ES2274299T3 - Estimulacion de la produccion in vivo de proteinas con una formulacion que comprende leucina. - Google Patents
Estimulacion de la produccion in vivo de proteinas con una formulacion que comprende leucina. Download PDFInfo
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- ES2274299T3 ES2274299T3 ES03782981T ES03782981T ES2274299T3 ES 2274299 T3 ES2274299 T3 ES 2274299T3 ES 03782981 T ES03782981 T ES 03782981T ES 03782981 T ES03782981 T ES 03782981T ES 2274299 T3 ES2274299 T3 ES 2274299T3
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- leucine
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- amino acids
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| ES03782981T Expired - Lifetime ES2274299T3 (es) | 2002-12-20 | 2003-12-15 | Estimulacion de la produccion in vivo de proteinas con una formulacion que comprende leucina. |
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| EP (1) | EP1455603B1 (https=) |
| JP (1) | JP2006510711A (https=) |
| CN (1) | CN100353866C (https=) |
| AT (1) | ATE341226T1 (https=) |
| AU (1) | AU2003290447B2 (https=) |
| CA (1) | CA2510760C (https=) |
| DE (1) | DE60308810T2 (https=) |
| DK (1) | DK1455603T3 (https=) |
| ES (1) | ES2274299T3 (https=) |
| WO (1) | WO2004056208A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4970694B2 (ja) * | 2002-12-02 | 2012-07-11 | 株式会社明治 | 持続性筋肉疲労改善剤 |
| US7288570B2 (en) * | 2002-12-20 | 2007-10-30 | Nutricia N.V. | Stimulation of in vivo production of proteins |
| EA012300B1 (ru) * | 2005-01-18 | 2009-08-28 | ДСМ АйПи АССЕТС Б.В. | Композиция для лечения или предотвращения сахарного диабета и ее применение |
| EP1774973A1 (en) * | 2005-10-12 | 2007-04-18 | Nutricia N.V. | Leucine rich composition |
| RU2383209C2 (ru) * | 2005-10-26 | 2010-03-10 | Хилл'С Пет Ньютришн, Инк. | Композиция и способы увеличения нежировой мышечной массы и/или снижения роста жира |
| ES2302463B1 (es) * | 2006-12-29 | 2009-06-05 | Madaus, S.A. | "composicion a base de fibra de cacao". |
| ATE468025T1 (de) | 2007-02-23 | 2010-06-15 | Hills Pet Nutrition Inc | Zusammensetzungen und verfahren für die gewichtskontrolle bei tieren |
| PL2098125T3 (pl) * | 2008-03-03 | 2012-02-29 | Nestec Sa | Zżelowany produkt spożywczy z wysoką skutecznością przyjmowania węglowodanów |
| EP2098126A1 (en) * | 2008-03-03 | 2009-09-09 | Nestec S.A. | Carbohydrate Bar |
| EP2098124A1 (en) * | 2008-03-03 | 2009-09-09 | Nestec S.A. | Carbohydrate gel |
| WO2010002242A1 (en) | 2008-07-02 | 2010-01-07 | N.V. Nutricia | Nutritional composition for improving muscle function and daily activity |
| EP3001912A1 (en) | 2009-08-26 | 2016-04-06 | Jeffrey M. Golini | Pharmaceutical or nutraceutical composition |
| EP2327315B1 (en) * | 2009-11-29 | 2013-10-09 | Nestec S.A. | Dosing protocols for increasing protein synthesis in an active individual |
| EP2327316B1 (en) * | 2009-11-29 | 2016-11-16 | Premier Nutrition Corporation | Method of enhancing muscle protein synthesis |
| WO2011078654A1 (en) * | 2009-12-24 | 2011-06-30 | N.V. Nutricia | Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis |
| JP2013519869A (ja) | 2010-02-10 | 2013-05-30 | ノバルティス アーゲー | 筋肉成長のための方法および化合物 |
| CA2792396C (en) * | 2010-03-12 | 2018-09-11 | Nestec S.A. | Compositions for masking the flavor of nutrients and methods for making same |
| WO2012005568A1 (en) | 2010-07-07 | 2012-01-12 | N.V. Nutricia | Nutritional composition for the stimulation of muscle protein synthesis |
| US8623924B2 (en) | 2011-07-15 | 2014-01-07 | Nusirt Sciences, Inc. | Compositions and methods for modulating metabolic pathways |
