ES2363725T3 - Método para elaborar dispersiones sólidas de midostaurina. - Google Patents
Método para elaborar dispersiones sólidas de midostaurina. Download PDFInfo
- Publication number
- ES2363725T3 ES2363725T3 ES07811314T ES07811314T ES2363725T3 ES 2363725 T3 ES2363725 T3 ES 2363725T3 ES 07811314 T ES07811314 T ES 07811314T ES 07811314 T ES07811314 T ES 07811314T ES 2363725 T3 ES2363725 T3 ES 2363725T3
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- Prior art keywords
- poloxamer
- mixture
- therapeutic compound
- extruder
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- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Colloid Chemistry (AREA)
- Glass Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82255606P | 2006-08-16 | 2006-08-16 | |
| US822556P | 2006-08-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2363725T3 true ES2363725T3 (es) | 2011-08-12 |
Family
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Family Applications (1)
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|---|---|---|---|
| ES07811314T Active ES2363725T3 (es) | 2006-08-16 | 2007-08-14 | Método para elaborar dispersiones sólidas de midostaurina. |
Country Status (16)
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| US (2) | US20100038816A1 (enExample) |
| EP (1) | EP2054040B1 (enExample) |
| JP (1) | JP5546860B2 (enExample) |
| KR (1) | KR101462693B1 (enExample) |
| CN (1) | CN101516339B (enExample) |
| AT (1) | ATE503484T1 (enExample) |
| AU (1) | AU2007284615B2 (enExample) |
| BR (1) | BRPI0714963A2 (enExample) |
| CA (1) | CA2660086C (enExample) |
| DE (1) | DE602007013567D1 (enExample) |
| ES (1) | ES2363725T3 (enExample) |
| MX (1) | MX2009001636A (enExample) |
| PL (1) | PL2054040T3 (enExample) |
| PT (1) | PT2054040E (enExample) |
| RU (1) | RU2454220C2 (enExample) |
| WO (1) | WO2008021347A2 (enExample) |
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|---|---|---|---|---|
| EP1923053A1 (en) | 2006-09-27 | 2008-05-21 | Novartis AG | Pharmaceutical compositions comprising nilotinib or its salt |
| WO2009100176A2 (en) * | 2008-02-07 | 2009-08-13 | Abbott Laboratories | Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor |
| MX2010011962A (es) * | 2008-04-30 | 2010-11-30 | Novartis Ag | Proceso continuo para hacer composiciones farmaceuticas. |
| EP2327706A1 (en) | 2009-11-30 | 2011-06-01 | Novartis AG | Polymorphous forms III and IV of N-benzoyl-staurosporine |
| UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
| CN102525879B (zh) * | 2010-12-31 | 2015-01-21 | 正大天晴药业集团股份有限公司 | 制备阿瑞匹坦固体分散组合物的方法 |
| HRP20200372T1 (hr) * | 2014-03-25 | 2020-06-12 | F. Hoffmann - La Roche Ag | Postupci proizvodnje poloksamera za upotrebu u mediju za staničnu kulturu |
| CA2970717A1 (en) | 2014-12-18 | 2016-06-23 | Merck Sharp & Dohme Corp. | (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3- (methylthio)pyrrolidine-3-carboxamide compositions for pharmaceutical preparations |
| GB201502073D0 (en) * | 2015-02-09 | 2015-03-25 | Cubic Pharmaceuticals Ltd And Delta Pharmaceuticals Ltd | HDEG technology |
| EP3337454B1 (en) | 2015-08-20 | 2018-12-26 | Unilever Plc. | Improved lactam solubility |
| EP3337448A1 (en) * | 2015-08-20 | 2018-06-27 | Unilever PLC, a company registered in England and Wales under company no. 41424 of | Dispersed lactams |
| WO2017029104A1 (en) | 2015-08-20 | 2017-02-23 | Unilever Plc | Process for the preparation of lactams from glyoxylic acid |
| WO2017029092A1 (en) | 2015-08-20 | 2017-02-23 | Unilever Plc | Improved lactam solubility |
| TR201901410T4 (tr) | 2015-08-20 | 2019-02-21 | Unilever Nv | Geliştirilmiş Laktam Çözünürlüğü |
| CN107920979A (zh) | 2015-08-20 | 2018-04-17 | 荷兰联合利华有限公司 | 改善的内酰胺溶解度 |
| CN108024939B (zh) | 2015-08-20 | 2024-06-07 | 联合利华知识产权控股有限公司 | 包封的内酰胺 |
| CA3018629A1 (en) * | 2016-03-24 | 2017-09-28 | Locate Therapeutics Limited | Scaffolding material, methods and uses |
| US11510986B2 (en) * | 2016-05-13 | 2022-11-29 | Merck Patent Gmbh | Hot melt extrusion composition using direct compressible excipient as plasticizer |
