CA2660086C - Method of making solid dispersions of highly crystalline therapeutic compounds - Google Patents

Method of making solid dispersions of highly crystalline therapeutic compounds Download PDF

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Publication number
CA2660086C
CA2660086C CA2660086A CA2660086A CA2660086C CA 2660086 C CA2660086 C CA 2660086C CA 2660086 A CA2660086 A CA 2660086A CA 2660086 A CA2660086 A CA 2660086A CA 2660086 C CA2660086 C CA 2660086C
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CA
Canada
Prior art keywords
poloxamer
mixture
therapeutic compound
therapeutic
therapeutic compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2660086A
Other languages
English (en)
French (fr)
Other versions
CA2660086A1 (en
Inventor
Indrajit Ghosh
Jennifer Snyder
Wei-Qin Tong
Sudha Vippagunta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CA2660086A1 publication Critical patent/CA2660086A1/en
Application granted granted Critical
Publication of CA2660086C publication Critical patent/CA2660086C/en
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Glass Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
CA2660086A 2006-08-16 2007-08-14 Method of making solid dispersions of highly crystalline therapeutic compounds Active CA2660086C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82255606P 2006-08-16 2006-08-16
US60/822,556 2006-08-16
PCT/US2007/017960 WO2008021347A2 (en) 2006-08-16 2007-08-14 Method for making solid dispersions of highly crystalline therapeutic compounds

Publications (2)

Publication Number Publication Date
CA2660086A1 CA2660086A1 (en) 2008-02-21
CA2660086C true CA2660086C (en) 2014-09-16

Family

ID=38657762

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2660086A Active CA2660086C (en) 2006-08-16 2007-08-14 Method of making solid dispersions of highly crystalline therapeutic compounds

Country Status (16)

Country Link
US (2) US20100038816A1 (enExample)
EP (1) EP2054040B1 (enExample)
JP (1) JP5546860B2 (enExample)
KR (1) KR101462693B1 (enExample)
CN (1) CN101516339B (enExample)
AT (1) ATE503484T1 (enExample)
AU (1) AU2007284615B2 (enExample)
BR (1) BRPI0714963A2 (enExample)
CA (1) CA2660086C (enExample)
DE (1) DE602007013567D1 (enExample)
ES (1) ES2363725T3 (enExample)
MX (1) MX2009001636A (enExample)
PL (1) PL2054040T3 (enExample)
PT (1) PT2054040E (enExample)
RU (1) RU2454220C2 (enExample)
WO (1) WO2008021347A2 (enExample)

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CN102525879B (zh) * 2010-12-31 2015-01-21 正大天晴药业集团股份有限公司 制备阿瑞匹坦固体分散组合物的方法
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EP3337454B1 (en) 2015-08-20 2018-12-26 Unilever Plc. Improved lactam solubility
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WO2017029092A1 (en) 2015-08-20 2017-02-23 Unilever Plc Improved lactam solubility
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CN107920979A (zh) 2015-08-20 2018-04-17 荷兰联合利华有限公司 改善的内酰胺溶解度
CN108024939B (zh) 2015-08-20 2024-06-07 联合利华知识产权控股有限公司 包封的内酰胺
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CN114796149A (zh) * 2022-04-27 2022-07-29 苏州中化药品工业有限公司 一种高生物利用度的双醋瑞因胶囊剂及其制备方法
AU2024353375A1 (en) 2023-09-29 2026-04-09 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
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Also Published As

Publication number Publication date
MX2009001636A (es) 2009-02-23
PL2054040T3 (pl) 2011-09-30
JP2010500411A (ja) 2010-01-07
PT2054040E (pt) 2011-06-30
US20100038816A1 (en) 2010-02-18
KR101462693B1 (ko) 2014-11-17
JP5546860B2 (ja) 2014-07-09
ES2363725T3 (es) 2011-08-12
AU2007284615B2 (en) 2011-10-27
CA2660086A1 (en) 2008-02-21
US20120190667A1 (en) 2012-07-26
RU2009109357A (ru) 2010-09-27
ATE503484T1 (de) 2011-04-15
RU2454220C2 (ru) 2012-06-27
AU2007284615A1 (en) 2008-02-21
EP2054040B1 (en) 2011-03-30
WO2008021347A2 (en) 2008-02-21
EP2054040A2 (en) 2009-05-06
DE602007013567D1 (de) 2011-05-12
BRPI0714963A2 (pt) 2013-07-30
CN101516339A (zh) 2009-08-26
WO2008021347A3 (en) 2008-08-07
KR20090042961A (ko) 2009-05-04
CN101516339B (zh) 2012-06-13
US8641948B2 (en) 2014-02-04

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