PT2054040E - Método para produzir dispersões sólidas de compostos terapêuticos altamente cristalinos - Google Patents

Método para produzir dispersões sólidas de compostos terapêuticos altamente cristalinos Download PDF

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Publication number
PT2054040E
PT2054040E PT07811314T PT07811314T PT2054040E PT 2054040 E PT2054040 E PT 2054040E PT 07811314 T PT07811314 T PT 07811314T PT 07811314 T PT07811314 T PT 07811314T PT 2054040 E PT2054040 E PT 2054040E
Authority
PT
Portugal
Prior art keywords
solid dispersions
midostaurin
making solid
highly crystalline
compounds
Prior art date
Application number
PT07811314T
Other languages
English (en)
Portuguese (pt)
Inventor
Wei-Qin Tong
Indrajit Ghosh
Jennifer Snyder
Sudha Vippagunta
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT2054040E publication Critical patent/PT2054040E/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Glass Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
PT07811314T 2006-08-16 2007-08-14 Método para produzir dispersões sólidas de compostos terapêuticos altamente cristalinos PT2054040E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82255606P 2006-08-16 2006-08-16

Publications (1)

Publication Number Publication Date
PT2054040E true PT2054040E (pt) 2011-06-30

Family

ID=38657762

Family Applications (1)

Application Number Title Priority Date Filing Date
PT07811314T PT2054040E (pt) 2006-08-16 2007-08-14 Método para produzir dispersões sólidas de compostos terapêuticos altamente cristalinos

Country Status (16)

Country Link
US (2) US20100038816A1 (enExample)
EP (1) EP2054040B1 (enExample)
JP (1) JP5546860B2 (enExample)
KR (1) KR101462693B1 (enExample)
CN (1) CN101516339B (enExample)
AT (1) ATE503484T1 (enExample)
AU (1) AU2007284615B2 (enExample)
BR (1) BRPI0714963A2 (enExample)
CA (1) CA2660086C (enExample)
DE (1) DE602007013567D1 (enExample)
ES (1) ES2363725T3 (enExample)
MX (1) MX2009001636A (enExample)
PL (1) PL2054040T3 (enExample)
PT (1) PT2054040E (enExample)
RU (1) RU2454220C2 (enExample)
WO (1) WO2008021347A2 (enExample)

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CN114796149A (zh) * 2022-04-27 2022-07-29 苏州中化药品工业有限公司 一种高生物利用度的双醋瑞因胶囊剂及其制备方法
AU2024353375A1 (en) 2023-09-29 2026-04-09 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
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Also Published As

Publication number Publication date
MX2009001636A (es) 2009-02-23
PL2054040T3 (pl) 2011-09-30
JP2010500411A (ja) 2010-01-07
US20100038816A1 (en) 2010-02-18
KR101462693B1 (ko) 2014-11-17
JP5546860B2 (ja) 2014-07-09
ES2363725T3 (es) 2011-08-12
AU2007284615B2 (en) 2011-10-27
CA2660086A1 (en) 2008-02-21
US20120190667A1 (en) 2012-07-26
RU2009109357A (ru) 2010-09-27
ATE503484T1 (de) 2011-04-15
RU2454220C2 (ru) 2012-06-27
AU2007284615A1 (en) 2008-02-21
EP2054040B1 (en) 2011-03-30
WO2008021347A2 (en) 2008-02-21
EP2054040A2 (en) 2009-05-06
DE602007013567D1 (de) 2011-05-12
BRPI0714963A2 (pt) 2013-07-30
CN101516339A (zh) 2009-08-26
WO2008021347A3 (en) 2008-08-07
KR20090042961A (ko) 2009-05-04
CN101516339B (zh) 2012-06-13
CA2660086C (en) 2014-09-16
US8641948B2 (en) 2014-02-04

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