| US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
| HK1206765A1 (en) | 2012-03-26 | 2016-01-15 | Axcella Health Inc. | Nutritive fragments, proteins and methods |
| HK1206761A1 (en) | 2012-03-26 | 2016-01-15 | Axcella Health Inc. | Nutritive fragments, proteins and methods |
| MX2014011459A (es) | 2012-03-26 | 2015-02-04 | Pronutria Inc | Proteinas nutritivas cargadas y metodos. |
| EP2831100A4 (en) | 2012-03-26 | 2016-02-10 | Pronutria Inc | NUTRIENT PROTEINS AND METHOD |
| MX2015006023A (es) | 2012-11-13 | 2016-03-31 | Nusirt Sciences Inc | Composiciones y metodos para incrementar el metabolismo energetico. |
| CN105228627B (zh) | 2013-03-15 | 2018-07-13 | 纽斯尔特科学公司 | 亮氨酸和烟酸降低脂质水平 |
| US9597367B2 (en) * | 2013-04-19 | 2017-03-21 | Bioventures, Llc | Methods for improving muscle and heart function |
| AU2013392167B2 (en) * | 2013-06-10 | 2017-04-27 | N.V. Nutricia | Muscle preservation in overweight or obese adult during weight loss program |
| EP3048904A2 (en) | 2013-09-25 | 2016-08-03 | Pronutria Biosciences, Inc. | Compositions and formulations for treatment of gastrointestinal tract malabsorption diseases and inflammatory conditions and methods of production and use thereof |
| EP3110507B1 (en) | 2014-02-27 | 2020-11-18 | NuSirt Sciences, Inc. | Compositions and methods for the reduction or prevention of hepatic steatosis |
| US20170258791A1 (en) | 2014-08-29 | 2017-09-14 | Project Pm Co., Ltd. | Pharmaceutical composition formed by combining pyridoxamine compound and thiamine compound |
| US10188135B2 (en) * | 2015-11-04 | 2019-01-29 | Stokley-Van Camp, Inc. | Method for inducing satiety |
| RU2601406C1 (ru) * | 2015-11-17 | 2016-11-10 | Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Саратовский Государственный Медицинский Университет Имени В.И. Разумовского" Министерства Здравоохранения Российской Федерации | Средство, обладающее антикахексическим, противоопухолевым свойствами и снижающее уровень эндогенной интоксикации |
| JP6105111B1 (ja) * | 2016-03-02 | 2017-03-29 | 国立大学法人東北大学 | 自閉スペクトラム症改善用組成物 |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| IL296055A (en) | 2017-08-14 | 2022-10-01 | Axcella Health Inc | Amino acid compositions for the treatment of liver disease |
| CH714189A1 (de) * | 2017-09-25 | 2019-03-29 | Omanda Ag | Verfahren zur Herstellung von L-Leucin und Molkenprotein L-Leucin zur Nahrungsanreicherung und dessen Anwendung. |
| US11273138B2 (en) | 2017-11-02 | 2022-03-15 | Bioventures, Llc | Use of amino acid supplementation for improved muscle protein synthesis |
| MA52971A (fr) | 2018-06-20 | 2021-04-28 | Axcella Health Inc | Compositions et procédés pour le traitement de l'infiltration de graisse dans le muscle |
| CH715997A1 (de) * | 2019-03-25 | 2020-09-30 | Omanda Ag | Proteingetränk und Darreichungseinheit zur Verabreichung von mit L-Leucin-angereicherten Molkenproteinkomponenten als Nahrungsanreicherung und dessen Herstellung. |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3928445A (en) * | 1973-12-26 | 1975-12-23 | Allied Chem | Synthesis of 2-halo-5-cyano alkyl valerate |
| JPS6049764A (ja) * | 1983-08-29 | 1985-03-19 | Ajinomoto Co Inc | 食品組成物 |
| JPS60186261A (ja) * | 1984-03-06 | 1985-09-21 | Ajinomoto Co Inc | 固体状食品組成物 |
| US4687782A (en) * | 1984-12-10 | 1987-08-18 | Nutri-Fuels Systems, Inc. | Nutritional composition for enhancing skeletal muscle adaptation to exercise training |
| US5639731A (en) * | 1987-05-22 | 1997-06-17 | Pripps Bryggerier Ab | Amino acids for the preparation of a beverage |
| FI892006L (fi) * | 1988-04-29 | 1989-10-30 | Phil Gold | Lactalbumin saosom tillaeggsaemne i mat. |
