ES2278170T3 - Composiciones farmaceuticas de anticolinergicos e inhibidores de la quinasa p38 en el tratamiento de enfermedades respiratorias. - Google Patents
Composiciones farmaceuticas de anticolinergicos e inhibidores de la quinasa p38 en el tratamiento de enfermedades respiratorias. Download PDFInfo
- Publication number
- ES2278170T3 ES2278170T3 ES03738089T ES03738089T ES2278170T3 ES 2278170 T3 ES2278170 T3 ES 2278170T3 ES 03738089 T ES03738089 T ES 03738089T ES 03738089 T ES03738089 T ES 03738089T ES 2278170 T3 ES2278170 T3 ES 2278170T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- optionally
- phenyl
- amino
- quad
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 72
- 239000003112 inhibitor Substances 0.000 title claims abstract description 36
- 201000010099 disease Diseases 0.000 title claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 8
- 230000000241 respiratory effect Effects 0.000 title description 2
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 734
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 266
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 228
- 150000002367 halogens Chemical class 0.000 claims abstract description 144
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 141
- 150000002825 nitriles Chemical class 0.000 claims abstract description 136
- 125000002883 imidazolyl group Chemical group 0.000 claims abstract description 93
- 125000001624 naphthyl group Chemical group 0.000 claims abstract description 78
- 150000001875 compounds Chemical class 0.000 claims abstract description 64
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims abstract description 59
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 48
- 239000000203 mixture Substances 0.000 claims abstract description 45
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims abstract description 39
- 125000000392 cycloalkenyl group Chemical group 0.000 claims abstract description 31
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims abstract description 28
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 claims abstract description 27
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims abstract description 26
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims abstract description 26
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 26
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims abstract description 23
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims abstract description 22
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims abstract description 20
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims abstract description 16
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims abstract description 16
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract description 15
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229930192474 thiophene Natural products 0.000 claims abstract description 14
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims abstract description 12
- UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 claims abstract description 10
- LBUJPTNKIBCYBY-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinoline Chemical compound C1=CC=C2CCCNC2=C1 LBUJPTNKIBCYBY-UHFFFAOYSA-N 0.000 claims abstract description 10
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims abstract description 10
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims abstract description 10
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims abstract description 10
- 150000001450 anions Chemical class 0.000 claims abstract description 10
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims abstract description 10
- 125000003282 alkyl amino group Chemical group 0.000 claims abstract description 9
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims abstract description 9
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims abstract description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims abstract description 7
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims abstract description 7
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 claims abstract description 7
- 239000000812 cholinergic antagonist Substances 0.000 claims abstract description 7
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims abstract description 6
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims abstract description 6
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims abstract description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 6
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims abstract description 5
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims abstract description 5
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims abstract description 5
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000012453 solvate Substances 0.000 claims abstract description 5
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims abstract description 5
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims abstract description 4
- 150000004677 hydrates Chemical class 0.000 claims abstract description 4
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims abstract description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims abstract description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims abstract description 3
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229910002651 NO3 Inorganic materials 0.000 claims abstract description 3
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims abstract description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 3
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims abstract description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims abstract description 3
- KZNICNPSHKQLFF-UHFFFAOYSA-N dihydromaleimide Natural products O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 claims abstract description 3
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims abstract description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 3
- 239000010452 phosphate Substances 0.000 claims abstract description 3
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 claims abstract description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims abstract description 3
- 229940095064 tartrate Drugs 0.000 claims abstract description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract 4
- -1 cyclopentanyl Chemical group 0.000 claims description 784
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 141
- 125000004076 pyridyl group Chemical group 0.000 claims description 130
- 125000000623 heterocyclic group Chemical group 0.000 claims description 124
- 229910052717 sulfur Inorganic materials 0.000 claims description 81
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 74
- 125000004043 oxo group Chemical group O=* 0.000 claims description 69
- 229910052760 oxygen Inorganic materials 0.000 claims description 69
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 69
- 125000001072 heteroaryl group Chemical group 0.000 claims description 67
- 125000003118 aryl group Chemical group 0.000 claims description 66
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 64
- 125000002541 furyl group Chemical group 0.000 claims description 59
- 125000002098 pyridazinyl group Chemical group 0.000 claims description 59
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 59
- 125000001544 thienyl group Chemical group 0.000 claims description 53
- 125000005843 halogen group Chemical group 0.000 claims description 49
- 125000004193 piperazinyl group Chemical group 0.000 claims description 47
- 229910052757 nitrogen Inorganic materials 0.000 claims description 44
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 42
- 125000002252 acyl group Chemical group 0.000 claims description 41
- 125000003386 piperidinyl group Chemical group 0.000 claims description 39
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 39
- 239000013543 active substance Substances 0.000 claims description 37
- 125000001786 isothiazolyl group Chemical group 0.000 claims description 35
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 35
- 125000003435 aroyl group Chemical group 0.000 claims description 34
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 34
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 33
- 125000004429 atom Chemical group 0.000 claims description 33
- 125000003831 tetrazolyl group Chemical group 0.000 claims description 30
- 239000003380 propellant Substances 0.000 claims description 29
- 229910052799 carbon Inorganic materials 0.000 claims description 28
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims description 28
- 238000009472 formulation Methods 0.000 claims description 27
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 26
- 239000000443 aerosol Substances 0.000 claims description 25
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 25
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 23
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 23
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims description 22
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 22
- 239000000843 powder Substances 0.000 claims description 22
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 22
- 239000001257 hydrogen Substances 0.000 claims description 21
- 229910052739 hydrogen Inorganic materials 0.000 claims description 21
- 125000003342 alkenyl group Chemical group 0.000 claims description 20
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims description 20
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 20
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims description 20
- 125000001041 indolyl group Chemical group 0.000 claims description 20
- 239000007789 gas Substances 0.000 claims description 19
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 18
- 125000001162 cycloheptenyl group Chemical group C1(=CCCCCC1)* 0.000 claims description 18
- 125000005842 heteroatom Chemical group 0.000 claims description 18
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 18
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 17
- 229920006395 saturated elastomer Polymers 0.000 claims description 17
- 239000000126 substance Substances 0.000 claims description 17
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 17
- QYCGBAJADAGLLK-UHFFFAOYSA-N 1-(cyclohepten-1-yl)cycloheptene Chemical group C1CCCCC=C1C1=CCCCCC1 QYCGBAJADAGLLK-UHFFFAOYSA-N 0.000 claims description 16
- VSIYJQNFMOOGCU-UHFFFAOYSA-N 1-(cyclohexen-1-yl)cyclohexene Chemical group C1CCCC(C=2CCCCC=2)=C1 VSIYJQNFMOOGCU-UHFFFAOYSA-N 0.000 claims description 16
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 16
- 125000003678 cyclohexadienyl group Chemical group C1(=CC=CCC1)* 0.000 claims description 16
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 16
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims description 16
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 15
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 15
- 125000005553 heteroaryloxy group Chemical group 0.000 claims description 15
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims description 15
- 125000000304 alkynyl group Chemical group 0.000 claims description 14
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 13
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 13
- 125000000723 dihydrobenzofuranyl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 claims description 12
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims description 12
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims description 12
- 125000002757 morpholinyl group Chemical group 0.000 claims description 12
- 125000004817 pentamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 claims description 12
- 125000003884 phenylalkyl group Chemical group 0.000 claims description 12
- 239000000725 suspension Substances 0.000 claims description 12
- 239000002775 capsule Substances 0.000 claims description 11
- ARUKYTASOALXFG-UHFFFAOYSA-N cycloheptylcycloheptane Chemical group C1CCCCCC1C1CCCCCC1 ARUKYTASOALXFG-UHFFFAOYSA-N 0.000 claims description 11
- WVIIMZNLDWSIRH-UHFFFAOYSA-N cyclohexylcyclohexane Chemical group C1CCCCC1C1CCCCC1 WVIIMZNLDWSIRH-UHFFFAOYSA-N 0.000 claims description 11
- MAWOHFOSAIXURX-UHFFFAOYSA-N cyclopentylcyclopentane Chemical group C1CCCC1C1CCCC1 MAWOHFOSAIXURX-UHFFFAOYSA-N 0.000 claims description 11
- 125000005879 dioxolanyl group Chemical group 0.000 claims description 11
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims description 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 10
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims description 10
- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- 125000005046 dihydronaphthyl group Chemical group 0.000 claims description 10
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims description 10
- 125000001425 triazolyl group Chemical group 0.000 claims description 10
- 125000006576 di-(C1-C3-alkyl)-aminocarbonyl group Chemical group 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 239000006199 nebulizer Substances 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 9
- 125000000081 (C5-C8) cycloalkenyl group Chemical group 0.000 claims description 8
- 125000005940 1,4-dioxanyl group Chemical group 0.000 claims description 8
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims description 8
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims description 8
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 claims description 8
- 125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 claims description 8
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims description 8
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims description 8
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- 125000004001 thioalkyl group Chemical group 0.000 claims description 8
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 239000004615 ingredient Substances 0.000 claims description 7
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- GAMYYCRTACQSBR-UHFFFAOYSA-N 4-azabenzimidazole Chemical compound C1=CC=C2NC=NC2=N1 GAMYYCRTACQSBR-UHFFFAOYSA-N 0.000 claims description 6
- 125000002243 cyclohexanonyl group Chemical group *C1(*)C(=O)C(*)(*)C(*)(*)C(*)(*)C1(*)* 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 6
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims description 6
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims description 6
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims description 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 5
