | Methods and compositions for normalizing lipid levels in mammalian tissues |
| EP2500018B1 (en) | 2002-03-08 | 2017-07-19 | PhilERA New Zealand Limited | Preventing and/or Treating Cardiovascular Disease and/or Associated Heart Failure |
| US6855340B2 (en) * | 2002-05-24 | 2005-02-15 | Regents Of The University Of Michigan | Copper lowering treatment of inflammatory and fibrotic diseases |
| US20070248689A1 (en) * | 2002-05-24 | 2007-10-25 | Regents Of The University Of Michigan | Copper lowering treatment of inflammatory and fibrotic diseases |
| US20040142393A1 (en) * | 2002-08-01 | 2004-07-22 | Cooper Garth James Smith | Methods of use of compounds with preptin function |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US20060100278A1 (en) * | 2002-08-20 | 2006-05-11 | Cooper Garth J S | Dosage forms and related therapies |
| US20050096256A1 (en) | 2003-07-01 | 2005-05-05 | President And Fellows Of Harvard College | Compositions for manipulating the lifespan and stress response of cells and organisms |
| CA2550505A1 (en) * | 2003-12-19 | 2005-06-30 | Protemix Corporation Limited | Copper antagonist compounds |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| EP1708689A2 (en) | 2003-12-29 | 2006-10-11 | The President and Fellows of Harvard College | Compositions for treating or preventing obesity and insulin resistance disorders |
| US7563460B2 (en) * | 2004-02-26 | 2009-07-21 | Med Five, Inc. | Enteric coated oral pharmaceutical to erode kidney stones |
| US20060211752A1 (en) * | 2004-03-16 | 2006-09-21 | Kohn Leonard D | Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression |
| EP1778618B1 (en) | 2004-07-19 | 2013-12-25 | PhilERA New Zealand Limited | Synthesis of triethylenetetramines |
| HU227588B1 (hu) * | 2004-12-03 | 2011-09-28 | Sinnex Mueszaki Fejlesztoe Es Tanacsado Kft | Többszörösen telítetlen zsírsavak észtereit tartalmazó vírusellenes és immunstimuláns gyógyászati készítmény |
| WO2006104402A1 (en) * | 2005-03-26 | 2006-10-05 | Protemix Corporation Limited | Copper antagonist compositions |
| WO2006104398A1 (en) * | 2005-03-26 | 2006-10-05 | Protemix Corporation Limited | Copper antagonist compositions |
| EP1874285B1 (en) * | 2005-04-07 | 2009-10-07 | Astrum Therapeutics Pty, Ltd. | Complementary compositions to reduce blood glucose levels and treat diabetes |
| AU2006240568A1 (en) * | 2005-04-25 | 2006-11-02 | Philera New Zealand Limited | Copper regulation evaluation and therapy |
| WO2006138418A2 (en) | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
| EP1948160A4 (en) * | 2005-11-09 | 2013-07-10 | Protemix Corp Ltd | TREATMENT OF MITOCHONDRIA-RELATED DISEASES AND IMPROVEMENT OF AGE-RELATED METABOLIC DEFICITS |
| JP2009523175A (ja) * | 2006-01-10 | 2009-06-18 | パイペックス，インコーポレイテッド | 目標とされる安定な銅状態を達成及び維持して銅関連中枢神経系疾患を予防及び治療するための医薬組成物及び方法 |
| KR100821649B1 (ko) | 2006-01-24 | 2008-04-11 | 서울시립대학교 산학협력단 | 클리오퀴놀을 유효성분으로 포함하는 ＨＩＦ-1α 활성제 |
| CN101437503A (zh) * | 2006-02-21 | 2009-05-20 | 阿斯特鲁姆医疗有限公司 | 用于降低血糖水平和治疗糖尿病的组合物 |
| WO2007116243A2 (en) * | 2006-04-10 | 2007-10-18 | Mintails Limited | Method for treating fibromyalgia and related conditions |
