ES2258777T3 - Monitorizacion electroquimiluminiscente de compuestos. - Google Patents
Monitorizacion electroquimiluminiscente de compuestos.Info
- Publication number
- ES2258777T3 ES2258777T3 ES96923255T ES96923255T ES2258777T3 ES 2258777 T3 ES2258777 T3 ES 2258777T3 ES 96923255 T ES96923255 T ES 96923255T ES 96923255 T ES96923255 T ES 96923255T ES 2258777 T3 ES2258777 T3 ES 2258777T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- electrochemiluminescent
- detectable
- luminescence
- pctq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- G01N2333/986—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides (3.5.2), e.g. beta-lactamase (penicillinase, 3.5.2.6), creatinine amidohydrolase (creatininase, EC 3.5.2.10), N-methylhydantoinase (3.5.2.6)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2415/00—Assays, e.g. immunoassays or enzyme assays, involving penicillins or cephalosporins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/30—Electrochemically active labels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/40—Rare earth chelates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Electroluminescent Light Sources (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US485419 | 1990-02-27 | ||
| US08/485,419 US5643713A (en) | 1995-06-07 | 1995-06-07 | Electrochemiluminescent monitoring of compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2258777T3 true ES2258777T3 (es) | 2006-09-01 |
Family
ID=23928088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96923255T Expired - Lifetime ES2258777T3 (es) | 1995-06-07 | 1996-06-07 | Monitorizacion electroquimiluminiscente de compuestos. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5643713A (enExample) |
| EP (1) | EP0836651B1 (enExample) |
| JP (2) | JP3997436B2 (enExample) |
| AT (1) | ATE317913T1 (enExample) |
| CA (1) | CA2222926C (enExample) |
| DE (1) | DE69635822T2 (enExample) |
| ES (1) | ES2258777T3 (enExample) |
| WO (1) | WO1996040978A1 (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6316180B1 (en) * | 1995-01-04 | 2001-11-13 | Igen International, Inc. | Electrochemiluminescent monitoring of compounds/electrochemiluminescence assays |
| US20010003647A1 (en) * | 1995-06-07 | 2001-06-14 | Ji Sun | Coreatant-including electrochemiluminescent compounds, methods, systems and kits utilizing same |
| US5641623A (en) * | 1995-01-04 | 1997-06-24 | Martin; Mark T. | Electrochemiluminescence assay |
| US6319670B1 (en) | 1995-05-09 | 2001-11-20 | Meso Scale Technology Llp | Methods and apparatus for improved luminescence assays using microparticles |
| US6613583B1 (en) | 1997-06-27 | 2003-09-02 | Igen International, Inc. | Electrochemiluminescent label based on multimetallic assemblies |
| US6312896B1 (en) * | 1998-09-17 | 2001-11-06 | Igen Inaternational, Inc. | Assays for measuring nucleic acid binding proteins and enzyme activities |
| US7141436B2 (en) * | 1999-11-03 | 2006-11-28 | Science And Technology Corp. | Immunoassay and reagents and kits for performing the same |
