CN100353866C - 用含亮氨酸的制剂刺激体内蛋白质的产生 - Google Patents

用含亮氨酸的制剂刺激体内蛋白质的产生 Download PDF

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Publication number
CN100353866C
CN100353866C CNB2003801098651A CN200380109865A CN100353866C CN 100353866 C CN100353866 C CN 100353866C CN B2003801098651 A CNB2003801098651 A CN B2003801098651A CN 200380109865 A CN200380109865 A CN 200380109865A CN 100353866 C CN100353866 C CN 100353866C
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CN
China
Prior art keywords
leucine
formulation
formulation according
amino acids
protein
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CNB2003801098651A
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English (en)
Chinese (zh)
Other versions
CN1753625A (zh
Inventor
乔治·维尔拉恩
鲁道夫·莱昂纳德斯·洛德韦克·斯梅茨
罗伯特·里斯·沃尔夫
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Nutricia NV
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Nutricia NV
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNB2003801098651A 2002-12-20 2003-12-15 用含亮氨酸的制剂刺激体内蛋白质的产生 Expired - Lifetime CN100353866C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/325,711 2002-12-20
US10/325,711 US7288570B2 (en) 2002-12-20 2002-12-20 Stimulation of in vivo production of proteins

Publications (2)

Publication Number Publication Date
CN1753625A CN1753625A (zh) 2006-03-29
CN100353866C true CN100353866C (zh) 2007-12-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2003801098651A Expired - Lifetime CN100353866C (zh) 2002-12-20 2003-12-15 用含亮氨酸的制剂刺激体内蛋白质的产生

Country Status (11)

Country Link
US (2) US7288570B2 (https=)
EP (1) EP1455603B1 (https=)
JP (1) JP2006510711A (https=)
CN (1) CN100353866C (https=)
AT (1) ATE341226T1 (https=)
AU (1) AU2003290447B2 (https=)
CA (1) CA2510760C (https=)
DE (1) DE60308810T2 (https=)
DK (1) DK1455603T3 (https=)
ES (1) ES2274299T3 (https=)
WO (1) WO2004056208A1 (https=)

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US9878004B2 (en) 2013-09-25 2018-01-30 Axcella Health Inc. Compositions and formulations for treatment of gastrointestinal tract malabsorption diseases and inflammatory conditions and methods of production and use thereof