- 150000003335 secondary amines Chemical class 0.000 claims description 5
- 150000003462 sulfoxides Chemical class 0.000 claims description 5
- 150000003536 tetrazoles Chemical class 0.000 claims description 5
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims description 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- GISSGHSMGKTVNP-UHFFFAOYSA-N C1=NC=CC2=CC=CC=C12.C1CCCC1 Chemical compound C1=NC=CC2=CC=CC=C12.C1CCCC1 GISSGHSMGKTVNP-UHFFFAOYSA-N 0.000 claims description 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 4
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims description 4
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims description 4
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 4
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims description 4
- 125000003113 cycloheptyloxy group Chemical group C1(CCCCCC1)O* 0.000 claims description 4
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 4
- 125000004582 dihydrobenzothienyl group Chemical group S1C(CC2=C1C=CC=C2)* 0.000 claims description 4
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 4
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims description 4
- 230000000414 obstructive effect Effects 0.000 claims description 4
- 125000002971 oxazolyl group Chemical group 0.000 claims description 4
- 210000002345 respiratory system Anatomy 0.000 claims description 4
- RAOIDOHSFRTOEL-UHFFFAOYSA-N tetrahydrothiophene Chemical compound C1CCSC1 RAOIDOHSFRTOEL-UHFFFAOYSA-N 0.000 claims description 4
- 125000000335 thiazolyl group Chemical group 0.000 claims description 4
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 3
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims description 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 3
- 150000002016 disaccharides Chemical class 0.000 claims description 3
- 150000002772 monosaccharides Chemical class 0.000 claims description 3
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 claims description 3
- 150000003512 tertiary amines Chemical class 0.000 claims description 3
- 238000002604 ultrasonography Methods 0.000 claims description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 2
- NQPJDJVGBDHCAD-UHFFFAOYSA-N 1,3-diazinan-2-one Chemical compound OC1=NCCCN1 NQPJDJVGBDHCAD-UHFFFAOYSA-N 0.000 claims description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 2
- LGEIYHAOVGKDBB-UHFFFAOYSA-N 1lambda4-thiacycloundecane 1-oxide Chemical compound C1CCCCCCCCCS1=O LGEIYHAOVGKDBB-UHFFFAOYSA-N 0.000 claims description 2
- MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 claims description 2
- KMTRUDSVKNLOMY-UHFFFAOYSA-N Ethylene carbonate Chemical compound O=C1OCCO1 KMTRUDSVKNLOMY-UHFFFAOYSA-N 0.000 claims description 2
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- 125000002619 bicyclic group Chemical group 0.000 claims description 2
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 claims description 2
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims description 2
- 150000004676 glycans Polymers 0.000 claims description 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 2
- 230000002757 inflammatory effect Effects 0.000 claims description 2
- 125000002950 monocyclic group Chemical group 0.000 claims description 2
- 150000002482 oligosaccharides Polymers 0.000 claims description 2
- XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical compound O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 125000004742 propyloxycarbonyl group Chemical group 0.000 claims description 2
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims description 2
- 150000005846 sugar alcohols Polymers 0.000 claims description 2
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 claims description 2
- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 claims description 2
- ISXOBTBCNRIIQO-UHFFFAOYSA-N tetrahydrothiophene 1-oxide Chemical compound O=S1CCCC1 ISXOBTBCNRIIQO-UHFFFAOYSA-N 0.000 claims description 2
- BUGOPWGPQGYYGR-UHFFFAOYSA-N thiane 1,1-dioxide Chemical compound O=S1(=O)CCCCC1 BUGOPWGPQGYYGR-UHFFFAOYSA-N 0.000 claims description 2
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 36
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 5
- OMOVVBIIQSXZSZ-UHFFFAOYSA-N [6-(4-acetyloxy-5,9a-dimethyl-2,7-dioxo-4,5a,6,9-tetrahydro-3h-pyrano[3,4-b]oxepin-5-yl)-5-formyloxy-3-(furan-3-yl)-3a-methyl-7-methylidene-1a,2,3,4,5,6-hexahydroindeno[1,7a-b]oxiren-4-yl] 2-hydroxy-3-methylpentanoate Chemical compound CC12C(OC(=O)C(O)C(C)CC)C(OC=O)C(C3(C)C(CC(=O)OC4(C)COC(=O)CC43)OC(C)=O)C(=C)C32OC3CC1C=1C=COC=1 OMOVVBIIQSXZSZ-UHFFFAOYSA-N 0.000 claims 1
- 150000004804 polysaccharides Polymers 0.000 claims 1
- 239000011833 salt mixture Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract description 83
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 description 186
- 229940043355 kinase inhibitor Drugs 0.000 description 24
- 239000003757 phosphotransferase inhibitor Substances 0.000 description 24
- 239000000243 solution Substances 0.000 description 23
- 239000002253 acid Substances 0.000 description 17
- 150000003839 salts Chemical class 0.000 description 15
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 13
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- 238000003860 storage Methods 0.000 description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 description 8
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 125000005494 pyridonyl group Chemical group 0.000 description 8
- 229960000257 tiotropium bromide Drugs 0.000 description 8
- 239000007921 spray Substances 0.000 description 7
- PZXHLFLLNPJDJD-UHFFFAOYSA-N 1-(3-amino-5-tert-butyl-2-methoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=C(N)C=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 PZXHLFLLNPJDJD-UHFFFAOYSA-N 0.000 description 6
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 6
- 125000005436 dihydrobenzothiophenyl group Chemical group S1C(CC2=C1C=CC=C2)* 0.000 description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 6
- 208000002815 pulmonary hypertension Diseases 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 150000007513 acids Chemical class 0.000 description 5
- 150000001408 amides Chemical class 0.000 description 5
- 208000006673 asthma Diseases 0.000 description 5
- 125000005872 benzooxazolyl group Chemical group 0.000 description 5
- 239000000460 chlorine Substances 0.000 description 5
- 229910052801 chlorine Inorganic materials 0.000 description 5
- 125000006518 morpholino carbonyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])N(C(*)=O)C1([H])[H] 0.000 description 5
- 229940037001 sodium edetate Drugs 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 235000010323 ascorbic acid Nutrition 0.000 description 4
- 239000011668 ascorbic acid Substances 0.000 description 4
- 229960005070 ascorbic acid Drugs 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 4
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- ZMQPIXAVYIDIBG-UHFFFAOYSA-N 1-(2,3-dimethyl-1h-indol-5-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C2C(C)=C(C)NC2=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 ZMQPIXAVYIDIBG-UHFFFAOYSA-N 0.000 description 3
- ITBZMXUGTUHWGK-UHFFFAOYSA-N 1-(2-methyl-5-phenylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC1=CC=C(C=2C=CC=CC=2)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 ITBZMXUGTUHWGK-UHFFFAOYSA-N 0.000 description 3
- SEHRPXLAFSFMSI-UHFFFAOYSA-N 1-(2-methyl-5-propan-2-ylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC(C)C1=CC=C(C)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 SEHRPXLAFSFMSI-UHFFFAOYSA-N 0.000 description 3
- OKJJYXJBKGPJLH-UHFFFAOYSA-N 1-(2-tert-butyl-5-methylpyridin-4-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC1=CN=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 OKJJYXJBKGPJLH-UHFFFAOYSA-N 0.000 description 3
- QCYRZCANKXBEHZ-UHFFFAOYSA-N 1-(3-tert-butylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC(C)(C)C1=CC=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 QCYRZCANKXBEHZ-UHFFFAOYSA-N 0.000 description 3
- FFBUDLJONCUVMD-UHFFFAOYSA-N 1-(5-butan-2-yl-2-methoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CCC(C)C1=CC=C(OC)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 FFBUDLJONCUVMD-UHFFFAOYSA-N 0.000 description 3
- GQLCRASPHLJOAW-UHFFFAOYSA-N 1-(5-chloro-2,4-dimethoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C(Cl)C(OC)=CC(OC)=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 GQLCRASPHLJOAW-UHFFFAOYSA-N 0.000 description 3
- FBPMUUXVDWZTBK-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[2-(morpholin-4-ylmethyl)pyrimidin-5-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CN=C1CN1CCOCC1 FBPMUUXVDWZTBK-UHFFFAOYSA-N 0.000 description 3
- GFGAVPLNMQVFHP-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-[(2,6-dimethylmorpholin-4-yl)methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CC(C)OC(C)C1 GFGAVPLNMQVFHP-UHFFFAOYSA-N 0.000 description 3
- BCYXSXJASCDAPJ-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCN(C)CC1 BCYXSXJASCDAPJ-UHFFFAOYSA-N 0.000 description 3
- DVBKZPSCTGHZHB-UHFFFAOYSA-N 1-(5-tert-butyl-2-methylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 DVBKZPSCTGHZHB-UHFFFAOYSA-N 0.000 description 3
- YNOBSNNZZPAJLM-UHFFFAOYSA-N 1-(5-tert-butyl-2-methylphenyl)-3-[4-[6-[3-methoxypropyl(methyl)amino]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=NC(N(C)CCCOC)=CC=C1C(C1=CC=CC=C11)=CC=C1NC(=O)NC1=CC(C(C)(C)C)=CC=C1C YNOBSNNZZPAJLM-UHFFFAOYSA-N 0.000 description 3
- UHWHXNSOZPFADL-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C(C(C)(C)C)=CC=C(C=2C=CC=CC=2)C=1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 UHWHXNSOZPFADL-UHFFFAOYSA-N 0.000 description 3
- KBYAIWPIVQYVDZ-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-[4-(trifluoromethoxy)phenyl]urea Chemical compound C1=CC(OC(F)(F)F)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 KBYAIWPIVQYVDZ-UHFFFAOYSA-N 0.000 description 3
- BBCMFRFQYUIZRS-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1h-pyrazol-4-yl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC1=CC(C(C)(C)C)=CC=C1C=1C=NNC=1 BBCMFRFQYUIZRS-UHFFFAOYSA-N 0.000 description 3
- WMRRCPFERWSFEX-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-hydroxypropyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC(C)(C)C1=CC=C(CCCO)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 WMRRCPFERWSFEX-UHFFFAOYSA-N 0.000 description 3
- WXBMMVPWYARDGV-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-(morpholin-4-ylmethyl)pyrimidin-5-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=NC=3)=CC=2)=CC(C(C)(C)C)=N1 WXBMMVPWYARDGV-UHFFFAOYSA-N 0.000 description 3
- XZMNYZSIMZGMEY-UHFFFAOYSA-N 1-[5-tert-butyl-2-(morpholine-4-carbonyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC1=CC(C(C)(C)C)=CC=C1C(=O)N1CCOCC1 XZMNYZSIMZGMEY-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 3
- 229910052794 bromium Inorganic materials 0.000 description 3
- 239000008139 complexing agent Substances 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 239000011737 fluorine Substances 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 229960001375 lactose Drugs 0.000 description 3
- CGONTLDBLAAPSU-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-[[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]carbamoylamino]phenyl]acetamide Chemical compound COC1=C(NC(C)=O)C=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 CGONTLDBLAAPSU-UHFFFAOYSA-N 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 3
- 125000005505 thiomorpholino group Chemical group 0.000 description 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 description 2
- FKASFBLJDCHBNZ-UHFFFAOYSA-N 1,3,4-oxadiazole Chemical compound C1=NN=CO1 FKASFBLJDCHBNZ-UHFFFAOYSA-N 0.000 description 2
- XMJCSEMZSSHAPU-UHFFFAOYSA-N 1-(3-amino-5-tert-butyl-2-methoxyphenyl)-3-[4-(6-methylpyridin-3-yl)naphthalen-1-yl]urea Chemical compound COC1=C(N)C=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C1=CC=C(C)N=C1 XMJCSEMZSSHAPU-UHFFFAOYSA-N 0.000 description 2
- HYSJPAQMILEQFY-UHFFFAOYSA-N 1-(3-methylnaphthalen-2-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC1=CC2=CC=CC=C2C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 HYSJPAQMILEQFY-UHFFFAOYSA-N 0.000 description 2
- HPQQHGUMMVKGPO-UHFFFAOYSA-N 1-(5-cyclohexyl-2-methoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C2CCCCC2)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 HPQQHGUMMVKGPO-UHFFFAOYSA-N 0.000 description 2
- CDGVKVKZQCDYCD-UHFFFAOYSA-N 1-(5-tert-butyl-1,3-benzoxazol-7-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=12OC=NC2=CC(C(C)(C)C)=CC=1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 CDGVKVKZQCDYCD-UHFFFAOYSA-N 0.000 description 2
- ZHEMIWZWBVZODY-UHFFFAOYSA-N 1-(5-tert-butyl-2-ethoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CCOC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 ZHEMIWZWBVZODY-UHFFFAOYSA-N 0.000 description 2
- NAZWEBNDZAMONP-UHFFFAOYSA-N 1-(5-tert-butyl-2-imidazol-1-ylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C(C(C)(C)C)=CC=C(N2C=NC=C2)C=1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 NAZWEBNDZAMONP-UHFFFAOYSA-N 0.000 description 2
- UVDHLVZENVKMSJ-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C(C(C)(C)C)C=C([N+]([O-])=O)C(OC)=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 UVDHLVZENVKMSJ-UHFFFAOYSA-N 0.000 description 2
- CAQYVODRHABUJH-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxy-3-propylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CCCC1=CC(C(C)(C)C)=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1OC CAQYVODRHABUJH-UHFFFAOYSA-N 0.000 description 2
- NNXDLNQHNUKICX-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-(1,3-dioxolan-2-yl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C1=CC=C(C2OCCO2)N=C1 NNXDLNQHNUKICX-UHFFFAOYSA-N 0.000 description 2
- OLHILEWECVENBS-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-(hydroxymethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C1=CC=C(CO)N=C1 OLHILEWECVENBS-UHFFFAOYSA-N 0.000 description 2
- TVJZPCWJLIDBMN-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 TVJZPCWJLIDBMN-UHFFFAOYSA-N 0.000 description 2
- VRQBVALNRMCCRQ-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-(morpholine-4-carbonyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C1=CC=C(C(=O)N2CCOCC2)N=C1 VRQBVALNRMCCRQ-UHFFFAOYSA-N 0.000 description 2
- USPQVAWOBXKNOF-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-(oxan-4-ylamino)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1NC1CCOCC1 USPQVAWOBXKNOF-UHFFFAOYSA-N 0.000 description 2