| US5242697A (en) * | 1990-10-26 | 1993-09-07 | Maurizio Luca | Method of preparing nutrified food products |
| JP3622271B2 (ja) | 1995-07-11 | 2005-02-23 | 味の素株式会社 | 馬用栄養組成物 |
| US5817329A (en) * | 1997-02-28 | 1998-10-06 | Gardiner; Paul T. | Nutritional supplement for increased muscle size and strength for body builders |
| IT1291127B1 (it) * | 1997-04-01 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica |
| DE29707308U1 (de) | 1997-04-23 | 1997-06-26 | Kunz, Armin, 66450 Bexbach | Präparat zur Muskelerhaltung bzw. zur Förderung des Muskelaufbaus |
| US6051236A (en) * | 1998-11-12 | 2000-04-18 | Pacifichealth Laboratories, Inc. | Composition for optimizing muscle performance during exercise |
| US6221418B1 (en) * | 1999-03-25 | 2001-04-24 | Focused Foods, Inc. | High protein edible composition and method of preparing the same |
| US6241996B1 (en) * | 1999-04-09 | 2001-06-05 | Novartis Nutrition Ag | Liquid soy nutritional products |
| EP1112693B1 (en) | 1999-12-30 | 2006-03-22 | Kerry Group Services Ltd | Composition comprising carbohydrate and peptide material and its use as an energy supplement after or during physical exercise or as a metabolic nutrient for oral consumption |
| US6521591B1 (en) * | 2000-02-10 | 2003-02-18 | N.V. Nutricia | Pharmaceutical composition for muscular anabolism |
| US6420342B1 (en) * | 2000-05-08 | 2002-07-16 | N.V. Nutricia | Nutritional preparation comprising ribose and medical use thereof |
| US6706295B2 (en) * | 2000-09-29 | 2004-03-16 | The Procter & Gamble Co. | Compositions comprising arabinogalactan and a defined protein component |
| GB0110288D0 (en) | 2001-04-26 | 2001-06-20 | Novartis Nutrition Ag | Composition and treatment method |
| US7288570B2 (en) * | 2002-12-20 | 2007-10-30 | Nutricia N.V. | Stimulation of in vivo production of proteins |
-
2002
- 2002-12-20 US US10/325,711 patent/US7288570B2/en not_active Expired - Lifetime
-
2003
- 2003-12-15 DK DK03782981T patent/DK1455603T3/da active
- 2003-12-15 EP EP03782981A patent/EP1455603B1/en not_active Expired - Lifetime
- 2003-12-15 CA CA2510760A patent/CA2510760C/en not_active Expired - Fee Related
- 2003-12-15 AU AU2003290447A patent/AU2003290447B2/en not_active Ceased
- 2003-12-15 JP JP2004562109A patent/JP2006510711A/ja active Pending
- 2003-12-15 DE DE60308810T patent/DE60308810T2/de not_active Expired - Lifetime
- 2003-12-15 AT AT03782981T patent/ATE341226T1/de active
- 2003-12-15 ES ES03782981T patent/ES2274299T3/es not_active Expired - Lifetime
- 2003-12-15 WO PCT/NL2003/000892 patent/WO2004056208A1/en not_active Ceased
- 2003-12-15 CN CNB2003801098651A patent/CN100353866C/zh not_active Expired - Lifetime
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2007
- 2007-10-16 US US11/872,804 patent/US20080161398A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2510760A1 (en) | 2004-07-08 |
| US20040122097A1 (en) | 2004-06-24 |
| CN100353866C (zh) | 2007-12-12 |
| AU2003290447A1 (en) | 2004-07-14 |
| JP2006510711A (ja) | 2006-03-30 |
| WO2004056208A1 (en) | 2004-07-08 |
| AU2003290447A2 (en) | 2005-08-25 |
| DK1455603T3 (da) | 2007-02-05 |
| AU2003290447B2 (en) | 2007-10-04 |
| DE60308810T2 (de) | 2007-08-02 |
| US7288570B2 (en) | 2007-10-30 |
| DE60308810D1 (de) | 2006-11-16 |
| CA2510760C (en) | 2011-09-20 |
| CN1753625A (zh) | 2006-03-29 |
| US20080161398A1 (en) | 2008-07-03 |
| ATE341226T1 (de) | 2006-10-15 |
| EP1455603A1 (en) | 2004-09-15 |
| HK1065447A1 (en) | 2005-02-25 |
| EP1455603B1 (en) | 2006-10-04 |
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