| WO2019152798A1 (en) | 2018-02-01 | 2019-08-08 | Corvus Pharmaceuticals, Inc. | Pharmaceutical formulations |
| EP3520782A3 (en) * | 2018-02-01 | 2019-11-13 | Corvus Pharmaceuticals, Inc. | Pharmaceutical formulations containing adenosine a2a receptor antagonists |
| CN113573712A (zh) | 2019-02-18 | 2021-10-29 | 斯莱班克制药有限责任公司 | 尼洛替尼的药物组合物 |
| CA3203975A1 (en) | 2020-12-03 | 2022-06-09 | Battelle Memorial Institute | Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery |
| CA3216359A1 (en) | 2021-04-07 | 2022-10-13 | Battelle Memorial Institute | Rapid design, build, test, and learn technologies for identifying and using non-viral carriers |
| CN114796149A (zh) * | 2022-04-27 | 2022-07-29 | 苏州中化药品工业有限公司 | 一种高生物利用度的双醋瑞因胶囊剂及其制备方法 |
| AU2024353375A1 (en) | 2023-09-29 | 2026-04-09 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| WO2025122954A1 (en) | 2023-12-08 | 2025-06-12 | Battelle Memorial Institute | Use of dna origami nanostructures for molecular information based data storage systems |
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| DE3346123A1 (de) | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
| IE80467B1 (en) | 1995-07-03 | 1998-07-29 | Elan Corp Plc | Controlled release formulations for poorly soluble drugs |
| US5837714A (en) * | 1997-03-03 | 1998-11-17 | Sanofi | Solid pharmaceutical dispersions |
| DE69811233T2 (de) | 1997-10-27 | 2003-11-20 | Merck Patent Gmbh | Feste lösungen und dispersionen von eines schlecht wasserlöslichen wirkstoffes |
| US6706283B1 (en) * | 1999-02-10 | 2004-03-16 | Pfizer Inc | Controlled release by extrusion of solid amorphous dispersions of drugs |
| GB9903547D0 (en) * | 1999-02-16 | 1999-04-07 | Novartis Ag | Organic compounds |
| US20060034937A1 (en) * | 1999-11-23 | 2006-02-16 | Mahesh Patel | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6593308B2 (en) * | 1999-12-03 | 2003-07-15 | The Regents Of The University Of California | Targeted drug delivery with a hyaluronan ligand |
| US20020015730A1 (en) * | 2000-03-09 | 2002-02-07 | Torsten Hoffmann | Pharmaceutical formulations and method for making |
| DE10013289A1 (de) * | 2000-03-17 | 2001-09-20 | Knoll Ag | Torasemid enthaltende pharmazeutische Zubereitungen |
| PT1372611E (pt) * | 2001-03-26 | 2006-08-31 | Novartis Ag | Composicao farmaceutica compreendendo uma estaurosporina francamente soluvel em agua, um tensioactivo et um polimero soluvel em agua |
| CN1255185C (zh) * | 2001-05-03 | 2006-05-10 | 弗·哈夫曼-拉罗切有限公司 | 无定形甲磺酸奈非那韦的药物剂型 |
| US20030212102A1 (en) * | 2001-06-12 | 2003-11-13 | Koretke Todd W | Novel solid dispersion compositions |
| JP4644397B2 (ja) * | 2001-09-05 | 2011-03-02 | 信越化学工業株式会社 | 難溶性薬物を含む医薬用固形製剤の製造方法 |
| US6756381B2 (en) * | 2002-02-21 | 2004-06-29 | Supergen, Inc. | Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use thereof |
| GB0205253D0 (en) * | 2002-03-06 | 2002-04-17 | Univ Gent | Immediate release pharmaceutical granule compositions and a continuous process for making them |
| US8268352B2 (en) * | 2002-08-05 | 2012-09-18 | Torrent Pharmaceuticals Limited | Modified release composition for highly soluble drugs |
| US7230012B2 (en) * | 2002-11-14 | 2007-06-12 | Celgene Corporation | Pharmaceutical compositions and dosage forms of thalidomide |
| GB0315012D0 (en) * | 2003-06-27 | 2003-07-30 | Leuven K U Res & Dev | Zeotiles |
| AR047938A1 (es) * | 2003-08-25 | 2006-03-15 | Combinatorx Inc | Formulaciones, conjugados y combinaciones de farmacos para el tratamiento de neoplasmas |
| US20050208095A1 (en) * | 2003-11-20 | 2005-09-22 | Angiotech International Ag | Polymer compositions and methods for their use |
| KR20060101762A (ko) * | 2003-11-21 | 2006-09-26 | 쉐링 코포레이션 | 포스포디에스테라제 ｖ 억제제 제형 |
| WO2005053727A2 (en) * | 2003-11-29 | 2005-06-16 | Sangstat Medical Corporation | Pharmaceutical compositions for bioactive peptide agents |
| UA85871C2 (uk) * | 2004-03-15 | 2009-03-10 | Такеда Фармасьютікал Компані Лімітед | Інгібітори дипептидилпептидази |
| US20060246109A1 (en) * | 2005-04-29 | 2006-11-02 | Hossainy Syed F | Concentration gradient profiles for control of agent release rates from polymer matrices |