- FBHTZEIJBMNUJC-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-[(1-oxothian-4-yl)amino]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1NC1CCS(=O)CC1 FBHTZEIJBMNUJC-UHFFFAOYSA-N 0.000 description 2
- OXGNMBLVMSVAPZ-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-[(2,6-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1C(C)CCCC1C OXGNMBLVMSVAPZ-UHFFFAOYSA-N 0.000 description 2
- YFMSNBUWORKEJK-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-[(3-oxopiperazin-1-yl)methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CC(=O)NCC1 YFMSNBUWORKEJK-UHFFFAOYSA-N 0.000 description 2
- LNMOYKCXUACLIC-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-[(oxolan-3-ylamino)methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CNC1COCC1 LNMOYKCXUACLIC-UHFFFAOYSA-N 0.000 description 2
- LFMQDEIBFGMGHX-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-[[2-(methoxymethyl)morpholin-4-yl]methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1COC(COC)CN1CC1=CC=C(C=2C3=CC=CC=C3C(NC(=O)NC=3C(=CC=C(C=3)C(C)(C)C)OC)=CC=2)C=N1 LFMQDEIBFGMGHX-UHFFFAOYSA-N 0.000 description 2
- QAMPLFFTYHFJJP-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxypyridin-3-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=NC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 QAMPLFFTYHFJJP-UHFFFAOYSA-N 0.000 description 2
- HZMQYZHTBFZUTB-UHFFFAOYSA-N 1-(5-tert-butyl-2-methylphenyl)-3-[4-[4-(morpholin-4-ylmethyl)imidazol-1-yl]naphthalen-1-yl]urea Chemical compound CC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1N1C=C(CN2CCOCC2)N=C1 HZMQYZHTBFZUTB-UHFFFAOYSA-N 0.000 description 2
- KFXVPIJOIPYPSH-UHFFFAOYSA-N 1-(5-tert-butyl-2-methylphenyl)-3-[4-[5-(methanesulfonamido)pyrazin-2-yl]naphthalen-1-yl]urea Chemical compound CC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C1=CN=C(NS(C)(=O)=O)C=N1 KFXVPIJOIPYPSH-UHFFFAOYSA-N 0.000 description 2
- ULCWMQOJQGXRRU-UHFFFAOYSA-N 1-(5-tert-butyl-2-methylphenyl)-3-[4-[6-(3-methoxypropylamino)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=NC(NCCCOC)=CC=C1C(C1=CC=CC=C11)=CC=C1NC(=O)NC1=CC(C(C)(C)C)=CC=C1C ULCWMQOJQGXRRU-UHFFFAOYSA-N 0.000 description 2
- HTEMUDPCVAMLEB-UHFFFAOYSA-N 1-(5-tert-butyl-2-methylpyrazol-3-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CN1N=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 HTEMUDPCVAMLEB-UHFFFAOYSA-N 0.000 description 2
- WUGLAQLTUHTAJZ-UHFFFAOYSA-N 1-(5-tert-butyl-2-methylpyridin-3-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC1=NC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 WUGLAQLTUHTAJZ-UHFFFAOYSA-N 0.000 description 2
- VKTLDTPBPJGRIJ-UHFFFAOYSA-N 1-(5-tert-butyl-2-morpholin-4-ylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC1=CC(C(C)(C)C)=CC=C1N1CCOCC1 VKTLDTPBPJGRIJ-UHFFFAOYSA-N 0.000 description 2
- BRZWHPXAPTYZID-UHFFFAOYSA-N 1-(5-tert-butyl-2-oxo-3h-1,3-benzoxazol-7-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=12OC(=O)NC2=CC(C(C)(C)C)=CC=1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 BRZWHPXAPTYZID-UHFFFAOYSA-N 0.000 description 2
- TYBHUHOIYNNGQO-UHFFFAOYSA-N 1-(5-tert-butyl-2-propan-2-yloxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC(C)OC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 TYBHUHOIYNNGQO-UHFFFAOYSA-N 0.000 description 2
- LPLXKSPOWLXYGG-UHFFFAOYSA-N 1-(5-tert-butyl-2-propoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CCCOC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 LPLXKSPOWLXYGG-UHFFFAOYSA-N 0.000 description 2
- GZRSLWDGXYUDLG-UHFFFAOYSA-N 1-(5-tert-butyl-2-pyrrolidin-1-ylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC1=CC(C(C)(C)C)=CC=C1N1CCCC1 GZRSLWDGXYUDLG-UHFFFAOYSA-N 0.000 description 2
- USGJETFWAMMMLN-UHFFFAOYSA-N 1-(5-tert-butyl-3-cyano-2-methoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C(C(C)(C)C)C=C(C#N)C(OC)=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 USGJETFWAMMMLN-UHFFFAOYSA-N 0.000 description 2
- HOULHNIBVCNAGC-UHFFFAOYSA-N 1-[2,4-dimethoxy-5-(trifluoromethyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC(OC)=C(C(F)(F)F)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 HOULHNIBVCNAGC-UHFFFAOYSA-N 0.000 description 2
- MOCYVOKWTBPIGE-UHFFFAOYSA-N 1-[2-methoxy-5-(2-methylbutan-2-yl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CCC(C)(C)C1=CC=C(OC)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 MOCYVOKWTBPIGE-UHFFFAOYSA-N 0.000 description 2
- FBVHTEUZJDFLTA-UHFFFAOYSA-N 1-[2-methoxy-5-(trifluoromethyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(F)(F)F)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 FBVHTEUZJDFLTA-UHFFFAOYSA-N 0.000 description 2
- MUQPJRRMNAGMKL-UHFFFAOYSA-N 1-[2-methylsulfinyl-5-(trifluoromethyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CS(=O)C1=CC=C(C(F)(F)F)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 MUQPJRRMNAGMKL-UHFFFAOYSA-N 0.000 description 2
- GSQKKUDSQVZUJV-UHFFFAOYSA-N 1-[4-[4-[[bis(2-cyanoethyl)amino]methyl]phenyl]naphthalen-1-yl]-3-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=CC(CN(CCC#N)CCC#N)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 GSQKKUDSQVZUJV-UHFFFAOYSA-N 0.000 description 2
- VJMISIPCJWKEGO-UHFFFAOYSA-N 1-[4-[4-[[bis(2-methoxyethyl)amino]methyl]phenyl]naphthalen-1-yl]-3-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]urea Chemical compound C1=CC(CN(CCOC)CCOC)=CC=C1C(C1=CC=CC=C11)=CC=C1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)N=C1 VJMISIPCJWKEGO-UHFFFAOYSA-N 0.000 description 2
- SVGQPGDMEXQRQN-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea Chemical compound FC(F)(F)C1=CC=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 SVGQPGDMEXQRQN-UHFFFAOYSA-N 0.000 description 2
- ICGUENJRUODDDI-UHFFFAOYSA-N 1-[4-[6-[[bis(2-cyanoethyl)amino]methyl]pyridin-3-yl]naphthalen-1-yl]-3-(5-tert-butyl-2-methoxyphenyl)urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C1=CC=C(CN(CCC#N)CCC#N)N=C1 ICGUENJRUODDDI-UHFFFAOYSA-N 0.000 description 2
- KVOJMIMBKVGVQO-UHFFFAOYSA-N 1-[4-[6-[[bis(2-methoxyethyl)amino]methyl]pyridin-3-yl]naphthalen-1-yl]-3-(5-tert-butyl-2-methoxyphenyl)urea Chemical compound C1=NC(CN(CCOC)CCOC)=CC=C1C(C1=CC=CC=C11)=CC=C1NC(=O)NC1=CC(C(C)(C)C)=CC=C1OC KVOJMIMBKVGVQO-UHFFFAOYSA-N 0.000 description 2
- HPNQMSKRZIBEMH-UHFFFAOYSA-N 1-[5-(1-cyanocyclopropyl)-2-methoxyphenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C2(CC2)C#N)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 HPNQMSKRZIBEMH-UHFFFAOYSA-N 0.000 description 2
- FQAMJOYQZKEDGX-UHFFFAOYSA-N 1-[5-(2,2-dimethylpropanoyl)-2-methylphenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC1=CC=C(C(=O)C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 FQAMJOYQZKEDGX-UHFFFAOYSA-N 0.000 description 2
- ZNYNPFIRXYNDQU-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-cyanoethyl)pyrazol-3-yl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound N#CCCN1N=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 ZNYNPFIRXYNDQU-UHFFFAOYSA-N 0.000 description 2
- YTISFTRMFXFAKS-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methylpyrimidin-5-yl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=NC=C1C1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 YTISFTRMFXFAKS-UHFFFAOYSA-N 0.000 description 2
- MCKFAVIMAYCFIH-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methylpyrimidin-5-yl)pyrazol-3-yl]-3-[4-[6-[(1-oxo-1,4-thiazinan-4-yl)methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=NC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCS(=O)CC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 MCKFAVIMAYCFIH-UHFFFAOYSA-N 0.000 description 2
- USGPKPYWOURZEK-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-(morpholine-4-carbonyl)pyrimidin-5-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(=NC=3)C(=O)N3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 USGPKPYWOURZEK-UHFFFAOYSA-N 0.000 description 2
- BMXNQGASYHVGST-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[3-(morpholin-4-ylmethyl)phenyl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=C(CN4CCOCC4)C=CC=3)=CC=2)=CC(C(C)(C)C)=N1 BMXNQGASYHVGST-UHFFFAOYSA-N 0.000 description 2
- JHCPOCAZTCPCQQ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[4-(morpholin-4-ylmethyl)phenyl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=CC(CN4CCOCC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 JHCPOCAZTCPCQQ-UHFFFAOYSA-N 0.000 description 2
- IKJJFZMMHAIPNB-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[5-(morpholin-4-ylmethyl)furan-2-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3OC(CN4CCOCC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 IKJJFZMMHAIPNB-UHFFFAOYSA-N 0.000 description 2
- BBOPRMNMLDLRKQ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[5-(morpholin-4-ylmethyl)pyridin-2-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3N=CC(CN4CCOCC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 BBOPRMNMLDLRKQ-UHFFFAOYSA-N 0.000 description 2
- KAZMQKPLIPWQNO-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 KAZMQKPLIPWQNO-UHFFFAOYSA-N 0.000 description 2
- HZOOQEANFBKRIM-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[6-[(1-oxothian-4-yl)amino]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(NC4CCS(=O)CC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 HZOOQEANFBKRIM-UHFFFAOYSA-N 0.000 description 2
- KNAHYEJUOBRJIC-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[3-hydroxy-4-(oxolan-3-ylmethyl)phenyl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=C(O)C(CC4COCC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 KNAHYEJUOBRJIC-UHFFFAOYSA-N 0.000 description 2
- OVPDTMKGYGGJNU-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[4-(morpholin-4-ylmethyl)phenyl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=CC(CN4CCOCC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 OVPDTMKGYGGJNU-UHFFFAOYSA-N 0.000 description 2
- ROGOQXDNDRXOAB-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[4-(thiomorpholin-4-ylmethyl)phenyl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=CC(CN4CCSCC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 ROGOQXDNDRXOAB-UHFFFAOYSA-N 0.000 description 2
- JOWNWKBUMSHNCS-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[4-[(2-methyl-3-oxopiperazin-1-yl)methyl]phenyl]naphthalen-1-yl]urea Chemical compound C1CNC(=O)C(C)N1CC1=CC=C(C=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=NC(C)=CC=3)=CC=2)C=C1 JOWNWKBUMSHNCS-UHFFFAOYSA-N 0.000 description 2
- AITNULMUNMWYTC-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[4-[[2-cyanoethyl(oxolan-2-ylmethyl)amino]methyl]phenyl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=CC(CN(CCC#N)CC4OCCC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 AITNULMUNMWYTC-UHFFFAOYSA-N 0.000 description 2
- OCYIIPQUEFWVOX-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[4-[[2-cyanoethyl(pyridin-3-ylmethyl)amino]methyl]phenyl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=CC(CN(CCC#N)CC=4C=NC=CC=4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 OCYIIPQUEFWVOX-UHFFFAOYSA-N 0.000 description 2
- MKQIWKMKTHHOCV-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[6-(1-morpholin-4-ylpropyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C=C(C=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=NC(C)=CC=3)=CC=2)C=NC=1C(CC)N1CCOCC1 MKQIWKMKTHHOCV-UHFFFAOYSA-N 0.000 description 2
- MXEDNULIXVIKDP-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[6-(2-oxa-5-azabicyclo[2.2.1]heptan-5-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4C5CC(OC5)C4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 MXEDNULIXVIKDP-UHFFFAOYSA-N 0.000 description 2
- YEBURKNDXZVPML-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[6-[(2,6-dimethylmorpholin-4-yl)methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1C(C)OC(C)CN1CC1=CC=C(C=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=NC(C)=CC=3)=CC=2)C=N1 YEBURKNDXZVPML-UHFFFAOYSA-N 0.000 description 2
- ZCPTVULXWYSYNL-UHFFFAOYSA-N 1-[5-tert-butyl-2-(dimethylamino)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CN(C)C1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 ZCPTVULXWYSYNL-UHFFFAOYSA-N 0.000 description 2
- JJHSDQDGIZUPON-UHFFFAOYSA-N 1-[5-tert-butyl-3-(ethylamino)-2-methoxyphenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CCNC1=CC(C(C)(C)C)=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1OC JJHSDQDGIZUPON-UHFFFAOYSA-N 0.000 description 2
- KLPFPTSVYVEKOL-UHFFFAOYSA-N 1-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 KLPFPTSVYVEKOL-UHFFFAOYSA-N 0.000 description 2
- NTBXCCHAPORVOV-UHFFFAOYSA-N 1-[[5-[4-[(5-tert-butyl-2-methoxyphenyl)carbamoylamino]naphthalen-1-yl]pyridin-2-yl]methyl]piperidine-3-carboxylic acid Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CC(C(O)=O)CCC1 NTBXCCHAPORVOV-UHFFFAOYSA-N 0.000 description 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 description 2
- TWTPPEZVNRJSQU-UHFFFAOYSA-N 2-[4-tert-butyl-2-[[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]carbamoylamino]phenoxy]acetamide Chemical compound CC(C)(C)C1=CC=C(OCC(N)=O)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 TWTPPEZVNRJSQU-UHFFFAOYSA-N 0.000 description 2
- 125000001731 2-cyanoethyl group Chemical group [H]C([H])(*)C([H])([H])C#N 0.000 description 2
- SMNDYUVBFMFKNZ-UHFFFAOYSA-N 2-furoic acid Chemical compound OC(=O)C1=CC=CO1 SMNDYUVBFMFKNZ-UHFFFAOYSA-N 0.000 description 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 description 2
- LZGNWLNIKHJOAH-UHFFFAOYSA-N 4-[4-(2-morpholin-4-ylthiomorpholin-4-yl)sulfinylthiomorpholin-2-yl]morpholine Chemical compound O1CCN(CC1)C1SCCN(C1)S(=O)N1CC(SCC1)N1CCOCC1 LZGNWLNIKHJOAH-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 230000001078 anti-cholinergic effect Effects 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 229960000686 benzalkonium chloride Drugs 0.000 description 2
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 description 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 125000001309 chloro group Chemical group Cl* 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 125000004652 decahydroisoquinolinyl group Chemical group C1(NCCC2CCCCC12)* 0.000 description 2
- 125000004856 decahydroquinolinyl group Chemical group N1(CCCC2CCCCC12)* 0.000 description 2
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000005043 dihydropyranyl group Chemical group O1C(CCC=C1)* 0.000 description 2
- 125000005044 dihydroquinolinyl group Chemical group N1(CC=CC2=CC=CC=C12)* 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 125000000532 dioxanyl group Chemical group 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 125000005883 dithianyl group Chemical group 0.000 description 2
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 2