| JP2004534226A (ja) | 2001-06-29 | 2004-11-11 | メソ スケイル テクノロジーズ，エルエルシー | 発光試験測定用のアッセイプレート、リーダシステム及び方法 |
| US8815577B2 (en) | 2001-07-30 | 2014-08-26 | Meso Scale Technologies, Llc | Assay electrode having immobilized lipid/protein layers, methods of making the same and methods of using the same for luminescence test measurements |
| EP1451348B1 (en) | 2001-09-10 | 2015-08-12 | Meso Scale Technologies, LLC | Methods, reagents, kits and apparatus for protein function analysis |
| AU2003295495A1 (en) * | 2002-11-15 | 2004-06-15 | Applera Corporation | Nucleic acid sequence detection |
| CA2587945A1 (en) * | 2004-11-17 | 2007-04-12 | Bioveris | Electrochemiluminescent assay |
| US20060275841A1 (en) * | 2004-12-20 | 2006-12-07 | Martin Blankfard | Assay method and apparatus with reduced sample matrix effects |
| EP1854160B1 (en) * | 2005-02-10 | 2017-06-21 | Yeda Research And Development Co., Ltd. | Redox-active structures and devices utilizing the same |
| US20070116600A1 (en) * | 2005-06-23 | 2007-05-24 | Kochar Manish S | Detection device and methods associated therewith |
| PL2271938T3 (pl) | 2008-04-11 | 2014-07-31 | Univ Texas | Sposób i urządzenie do wzmacniania elektrogenerowanej chemiluminescencji nanocząsteczek |
| AU2009244904B2 (en) | 2008-05-08 | 2014-04-17 | Board Of Regents Of The University Of Texas System | Luminescent nanostructured materials for use in electrogenerated chemiluminescence |
| US20100261292A1 (en) * | 2009-04-10 | 2010-10-14 | Meso Scale Technologies, Llc | Methods for Conducting Assays |
| EP2470914B1 (en) * | 2009-07-27 | 2020-05-13 | Meso Scale Technologies, LLC | Assay apparatuses and methods |
| CA3139049C (en) | 2010-10-14 | 2024-10-15 | Meso Scale Technologies, Llc | REAGENT STORAGE IN A TEST DEVICE |
| WO2012055815A1 (en) | 2010-10-25 | 2012-05-03 | Roche Diagnostics Gmbh | Use of signal enhancing compounds in electrochemiluminescence detection |
| DK2776833T3 (da) | 2011-11-11 | 2019-01-02 | Eli N Glezer | Cobinder-understøttet testfremgangsmåde |
| US9081001B2 (en) | 2012-05-15 | 2015-07-14 | Wellstat Diagnostics, Llc | Diagnostic systems and instruments |
| US9625465B2 (en) | 2012-05-15 | 2017-04-18 | Defined Diagnostics, Llc | Clinical diagnostic systems |
| US9213043B2 (en) | 2012-05-15 | 2015-12-15 | Wellstat Diagnostics, Llc | Clinical diagnostic system including instrument and cartridge |
| CN105209886B (zh) | 2013-01-04 | 2019-04-02 | 梅索磅秤技术有限公司 | 适合询问样品的仪器和方法 |
| ES2942031T3 (es) | 2013-03-11 | 2023-05-29 | Meso Scale Technologies Llc | Métodos mejorados para realizar ensayos multiplexados |
| CN117288934A (zh) | 2013-03-13 | 2023-12-26 | 中尺度技术有限责任公司 | 改进的测定方法 |
| US10114015B2 (en) | 2013-03-13 | 2018-10-30 | Meso Scale Technologies, Llc. | Assay methods |
| CN105209532B (zh) | 2013-03-15 | 2017-11-28 | 路博润先进材料公司 | 不含重金属的cpvc组合物 |
| IL229525A0 (en) | 2013-11-20 | 2014-01-30 | Yeda Res & Dev | Metal complexes of tris-bipyridyl and their uses in electrochromic applications |
| CA2947747C (en) | 2014-05-09 | 2024-03-05 | Meso Scale Technologies, Llc. | Graphene-modified electrodes |