| US20050288481A1 (en) * | 2004-04-30 | 2005-12-29 | Desnoyer Jessica R | Design of poly(ester amides) for the control of agent-release from polymeric compositions |
| RU2410098C2 (ru) * | 2004-08-31 | 2011-01-27 | Новартис Аг | Применение мидостаурина для лечения желудочно-кишечных стромальных опухолей |
| US20080038316A1 (en) * | 2004-10-01 | 2008-02-14 | Wong Vernon G | Conveniently implantable sustained release drug compositions |
| JO2897B1 (en) * | 2004-11-05 | 2015-09-15 | نوفارتيس ايه جي | Organic compounds |
| JP2008521878A (ja) * | 2004-12-02 | 2008-06-26 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 非晶質アトルバスタチンの医薬組成物及びその製造のための方法 |
| PT1962808E (pt) * | 2005-12-14 | 2010-10-29 | Hoffmann La Roche | Formulação de precursor de fármaco para o hcv |
| DK2526933T3 (en) * | 2006-09-22 | 2015-05-18 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
| US8258137B2 (en) * | 2008-01-29 | 2012-09-04 | Katholieke Universiteit Leuven | Process for release of biologically active species from mesoporous oxide systems |
| CN102413839A (zh) * | 2009-03-06 | 2012-04-11 | 医学免疫有限责任公司 | 人源化抗cd19抗体制剂 |
| TW201120037A (en) * | 2009-10-26 | 2011-06-16 | Sunesis Pharmaceuticals Inc | Compounds and methods for treatment of cancer |
| EP2327706A1 (en) * | 2009-11-30 | 2011-06-01 | Novartis AG | Polymorphous forms III and IV of N-benzoyl-staurosporine |
| CA3007787C (en) * | 2010-06-03 | 2020-03-10 | Pharmacyclics Llc | The use of inhibitors of bruton's tyrosine kinase (btk) |
| EP2618846A1 (en) * | 2010-09-24 | 2013-07-31 | Mallinckrodt LLC | Aptamer conjugates for targeting of therapeutic and/or diagnostic nanocarriers |
| US9295673B2 (en) * | 2011-02-23 | 2016-03-29 | Intellikine Llc | Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof |
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2007
- 2007-08-14 JP JP2009524659A patent/JP5546860B2/ja not_active Expired - Fee Related
- 2007-08-14 MX MX2009001636A patent/MX2009001636A/es active IP Right Grant
- 2007-08-14 AT AT07811314T patent/ATE503484T1/de active
- 2007-08-14 PT PT07811314T patent/PT2054040E/pt unknown
- 2007-08-14 KR KR1020097005216A patent/KR101462693B1/ko not_active Expired - Fee Related
- 2007-08-14 RU RU2009109357/15A patent/RU2454220C2/ru not_active IP Right Cessation
- 2007-08-14 EP EP07811314A patent/EP2054040B1/en not_active Not-in-force
- 2007-08-14 PL PL07811314T patent/PL2054040T3/pl unknown
- 2007-08-14 AU AU2007284615A patent/AU2007284615B2/en not_active Ceased
- 2007-08-14 WO PCT/US2007/017960 patent/WO2008021347A2/en not_active Ceased
- 2007-08-14 ES ES07811314T patent/ES2363725T3/es active Active
- 2007-08-14 DE DE602007013567T patent/DE602007013567D1/de active Active
- 2007-08-14 US US12/376,692 patent/US20100038816A1/en not_active Abandoned
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- 2007-08-14 BR BRPI0714963-8A patent/BRPI0714963A2/pt not_active IP Right Cessation
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2012
- 2012-03-19 US US13/423,329 patent/US8641948B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009001636A (es) | 2009-02-23 |
| PL2054040T3 (pl) | 2011-09-30 |
| JP2010500411A (ja) | 2010-01-07 |
| PT2054040E (pt) | 2011-06-30 |
| US20100038816A1 (en) | 2010-02-18 |
| KR101462693B1 (ko) | 2014-11-17 |
| JP5546860B2 (ja) | 2014-07-09 |
| AU2007284615B2 (en) | 2011-10-27 |
| CA2660086A1 (en) | 2008-02-21 |
| US20120190667A1 (en) | 2012-07-26 |
| RU2009109357A (ru) | 2010-09-27 |
| ATE503484T1 (de) | 2011-04-15 |
| RU2454220C2 (ru) | 2012-06-27 |
| AU2007284615A1 (en) | 2008-02-21 |
| EP2054040B1 (en) | 2011-03-30 |
| WO2008021347A2 (en) | 2008-02-21 |
| EP2054040A2 (en) | 2009-05-06 |
| DE602007013567D1 (de) | 2011-05-12 |
| BRPI0714963A2 (pt) | 2013-07-30 |
| CN101516339A (zh) | 2009-08-26 |
| WO2008021347A3 (en) | 2008-08-07 |
| KR20090042961A (ko) | 2009-05-04 |
| CN101516339B (zh) | 2012-06-13 |
| CA2660086C (en) | 2014-09-16 |
| US8641948B2 (en) | 2014-02-04 |
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