- 239000001530 fumaric acid Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 229940093915 gynecological organic acid Drugs 0.000 description 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 2
- 125000002636 imidazolinyl group Chemical group 0.000 description 2
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- DAIAIOBTYVJHHJ-UHFFFAOYSA-N n-[1-[[5-[4-[(5-tert-butyl-2-methoxyphenyl)carbamoylamino]naphthalen-1-yl]pyridin-2-yl]methyl]pyrrolidin-3-yl]acetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CC(NC(C)=O)CC1 DAIAIOBTYVJHHJ-UHFFFAOYSA-N 0.000 description 2
- KGJOEOIQYVJQFZ-UHFFFAOYSA-N n-[5-[4-[(5-tert-butyl-2-methoxyphenyl)carbamoylamino]naphthalen-1-yl]pyridin-2-yl]acetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C1=CC=C(NC(C)=O)N=C1 KGJOEOIQYVJQFZ-UHFFFAOYSA-N 0.000 description 2
- TVBZKMHBLROHSN-UHFFFAOYSA-N n-[5-[4-[[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC=C1C(C1=CC=CC=C11)=CC=C1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)N=C1 TVBZKMHBLROHSN-UHFFFAOYSA-N 0.000 description 2
- VZTPVFAWGLVYSE-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-[[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]carbamoylamino]phenyl]-2,2,2-trifluoroacetamide Chemical compound C1=C(C(C)(C)C)C=C(NC(=O)C(F)(F)F)C(OC)=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 VZTPVFAWGLVYSE-UHFFFAOYSA-N 0.000 description 2
- CBBNEQNYUJVZPQ-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-[[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]carbamoylamino]phenyl]-2-methylpropanamide Chemical compound C1=C(C(C)(C)C)C=C(NC(=O)C(C)C)C(OC)=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 CBBNEQNYUJVZPQ-UHFFFAOYSA-N 0.000 description 2
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 2
- 125000001326 naphthylalkyl group Chemical group 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 125000005968 oxazolinyl group Chemical group 0.000 description 2
- 125000003566 oxetanyl group Chemical group 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 125000005545 phthalimidyl group Chemical group 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229940080818 propionamide Drugs 0.000 description 2
- 125000001422 pyrrolinyl group Chemical group 0.000 description 2
- 208000023504 respiratory system disease Diseases 0.000 description 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 125000003507 tetrahydrothiofenyl group Chemical group 0.000 description 2
- 125000001984 thiazolidinyl group Chemical group 0.000 description 2
- 125000002769 thiazolinyl group Chemical group 0.000 description 2
- 125000005503 thioxanyl group Chemical group 0.000 description 2
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- AZKYYCONBBTJBS-UHFFFAOYSA-N (5-tert-butyl-2-methylphenyl)carbamic acid Chemical compound CC1=CC=C(C(C)(C)C)C=C1NC(O)=O AZKYYCONBBTJBS-UHFFFAOYSA-N 0.000 description 1
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 description 1
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 description 1
- RGDYCIHVZRSMAR-UHFFFAOYSA-N 1,3-bis[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 RGDYCIHVZRSMAR-UHFFFAOYSA-N 0.000 description 1
- REERFUMNYQUJQG-UHFFFAOYSA-N 1-(1,3-benzothiazol-6-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C=C2N=CSC2=CC=1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 REERFUMNYQUJQG-UHFFFAOYSA-N 0.000 description 1
- CBEQVMLALWOOQZ-UHFFFAOYSA-N 1-(1-acetyl-2,3-dihydroindol-5-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C=C2N(C(=O)C)CCC2=CC=1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 CBEQVMLALWOOQZ-UHFFFAOYSA-N 0.000 description 1
- ULZLBCDVMYGAHV-UHFFFAOYSA-N 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C2OC(F)(F)OC2=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 ULZLBCDVMYGAHV-UHFFFAOYSA-N 0.000 description 1
- SUAXLPQBMQNTSP-UHFFFAOYSA-N 1-(2,3-dimethylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC1=CC=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1C SUAXLPQBMQNTSP-UHFFFAOYSA-N 0.000 description 1
- WUQGLNIDHPPBNI-UHFFFAOYSA-N 1-(2,4-dichlorophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound ClC1=CC(Cl)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 WUQGLNIDHPPBNI-UHFFFAOYSA-N 0.000 description 1
- SYBGVADGOHETFE-UHFFFAOYSA-N 1-(2,4-dimethoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC(OC)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 SYBGVADGOHETFE-UHFFFAOYSA-N 0.000 description 1
- RXDWJZREJOZEGL-UHFFFAOYSA-N 1-(2,4-dimethylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC1=CC(C)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 RXDWJZREJOZEGL-UHFFFAOYSA-N 0.000 description 1
- SFPBHNAFVHSBPU-UHFFFAOYSA-N 1-(2,5-dichlorophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound ClC1=CC=C(Cl)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 SFPBHNAFVHSBPU-UHFFFAOYSA-N 0.000 description 1
- AWEJMFLMIIIWQH-UHFFFAOYSA-N 1-(2,5-difluorophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound FC1=CC=C(F)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 AWEJMFLMIIIWQH-UHFFFAOYSA-N 0.000 description 1
- FAZWSMQUSZIVSV-UHFFFAOYSA-N 1-(2,5-dimethoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(OC)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 FAZWSMQUSZIVSV-UHFFFAOYSA-N 0.000 description 1
- YNCLMYJXNRLKIU-UHFFFAOYSA-N 1-(2,5-ditert-butylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC(C)(C)C1=CC=C(C(C)(C)C)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 YNCLMYJXNRLKIU-UHFFFAOYSA-N 0.000 description 1
- WUXVANAGFKJIES-UHFFFAOYSA-N 1-(2,6-dibromo-4-propan-2-ylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound BrC1=CC(C(C)C)=CC(Br)=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 WUXVANAGFKJIES-UHFFFAOYSA-N 0.000 description 1
- MPSHBBUNTWUBGK-UHFFFAOYSA-N 1-(2-amino-5-tert-butylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC(C)(C)C1=CC=C(N)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 MPSHBBUNTWUBGK-UHFFFAOYSA-N 0.000 description 1
- CRTPUTWKRSDIKT-UHFFFAOYSA-N 1-(2-chloro-6-methylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC1=CC=CC(Cl)=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 CRTPUTWKRSDIKT-UHFFFAOYSA-N 0.000 description 1
- BKVJLRPQHGWDNH-UHFFFAOYSA-N 1-(2-methoxy-4-nitrophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC([N+]([O-])=O)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 BKVJLRPQHGWDNH-UHFFFAOYSA-N 0.000 description 1
- YRWFTPPPNBPMNF-UHFFFAOYSA-N 1-(2-methoxy-5-methylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 YRWFTPPPNBPMNF-UHFFFAOYSA-N 0.000 description 1
- NVRRPPBQBVYFJF-UHFFFAOYSA-N 1-(2-methoxy-5-nitrophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C([N+]([O-])=O)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 NVRRPPBQBVYFJF-UHFFFAOYSA-N 0.000 description 1
- NZLMNKKHXFTHNB-UHFFFAOYSA-N 1-(2-methoxy-5-phenoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)C(OC)=CC=C1OC1=CC=CC=C1 NZLMNKKHXFTHNB-UHFFFAOYSA-N 0.000 description 1
- JBQZUUIMGVSOBI-UHFFFAOYSA-N 1-(2-methoxydibenzofuran-3-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC(C2=CC=CC=C2O2)=C2C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 JBQZUUIMGVSOBI-UHFFFAOYSA-N 0.000 description 1
- IZUDERUUDIJAIC-UHFFFAOYSA-N 1-(2-methoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 IZUDERUUDIJAIC-UHFFFAOYSA-N 0.000 description 1
- SLCLHNJCNWDURK-UHFFFAOYSA-N 1-(2-methyl-3-nitrophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=CC=C([N+]([O-])=O)C(C)=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 SLCLHNJCNWDURK-UHFFFAOYSA-N 0.000 description 1
- DNIOFXKFGFGVAV-UHFFFAOYSA-N 1-(2-methyl-4-nitrophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC1=CC([N+]([O-])=O)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 DNIOFXKFGFGVAV-UHFFFAOYSA-N 0.000 description 1
- VTOFXBYEZWMSIR-UHFFFAOYSA-N 1-(2-methyl-6-propan-2-ylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC(C)C1=CC=CC(C)=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 VTOFXBYEZWMSIR-UHFFFAOYSA-N 0.000 description 1
- MYUPRBWNKVNHHN-UHFFFAOYSA-N 1-(3,4-dimethylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C(C)C(C)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 MYUPRBWNKVNHHN-UHFFFAOYSA-N 0.000 description 1
- DELSLEWHRQVXEV-UHFFFAOYSA-N 1-(3-chloro-2-methoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=C(Cl)C=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 DELSLEWHRQVXEV-UHFFFAOYSA-N 0.000 description 1
- NVYYWTXAJCTIRC-UHFFFAOYSA-N 1-(3-chloro-4-methylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C(Cl)C(C)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 NVYYWTXAJCTIRC-UHFFFAOYSA-N 0.000 description 1
- SKGOFDWOHKOHPM-UHFFFAOYSA-N 1-(3-chlorophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound ClC1=CC=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 SKGOFDWOHKOHPM-UHFFFAOYSA-N 0.000 description 1
- GTNFKGBUXGFUIS-UHFFFAOYSA-N 1-(3-cyanophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC1=CC=CC(C#N)=C1 GTNFKGBUXGFUIS-UHFFFAOYSA-N 0.000 description 1
- GCEWIOVJYXKEEO-UHFFFAOYSA-N 1-(3-cyclopentyloxy-4-methoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C(OC2CCCC2)C(OC)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 GCEWIOVJYXKEEO-UHFFFAOYSA-N 0.000 description 1
- GMCBUMYNOUFINM-UHFFFAOYSA-N 1-(3-ethylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CCC1=CC=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 GMCBUMYNOUFINM-UHFFFAOYSA-N 0.000 description 1
- RMRDSOFRYIUFBR-UHFFFAOYSA-N 1-(3-fluorophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound FC1=CC=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 RMRDSOFRYIUFBR-UHFFFAOYSA-N 0.000 description 1
- TZQUDCVXRIQQNV-UHFFFAOYSA-N 1-(3-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound OC1=CC=2CCCCC=2C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 TZQUDCVXRIQQNV-UHFFFAOYSA-N 0.000 description 1
- YOTMDOZVZLPFOE-UHFFFAOYSA-N 1-(3-hydroxynaphthalen-2-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound OC1=CC2=CC=CC=C2C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 YOTMDOZVZLPFOE-UHFFFAOYSA-N 0.000 description 1
- OSHNTNCCRAGCQP-UHFFFAOYSA-N 1-(3-iodophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound IC1=CC=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 OSHNTNCCRAGCQP-UHFFFAOYSA-N 0.000 description 1
- QDPZFULULDYXQB-UHFFFAOYSA-N 1-(3-methoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 QDPZFULULDYXQB-UHFFFAOYSA-N 0.000 description 1
- OVHYJLACXNXRRN-UHFFFAOYSA-N 1-(3-methylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC1=CC=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 OVHYJLACXNXRRN-UHFFFAOYSA-N 0.000 description 1
- RTKWZFFSSWSSOK-UHFFFAOYSA-N 1-(3-methylsulfanylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CSC1=CC=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 RTKWZFFSSWSSOK-UHFFFAOYSA-N 0.000 description 1
- KZSAABCCRZPRJK-UHFFFAOYSA-N 1-(3-tert-butylphenyl)-3-[4-[4-(morpholin-4-ylmethyl)phenyl]naphthalen-1-yl]urea Chemical compound CC(C)(C)C1=CC=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=CC(CN4CCOCC4)=CC=3)=CC=2)=C1 KZSAABCCRZPRJK-UHFFFAOYSA-N 0.000 description 1
- QWXGKJCBIRHWBX-UHFFFAOYSA-N 1-(4-amino-3,5-dibromophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C(Br)C(N)=C(Br)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 QWXGKJCBIRHWBX-UHFFFAOYSA-N 0.000 description 1
- ITPDMJOSPFQMSH-UHFFFAOYSA-N 1-(4-anilino-2-methoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C=C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)C(OC)=CC=1NC1=CC=CC=C1 ITPDMJOSPFQMSH-UHFFFAOYSA-N 0.000 description 1
- UJQAWNVZBADKJV-UHFFFAOYSA-N 1-(4-butyl-2-methylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC1=CC(CCCC)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 UJQAWNVZBADKJV-UHFFFAOYSA-N 0.000 description 1
- MTKUHPDTFAQCFX-UHFFFAOYSA-N 1-(4-chloro-2-nitrophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound [O-][N+](=O)C1=CC(Cl)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 MTKUHPDTFAQCFX-UHFFFAOYSA-N 0.000 description 1
- OAOJFUBUJNSPAI-UHFFFAOYSA-N 1-(4-chloro-3-nitrophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C(Cl)C([N+](=O)[O-])=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 OAOJFUBUJNSPAI-UHFFFAOYSA-N 0.000 description 1
- BOKYQOSMBRSLII-UHFFFAOYSA-N 1-(4-cyanophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC1=CC=C(C#N)C=C1 BOKYQOSMBRSLII-UHFFFAOYSA-N 0.000 description 1
- SJIPXUFJHFYJLW-UHFFFAOYSA-N 1-(4-ethoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=CC(OCC)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 SJIPXUFJHFYJLW-UHFFFAOYSA-N 0.000 description 1
- DRWRBWVNLUABQH-UHFFFAOYSA-N 1-(4-methoxy-2-methylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC1=CC(OC)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 DRWRBWVNLUABQH-UHFFFAOYSA-N 0.000 description 1
- FJKDPIXCLCCJAW-UHFFFAOYSA-N 1-(4-methoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=CC(OC)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 FJKDPIXCLCCJAW-UHFFFAOYSA-N 0.000 description 1
- CMADJBMFLMNTPD-UHFFFAOYSA-N 1-(4-methyl-2-nitrophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound [O-][N+](=O)C1=CC(C)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 CMADJBMFLMNTPD-UHFFFAOYSA-N 0.000 description 1
- HLZMRNBZAURXQE-UHFFFAOYSA-N 1-(4-methyl-3-nitrophenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C([N+]([O-])=O)C(C)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 HLZMRNBZAURXQE-UHFFFAOYSA-N 0.000 description 1
- MEEUJAATDOYEJC-UHFFFAOYSA-N 1-(4-methylsulfanylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=CC(SC)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 MEEUJAATDOYEJC-UHFFFAOYSA-N 0.000 description 1
- ZRJLFXTYVMVNFT-UHFFFAOYSA-N 1-(4-tert-butylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C(C)(C)C)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 ZRJLFXTYVMVNFT-UHFFFAOYSA-N 0.000 description 1
- ADFIJYZEBBRIIT-UHFFFAOYSA-N 1-(5-chloro-2-methoxyphenyl)-3-[4-(2-methyl-6-morpholin-4-ylpyridin-3-yl)naphthalen-1-yl]urea Chemical compound ClC=1C=CC(=C(C=1)NC(=O)NC1=CC=C(C2=CC=CC=C12)C=1C(=NC(=CC=1)N1CCOCC1)C)OC ADFIJYZEBBRIIT-UHFFFAOYSA-N 0.000 description 1
- FEMSKAZXWCRQRB-UHFFFAOYSA-N 1-(5-ethylsulfonyl-2-methoxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CCS(=O)(=O)C1=CC=C(OC)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 FEMSKAZXWCRQRB-UHFFFAOYSA-N 0.000 description 1
- GGRJYGKEBOTNHP-UHFFFAOYSA-N 1-(5-methoxy-2-methylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 GGRJYGKEBOTNHP-UHFFFAOYSA-N 0.000 description 1