| KR102757668B1 (ko) | 2014-05-15 | 2025-01-21 | 메소 스케일 테크놀러지즈, 엘엘시 | 개선된 분석 방법 |
| WO2016091755A1 (en) | 2014-12-08 | 2016-06-16 | F. Hoffmann-La Roche Ag | Method for measurement of vitamin d |
| KR102601323B1 (ko) | 2015-08-20 | 2023-11-10 | 에프. 호프만-라 로슈 아게 | 페길화 분석물-특이적 결합제를 사용하는 입자-기반 면역어세이 |
| BR112018017336A2 (pt) | 2016-03-07 | 2018-12-26 | Hoffmann La Roche | método in vitro para detectar um anticorpo para p53 (anticorpo anti-p53) em uma amostra e polipeptídeo de fusão |
| ES2974284T3 (es) | 2016-03-11 | 2024-06-26 | Roche Diagnostics Gmbh | Aminas de cadena ramificada en la detección de electroquimioluminiscencia |
| JP7068323B2 (ja) | 2017-02-02 | 2022-05-16 | エフ．ホフマン－ラ ロシュ アーゲー | 少なくとも２種のペグ化された分析物特異的結合剤を使用する免疫アッセイ |
| WO2019164180A1 (ko) * | 2018-02-21 | 2019-08-29 | 고려대학교 세종산학협력단 | 유기전계발광소자용 조성물, 이로부터 제조된 정공주입층 재료 및 정공주입층을 포함하는 유기전계발광소자 |
| EP3756009B1 (en) | 2018-02-23 | 2023-09-06 | Meso Scale Technologies, LLC | Methods of screening antigen-binding molecules by normalizing for the concentration of antigen-binding molecule |
| EP3781600A1 (en) | 2018-04-18 | 2021-02-24 | F. Hoffmann-La Roche AG | Novel anti-thymidine kinase antibodies |
| ES2983797T3 (es) | 2018-08-31 | 2024-10-24 | Hoffmann La Roche | Timidina cinasa (TK-1) en índices pronóstico para LDLBG |
| SG11202106924VA (en) | 2019-01-03 | 2021-07-29 | Meso Scale Technologies Llc | Compositions and methods for carrying out assay measurements |
| CN120098057A (zh) | 2019-03-01 | 2025-06-06 | 中尺度技术有限责任公司 | 用于免疫方法的被电化学发光标记的探针、使用这类探针的方法和包含这类探针的试剂盒 |
| CN120665985A (zh) | 2019-06-07 | 2025-09-19 | 豪夫迈·罗氏有限公司 | 杂交全lna寡核苷酸 |
| IL325928A (en) | 2019-07-16 | 2026-03-01 | Meso Scale Technologies Llc | Assay apparatuses, methods and reagents |
| JP2022542056A (ja) | 2019-07-22 | 2022-09-29 | エフ．ホフマン－ラ ロシュ アーゲー | 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｓ１００ａ６ |
| JP7315781B2 (ja) | 2019-07-22 | 2023-07-26 | エフ． ホフマン－ラ ロシュ アーゲー | 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｓ１００ａ１２ |
| JP7421631B2 (ja) | 2019-07-22 | 2024-01-24 | エフ． ホフマン－ラ ロシュ アーゲー | 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｓ１００ａ８ |
| KR20220016210A (ko) | 2019-07-22 | 2022-02-08 | 에프. 호프만-라 로슈 아게 | 자궁내막증의 비-침습적 진단용 혈액 생물표지자로써 s100a9 |
| EP4004551A1 (en) | 2019-07-22 | 2022-06-01 | F. Hoffmann-La Roche AG | Substance p as blood biomarker for the non-invasive diagnosis of endometriosis |
| BR112022009371A2 (pt) | 2019-11-15 | 2022-08-09 | Hoffmann La Roche | Métodos para determinar a quantidade ou concentração de um ou mais analitos antibióticos, tubos de amostragem, usos de um reagente de derivatização nucleofílica e analito antibiótico |
| US20240018571A1 (en) | 2020-05-19 | 2024-01-18 | Meso Scale Technologies, Llc. | Methods, compositions, and kits for nucleic acid detection |
| JP7875821B2 (ja) | 2020-07-01 | 2026-06-18 | メソ スケール テクノロジーズ エルエルシー | アッセイ測定のための組成物及び方法 |
| KR20230065272A (ko) | 2020-08-21 | 2023-05-11 | 메소 스케일 테크놀러지즈, 엘엘시 | 정의된 계면 전위를 갖는 보조 전극을 구비한 전기화학 셀 및 이를 사용하는 방법 |
| WO2022090455A1 (en) | 2020-11-02 | 2022-05-05 | F. Hoffmann-La Roche Ag | Sars-cov-2 nucleocapsid antibodies |