| US20090270420A1 (en) * | 2006-06-01 | 2009-10-29 | Sobel Burton E | Methods for inhibiting cardiac pai-1 |
| KR100816798B1 (ko) * | 2006-09-08 | 2008-03-25 | (주)팜스웰 | 의약용 트리에틸렌테트라민 이염산염의 제조방법 |
| CN101702884A (zh) * | 2007-03-09 | 2010-05-05 | 西姆科皮亚公司 | 用于治疗高血糖症及相关病症的脂肪酸氧化抑制剂 |
| US20100311092A1 (en) * | 2007-11-30 | 2010-12-09 | Kurland Irwin J | Metabolic fuel switching biomarker |
| WO2010020959A1 (en) * | 2008-08-21 | 2010-02-25 | University Of Cape Town | Resveratrol-containing composition for treating heart failure |
| US20100234906A1 (en) * | 2009-03-16 | 2010-09-16 | Pacesetter, Inc. | System and method for controlling rate-adaptive pacing based on a cardiac force-frequency relation detected by an implantable medical device |
| JP5896375B2 (ja) | 2011-09-09 | 2016-03-30 | 池田食研株式会社 | 改変型グルコース脱水素酵素遺伝子 |
| WO2014145705A2 (en) | 2013-03-15 | 2014-09-18 | Battelle Memorial Institute | Progression analytics system |
| WO2014152207A1 (en) | 2013-03-15 | 2014-09-25 | Mylan Laboratories, Inc. | Hot melt granulation formulations of poorly water-soluble active agents |
| CZ307108B6 (cs) * | 2013-09-06 | 2018-01-17 | Vysoké Učení Technické V Brně | Multifunkční poloprovozní jednotka pro snižování polutantů z odpadního plynu |
| EP2845640B1 (en) | 2013-09-06 | 2018-10-24 | Vysoké Ucení Technické V Brne | Multifunction operation unit for reducing pollutant concentration in a waste gas |
| JP2018505407A (ja) | 2015-01-07 | 2018-02-22 | ノッティンガム ユニバーシティ ホスピタルズ エヌエイチエス トラストＮｏｔｔｉｎｇｈａｍ Ｕｎｉｖｅｒｓｉｔｙ Ｈｏｓｐｉｔａｌｓ Ｎｈｓ Ｔｒｕｓｔ | 検査方法、原子種の使用方法、検査装置、及び、テストキット |
| WO2017049529A1 (en) * | 2015-09-24 | 2017-03-30 | Innolife Co., Ltd. | A pharmaceutical composition comprising a copper chelating tetramine and the use thereof |
| WO2018005990A2 (en) * | 2016-07-01 | 2018-01-04 | Marshall University Research Corporation | Compositions and methods for treating uremic cardiomyopathy |
| CN107811997A (zh) * | 2017-11-10 | 2018-03-20 | 大连医科大学附属第医院 | 蛋白酶体抑制剂白藜芦醇在预防和治疗心血管疾病中的应用 |
| TWI902661B (zh) | 2018-05-04 | 2025-11-01 | 法商奧法蘭股份公司 | 三伸乙基四胺四鹽酸鹽之結晶型及其醫藥用途 |
| US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
| EP3947433A4 (en) * | 2019-04-02 | 2022-11-23 | The Regents of The University of Michigan | USE OF SOLUBLE UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR LEVELS IN THE MANAGEMENT OF PATIENTS WITH CARDIOVASCULAR DISEASES |
| CN114867474A (zh) * | 2019-06-17 | 2022-08-05 | 菲勒拉新西兰有限责任公司 | 中枢神经系统病症的联合治疗 |
| CN112138024A (zh) | 2019-06-26 | 2020-12-29 | 里弗斯Pah有限责任公司 | 治疗严重形式的肺动脉高压的方法 |
| CN110464717B (zh) * | 2019-09-23 | 2022-02-18 | 张建国 | 一种2,4-二羟基苯甲酸在制备降低血糖的药物的应用 |
| GB2612210B (en) * | 2020-06-24 | 2025-08-27 | Reverspah Llc | Pharmaceutical composition comprising a tetrathiomolybdate salt and a diethylcarbamazine |
| CN115998955B (zh) * | 2022-12-09 | 2024-12-20 | 首都医科大学附属北京安贞医院 | 一种静脉桥的醛铬复合交联方法 |
| KR102878403B1 (ko) * | 2023-01-25 | 2025-10-28 | 김성국 | 동맥경화 치료용 킬레이션 약학 조성물 및 체외 역박동기를 이용한 동맥경화 치료용 킬레이션 약학 조성물의 투여방법 |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3791988A (en) | 1972-03-23 | 1974-02-12 | Hoffmann La Roche | Diagnostic test for glucose |
| PL105793B1 (pl) | 1977-11-24 | 1979-10-31 | Sposob otrzymywania soli kwasow dwukarboksylowych i poliamin | |