- PNRCNWGZYUYWER-UHFFFAOYSA-N 1-(5-tert-butyl-2-cyclopentyloxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC1=CC(C(C)(C)C)=CC=C1OC1CCCC1 PNRCNWGZYUYWER-UHFFFAOYSA-N 0.000 description 1
- OOZAZFBOXVEMTO-UHFFFAOYSA-N 1-(5-tert-butyl-2-hydroxyphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC(C)(C)C1=CC=C(O)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 OOZAZFBOXVEMTO-UHFFFAOYSA-N 0.000 description 1
- XKQIJJXVJVTKRW-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-(2-methyl-6-thiomorpholin-4-ylpyridin-3-yl)naphthalen-1-yl]urea Chemical compound COc1ccc(cc1NC(=O)Nc1ccc(-c2ccc(nc2C)N2CCSCC2)c2ccccc12)C(C)(C)C XKQIJJXVJVTKRW-UHFFFAOYSA-N 0.000 description 1
- VVADCVAKMLBGPC-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-(6-pyridin-3-yloxypyridin-3-yl)naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1OC1=CC=CN=C1 VVADCVAKMLBGPC-UHFFFAOYSA-N 0.000 description 1
- MIBYPKINMBREPE-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[2-(morpholin-4-ylmethyl)phenyl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C1=CC=CC=C1CN1CCOCC1 MIBYPKINMBREPE-UHFFFAOYSA-N 0.000 description 1
- RDBWUJDARKEUNS-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[4-(oxan-4-ylamino)phenyl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=C1)=CC=C1NC1CCOCC1 RDBWUJDARKEUNS-UHFFFAOYSA-N 0.000 description 1
- SYGFXFLLYOMQKH-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[4-(thiomorpholin-4-ylmethyl)phenyl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=C1)=CC=C1CN1CCSCC1 SYGFXFLLYOMQKH-UHFFFAOYSA-N 0.000 description 1
- JNWZPGHDLVFOHU-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[5-(morpholin-4-ylmethyl)pyrazin-2-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(N=C1)=CN=C1CN1CCOCC1 JNWZPGHDLVFOHU-UHFFFAOYSA-N 0.000 description 1
- OOCWXPQLMUBOTM-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-(pyridin-3-ylamino)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1NC1=CC=CN=C1 OOCWXPQLMUBOTM-UHFFFAOYSA-N 0.000 description 1
- SYRCZMWWOSOYQG-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-(thiomorpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCSCC1 SYRCZMWWOSOYQG-UHFFFAOYSA-N 0.000 description 1
- SYEWQIACIPTFRA-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-[(2-methylsulfanylethylamino)methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C1=CC=C(CNCCSC)N=C1 SYEWQIACIPTFRA-UHFFFAOYSA-N 0.000 description 1
- FPQDJMDZVOJUJL-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-[[2-cyanoethyl(oxolan-2-ylmethyl)amino]methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN(CCC#N)CC1OCCC1 FPQDJMDZVOJUJL-UHFFFAOYSA-N 0.000 description 1
- ULVQEVVJODEZCC-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-[[3-(dimethylamino)pyrrolidin-1-yl]methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CC(N(C)C)CC1 ULVQEVVJODEZCC-UHFFFAOYSA-N 0.000 description 1
- SXWHJWVLUMVFGS-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[4-[6-[[4-(3-methoxyphenyl)piperazin-1-yl]methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=CC(N2CCN(CC=3N=CC(=CC=3)C=3C4=CC=CC=C4C(NC(=O)NC=4C(=CC=C(C=4)C(C)(C)C)OC)=CC=3)CC2)=C1 SXWHJWVLUMVFGS-UHFFFAOYSA-N 0.000 description 1
- RSRIISDWBQWUPX-UHFFFAOYSA-N 1-(5-tert-butyl-2-methyl-1,3-benzoxazol-7-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=12OC(C)=NC2=CC(C(C)(C)C)=CC=1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 RSRIISDWBQWUPX-UHFFFAOYSA-N 0.000 description 1
- NMJPRGQFIVOUJR-UHFFFAOYSA-N 1-(5-tert-butyl-2-methylphenyl)-3-[4-[4-(morpholin-4-ylmethyl)phenyl]naphthalen-1-yl]urea Chemical compound CC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=C1)=CC=C1CN1CCOCC1 NMJPRGQFIVOUJR-UHFFFAOYSA-N 0.000 description 1
- ZEZSFDXTRYVVAM-UHFFFAOYSA-N 1-(5-tert-butyl-2-methylphenyl)-3-[4-[4-(morpholin-4-ylmethyl)piperidin-1-yl]naphthalen-1-yl]urea Chemical compound CC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1N1CCC(CN2CCOCC2)CC1 ZEZSFDXTRYVVAM-UHFFFAOYSA-N 0.000 description 1
- HAFLCPWYDZTTHH-UHFFFAOYSA-N 1-(5-tert-butyl-2-methylpyridin-3-yl)-3-[4-(2-methyl-6-morpholin-4-ylpyridin-3-yl)naphthalen-1-yl]urea Chemical compound CC1=NC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C1=CC=C(N2CCOCC2)N=C1C HAFLCPWYDZTTHH-UHFFFAOYSA-N 0.000 description 1
- BFMKWXXXLFBTMH-UHFFFAOYSA-N 1-(5-tert-butyl-2-methylsulfanylphenyl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CSC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 BFMKWXXXLFBTMH-UHFFFAOYSA-N 0.000 description 1
- PFHCERCJWUXQSI-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-[4-[4-(piperidin-1-ylmethyl)phenyl]naphthalen-1-yl]urea Chemical compound C=1C=CC=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=C1)=CC=C1CN1CCCCC1 PFHCERCJWUXQSI-UHFFFAOYSA-N 0.000 description 1
- PJOXIJLFHGXSBL-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-[4-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]naphthalen-1-yl]urea Chemical compound C1CN(C)CCN1CC1=CC=C(C=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC=CC=3)=CC=2)C=C1 PJOXIJLFHGXSBL-UHFFFAOYSA-N 0.000 description 1
- RFSCUKVBDSZLJK-UHFFFAOYSA-N 1-(6-tert-butyl-1,3-benzodioxol-5-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC(C)(C)C1=CC=2OCOC=2C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 RFSCUKVBDSZLJK-UHFFFAOYSA-N 0.000 description 1
- VEZUUSJWADNERS-UHFFFAOYSA-N 1-(6-tert-butyl-2-chloro-3-methylpyridin-4-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC1=C(Cl)N=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 VEZUUSJWADNERS-UHFFFAOYSA-N 0.000 description 1
- YIBZEBREYBDTGG-UHFFFAOYSA-N 1-(6-tert-butyl-3-oxo-4h-1,4-benzoxazin-7-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC(C)(C)C1=CC=2NC(=O)COC=2C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 YIBZEBREYBDTGG-UHFFFAOYSA-N 0.000 description 1
- AHZOPOQRANAHAY-UHFFFAOYSA-N 1-(6-tert-butyl-3-oxo-4h-1,4-benzoxazin-8-yl)-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=12OCC(=O)NC2=CC(C(C)(C)C)=CC=1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 AHZOPOQRANAHAY-UHFFFAOYSA-N 0.000 description 1
- JRUKMXCPKKAGES-UHFFFAOYSA-N 1-[2-(2-methoxyphenoxy)-5-(trifluoromethyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=CC=C1OC1=CC=C(C(F)(F)F)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 JRUKMXCPKKAGES-UHFFFAOYSA-N 0.000 description 1
- GPGIZCCQTKUMAX-UHFFFAOYSA-N 1-[2-(4-methylphenoxy)-5-(trifluoromethyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1OC1=CC=C(C(F)(F)F)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 GPGIZCCQTKUMAX-UHFFFAOYSA-N 0.000 description 1
- MHRIZTNZAKDVOM-UHFFFAOYSA-N 1-[2-(hydroxymethyl)-4-phenylcyclohexyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound OCC1CC(C=2C=CC=CC=2)CCC1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 MHRIZTNZAKDVOM-UHFFFAOYSA-N 0.000 description 1
- QVSLQEKXVVLVLF-UHFFFAOYSA-N 1-[2-chloro-5-(trifluoromethyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound FC(F)(F)C1=CC=C(Cl)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 QVSLQEKXVVLVLF-UHFFFAOYSA-N 0.000 description 1
- PRPNFLYMCIAXMC-UHFFFAOYSA-N 1-[2-ethylsulfonyl-5-(trifluoromethyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CCS(=O)(=O)C1=CC=C(C(F)(F)F)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 PRPNFLYMCIAXMC-UHFFFAOYSA-N 0.000 description 1
- FXELSCIRQCPZSX-UHFFFAOYSA-N 1-[2-fluoro-3-(trifluoromethyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=CC=C(C(F)(F)F)C(F)=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 FXELSCIRQCPZSX-UHFFFAOYSA-N 0.000 description 1
- QZSMGFLWRPYBMA-UHFFFAOYSA-N 1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound FC1=CC=C(C(F)(F)F)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 QZSMGFLWRPYBMA-UHFFFAOYSA-N 0.000 description 1
- XIQRXBRRDXIGRH-UHFFFAOYSA-N 1-[2-fluoro-6-(trifluoromethyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound FC1=CC=CC(C(F)(F)F)=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 XIQRXBRRDXIGRH-UHFFFAOYSA-N 0.000 description 1
- DIPZYLWYNOYUJR-UHFFFAOYSA-N 1-[2-methoxy-5-(2-methylbutan-2-yl)phenyl]-3-[4-[4-(thiomorpholin-4-ylmethyl)phenyl]naphthalen-1-yl]urea Chemical compound CCC(C)(C)C1=CC=C(OC)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=CC(CN4CCSCC4)=CC=3)=CC=2)=C1 DIPZYLWYNOYUJR-UHFFFAOYSA-N 0.000 description 1
- KLESEJISLAVJCW-UHFFFAOYSA-N 1-[2-methoxy-5-(2-phenylpropan-2-yl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C(C)(C)C=2C=CC=CC=2)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 KLESEJISLAVJCW-UHFFFAOYSA-N 0.000 description 1
- RIBKEQQWNPUDDP-UHFFFAOYSA-N 1-[2-methoxy-5-[(2-methylpropan-2-yl)oxy]phenyl]-3-[4-(2-methyl-6-morpholin-4-ylpyridin-3-yl)naphthalen-1-yl]urea Chemical compound C(C)(C)(C)OC=1C=CC(=C(C=1)NC(=O)NC1=CC=C(C2=CC=CC=C12)C=1C(=NC(=CC=1)N1CCOCC1)C)OC RIBKEQQWNPUDDP-UHFFFAOYSA-N 0.000 description 1
- BUNHUXDJKLVIBC-UHFFFAOYSA-N 1-[2-methoxy-5-[(2-methylpropan-2-yl)oxy]phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(OC(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 BUNHUXDJKLVIBC-UHFFFAOYSA-N 0.000 description 1
- YWSQDZYHPYLOFB-UHFFFAOYSA-N 1-[2-methylsulfanyl-5-(trifluoromethyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CSC1=CC=C(C(F)(F)F)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 YWSQDZYHPYLOFB-UHFFFAOYSA-N 0.000 description 1
- UPXGUSBHVAVLGH-UHFFFAOYSA-N 1-[2-tert-butyl-4-(methanesulfonamido)-5-methoxyphenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C(NS(C)(=O)=O)C(OC)=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1C(C)(C)C UPXGUSBHVAVLGH-UHFFFAOYSA-N 0.000 description 1
- SBOIKWPUEBZGJT-UHFFFAOYSA-N 1-[3,5-bis(trifluoromethyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 SBOIKWPUEBZGJT-UHFFFAOYSA-N 0.000 description 1
- LHRSCHWQXZSVDM-UHFFFAOYSA-N 1-[3-(benzenesulfonamido)-5-tert-butyl-2-methoxyphenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C(C(C)(C)C)C=C(NS(=O)(=O)C=2C=CC=CC=2)C(OC)=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 LHRSCHWQXZSVDM-UHFFFAOYSA-N 0.000 description 1
- FPUUGIBFPPUPNA-UHFFFAOYSA-N 1-[3-methoxy-5-(trifluoromethyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound FC(F)(F)C1=CC(OC)=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 FPUUGIBFPPUPNA-UHFFFAOYSA-N 0.000 description 1
- UUAXUBVBEGLBSR-UHFFFAOYSA-N 1-[4-(difluoromethoxy)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=CC(OC(F)F)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 UUAXUBVBEGLBSR-UHFFFAOYSA-N 0.000 description 1
- KFXMQRZKAQTZCF-UHFFFAOYSA-N 1-[4-[3-(benzylamino)cyclohexen-1-yl]naphthalen-1-yl]-3-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCCC(C=3)NCC=3C=CC=CC=3)=CC=2)=CC(C(C)(C)C)=N1 KFXMQRZKAQTZCF-UHFFFAOYSA-N 0.000 description 1
- YYVVBVYHDUPJNZ-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-(2,4,5-trimethylphenyl)urea Chemical compound C1=C(C)C(C)=CC(C)=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 YYVVBVYHDUPJNZ-UHFFFAOYSA-N 0.000 description 1
- OKTQQECLESQZMT-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-(2-pentoxy-5-phenylphenyl)urea Chemical compound CCCCCOC1=CC=C(C=2C=CC=CC=2)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 OKTQQECLESQZMT-UHFFFAOYSA-N 0.000 description 1
- QOVMEGLQDPRYJR-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-(2-phenoxyphenyl)urea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC1=CC=CC=C1OC1=CC=CC=C1 QOVMEGLQDPRYJR-UHFFFAOYSA-N 0.000 description 1
- JZQIYUOWHSFMHD-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-(3,4,5-trimethoxyphenyl)urea Chemical compound COC1=C(OC)C(OC)=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 JZQIYUOWHSFMHD-UHFFFAOYSA-N 0.000 description 1
- RVNIHSVMRBJWGV-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-(3-phenoxyphenyl)urea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC(C=1)=CC=CC=1OC1=CC=CC=C1 RVNIHSVMRBJWGV-UHFFFAOYSA-N 0.000 description 1
- VGYHEUSLDXFJCX-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-(4-phenylmethoxyphenyl)urea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC(C=C1)=CC=C1OCC1=CC=CC=C1 VGYHEUSLDXFJCX-UHFFFAOYSA-N 0.000 description 1
- XTRFOLYPDHICQA-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-(4-phenylphenyl)urea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC(C=C1)=CC=C1C1=CC=CC=C1 XTRFOLYPDHICQA-UHFFFAOYSA-N 0.000 description 1
- HPGCGTTYJWYWKO-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-[3-(1,3-oxazol-5-yl)phenyl]urea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC(C=1)=CC=CC=1C1=CN=CO1 HPGCGTTYJWYWKO-UHFFFAOYSA-N 0.000 description 1
- HCSXXHQZLIWWCF-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-[3-(trifluoromethylsulfanyl)phenyl]urea Chemical compound FC(F)(F)SC1=CC=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 HCSXXHQZLIWWCF-UHFFFAOYSA-N 0.000 description 1
- MUNNAQCVMSTQDD-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-[3-(trifluoromethylsulfonyl)phenyl]urea Chemical compound FC(F)(F)S(=O)(=O)C1=CC=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 MUNNAQCVMSTQDD-UHFFFAOYSA-N 0.000 description 1
- MSYXLPKGQJTTIR-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-[4-(trifluoromethyl)phenyl]urea Chemical compound C1=CC(C(F)(F)F)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 MSYXLPKGQJTTIR-UHFFFAOYSA-N 0.000 description 1
- LEEKRWMUGPKUQK-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-[4-(trifluoromethylsulfanyl)phenyl]urea Chemical compound C1=CC(SC(F)(F)F)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 LEEKRWMUGPKUQK-UHFFFAOYSA-N 0.000 description 1
- MEGAZNOEWHRNPW-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-naphthalen-1-ylurea Chemical compound C=1C=CC2=CC=CC=C2C=1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 MEGAZNOEWHRNPW-UHFFFAOYSA-N 0.000 description 1
- ITLMWHYFKHLGOI-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-naphthalen-2-ylurea Chemical compound C=1C=C2C=CC=CC2=CC=1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 ITLMWHYFKHLGOI-UHFFFAOYSA-N 0.000 description 1
- ZDXNVBXXPNTCDV-UHFFFAOYSA-N 1-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-3-phenylurea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC1=CC=CC=C1 ZDXNVBXXPNTCDV-UHFFFAOYSA-N 0.000 description 1
- UMURFXAIRXJCDG-UHFFFAOYSA-N 1-[4-[6-[(4-acetylpiperazin-1-yl)methyl]pyridin-3-yl]naphthalen-1-yl]-3-(5-tert-butyl-2-methoxyphenyl)urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCN(C(C)=O)CC1 UMURFXAIRXJCDG-UHFFFAOYSA-N 0.000 description 1
- VZIXIXFJOBLOKV-UHFFFAOYSA-N 1-[4-chloro-2-(trifluoromethyl)phenyl]-3-[4-(2-methyl-6-morpholin-4-ylpyridin-3-yl)naphthalen-1-yl]urea Chemical compound ClC1=CC(=C(C=C1)NC(=O)NC1=CC=C(C2=CC=CC=C12)C=1C(=NC(=CC=1)N1CCOCC1)C)C(F)(F)F VZIXIXFJOBLOKV-UHFFFAOYSA-N 0.000 description 1