| WO2022136234A1 (en) | 2020-12-22 | 2022-06-30 | F. Hoffmann-La Roche Ag | Method for detecting an analyte of interest in a sample |
| WO2022207628A1 (en) | 2021-03-30 | 2022-10-06 | F. Hoffmann-La Roche Ag | Scf as blood biomarker for the non-invasive diagnosis of endometriosis |
| CN117099001A (zh) | 2021-04-01 | 2023-11-21 | 豪夫迈·罗氏有限公司 | Psp94作为血液生物标志物用于子宫内膜异位症的非侵入性诊断 |
| EP4341700A1 (en) | 2021-05-17 | 2024-03-27 | F. Hoffmann-La Roche AG | Sfrp4 as blood biomarker for the non-invasive diagnosis of adenomyosis |
| AU2022304570A1 (en) | 2021-06-28 | 2024-01-18 | Meso Scale Technologies, Llc. | Methods, compositions, and kits for assay signal amplification |
| AU2022325891B2 (en) | 2021-08-13 | 2026-03-26 | Meso Scale Technologies, Llc. | Electrochemical cell devices and methods of manufacturing |
| US20250042976A1 (en) | 2021-10-26 | 2025-02-06 | Roche Diagnostics Operations, Inc. | Monoclonal antibodies specific for sars-cov-2 rbd |
| CN118922555A (zh) | 2021-12-30 | 2024-11-08 | 中尺度技术有限责任公司 | 用于电化学发光检测的方法 |
| JP2025501000A (ja) | 2022-01-04 | 2025-01-15 | メソ スケール テクノロジーズ エルエルシー | 電気化学セルデバイスおよびその製造方法 |
| WO2023131594A1 (en) | 2022-01-05 | 2023-07-13 | F. Hoffmann-La Roche Ag | Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm) |
| WO2023156510A1 (en) | 2022-02-18 | 2023-08-24 | F. Hoffmann-La Roche Ag | Method for detecting an analyte of interest in a sample |
| WO2023247752A1 (en) | 2022-06-23 | 2023-12-28 | F. Hoffmann-La Roche Ag | Method for diagnosing endometriosis and for classifying the stage of endometriosis |
| EP4558826A1 (en) | 2022-07-22 | 2025-05-28 | F. Hoffmann-La Roche AG | Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| JP2025524025A (ja) | 2022-07-22 | 2025-07-25 | エフ． ホフマン－ラ ロシュ アーゲー | 多嚢胞性卵巣症候群の診断のための（血液）バイオマーカーとしてのロイコトリエンａ４ヒドロラーゼ（ｌｔａ４ｈ） |
| EP4558825A1 (en) | 2022-07-22 | 2025-05-28 | F. Hoffmann-La Roche AG | Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| IL322791A (en) | 2023-02-15 | 2025-10-01 | Meso Scale Technologies Llc | Electrochemical cell devices and methods for their manufacture |
| EP4747637A1 (en) | 2023-07-20 | 2026-05-27 | F. Hoffmann-La Roche AG | Screening methods for antibody compositions |
| JP2026526931A (ja) | 2023-07-28 | 2026-08-10 | エフ ホフマン－ラ ロッシュ アクチェン ゲゼルシャフト | 子宮内膜症のバイオマーカーとしての血清ＥｐｈＡ１ |
| WO2026039455A1 (en) | 2024-08-13 | 2026-02-19 | Meso Scale Technologies, Llc. | Detection of nucleic acids |
| WO2026120128A1 (en) | 2024-12-05 | 2026-06-11 | Roche Diagnostics Gmbh | Serum transcriptional regulator erg as biomarker for endometriosis |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3905871A (en) * | 1971-05-14 | 1975-09-16 | Syva Co | Lactam conjugates to enzymes |
| US4238195A (en) * | 1979-01-18 | 1980-12-09 | Miles Laboratories, Inc. | Fluorescer-labeled specific binding assays |
| US4372745A (en) * | 1979-12-19 | 1983-02-08 | Electro-Nucleonics, Inc. | Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer |
| EP0050965A1 (en) * | 1980-10-23 | 1982-05-05 | Takeda Chemical Industries, Ltd. | Beta-lactamase inhibitory composition |