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JP4970694B2 (ja) * 2002-12-02 2012-07-11 株式会社明治 持続性筋肉疲労改善剤
US7288570B2 (en) * 2002-12-20 2007-10-30 Nutricia N.V. Stimulation of in vivo production of proteins
BRPI0606687A2 (pt) * 2005-01-18 2009-07-14 Dsm Ip Assets Bv composições nutracêuticas
EP1774973A1 (en) * 2005-10-12 2007-04-18 Nutricia N.V. Leucine rich composition
EP1945044B1 (en) * 2005-10-26 2009-04-15 Hill's Pet Nutrition Inc. Compositions for increasing lean muscle mass and/or reducing fat gain
ES2302463B1 (es) * 2006-12-29 2009-06-05 Madaus, S.A. "composicion a base de fibra de cacao".
US8597677B2 (en) 2007-02-23 2013-12-03 Hill's Pet Nutrition, Inc. Compositions and methods for controlling the weight of animals
EP2098124A1 (en) * 2008-03-03 2009-09-09 Nestec S.A. Carbohydrate gel
ES2371789T3 (es) * 2008-03-03 2012-01-10 Nestec S.A. Producto alimenticio gelificado con una elevada eficacia en aporte de hidratos de carbono.
EP2098126A1 (en) * 2008-03-03 2009-09-09 Nestec S.A. Carbohydrate Bar
WO2010002242A1 (en) * 2008-07-02 2010-01-07 N.V. Nutricia Nutritional composition for improving muscle function and daily activity
EP2298090B1 (en) 2009-08-26 2016-01-13 Jeffrey M. Golini Pharmaceutical or nutraceutical composition
EP2327316B1 (en) * 2009-11-29 2016-11-16 Premier Nutrition Corporation Method of enhancing muscle protein synthesis
ES2441365T3 (es) * 2009-11-29 2014-02-04 Nestec S.A. Protocolos de dosificación para incrementar la síntesis de proteínas en un individuo activo
WO2011078654A1 (en) * 2009-12-24 2011-06-30 N.V. Nutricia Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis
US20120296403A1 (en) 2010-02-10 2012-11-22 Novartis Ag Methods and compounds for muscle growth
AU2011224427B2 (en) * 2010-03-12 2014-07-31 Société des Produits Nestlé S.A. Compositions for masking the flavor of nutrients and methods for making same
WO2012005568A1 (en) * 2010-07-07 2012-01-12 N.V. Nutricia Nutritional composition for the stimulation of muscle protein synthesis
RU2631597C2 (ru) 2011-07-15 2017-09-25 Нусерт Сайенсиз, Инк. Композиции и способы модулирования метаболических путей
US9198454B2 (en) 2012-03-08 2015-12-01 Nusirt Sciences, Inc. Compositions, methods, and kits for regulating energy metabolism
US9700071B2 (en) 2012-03-26 2017-07-11 Axcella Health Inc. Nutritive fragments, proteins and methods
EP2831100A4 (en) 2012-03-26 2016-02-10 Pronutria Inc NUTRIENT PROTEINS AND METHOD
EP2831098A4 (en) 2012-03-26 2016-12-07 Axcella Health Inc LOADED NUTRIENT PROTEINS AND METHODS
RU2634407C2 (ru) 2012-03-26 2017-10-26 Эксселла Хелт Инк. Фрагменты пищевых белков и способы их применения
SG10201709195TA (en) 2012-11-13 2017-12-28 Nusirt Sciences Inc Compositions and methods for increasing energy metabolism
CN105228627B (zh) 2013-03-15 2018-07-13 纽斯尔特科学公司 亮氨酸和烟酸降低脂质水平
US9597367B2 (en) 2013-04-19 2017-03-21 Bioventures, Llc Methods for improving muscle and heart function
CA2914811C (en) * 2013-06-10 2020-10-27 N.V. Nutricia Muscle preservation in overweight or obese adult during weight loss program
KR20160119863A (ko) 2014-02-27 2016-10-14 뉴서트 사이언시스, 인크. 간 지방증의 감소 또는 예방을 위한 조성물 및 방법
CN107148272A (zh) 2014-08-29 2017-09-08 吡哆胺研究有限公司 通过组合吡哆胺化合物和硫胺化合物形成的药物组合物
US10188135B2 (en) * 2015-11-04 2019-01-29 Stokley-Van Camp, Inc. Method for inducing satiety
RU2601406C1 (ru) * 2015-11-17 2016-11-10 Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Саратовский Государственный Медицинский Университет Имени В.И. Разумовского" Министерства Здравоохранения Российской Федерации Средство, обладающее антикахексическим, противоопухолевым свойствами и снижающее уровень эндогенной интоксикации
JP6105111B1 (ja) * 2016-03-02 2017-03-29 国立大学法人東北大学 自閉スペクトラム症改善用組成物
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
MX2020001765A (es) 2017-08-14 2020-07-29 Axcella Health Inc Composiciones de aminoacidos para el tratamiento de enfermedad hepatica.
CH714189A1 (de) * 2017-09-25 2019-03-29 Omanda Ag Verfahren zur Herstellung von L-Leucin und Molkenprotein L-Leucin zur Nahrungsanreicherung und dessen Anwendung.
EP3703516A4 (en) 2017-11-02 2021-08-18 BioVentures, LLC USE OF AMINO ACID SUPPLEMENTATION FOR IMPROVED MUSCLE PROTEIN SYNTHESIS
CN112839643A (zh) 2018-06-20 2021-05-25 胺细拉健康公司 用于治疗肌肉中脂肪浸润的组合物及方法
CH715997A1 (de) * 2019-03-25 2020-09-30 Omanda Ag Proteingetränk und Darreichungseinheit zur Verabreichung von mit L-Leucin-angereicherten Molkenproteinkomponenten als Nahrungsanreicherung und dessen Herstellung.

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FR2758243A1 (fr) * 1995-07-11 1998-07-17 Ajinomoto Kk Compositions nutritives pour animaux, notamment pour chevaux
WO2001058284A1 (en) * 2000-02-10 2001-08-16 N.V. Nutricia Pharmaceutical composition for muscular anabolism
WO2002087562A1 (en) * 2001-04-26 2002-11-07 Novartis Nutrition Ag Use of protein and essential amino acids to treat amenorrhea and related disorders

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9878004B2 (en) 2013-09-25 2018-01-30 Axcella Health Inc. Compositions and formulations for treatment of gastrointestinal tract malabsorption diseases and inflammatory conditions and methods of production and use thereof
US10463711B2 (en) 2013-09-25 2019-11-05 Axcella Health Inc. Nutritive polypeptides and formulations thereof, and methods of production and use thereof
US11357824B2 (en) 2013-09-25 2022-06-14 Axcella Health Inc. Nutritive polypeptides and formulations thereof, and methods of production and use thereof

Also Published As

Publication number Publication date
US7288570B2 (en) 2007-10-30
DK1455603T3 (da) 2007-02-05
HK1065447A1 (en) 2005-02-25
WO2004056208A1 (en) 2004-07-08
US20040122097A1 (en) 2004-06-24
US20080161398A1 (en) 2008-07-03
EP1455603A1 (en) 2004-09-15
DE60308810D1 (de) 2006-11-16
CA2510760C (en) 2011-09-20
AU2003290447A1 (en) 2004-07-14
AU2003290447A2 (en) 2005-08-25
ATE341226T1 (de) 2006-10-15
DE60308810T2 (de) 2007-08-02
CN1753625A (zh) 2006-03-29
EP1455603B1 (en) 2006-10-04
JP2006510711A (ja) 2006-03-30
CA2510760A1 (en) 2004-07-08
ES2274299T3 (es) 2007-05-16
AU2003290447B2 (en) 2007-10-04

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