- BDCNTBMKZQYZPK-UHFFFAOYSA-N 1-[4-fluoro-3-(trifluoromethyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C(C(F)(F)F)C(F)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 BDCNTBMKZQYZPK-UHFFFAOYSA-N 0.000 description 1
- XYCOYKZYTVPXSZ-UHFFFAOYSA-N 1-[5-(1-cyanocyclopropyl)-2-methoxyphenyl]-3-[4-[2-(morpholin-4-ylmethyl)pyrimidin-5-yl]naphthalen-1-yl]urea Chemical compound COC1=CC=C(C2(CC2)C#N)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CN=C1CN1CCOCC1 XYCOYKZYTVPXSZ-UHFFFAOYSA-N 0.000 description 1
- JCRCYQYGUOZTJN-UHFFFAOYSA-N 1-[5-(2-methylbutan-2-yl)-2-phenoxyphenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC1=CC(C(C)(C)CC)=CC=C1OC1=CC=CC=C1 JCRCYQYGUOZTJN-UHFFFAOYSA-N 0.000 description 1
- LMXXQARHVCAHKT-UHFFFAOYSA-N 1-[5-(diethylsulfamoyl)-2-methoxyphenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CCN(CC)S(=O)(=O)C1=CC=C(OC)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 LMXXQARHVCAHKT-UHFFFAOYSA-N 0.000 description 1
- PFEMRUFOORUDMI-UHFFFAOYSA-N 1-[5-(hydroxymethyl)-2-methylphenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CC1=CC=C(CO)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 PFEMRUFOORUDMI-UHFFFAOYSA-N 0.000 description 1
- FHLQPCUMQVYGNX-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methylpyrimidin-5-yl)pyrazol-3-yl]-3-[4-[6-(oxan-4-ylamino)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=NC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(NC4CCOCC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 FHLQPCUMQVYGNX-UHFFFAOYSA-N 0.000 description 1
- XCSLQLYSVUTKIS-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methylpyrimidin-5-yl)pyrazol-3-yl]-3-[4-[6-[(2-methyl-3-oxopiperazin-1-yl)methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1CNC(=O)C(C)N1CC1=CC=C(C=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=NC(C)=NC=3)=CC=2)C=N1 XCSLQLYSVUTKIS-UHFFFAOYSA-N 0.000 description 1
- GNURXJLCVXAFJJ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-pyrrolidin-1-ylethoxy)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=1C=C(C=2C=NC(CN3CCOCC3)=CC=2)C2=CC=CC=C2C=1NC(=O)NC1=CC(C(C)(C)C)=CC=C1OCCN1CCCC1 GNURXJLCVXAFJJ-UHFFFAOYSA-N 0.000 description 1
- UEQRWQVJAQYPAI-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[3-(2-methyl-4-morpholin-4-ylphenyl)naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C=C(C=2)C=2C(=CC(=CC=2)N2CCOCC2)C)=CC(C(C)(C)C)=N1 UEQRWQVJAQYPAI-UHFFFAOYSA-N 0.000 description 1
- SMJMNVALWCFSQR-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(1-morpholin-4-yl-2,3-dihydro-1h-inden-5-yl)naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=C4CCC(C4=CC=3)N3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 SMJMNVALWCFSQR-UHFFFAOYSA-N 0.000 description 1
- IHQYQTOVSWVUSK-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-methyl-4-morpholin-4-ylphenyl)naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C(=CC(=CC=3)N3CCOCC3)C)=CC=2)=CC(C(C)(C)C)=N1 IHQYQTOVSWVUSK-UHFFFAOYSA-N 0.000 description 1
- UFNMQOJNVUDGDG-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(3-methyl-5-morpholin-4-ylfuran-2-yl)naphthalen-1-yl]urea Chemical compound CC=1C=C(N2CCOCC2)OC=1C(C1=CC=CC=C11)=CC=C1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 UFNMQOJNVUDGDG-UHFFFAOYSA-N 0.000 description 1
- ALGANHBCSBPFLJ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(3-methylsulfinylphenyl)naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=C(C=CC=3)S(C)=O)=CC=2)=CC(C(C)(C)C)=N1 ALGANHBCSBPFLJ-UHFFFAOYSA-N 0.000 description 1
- ASJFQKWXDUOSDG-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(3-morpholin-4-ylcyclohepten-1-yl)naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCCCC(C=3)N3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 ASJFQKWXDUOSDG-UHFFFAOYSA-N 0.000 description 1
- HZCMATDIMJCKIP-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(3-morpholin-4-ylcyclohexen-1-yl)naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCCC(C=3)N3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 HZCMATDIMJCKIP-UHFFFAOYSA-N 0.000 description 1
- SKTLTPXXGDRZGT-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(3-morpholin-4-ylphenyl)naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=C(C=CC=3)N3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 SKTLTPXXGDRZGT-UHFFFAOYSA-N 0.000 description 1
- VGXFLFBXAFHANE-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(4-morpholin-4-ylphenyl)naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=CC(=CC=3)N3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 VGXFLFBXAFHANE-UHFFFAOYSA-N 0.000 description 1
- CARWVQWRYKBXLE-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(6-oxo-1-pyridin-4-yl-2,3-dihydropyridin-4-yl)naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCN(C(=O)C=3)C=3C=CN=CC=3)=CC=2)=CC(C(C)(C)C)=N1 CARWVQWRYKBXLE-UHFFFAOYSA-N 0.000 description 1
- JIIKGDUUABJJLU-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(6-pyridin-3-yloxypyridin-3-yl)naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(OC=4C=NC=CC=4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 JIIKGDUUABJJLU-UHFFFAOYSA-N 0.000 description 1
- OSNKQXUAVYDKAG-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-(pyridin-3-ylamino)pyrimidin-5-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(NC=4C=NC=CC=4)=NC=3)=CC=2)=CC(C(C)(C)C)=N1 OSNKQXUAVYDKAG-UHFFFAOYSA-N 0.000 description 1
- NAQVMJURUKMKMV-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[3-(2-morpholin-4-ylethylamino)cyclohexen-1-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCCC(C=3)NCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 NAQVMJURUKMKMV-UHFFFAOYSA-N 0.000 description 1
- RLXSICBLXUVGCB-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[3-(morpholin-4-ylmethyl)cyclohexen-1-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCCC(CN4CCOCC4)C=3)=CC=2)=CC(C(C)(C)C)=N1 RLXSICBLXUVGCB-UHFFFAOYSA-N 0.000 description 1
- PEYFPLYHYJCFLS-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[3-(morpholine-4-carbonyl)phenyl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=C(C=CC=3)C(=O)N3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 PEYFPLYHYJCFLS-UHFFFAOYSA-N 0.000 description 1
- YMTLTNAESUCGOE-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[3-oxo-4-[(1-oxo-1,4-thiazinan-4-yl)methyl]cyclohexen-1-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCC(CN4CCS(=O)CC4)C(=O)C=3)=CC=2)=CC(C(C)(C)C)=N1 YMTLTNAESUCGOE-UHFFFAOYSA-N 0.000 description 1
- VVULTIQZIBDJBN-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[3-oxo-4-[(1-oxothiolan-3-yl)methyl]cyclohexen-1-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCC(CC4CS(=O)CC4)C(=O)C=3)=CC=2)=CC(C(C)(C)C)=N1 VVULTIQZIBDJBN-UHFFFAOYSA-N 0.000 description 1
- BSQWOONHGXKYPN-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[4-[(dimethylamino)methyl]phenyl]naphthalen-1-yl]urea Chemical compound C1=CC(CN(C)C)=CC=C1C(C1=CC=CC=C11)=CC=C1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 BSQWOONHGXKYPN-UHFFFAOYSA-N 0.000 description 1
- HZNVECNCISLZLO-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[4-[(pyridin-3-ylmethylamino)methyl]phenyl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=CC(CNCC=4C=NC=CC=4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 HZNVECNCISLZLO-UHFFFAOYSA-N 0.000 description 1
- DHUMLLIDHZANKX-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[5-(morpholine-4-carbonyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=C(C=NC=3)C(=O)N3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 DHUMLLIDHZANKX-UHFFFAOYSA-N 0.000 description 1
- GNLOYKZLDCXBOL-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[6-(pyridin-3-ylamino)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(NC=4C=NC=CC=4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 GNLOYKZLDCXBOL-UHFFFAOYSA-N 0.000 description 1
- HWPPZXCPZJQDSK-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[6-(thiomorpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCSCC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 HWPPZXCPZJQDSK-UHFFFAOYSA-N 0.000 description 1
- HWLKVWAXMATBJX-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[6-[(1-oxo-1,4-thiazinan-4-yl)methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCS(=O)CC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 HWLKVWAXMATBJX-UHFFFAOYSA-N 0.000 description 1
- HZMRKDCJYRCOBI-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[6-[hydroxy(pyridin-3-yl)methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(=CC=3)C(O)C=3C=NC=CC=3)=CC=2)=CC(C(C)(C)C)=N1 HZMRKDCJYRCOBI-UHFFFAOYSA-N 0.000 description 1
- BCRSNFJKYNVRJZ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-(6-oxo-1-pyridin-4-yl-2,3-dihydropyridin-4-yl)naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCN(C(=O)C=3)C=3C=CN=CC=3)=CC=2)=CC(C(C)(C)C)=N1 BCRSNFJKYNVRJZ-UHFFFAOYSA-N 0.000 description 1
- HEZQFXSUBYYSAA-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[2-oxo-1-(pyridin-4-ylmethyl)piperidin-4-yl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C3CC(=O)N(CC=4C=CN=CC=4)CC3)=CC=2)=CC(C(C)(C)C)=N1 HEZQFXSUBYYSAA-UHFFFAOYSA-N 0.000 description 1
- BTXSUHRRFKXYQH-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[3-(2-piperidin-1-ylethylamino)cyclohexen-1-yl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCCC(C=3)NCCN3CCCCC3)=CC=2)=CC(C(C)(C)C)=N1 BTXSUHRRFKXYQH-UHFFFAOYSA-N 0.000 description 1
- FZCFXZARDIWKGU-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[3-(2-pyridin-2-ylethylamino)cyclohexen-1-yl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCCC(C=3)NCCC=3N=CC=CC=3)=CC=2)=CC(C(C)(C)C)=N1 FZCFXZARDIWKGU-UHFFFAOYSA-N 0.000 description 1
- LEDSDHBTJKCFQD-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[3-(furan-2-ylmethylamino)cyclohexen-1-yl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCCC(C=3)NCC=3OC=CC=3)=CC=2)=CC(C(C)(C)C)=N1 LEDSDHBTJKCFQD-UHFFFAOYSA-N 0.000 description 1
- SIOKWKLHLCPFPN-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[3-(morpholin-4-ylmethyl)cyclohexen-1-yl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCCC(CN4CCOCC4)C=3)=CC=2)=CC(C(C)(C)C)=N1 SIOKWKLHLCPFPN-UHFFFAOYSA-N 0.000 description 1
- LSKIPTZYPNXPSY-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[3-(pyridin-2-ylmethylamino)cyclohexen-1-yl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCCC(C=3)NCC=3N=CC=CC=3)=CC=2)=CC(C(C)(C)C)=N1 LSKIPTZYPNXPSY-UHFFFAOYSA-N 0.000 description 1
- CKIJBSMXNHTFBG-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[3-(pyridin-3-ylmethylamino)cyclohexen-1-yl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCCC(C=3)NCC=3C=NC=CC=3)=CC=2)=CC(C(C)(C)C)=N1 CKIJBSMXNHTFBG-UHFFFAOYSA-N 0.000 description 1
- XVWBHMREMDDVHA-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[3-(pyridin-4-ylmethylamino)cyclohexen-1-yl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCCC(C=3)NCC=3C=CN=CC=3)=CC=2)=CC(C(C)(C)C)=N1 XVWBHMREMDDVHA-UHFFFAOYSA-N 0.000 description 1
- GLBJVRFLTJXPFP-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[3-[2-(1h-imidazol-5-yl)ethylamino]cyclohexen-1-yl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3CCCC(C=3)NCCC=3N=CNC=3)=CC=2)=CC(C(C)(C)C)=N1 GLBJVRFLTJXPFP-UHFFFAOYSA-N 0.000 description 1
- QHNFIMMYAMKZGG-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[3-[2-(4-methoxyphenyl)ethylamino]cyclohexen-1-yl]naphthalen-1-yl]urea Chemical compound C1=CC(OC)=CC=C1CCNC1C=C(C=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=NC(C)=CC=3)=CC=2)CCC1 QHNFIMMYAMKZGG-UHFFFAOYSA-N 0.000 description 1
- FIUPTBDERXQHNT-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[3-hydroxy-4-(1h-imidazol-2-ylmethyl)phenyl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=C(O)C(CC=4NC=CN=4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 FIUPTBDERXQHNT-UHFFFAOYSA-N 0.000 description 1
- GIAVPYIFVUYJDJ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[3-hydroxy-4-(pyridin-3-ylmethyl)phenyl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=C(O)C(CC=4C=NC=CC=4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 GIAVPYIFVUYJDJ-UHFFFAOYSA-N 0.000 description 1
- JAYHQWUBYOMJDE-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[3-methoxy-5-(2-morpholin-4-ylethoxy)phenyl]naphthalen-1-yl]urea Chemical compound C=1C(C=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=NC(C)=CC=3)=CC=2)=CC(OC)=CC=1OCCN1CCOCC1 JAYHQWUBYOMJDE-UHFFFAOYSA-N 0.000 description 1
- XFJUDEHDAGOXMR-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[4-(furan-2-ylmethyl)-3-hydroxyphenyl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=C(O)C(CC=4OC=CC=4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 XFJUDEHDAGOXMR-UHFFFAOYSA-N 0.000 description 1
- LYXKKQJAFLTMSN-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[4-(furan-2-ylmethyl)-3-methoxyphenyl]naphthalen-1-yl]urea Chemical compound COC1=CC(C=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=NC(C)=CC=3)=CC=2)=CC=C1CC1=CC=CO1 LYXKKQJAFLTMSN-UHFFFAOYSA-N 0.000 description 1
- SGUUMAQWHXLAAC-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[4-(furan-3-ylmethyl)-3-hydroxyphenyl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=C(O)C(CC4=COC=C4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 SGUUMAQWHXLAAC-UHFFFAOYSA-N 0.000 description 1
- ICQKLSHONDDLAY-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[4-[(3,4-dimethoxyphenyl)methyl]-3-hydroxyphenyl]naphthalen-1-yl]urea Chemical compound C1=C(OC)C(OC)=CC=C1CC1=CC=C(C=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=NC(C)=CC=3)=CC=2)C=C1O ICQKLSHONDDLAY-UHFFFAOYSA-N 0.000 description 1
- XQYVRZQMNKTDKE-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[4-[[2-cyanoethyl(pyridin-2-ylmethyl)amino]methyl]phenyl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=CC(CN(CCC#N)CC=4N=CC=CC=4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 XQYVRZQMNKTDKE-UHFFFAOYSA-N 0.000 description 1
- GUFFIMDDQASHSZ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[4-methoxy-6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound N=1C=C(C=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=NC(C)=CC=3)=CC=2)C(OC)=CC=1CN1CCOCC1 GUFFIMDDQASHSZ-UHFFFAOYSA-N 0.000 description 1
- WBRPYBZVNDGOPW-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[6-[(1-methylpiperidin-4-yl)amino]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1CN(C)CCC1NC1=CC=C(C=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=NC(C)=CC=3)=CC=2)C=N1 WBRPYBZVNDGOPW-UHFFFAOYSA-N 0.000 description 1
- QQWQPWRNNKDCIT-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[6-[(1-oxothiolan-3-yl)methyl]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CC4CS(=O)CC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 QQWQPWRNNKDCIT-UHFFFAOYSA-N 0.000 description 1