| US4396579A (en) * | 1981-08-06 | 1983-08-02 | Miles Laboratories, Inc. | Luminescence detection device |
| US4713328A (en) * | 1981-09-30 | 1987-12-15 | Yolken Robert H | Microbial Enzyme assays |
| JPS60200167A (ja) * | 1984-03-24 | 1985-10-09 | Toyobo Co Ltd | 化学発光法による過酸化水素の定量法 |
| US5310687A (en) * | 1984-10-31 | 1994-05-10 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5221605A (en) * | 1984-10-31 | 1993-06-22 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US4764462A (en) * | 1985-08-23 | 1988-08-16 | Georgetown University | Detectably labeled cephalosporin assay for beta-lactamase |
| EP0261591B1 (en) * | 1986-09-22 | 1993-03-10 | Nippon Kayaku Kabushiki Kaisha | Method for assaying 1,5-anhydroglucitol and kit therefor |
| US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
| JPH0630628B2 (ja) * | 1987-12-16 | 1994-04-27 | キング醸造株式会社 | 生細胞数及び活力の測定方法 |
| US5321143A (en) * | 1988-05-26 | 1994-06-14 | Massachusetts Institute Of Technology | Ruthenium-catalyzed production of cyclic sulfates |
| US5238610A (en) * | 1988-10-06 | 1993-08-24 | The United States Of America As Represented By The Secretary Of The Navy | Method of detecting oxidizing agents in aqueous media through the use of chemiluminescent microemulsions |
| US5264346A (en) * | 1991-06-03 | 1993-11-23 | Chen Kirk C S | Colorimetric method for beta-lactamase assay and its applications |
| US5321243A (en) * | 1992-02-18 | 1994-06-14 | International Verifact Inc. | Card reader apparatus with read head mounting structure and card guide |
-
1995
- 1995-06-07 US US08/485,419 patent/US5643713A/en not_active Expired - Lifetime
-
1996
- 1996-06-07 WO PCT/US1996/009805 patent/WO1996040978A1/en not_active Ceased
- 1996-06-07 EP EP96923255A patent/EP0836651B1/en not_active Expired - Lifetime
- 1996-06-07 DE DE69635822T patent/DE69635822T2/de not_active Expired - Fee Related
- 1996-06-07 JP JP50202097A patent/JP3997436B2/ja not_active Expired - Fee Related
- 1996-06-07 CA CA002222926A patent/CA2222926C/en not_active Expired - Fee Related
- 1996-06-07 AT AT96923255T patent/ATE317913T1/de not_active IP Right Cessation
- 1996-06-07 ES ES96923255T patent/ES2258777T3/es not_active Expired - Lifetime
-
1997
- 1997-06-23 US US08/880,209 patent/US6165708A/en not_active Expired - Fee Related
-
2006
- 2006-12-13 JP JP2006335216A patent/JP2007176939A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996040978A1 (en) | 1996-12-19 |
| AU6381796A (en) | 1996-12-30 |
| JP3997436B2 (ja) | 2007-10-24 |
| EP0836651A1 (en) | 1998-04-22 |
| US6165708A (en) | 2000-12-26 |
| DE69635822T2 (de) | 2006-10-19 |
| CA2222926A1 (en) | 1996-12-19 |
| DE69635822D1 (de) | 2006-04-20 |
| US5643713A (en) | 1997-07-01 |
| EP0836651B1 (en) | 2006-02-15 |
| JPH11507533A (ja) | 1999-07-06 |
| EP0836651A4 (en) | 2004-07-14 |
| JP2007176939A (ja) | 2007-07-12 |
| ATE317913T1 (de) | 2006-03-15 |
| AU708865B2 (en) | 1999-08-12 |
| CA2222926C (en) | 2008-09-16 |
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