| IL58849A (en) | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| US4323558A (en) | 1979-09-10 | 1982-04-06 | Nelson Research & Development Co. | Topical trien containing pharmaceutical compositions and methods of use |
| US4371374A (en) | 1980-11-17 | 1983-02-01 | The Rockefeller University | Monitoring metabolic control in diabetic patients by measuring glycosylated amino acids and peptides in urine |
| JPS57144215A (en) | 1981-03-02 | 1982-09-06 | Nippon Nousan Kogyo Kk | Composition for improving lipometabolism |
| DE3217071A1 (de) | 1982-05-06 | 1983-11-10 | Rüdiger Dr. 6365 Rosbach Gröning | Arzneimittel fuer die perorale applikation mit verbesserter biologischer verfuegbarkeit der wirkstoffe |
| US4758583A (en) | 1984-03-19 | 1988-07-19 | The Rockefeller University | Method and agents for inhibiting protein aging |
| US4665192A (en) | 1984-03-19 | 1987-05-12 | The Rockefeller University | 2-(2-furoyl)-4(5)-2(furanyl)-1H-imidazole |
| US5852009A (en) | 1984-03-19 | 1998-12-22 | The Rockefeller University | Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon |
| EP0302065B1 (en) | 1986-03-21 | 1994-08-10 | Eurasiam Laboratories, Inc. | Pharmaceutical compositions |
| CH666814A5 (it) | 1986-07-24 | 1988-08-31 | Inpharzam Int Sa | Composizione farmaceutica idrosolubile contenente n-acetil-cisteina. |
| CH667590A5 (it) | 1986-07-24 | 1988-10-31 | Inpharzam Int Sa | Composizione farmaceutica effervescente idrosolubile contenente n-acetil-cisteina. . |
| US4866090A (en) | 1988-01-07 | 1989-09-12 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| EP0331014A3 (de) | 1988-03-02 | 1991-10-23 | THERA - Patent Verwaltungs-GmbH | Verwendung von ACE-Inhibitoren für die Diabetesprophylaxe |
| JPH01294631A (ja) | 1988-05-19 | 1989-11-28 | Sanwa Kagaku Kenkyusho Co Ltd | 糖尿性疾患治療予防剤及び飲食、し好物 |
| US5077313A (en) | 1988-11-25 | 1991-12-31 | Gert Lubec | Process for inhibiting pathological collagen cross-linking in diabetes patients |
| CA2026686A1 (en) | 1989-10-30 | 1991-05-01 | Werner Tschollar | Method for preventing onset of type ii diabetes employing an ace inhibitor |
| US5447728A (en) | 1992-06-15 | 1995-09-05 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
| AU667069B2 (en) | 1991-12-06 | 1996-03-07 | North Shore University Hospital Research Corporation | Method of reducing medical device related infections |
| US5246970A (en) | 1991-12-16 | 1993-09-21 | Washington University | Method of inhibiting nitric oxide formation |
| JP3157622B2 (ja) | 1992-06-05 | 2001-04-16 | 株式会社ミツカングループ本社 | フルクトシルアミンデグリカーゼ、その製造法及び該酵素を用いたアマドリ化合物の定量方法 |
| JPH06298738A (ja) * | 1993-04-15 | 1994-10-25 | Yamanouchi Pharmaceut Co Ltd | ５−アミノピラゾール誘導体 |
| JPH07118148A (ja) | 1993-10-26 | 1995-05-09 | Tsumura & Co | 肝癌予防剤 |
| US5420120A (en) | 1993-12-17 | 1995-05-30 | Alcon Laboratories, Inc. | Anti-inflammatory glucocorticoid compounds for topical ophthalmic use |
| AU1447095A (en) | 1993-12-30 | 1995-07-17 | Arcturus Pharmaceutical Corporation | Methods for the treatment of the central nervous system or eye involving pathogenic oxidation pathways |