- ILSAXKWINSZDNL-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-3-[4-[6-[3-methoxypropyl(methyl)amino]pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=NC(N(C)CCCOC)=CC=C1C(C1=CC=CC=C11)=CC=C1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)N=C1 ILSAXKWINSZDNL-UHFFFAOYSA-N 0.000 description 1
- UJENWMZJKPSOKD-UHFFFAOYSA-N 1-[5-tert-butyl-2-(methoxymethyl)phenyl]-3-[4-(2-methyl-6-morpholin-4-ylpyridin-3-yl)naphthalen-1-yl]urea Chemical compound C(C)(C)(C)C=1C=CC(=C(C=1)NC(=O)NC1=CC=C(C2=CC=CC=C12)C=1C(=NC(=CC=1)N1CCOCC1)C)COC UJENWMZJKPSOKD-UHFFFAOYSA-N 0.000 description 1
- BOAGBUKUGQYVKM-UHFFFAOYSA-N 1-[5-tert-butyl-2-(methoxymethyl)phenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COCC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 BOAGBUKUGQYVKM-UHFFFAOYSA-N 0.000 description 1
- TUBMTBGAIWWEQK-UHFFFAOYSA-N 1-[5-tert-butyl-3-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-2-hydroxyphenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound OC=1C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=CC(C(C)(C)C)=CC=1CC1COC(C)(C)O1 TUBMTBGAIWWEQK-UHFFFAOYSA-N 0.000 description 1
- ZKKCYGKTHPYSLR-UHFFFAOYSA-N 1-[5-tert-butyl-3-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-2-methoxyphenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C1=C(C(C)(C)C)C=C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)C(OC)=C1CC1COC(C)(C)O1 ZKKCYGKTHPYSLR-UHFFFAOYSA-N 0.000 description 1
- LJJFRDKKIIEGQB-UHFFFAOYSA-N 1-[6-chloro-4-(trifluoromethyl)pyridin-2-yl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound FC(F)(F)C1=CC(Cl)=NC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 LJJFRDKKIIEGQB-UHFFFAOYSA-N 0.000 description 1
- MFSCEESLLCMMGE-UHFFFAOYSA-N 1-[6-tert-butyl-3-cyano-2-(methoxymethoxy)pyridin-4-yl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound COCOC1=NC(C(C)(C)C)=CC(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1C#N MFSCEESLLCMMGE-UHFFFAOYSA-N 0.000 description 1
- AWHKQZGPADWBLT-UHFFFAOYSA-N 1-[6-tert-butyl-4-(2-morpholin-4-ylethyl)-3-oxo-1,4-benzoxazin-8-yl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound C=12OCC(=O)N(CCN3CCOCC3)C2=CC(C(C)(C)C)=CC=1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 AWHKQZGPADWBLT-UHFFFAOYSA-N 0.000 description 1
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 1
- 125000006432 1-methyl cyclopropyl group Chemical group [H]C([H])([H])C1(*)C([H])([H])C1([H])[H] 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- DYHSPTUMGZFPAR-UHFFFAOYSA-N 2-[4-tert-butyl-2-[[4-[6-[(2,6-dimethylmorpholin-4-yl)methyl]pyridin-3-yl]naphthalen-1-yl]carbamoylamino]phenoxy]acetamide Chemical compound C1C(C)OC(C)CN1CC1=CC=C(C=2C3=CC=CC=C3C(NC(=O)NC=3C(=CC=C(C=3)C(C)(C)C)OCC(N)=O)=CC=2)C=N1 DYHSPTUMGZFPAR-UHFFFAOYSA-N 0.000 description 1
- UQZPGHOJMQTOHB-UHFFFAOYSA-N 2-chloro-n-(2-chloroethyl)-n-ethylethanamine Chemical compound ClCCN(CC)CCCl UQZPGHOJMQTOHB-UHFFFAOYSA-N 0.000 description 1
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical compound C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 description 1
- WOJATDXXHKRDIF-UHFFFAOYSA-N 3-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(4-morpholin-4-ylphenyl)propan-1-one;dihydrochloride Chemical group Cl.Cl.COC1=CC=CC=C1N1CCN(CCC(=O)C=2C=CC(=CC=2)N2CCOCC2)CC1 WOJATDXXHKRDIF-UHFFFAOYSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- NGFHMIKXGYTUSJ-UHFFFAOYSA-N 4-[[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]carbamoylamino]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 NGFHMIKXGYTUSJ-UHFFFAOYSA-N 0.000 description 1
- 125000004861 4-isopropyl phenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- OGPJKXOXSPAMGV-UHFFFAOYSA-N 4-methoxy-3-[[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]carbamoylamino]-n-phenylbenzamide Chemical compound COC1=CC=C(C(=O)NC=2C=CC=CC=2)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 OGPJKXOXSPAMGV-UHFFFAOYSA-N 0.000 description 1
- RZBFJKANZHTGNJ-UHFFFAOYSA-N 4-tert-butyl-2-[[4-[2-chloro-4-(morpholin-4-ylmethyl)phenyl]naphthalen-1-yl]carbamoylamino]benzamide Chemical compound CC(C)(C)C1=CC=C(C(N)=O)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C(=CC(CN4CCOCC4)=CC=3)Cl)=CC=2)=C1 RZBFJKANZHTGNJ-UHFFFAOYSA-N 0.000 description 1
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
- FSZDLJBELRDCIB-UHFFFAOYSA-N C(C)(C)(C)C=1C=CC(=C(C1)CC(=O)NC1=CC=C(C2=CC=CC=C12)C=1C(=NC(=CC1)N1CCOCC1)C)OC Chemical compound C(C)(C)(C)C=1C=CC(=C(C1)CC(=O)NC1=CC=C(C2=CC=CC=C12)C=1C(=NC(=CC1)N1CCOCC1)C)OC FSZDLJBELRDCIB-UHFFFAOYSA-N 0.000 description 1
- HITCDZGCKRPBBJ-UHFFFAOYSA-N COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCN(C(O)=O)CC1 Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCN(C(O)=O)CC1 HITCDZGCKRPBBJ-UHFFFAOYSA-N 0.000 description 1
- 229940126062 Compound A Drugs 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- PMPVIKIVABFJJI-UHFFFAOYSA-N Cyclobutane Chemical class C1CCC1 PMPVIKIVABFJJI-UHFFFAOYSA-N 0.000 description 1
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical class C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical class CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 241001482175 Pythonidae Species 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- PPWHTZKZQNXVAE-UHFFFAOYSA-N Tetracaine hydrochloride Chemical compound Cl.CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 PPWHTZKZQNXVAE-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- NOUQQZJKOYIAAE-UHFFFAOYSA-N [4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]carbamic acid Chemical compound C12=CC=CC=C2C(NC(=O)O)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 NOUQQZJKOYIAAE-UHFFFAOYSA-N 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 235000019568 aromas Nutrition 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 229960004365 benzoic acid Drugs 0.000 description 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 239000001273 butane Chemical class 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- NEUSVAOJNUQRTM-UHFFFAOYSA-N cetylpyridinium Chemical compound CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 NEUSVAOJNUQRTM-UHFFFAOYSA-N 0.000 description 1
- 229960004830 cetylpyridinium Drugs 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000001282 iso-butane Substances 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229960001021 lactose monohydrate Drugs 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical class C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
- MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- GPSIHAPGAMCMDF-UHFFFAOYSA-N n-[2,5-diethoxy-4-[[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]carbamoylamino]phenyl]benzamide Chemical compound CCOC=1C=C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)C(OCC)=CC=1NC(=O)C1=CC=CC=C1 GPSIHAPGAMCMDF-UHFFFAOYSA-N 0.000 description 1
- GMIGDYDIMXGYOL-UHFFFAOYSA-N n-acetyl-n-[5-tert-butyl-2-methoxy-3-[[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]carbamoylamino]phenyl]acetamide Chemical compound C1=C(C(C)(C)C)C=C(N(C(C)=O)C(C)=O)C(OC)=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 GMIGDYDIMXGYOL-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Chemical class CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 208000037916 non-allergic rhinitis Diseases 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000001294 propane Chemical class 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 125000006513 pyridinyl methyl group Chemical group 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 125000004953 trihalomethyl group Chemical group 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02015231 | 2002-07-09 | ||
| EP02015231 | 2002-07-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2278170T3 true ES2278170T3 (es) | 2007-08-01 |
Family
ID=30011064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03738089T Expired - Lifetime ES2278170T3 (es) | 2002-07-09 | 2003-06-26 | Composiciones farmaceuticas de anticolinergicos e inhibidores de la quinasa p38 en el tratamiento de enfermedades respiratorias. |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP1707205A2 (https=) |
| JP (1) | JP2005538066A (https=) |
| AT (1) | ATE349210T1 (https=) |
| AU (1) | AU2003245989A1 (https=) |
| CA (1) | CA2492033A1 (https=) |
| DE (1) | DE60310730T2 (https=) |
| ES (1) | ES2278170T3 (https=) |
| WO (1) | WO2004004725A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7749999B2 (en) | 2003-09-11 | 2010-07-06 | Itherx Pharmaceuticals, Inc. | Alpha-ketoamides and derivatives thereof |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| CA2710039C (en) | 2007-12-26 | 2018-07-03 | Critical Outcome Technologies, Inc. | Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer |
| EP2318406B1 (en) | 2008-07-17 | 2016-01-27 | Critical Outcome Technologies, Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
| CA2999435A1 (en) | 2010-04-01 | 2011-10-06 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
| ES2396764B1 (es) | 2011-11-02 | 2013-12-19 | Universidad Autónoma de Madrid | FÁRMACOS INHIBIDORES DE p38 Y APLICACIONES. |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| WO2019071147A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD |
Family Cites Families (146)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4570630A (en) | 1983-08-03 | 1986-02-18 | Miles Laboratories, Inc. | Medicament inhalation device |
| DE3682457D1 (de) | 1985-07-30 | 1991-12-19 | Glaxo Group Ltd | Geraet zur verabreichung von medikamenten an patienten. |
| SE453566B (sv) | 1986-03-07 | 1988-02-15 | Draco Ab | Anordning vid pulverinhalatorer |
| SG45171A1 (en) | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
| WO1992012154A1 (en) | 1990-12-31 | 1992-07-23 | Fujisawa Pharmaceutical Co., Ltd. | Imidazotriazine derivatives |
| GB9816837D0 (en) | 1998-08-04 | 1998-09-30 | Zeneca Ltd | Amide derivatives |
| MX9300141A (es) | 1992-01-13 | 1994-07-29 | Smithkline Beecham Corp | Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen. |
| US5716972A (en) | 1993-01-13 | 1998-02-10 | Smithkline Beecham Corporation | Pyridyl substituted imidazoles |
| US5656644A (en) | 1994-07-20 | 1997-08-12 | Smithkline Beecham Corporation | Pyridyl imidazoles |
| IL107120A (en) | 1992-09-29 | 1997-09-30 | Boehringer Ingelheim Int | Atomising nozzle and filter and spray generating device |
| GB9303993D0 (en) | 1993-02-26 | 1993-04-14 | Fujisawa Pharmaceutical Co | New heterocyclic derivatives |
| DE4318455A1 (de) | 1993-06-03 | 1994-12-08 | Boehringer Ingelheim Kg | Kapselhalterung |
| US5593992A (en) | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
| US5670527A (en) | 1993-07-16 | 1997-09-23 | Smithkline Beecham Corporation | Pyridyl imidazole compounds and compositions |
| US5593991A (en) | 1993-07-16 | 1997-01-14 | Adams; Jerry L. | Imidazole compounds, use and process of making |
| WO1995009851A1 (en) | 1993-10-01 | 1995-04-13 | Ciba-Geigy Ag | Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof |
| JPH08503971A (ja) | 1993-10-01 | 1996-04-30 | チバ−ガイギー アクチェンゲゼルシャフト | ピリミジンアミン誘導体及びその調製のための方法 |
| KR100330553B1 (ko) | 1993-10-01 | 2002-11-27 | 노파르티스 아게 | 약물학적활성피리딘유도체및그의제조방법 |
| US5543520A (en) | 1993-10-01 | 1996-08-06 | Ciba-Geigy Corporation | Pyrimidine derivatives |
| US5559137A (en) | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| IL118544A (en) | 1995-06-07 | 2001-08-08 | Smithkline Beecham Corp | History of imidazole, the process for their preparation and the pharmaceutical preparations containing them |
| US5739143A (en) | 1995-06-07 | 1998-04-14 | Smithkline Beecham Corporation | Imidazole compounds and compositions |
| DE19536903C2 (de) | 1995-10-04 | 1998-09-10 | Boehringer Ingelheim Int | Vorrichtung zum Haltern eines fluidischen Bauteils |
| DE19536902A1 (de) | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung |
| PL184819B1 (pl) | 1995-10-06 | 2002-12-31 | Merck & Co Inc | Podstawione związki imidazolilowe oraz zawierające je kompozycje farmaceutyczne |
| EP0859771A4 (en) | 1995-10-31 | 2000-03-15 | Merck & Co Inc | SUBSTITUTED PYRIDYLPYRROLE, PREPARATIONS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE USE THEREOF |
| WO1997016441A1 (en) | 1995-10-31 | 1997-05-09 | Merck & Co., Inc. | Substituted aryl pyrroles, compositions containing such compounds and methods of use |
| DE19545226C1 (de) | 1995-12-05 | 1997-06-19 | Boehringer Ingelheim Int | Sperrspannwerk für einen federbetätigten Abtrieb |
| PL187516B1 (pl) | 1996-01-11 | 2004-07-30 | Smithkline Beecham Corp | Nowe podstawione pochodne imidazolu, sposób ich wytwarzania oraz kompozycja farmaceutyczna zawierająca te związki |
| WO1997025047A1 (en) | 1996-01-11 | 1997-07-17 | Smithkline Beecham Corporation | Novel cycloalkyl substituded imidazoles |
| ZA97175B (en) | 1996-01-11 | 1997-11-04 | Smithkline Beecham Corp | Novel substituted imidazole compounds. |
| AP9700912A0 (en) | 1996-01-11 | 1997-01-31 | Smithkline Beecham Corp | Novel cycloalkyl substituted imidazoles |
| US6096748A (en) | 1996-03-13 | 2000-08-01 | Smithkline Beecham Corporation | Pyrimidine compounds useful in treating cytokine mediated diseases |
| JP2000507558A (ja) | 1996-03-25 | 2000-06-20 | スミスクライン・ビーチャム・コーポレイション | Ｃｎｓ損傷についての新規な治療 |
| US6235760B1 (en) | 1996-03-25 | 2001-05-22 | Smithkline Beecham Corporation | Treatment for CNS injuries |
| CA2250232A1 (en) | 1996-04-03 | 1997-10-09 | Allen I. Oliff | A method of treating cancer |
| EP0906307B1 (en) | 1996-06-10 | 2005-04-27 | Merck & Co., Inc. | Substituted imidazoles having cytokine inhibitory activity |
| EP0922042A1 (en) | 1996-08-09 | 1999-06-16 | Smithkline Beecham Corporation | Novel piperazine containing compounds |
| DE19633640C2 (de) | 1996-08-21 | 1999-05-06 | Ford Global Tech Inc | Vorrichtung zur Winkelverstellung einer Welle gegenüber einem Antriebsrad |
| WO1998007425A1 (en) | 1996-08-21 | 1998-02-26 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
| DE69728688T2 (de) | 1996-11-19 | 2004-08-19 | Amgen Inc., Thousand Oaks | Aryl und heteroaryl substituierte kondensierte pyrrole als entzündunghemmende mittel |
| WO1998022109A1 (en) | 1996-11-20 | 1998-05-28 | Merck & Co., Inc. | Triaryl substituted imidazoles as glucagon antagonists |
| AR038955A1 (es) | 1996-12-05 | 2005-02-02 | Amgen Inc | Compuestos de pirimidinona y piridona sustituidos y metodos para su uso |
| IL130181A0 (en) | 1996-12-05 | 2000-06-01 | Amgen Inc | Substituted pyrimidone and pyridone compounds and methods of use |
| ZA9711092B (en) | 1996-12-11 | 1999-07-22 | Smithkline Beecham Corp | Novel compounds. |
| US6147080A (en) | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| WO1998028292A1 (en) | 1996-12-23 | 1998-07-02 | Smithkline Beecham Corporation | Novel piperidine containing compounds |
