JP5546860B2 - 高結晶性治療化合物の固体分散体を製造するための方法 - Google Patents

高結晶性治療化合物の固体分散体を製造するための方法 Download PDF

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Publication number
JP5546860B2
JP5546860B2 JP2009524659A JP2009524659A JP5546860B2 JP 5546860 B2 JP5546860 B2 JP 5546860B2 JP 2009524659 A JP2009524659 A JP 2009524659A JP 2009524659 A JP2009524659 A JP 2009524659A JP 5546860 B2 JP5546860 B2 JP 5546860B2
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therapeutic compound
mixture
present
therapeutic
highly crystalline
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JP2010500411A (ja
JP2010500411A5 (enExample
Inventor
インドラジト・ゴーシュ
ジェニファー・スナイダー
ウェイ−キン・トン
スーダ・ビッパグンタ
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ノバルティス アーゲー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Glass Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
JP2009524659A 2006-08-16 2007-08-14 高結晶性治療化合物の固体分散体を製造するための方法 Expired - Fee Related JP5546860B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82255606P 2006-08-16 2006-08-16
US60/822,556 2006-08-16
PCT/US2007/017960 WO2008021347A2 (en) 2006-08-16 2007-08-14 Method for making solid dispersions of highly crystalline therapeutic compounds

Publications (3)

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JP2010500411A JP2010500411A (ja) 2010-01-07
JP2010500411A5 JP2010500411A5 (enExample) 2010-09-24
JP5546860B2 true JP5546860B2 (ja) 2014-07-09

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JP2009524659A Expired - Fee Related JP5546860B2 (ja) 2006-08-16 2007-08-14 高結晶性治療化合物の固体分散体を製造するための方法

Country Status (16)

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US (2) US20100038816A1 (enExample)
EP (1) EP2054040B1 (enExample)
JP (1) JP5546860B2 (enExample)
KR (1) KR101462693B1 (enExample)
CN (1) CN101516339B (enExample)
AT (1) ATE503484T1 (enExample)
AU (1) AU2007284615B2 (enExample)
BR (1) BRPI0714963A2 (enExample)
CA (1) CA2660086C (enExample)
DE (1) DE602007013567D1 (enExample)
ES (1) ES2363725T3 (enExample)
MX (1) MX2009001636A (enExample)
PL (1) PL2054040T3 (enExample)
PT (1) PT2054040E (enExample)
RU (1) RU2454220C2 (enExample)
WO (1) WO2008021347A2 (enExample)

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Also Published As

Publication number Publication date
MX2009001636A (es) 2009-02-23
PL2054040T3 (pl) 2011-09-30
JP2010500411A (ja) 2010-01-07
PT2054040E (pt) 2011-06-30
US20100038816A1 (en) 2010-02-18
KR101462693B1 (ko) 2014-11-17
ES2363725T3 (es) 2011-08-12
AU2007284615B2 (en) 2011-10-27
CA2660086A1 (en) 2008-02-21
US20120190667A1 (en) 2012-07-26
RU2009109357A (ru) 2010-09-27
ATE503484T1 (de) 2011-04-15
RU2454220C2 (ru) 2012-06-27
AU2007284615A1 (en) 2008-02-21
EP2054040B1 (en) 2011-03-30
WO2008021347A2 (en) 2008-02-21
EP2054040A2 (en) 2009-05-06
DE602007013567D1 (de) 2011-05-12
BRPI0714963A2 (pt) 2013-07-30
CN101516339A (zh) 2009-08-26
WO2008021347A3 (en) 2008-08-07
KR20090042961A (ko) 2009-05-04
CN101516339B (zh) 2012-06-13
CA2660086C (en) 2014-09-16
US8641948B2 (en) 2014-02-04

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