| US5854271A (en) | 1994-05-02 | 1998-12-29 | Cytos Pharmaceuticals, L.L.C. | Effective method for the amelioration and prevention of tissue and cellular damage |
| AU4134996A (en) | 1994-10-25 | 1996-05-15 | Washington University | Method of inhibiting nitric oxide formation |
| AU716005B2 (en) | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
| JP3988838B2 (ja) * | 1996-05-29 | 2007-10-10 | 日本製粉株式会社 | 化粧料 |
| US5906996A (en) | 1996-08-21 | 1999-05-25 | Murphy; Michael A. | Tetramine treatment of neurological disorders |
| EP1007048A4 (en) | 1997-03-11 | 2004-09-22 | Gen Hospital Corp | IDENTIFICATION OF MEANS FOR TREATING ALZHEIMERISCHEN DISEASE |
| JPH10324629A (ja) * | 1997-03-28 | 1998-12-08 | Otsuka Pharmaceut Co Ltd | Ａｇｅ生成阻害組成物 |
| US5811446A (en) | 1997-04-18 | 1998-09-22 | Cytos Pharmaceuticals Llc | Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor |
| US20030013772A1 (en) | 2000-02-23 | 2003-01-16 | Murphy Michael A. | Composition, synthesis and therapeutic applications of polyamines |
| US20050085555A1 (en) | 1997-08-21 | 2005-04-21 | Murphy Michael A. | Composition, synthesis and therapeutic applications of polyamines |
| US6576672B1 (en) | 1998-08-21 | 2003-06-10 | Michael A. Murphy | Polyamine treatment of neurological disorders |
| US5980914A (en) | 1997-08-22 | 1999-11-09 | P.N. Gerolymatos S.A. | Clioquinol for the treatment of Parkinson's disease |
| US6821954B2 (en) | 1997-09-18 | 2004-11-23 | Auckland Uniservices Limited | Compounds and uses thereof in treating bone disorders |
| US5972985A (en) | 1997-11-03 | 1999-10-26 | Cytos Pharmaceuticals, Llc | Histidine containing nutriceutical compositions |
| AU754681B2 (en) | 1998-02-04 | 2002-11-21 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
| US6323218B1 (en) | 1998-03-11 | 2001-11-27 | The General Hospital Corporation | Agents for use in the treatment of Alzheimer's disease |
| US6147070A (en) * | 1998-06-05 | 2000-11-14 | Facchini; Francesco | Methods and compositions for controlling iron stores to treat and cure disease states |
| EP1234585A3 (en) | 1998-09-04 | 2004-01-21 | The Regents Of The University Of Michigan | Methods and compositions for the prevention or treatment of cancer |
| WO2000018392A1 (en) | 1998-09-25 | 2000-04-06 | Glycox Corporation Limited | Fructosamine oxidase: antagonists and inhibitors |
| CN1320160A (zh) | 1998-09-25 | 2001-10-31 | 格利科克斯有限公司 | 果糖胺氧化酶测定的方法和材料 |
| JP2000204037A (ja) | 1999-01-12 | 2000-07-25 | Tsumura & Co | 筋萎縮性側索硬化症治療薬 |
| US6309380B1 (en) | 1999-01-27 | 2001-10-30 | Marian L. Larson | Drug delivery via conformal film |
| EP1185558A4 (en) | 1999-06-18 | 2006-02-15 | Protemix Discovery Ltd | PEPTIDES WITH PREPTID FUNCTIONALITY |
| US20030050434A1 (en) | 1999-06-18 | 2003-03-13 | Cooper Garth J.S. | Peptide |
| US20030166561A1 (en) | 1999-06-18 | 2003-09-04 | Cooper Garth J. S. | Peptide |
| DE60129427T3 (de) | 2000-05-11 | 2014-07-24 | The Procter & Gamble Company | Hochkonzentrierte wäscheweichspülerzusammensetzungen und diese enthaltende mittel |
| EP1370254B1 (en) | 2000-12-01 | 2008-01-16 | Radical Vision Therapeutics Inc. | Copper chelators for treating ocular inflammation |