| PT1270565E (pt) | 1997-01-29 | 2004-09-30 | Pfizer | Furano-2-sulfonamida 4-substituida e sua utilizacao na preparacao de derivados de sulfonilureia |
| RU2222534C2 (ru) | 1997-04-24 | 2004-01-27 | Орто-Макнейл Фармасьютикал, Инк. | Замещенные имидазолы, способ их получения, фармацевтическая композиция на их основе, способы лечения цитокин-опосредованных заболеваний |
| AU7132998A (en) | 1997-04-24 | 1998-11-13 | Ortho-Mcneil Corporation, Inc. | Substituted pyrrolopyridines useful in the treatment of inflammatory diseases |
| EP0984930B1 (en) | 1997-05-07 | 2005-04-06 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| PL337020A1 (en) | 1997-05-22 | 2000-07-31 | Searle & Co | Substituted pyrazoles as kinase p38 inhibitors |
| EP0983260A2 (en) | 1997-05-22 | 2000-03-08 | G.D. Searle & Co. | 3(5)-HETEROARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS |
| US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| AU7726898A (en) | 1997-05-22 | 1998-12-11 | G.D. Searle & Co. | Pyrazole derivatives as p38 kinase inhibitors |
| ATE399007T1 (de) | 1997-05-23 | 2008-07-15 | Bayer Pharmaceuticals Corp | Raf kinase hemmer |
| WO1998052558A1 (en) | 1997-05-23 | 1998-11-26 | Bayer Corporation | INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS |
| KR100704059B1 (ko) | 1997-06-12 | 2007-04-05 | 롱프랑 로라 리미티드 | 이미다졸릴-사이클릭 아세탈 |
| CA2294057A1 (en) | 1997-06-13 | 1998-12-17 | Smithkline Beecham Corporation | Novel pyrazole and pyrazoline substituted compounds |
| US6093742A (en) | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| GB9713726D0 (en) | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
| EP0994858A1 (en) | 1997-06-30 | 2000-04-26 | Ortho-McNeil Pharmaceutical, Inc. | 2-substituted imidazoles useful in the treatment of inflammatory diseases |
| US5939421A (en) | 1997-07-01 | 1999-08-17 | Signal Pharmaceuticals, Inc. | Quinazoline analogs and related compounds and methods for treating inflammatory conditions |
| AR016294A1 (es) * | 1997-07-02 | 2001-07-04 | Smithkline Beecham Corp | Compuesto de imidazol sustituido, composicion farmaceutica que la contiene, su uso en la fabricacion de un medicamento y procedimiento para supreparacion |
| TW517055B (en) | 1997-07-02 | 2003-01-11 | Smithkline Beecham Corp | Novel substituted imidazole compounds |
| WO1999001452A1 (en) | 1997-07-02 | 1999-01-14 | Smithkline Beecham Corporation | Novel cycloalkyl substituted imidazoles |
| US5981710A (en) | 1997-07-21 | 1999-11-09 | Baxter International, Inc. | Therapeutic hemoglobin composition having isotropically increased size |
| AU739066B2 (en) | 1997-09-23 | 2001-10-04 | Astrazeneca Ab | Amide derivatives for the treatment of diseases mediated by cytokines |
| US5975738A (en) | 1997-09-30 | 1999-11-02 | Lsi Logic Corporation | Method for detecting failure in redundant controllers using a private LUN |
| WO1999017776A1 (en) | 1997-10-08 | 1999-04-15 | Smithkline Beecham Corporation | Novel cycloalkenyl substituted compounds |
| HUP0004947A2 (hu) | 1997-11-14 | 2002-03-28 | Sankyo Co., Ltd. | Piridilpirrol-származékok |
| WO1999032121A1 (en) | 1997-12-19 | 1999-07-01 | Smithkline Beecham Corporation | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses |
| MXPA00006233A (es) | 1997-12-22 | 2002-09-18 | Bayer Ag | Inhibicion de la actividad de la cinasa p38 utilizando ureas heterociclicas sustituidas. |
| JP3887769B2 (ja) | 1997-12-22 | 2007-02-28 | バイエル コーポレイション | 対称および非対称ジフェニル尿素を用いるｐ３８キナーゼの阻害 |
| DE69836563T2 (de) | 1997-12-22 | 2007-05-16 | Bayer Pharmaceuticals Corp., West Haven | INHIBIERUNG DER p38 KINASE-AKTIVITÄT DURCH DIE VERWENDUNG VON ARYL- UND HETEROARYL-SUBSTITUIERTEN HARNSTOFFEN |
| DE69917005T2 (de) | 1998-02-26 | 2005-03-24 | Ortho-Mcneil Pharmaceutical, Inc. | Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung |
| CN1305846C (zh) | 1998-03-26 | 2007-03-21 | 参天制药株式会社 | 脲衍生物 |
| US6316466B1 (en) | 1998-05-05 | 2001-11-13 | Syntex (U.S.A.) Llc | Pyrazole derivatives P-38 MAP kinase inhibitors |
| CA2329065A1 (en) | 1998-05-05 | 1999-11-11 | Francisco Xavier Talamas | Pyrazole derivatives as p-38 map kinase inhibitors |
| MY132496A (en) | 1998-05-11 | 2007-10-31 | Vertex Pharma | Inhibitors of p38 |
| WO1999058523A1 (en) | 1998-05-14 | 1999-11-18 | G.D. Searle & Co. | 1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS |
| PT1077930E (pt) | 1998-05-15 | 2005-03-31 | Astrazeneca Ab | Derivados de benzamida para o tratamento de doencas mediadas por citocinas |
| CA2328927C (en) | 1998-05-15 | 2008-02-19 | Astrazeneca Ab | Benzamide derivatives for the treatment of diseases mediated by cytokines |
| CN1548436A (zh) | 1998-05-22 | 2004-11-24 | ʷ��˿�������ȳ�ķ����˾ | 新的2-烷基取代咪唑化合物 |
| US6589954B1 (en) | 1998-05-22 | 2003-07-08 | Scios, Inc. | Compounds and methods to treat cardiac failure and other disorders |
| ATE316961T1 (de) | 1998-05-22 | 2006-02-15 | Scios Inc | Heterozyclische derivate für die behandlung von herzversagen und andere erkrankungen |
| US6340685B1 (en) | 1998-05-22 | 2002-01-22 | Scios, Inc. | Compounds and methods to treat cardiac failure and other disorders |
| WO1999061440A1 (en) | 1998-05-26 | 1999-12-02 | Smithkline Beecham Corporation | Novel substituted imidazole compounds |
| JP2002517486A (ja) | 1998-06-12 | 2002-06-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | ｐ３８のインヒビター |
| WO2000001688A1 (en) | 1998-07-02 | 2000-01-13 | Sankyo Company, Limited | Five-membered heteroaryl compounds |
| US6207687B1 (en) | 1998-07-31 | 2001-03-27 | Merck & Co., Inc. | Substituted imidazoles having cytokine inhibitory activity |
| CA2338121A1 (en) | 1998-08-04 | 2000-02-17 | Astrazeneca Ab | Amide derivatives useful as inhibitors of the production of cytokines |
| CN1147469C (zh) | 1998-08-05 | 2004-04-28 | 参天制药株式会社 | 带有芳香族含氮杂环的新型脲衍生物 |
| JP2003525201A (ja) | 1998-08-20 | 2003-08-26 | スミスクライン・ビーチャム・コーポレイション | 新規な置換トリアゾール化合物 |
| CA2342251A1 (en) | 1998-08-28 | 2000-03-09 | Scios Inc. | Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| JP4191825B2 (ja) | 1998-09-10 | 2008-12-03 | あすか製薬株式会社 | ５−アミノイソキサゾール誘導体 |
| AR023659A1 (es) | 1998-09-18 | 2002-09-04 | Vertex Pharma | Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos |
| DE19842833B4 (de) | 1998-09-18 | 2005-04-14 | Merckle Gmbh | 2-Arylalkylthio-imidazole, 2-Arylalkenylthio-imidazole und 2-Arylalkinylthio-imidazole als Entzündungs-Hemmstoffe und Hemmstoffe der Cytokin-Freisetzung |
| WO2000017175A1 (en) | 1998-09-18 | 2000-03-30 | Vertex Pharmaceuticals Incorporated | INHIBITORS OF p38 |
| EP1115707B1 (en) | 1998-09-25 | 2003-11-12 | AstraZeneca AB | Benzamide derivatives and ther use as cytokine inhibitors |
| ATE232205T1 (de) | 1998-10-01 | 2003-02-15 | Astrazeneca Ab | Chinolin- und chinazolin derivate und ihre verwendung als inhibitoren von krankheiten, bei denen cytokine beteiligt wird |
| DE19847968A1 (de) | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen |
| AU1127700A (en) | 1998-10-20 | 2000-05-08 | Omeros Medical Systems, Inc. | Irrigation solution containing mapk inhibitors and their use for treating pain and inflammation |
| AU6476599A (en) | 1998-11-03 | 2000-05-22 | Novartis Ag | Anti-inflammatory 4-phenyl-5-pyrimidinyl-imidazoles |
| WO2000025791A1 (en) | 1998-11-04 | 2000-05-11 | Smithkline Beecham Corporation | Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines |
| US6350744B1 (en) | 1998-11-20 | 2002-02-26 | Merck & Co., Inc. | Compounds having cytokine inhibitory activity |
| US6143892A (en) | 1998-11-20 | 2000-11-07 | G. D. Searle & Co. | Process for making 5-substituted pyrazoles |
| WO2000035911A1 (en) | 1998-12-16 | 2000-06-22 | Aventis Pharma Limited | Heteroaryl-cyclic acetals |
| AU3114600A (en) | 1998-12-16 | 2000-07-03 | Vertex Pharmaceuticals Incorporated | Crystallized p38 complexes |
| AU765492B2 (en) | 1998-12-25 | 2003-09-18 | Teikoku Hormone Mfg. Co., Ltd. | Aminopyrazole derivatives |
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| UA73492C2 (en) | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
| WO2000055152A1 (en) | 1999-03-12 | 2000-09-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
| NZ528846A (en) | 1999-03-12 | 2005-05-27 | Boehringer Ingelheim Pharma | Compounds useful as anti-inflammatory agents |
| AU761291B2 (en) | 1999-03-17 | 2003-05-29 | Astrazeneca Ab | Amide derivatives |
| RU2260007C2 (ru) | 1999-03-17 | 2005-09-10 | Астразенека Аб | Производные амида, способ их получения (варианты), фармацевтическая композиция, способ ингибирования |
| GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
| CO5170501A1 (es) | 1999-04-14 | 2002-06-27 | Novartis Ag | AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO |
| US6492516B1 (en) | 1999-05-14 | 2002-12-10 | Merck & Co., Inc. | Compounds having cytokine inhibitory activity |
| JP2003500403A (ja) | 1999-05-21 | 2003-01-07 | サイオス，インコーポレーテッド | ｐ３８キナーゼのインヒビターとしてのインドール型誘導体 |
| US6403596B1 (en) | 1999-06-28 | 2002-06-11 | Merck & Co., Inc. | Substituted pyridones having cytokine inhibitory activity |
| EP1210325B1 (en) | 1999-07-16 | 2004-10-06 | Leo Pharma A/S | Aminobenzophenones as inhibitors of il-1beta and tnf-alpha |
| AU768473B2 (en) | 1999-07-16 | 2003-12-11 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | Novel aminobenzophenones |
| ATE277889T1 (de) | 1999-07-16 | 2004-10-15 | Leo Pharma As | Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha |
| ES2228555T3 (es) | 1999-07-16 | 2005-04-16 | Leo Pharma A/S | Aminobenzofenonas con inhibidores de la il-1beta y tnf-alfa. |
| RU2240995C2 (ru) | 1999-07-16 | 2004-11-27 | Лео Фармасьютикал Продактс Лтд.А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) | Аминобензофеноны в качестве ингибиторов интерлейкина il-1бета и фактора некроза опухолей tnf-альфа |
| AU7584500A (en) * | 1999-09-17 | 2001-04-17 | Smithkline Beecham Corporation | Use of csaids in rhinovirus infection |
| GB9924092D0 (en) | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
| AU7269600A (en) | 1999-10-13 | 2001-04-23 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | A method of screening for substances acting on MSK1 |
| KR100537241B1 (ko) | 1999-10-21 | 2005-12-19 | 에프. 호프만-라 로슈 아게 | Ｐ38 단백질 키나제의 억제제로서의 알킬아미노 치환된이중고리 질소 헤테로고리 화합물 |
| DE60033307T2 (de) | 1999-10-21 | 2007-07-12 | F. Hoffmann-La Roche Ag | Heteroalkylamino-substituierte bicyclische stickstoffheterocyclen als p38-proteinkinase-inhibitoren |
| DE60018037T2 (de) | 1999-11-10 | 2006-01-12 | Ortho-Mcneil Pharmaceutical, Inc. | Substituierte 2-aryl-3-(heteroaryl)-imidazo[1,2-alpha]pyrimidine und ihren verwandten arzneimittel und verfahren |
| WO2001036403A1 (en) | 1999-11-16 | 2001-05-25 | Boehringer Ingelheim Pharmaceuticals, Inc. | Urea derivatives as anti-inflammatory agents |
| EP1233951B1 (en) | 1999-11-23 | 2005-06-01 | SmithKline Beecham Corporation | 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors |
| AU1781601A (en) | 1999-11-23 | 2001-06-04 | Smithkline Beecham Corporation | 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors |
| ATE305787T1 (de) | 1999-11-23 | 2005-10-15 | Smithkline Beecham Corp | 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren |
| EP1248624A4 (en) | 1999-11-23 | 2003-01-22 | Smithkline Beecham Corp | 3,4-DIHYDRO- (1H) -CHIRAZOLINE-2-ONES AND THE USE THEREOF AS CSBP / P38 KINASE INHIBITORS |
| MXPA02005604A (es) | 1999-12-06 | 2004-09-10 | Leo Pharma As | Aminobenzofenonas como inhibidores de il-1beta y tnf-alfa. |
| US6602872B1 (en) | 1999-12-13 | 2003-08-05 | Merck & Co., Inc. | Substituted pyridazines having cytokine inhibitory activity |
| CA2394727A1 (en) | 1999-12-28 | 2001-07-05 | Pharmacopeia, Inc. | Pyrimidine and triazine kinase inhibitors |
| US6537996B2 (en) | 2000-02-23 | 2003-03-25 | Iconix Pharmaceuticals, Inc. | Modulators of p38 MAP kinase |
| AU2001241927A1 (en) | 2000-02-28 | 2001-09-12 | Scios Inc. | Inhibitors of p38-alpha kinase |
| AU2001260081B2 (en) * | 2000-05-22 | 2005-07-28 | Leo Pharma A/S | Benzophenones as inhibitors of il-1beta and tnf-alpha |
| DE10050994A1 (de) * | 2000-10-14 | 2002-04-18 | Boehringer Ingelheim Pharma | Neue als Arneimittel einsetzbare Anticholinergika sowie Verfahren zu deren Herstellung |
| US20030225089A1 (en) * | 2002-04-10 | 2003-12-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors |
-
2003
- 2003-06-26 DE DE60310730T patent/DE60310730T2/de not_active Expired - Fee Related
- 2003-06-26 JP JP2004518584A patent/JP2005538066A/ja active Pending
- 2003-06-26 EP EP06116683A patent/EP1707205A2/en not_active Withdrawn
- 2003-06-26 EP EP03738089A patent/EP1534282B1/en not_active Expired - Lifetime
- 2003-06-26 ES ES03738089T patent/ES2278170T3/es not_active Expired - Lifetime
- 2003-06-26 AT AT03738089T patent/ATE349210T1/de not_active IP Right Cessation
- 2003-06-26 WO PCT/EP2003/006739 patent/WO2004004725A2/en not_active Ceased
- 2003-06-26 AU AU2003245989A patent/AU2003245989A1/en not_active Abandoned
- 2003-06-26 CA CA002492033A patent/CA2492033A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004004725A3 (en) | 2004-05-27 |
| EP1534282B1 (en) | 2006-12-27 |
| WO2004004725A2 (en) | 2004-01-15 |
| AU2003245989A8 (en) | 2004-01-23 |
| DE60310730D1 (de) | 2007-02-08 |
| CA2492033A1 (en) | 2004-01-15 |
| DE60310730T2 (de) | 2007-05-16 |
| JP2005538066A (ja) | 2005-12-15 |
| EP1534282A2 (en) | 2005-06-01 |
| AU2003245989A1 (en) | 2004-01-23 |
| EP1707205A2 (en) | 2006-10-04 |
| ATE349210T1 (de) | 2007-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20030225089A1 (en) | Pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors | |
| US20090017036A1 (en) | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders | |
| US20040044020A1 (en) | Pharmaceutical compositions based on novel anticholinergics and p38 kinase inhibitors | |
| EP1658060A2 (en) | Methods of treating copd and pulmonary hypertension | |
| ES2278170T3 (es) | Composiciones farmaceuticas de anticolinergicos e inhibidores de la quinasa p38 en el tratamiento de enfermedades respiratorias. | |
| JP2005528374A (ja) | 粘液分泌過多の治療方法 | |
| US20030220336A1 (en) | Method of treating mucus hypersecretion | |
| DE10205274A1 (de) | Neue Arzneimittelkompositionen enthaltend neben Anticholinergika heterocyclische Verbindungen | |
| US7276491B2 (en) | Anticoagulant and fibrinolytic therapy using p38 MAP kinase inhibitors | |
| EP1706119A1 (de) | Neue arzneimittelkombinationen enthaltend scopin-oder tropensäureestern und egfr-kinase-hemmer | |
| HK1080738A (en) | New pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors | |
| KR20070035466A (ko) | Ｃｏｐｄ 및 폐고혈압 치료 방법 | |
| KR20050016999A (ko) | 신규한 항콜린제 및 ｅｇｆｒ-키나제의 억제제를 기초로한 신규한 약물 조성물 | |
| HK1080740A (en) | Method of treating mucus hypersecretion |