| US7754765B2 (en) | 2000-12-01 | 2010-07-13 | Radical Vision Therapeutics Inc | Copper chelators for treating ocular inflammation |
| EP1373893A2 (en) | 2001-03-30 | 2004-01-02 | Protemix Corporation Limited | Phosphoprotein target for insulin and its antagonists |
| WO2003002732A1 (en) | 2001-06-27 | 2003-01-09 | Biovitrum Ab | Citrate lyase poly peptides |
| EP1417055A4 (en) | 2001-07-19 | 2007-09-26 | Dmi Biosciences Inc | USE OF COPPER CHELATORS TO PREVENT THE INACTIVATION OF PROTEIN C |
| EP1461068A4 (en) | 2001-11-26 | 2006-03-29 | Protemix Corp Ltd | METHOD AND COMPOSITIONS FOR NORMALIZING LIPID MIRRORS IN MIRACLE TISSUE |
| US20040038861A1 (en) | 2001-11-26 | 2004-02-26 | Cooper Garth J. S. | Methods and compositions for normalizing lipid levels in mammalian tissues |
| US7144706B2 (en) | 2002-01-03 | 2006-12-05 | Duke University | Methods of modulating localization and physiological function of IP3 receptors |
| JP2005535561A (ja) | 2002-01-18 | 2005-11-24 | プロテミックス コーポレイション リミティド | アディポネクチンのグリコアイソフォームとその使用 |
| EP1465982A4 (en) | 2002-01-25 | 2006-06-07 | Gamida Cell Ltd | PROCESS FOR EXPANSION OF STEM AND PRESERVATIVE CELLS AND EXPANDED CELL POPULATIONS THEREWITH OBTAINED |
| CN1688299A (zh) | 2002-01-29 | 2005-10-26 | 普罗特米克斯公司 | 抑制细胞毒性蛋白构象异构体 |
| AU2003225440A1 (en) | 2002-03-01 | 2003-09-16 | Protemix Discovery Limited | Falp proteins |
| EP2500018B1 (en) | 2002-03-08 | 2017-07-19 | PhilERA New Zealand Limited | Preventing and/or Treating Cardiovascular Disease and/or Associated Heart Failure |
| AU2003222513A1 (en) * | 2002-03-08 | 2003-09-22 | Protemix Corporation Limited | Preventing and/or treating vascular disease, cardiomyopathy and/or associated heart failure |
| EP1494658B1 (en) | 2002-04-03 | 2006-01-04 | Puleva Biotech, S.A. | Natural phenolic products and derivatives thereof for protection against neurodegenerative diseases |
| WO2003093311A1 (en) | 2002-04-29 | 2003-11-13 | Protemix Corporation Limited | Proteins with deglycating activities and methods of using same |
| US6855340B2 (en) | 2002-05-24 | 2005-02-15 | Regents Of The University Of Michigan | Copper lowering treatment of inflammatory and fibrotic diseases |
| JP2003343552A (ja) * | 2002-05-27 | 2003-12-03 | Koyo Seiko Co Ltd | 円錐ころ軸受 |
| GEP20074270B (en) | 2002-07-23 | 2007-12-25 | Univ Michigan | Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies |
| US7189865B2 (en) | 2002-07-23 | 2007-03-13 | Attenuon, Llc | Thiomolybdate analogues and uses thereof |
| WO2004012760A1 (en) | 2002-08-01 | 2004-02-12 | Auckland Uniservices Limited | Preptin methods of use |
| EP1534321A1 (en) | 2002-08-01 | 2005-06-01 | Protemix Corporation Limited | Methods of use of compounds with preptin function |
| US20040142393A1 (en) | 2002-08-01 | 2004-07-22 | Cooper Garth James Smith | Methods of use of compounds with preptin function |
| AU2003214725A1 (en) | 2002-08-20 | 2004-03-11 | Protemix Corporation Limited | Preventing and/or treating cardiovascular disease and/or associated heart failure |
| US20060100278A1 (en) | 2002-08-20 | 2006-05-11 | Cooper Garth J S | Dosage forms and related therapies |
| AU2003285686A1 (en) | 2002-12-23 | 2004-07-14 | Protemix Corporation Limited | Glycoisoforms of adiponectin and uses thereof |
| US20050031651A1 (en) | 2002-12-24 | 2005-02-10 | Francine Gervais | Therapeutic formulations for the treatment of beta-amyloid related diseases |
| EP1606292A2 (en) | 2003-03-21 | 2005-12-21 | Palumed SA | Nitrogeneous polycyclic derivatives useful as chelators of metal ions and their applications |
| EP1617844A4 (en) | 2003-04-03 | 2009-07-22 | Prana Biotechnology Ltd | TREATMENT OF NEUROLOGICAL DISEASES |
| AU2004238285A1 (en) | 2003-05-07 | 2004-11-25 | Dmi Biosciences, Inc | Oral care methods and products |
| US7176239B2 (en) | 2003-07-11 | 2007-02-13 | Suming Wang | Methods and compositions for treatment of Ataxia-telangeictasia |
| WO2005040205A1 (en) | 2003-10-28 | 2005-05-06 | Protemix Discovery Limited | Peptides with anti-obesity activity and other related uses |
| CA2550505A1 (en) | 2003-12-19 | 2005-06-30 | Protemix Corporation Limited | Copper antagonist compounds |
| EP1778618B1 (en) | 2004-07-19 | 2013-12-25 | PhilERA New Zealand Limited | Synthesis of triethylenetetramines |
| WO2006068516A1 (en) | 2004-12-20 | 2006-06-29 | Protemix Corporation Limited | Implantable medical devices coated with or containing copper chelating compounds |
-
2003
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- 2003-03-10 DK DK03744567.3T patent/DK1487431T3/da active
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- 2003-03-10 AU AU2003225442A patent/AU2003225442B2/en not_active Ceased
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- 2003-03-10 ES ES03744567T patent/ES2386782T3/es not_active Expired - Lifetime
- 2003-03-10 CN CNA038101513A patent/CN1649577A/zh active Pending
- 2003-03-10 DK DK11187394.9T patent/DK2500018T3/en active
- 2003-03-10 EP EP03744567A patent/EP1487431B1/en not_active Expired - Lifetime
- 2003-03-10 AT AT03744567T patent/ATE555782T1/de active
- 2003-03-12 US US10/388,213 patent/US6951890B2/en not_active Expired - Lifetime
-
2005
- 2005-09-07 US US11/221,298 patent/US8034799B2/en not_active Expired - Fee Related
-
2011
- 2011-02-28 US US13/037,223 patent/US8563538B2/en not_active Expired - Fee Related
-
2013
- 2013-09-18 US US14/029,984 patent/US8987244B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003225442A1 (en) | 2003-09-29 |
| US20110212188A1 (en) | 2011-09-01 |
| US8563538B2 (en) | 2013-10-22 |
| JP2005533003A (ja) | 2005-11-04 |
| CA2478997C (en) | 2013-12-17 |
| CA2478997A1 (en) | 2003-09-25 |
| EP2500018A1 (en) | 2012-09-19 |
| US20060009534A1 (en) | 2006-01-12 |
| US20140113969A1 (en) | 2014-04-24 |
| AU2003225442B2 (en) | 2010-02-04 |
| US8987244B2 (en) | 2015-03-24 |
| WO2003077901A1 (en) | 2003-09-25 |
| US6951890B2 (en) | 2005-10-04 |
| US20030203973A1 (en) | 2003-10-30 |
| EP2500018B1 (en) | 2017-07-19 |
| DK2500018T3 (en) | 2017-10-02 |
| JP4860906B2 (ja) | 2012-01-25 |
| EP1487431A4 (en) | 2006-10-25 |
| HK1071313A1 (en) | 2005-07-15 |
| EP1487431B1 (en) | 2012-05-02 |
| DK1487431T3 (da) | 2012-08-20 |
| CN1649577A (zh) | 2005-08-03 |
| US8034799B2 (en) | 2011-10-11 |
| EP1487431A1 (en) | 2004-12-22 |
| ATE555782T1 (de) | 2012-05-15 |
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