ATE317913T1 - Beobachtung von verbindungen mittels elektrochemilumineszenz - Google Patents

Beobachtung von verbindungen mittels elektrochemilumineszenz

Info

Publication number
ATE317913T1
ATE317913T1 AT96923255T AT96923255T ATE317913T1 AT E317913 T1 ATE317913 T1 AT E317913T1 AT 96923255 T AT96923255 T AT 96923255T AT 96923255 T AT96923255 T AT 96923255T AT E317913 T1 ATE317913 T1 AT E317913T1
Authority
AT
Austria
Prior art keywords
compounds
electrochemiluminescence
observation
compound
transformable
Prior art date
Application number
AT96923255T
Other languages
German (de)
English (en)
Inventor
Mark T Martin
Pam Liang
Liwen Dong
Original Assignee
Bioveris Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioveris Corp filed Critical Bioveris Corp
Application granted granted Critical
Publication of ATE317913T1 publication Critical patent/ATE317913T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • G01N2333/986—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides (3.5.2), e.g. beta-lactamase (penicillinase, 3.5.2.6), creatinine amidohydrolase (creatininase, EC 3.5.2.10), N-methylhydantoinase (3.5.2.6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2415/00—Assays, e.g. immunoassays or enzyme assays, involving penicillins or cephalosporins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/30—Electrochemically active labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/40—Rare earth chelates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Electroluminescent Light Sources (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
AT96923255T 1995-06-07 1996-06-07 Beobachtung von verbindungen mittels elektrochemilumineszenz ATE317913T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/485,419 US5643713A (en) 1995-06-07 1995-06-07 Electrochemiluminescent monitoring of compounds

Publications (1)

Publication Number Publication Date
ATE317913T1 true ATE317913T1 (de) 2006-03-15

Family

ID=23928088

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96923255T ATE317913T1 (de) 1995-06-07 1996-06-07 Beobachtung von verbindungen mittels elektrochemilumineszenz

Country Status (8)

Country Link
US (2) US5643713A (enExample)
EP (1) EP0836651B1 (enExample)
JP (2) JP3997436B2 (enExample)
AT (1) ATE317913T1 (enExample)
CA (1) CA2222926C (enExample)
DE (1) DE69635822T2 (enExample)
ES (1) ES2258777T3 (enExample)
WO (1) WO1996040978A1 (enExample)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6316180B1 (en) * 1995-01-04 2001-11-13 Igen International, Inc. Electrochemiluminescent monitoring of compounds/electrochemiluminescence assays
US20010003647A1 (en) * 1995-06-07 2001-06-14 Ji Sun Coreatant-including electrochemiluminescent compounds, methods, systems and kits utilizing same
US5641623A (en) * 1995-01-04 1997-06-24 Martin; Mark T. Electrochemiluminescence assay
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US6613583B1 (en) 1997-06-27 2003-09-02 Igen International, Inc. Electrochemiluminescent label based on multimetallic assemblies
US6312896B1 (en) * 1998-09-17 2001-11-06 Igen Inaternational, Inc. Assays for measuring nucleic acid binding proteins and enzyme activities
US7141436B2 (en) * 1999-11-03 2006-11-28 Science And Technology Corp. Immunoassay and reagents and kits for performing the same
DK2423673T3 (da) 2001-06-29 2020-09-07 Meso Scale Technologies Llc Indretning til måling af luminescens fra en flerbrønds-assayplade med en flerhed af brønde, fremgangsmåde til måling af luminescens med anvendelse af indretningen og system omfattende indretningen
ATE471369T1 (de) 2001-07-30 2010-07-15 Meso Scale Technologies Llc Assay-elektroden mit schichten aus immobilisiertem lipid/protein sowie verfahren zu deren herstellung und verwendung
CA2459893C (en) 2001-09-10 2014-01-21 Meso Scale Technologies, Llc Methods and apparatus for conducting multiple measurements on a sample
EP1560930A4 (en) * 2002-11-15 2007-05-16 Applera Corp NUKLEINSûURESEQUENZNACHWEIS
WO2007040559A2 (en) * 2004-11-17 2007-04-12 Bioveris Electrochemiluminescent assay
US20060275841A1 (en) * 2004-12-20 2006-12-07 Martin Blankfard Assay method and apparatus with reduced sample matrix effects
WO2006085319A2 (en) * 2005-02-10 2006-08-17 Yeda Research And Development Company Ltd. Redox-active structures and devices utilizing the same
WO2007002580A2 (en) * 2005-06-23 2007-01-04 Bioveris Corporation Diagnostic as say system with multi -well reagent container
WO2009126249A1 (en) 2008-04-11 2009-10-15 Board Of Regents Of The University Of Texas System Method and apparatus for nanoparticle electrogenerated chemiluminescence amplification
EP2626693A3 (en) 2008-05-08 2014-10-01 Board of Regents of the University of Texas System Luminescent nanostructured materials for use in electrogenerated chemiluminescence
US20100261292A1 (en) 2009-04-10 2010-10-14 Meso Scale Technologies, Llc Methods for Conducting Assays
EP3611510A1 (en) 2009-07-27 2020-02-19 Meso Scale Technologies, LLC Assay apparatuses, consumables and methods
WO2012051386A2 (en) 2010-10-14 2012-04-19 Meso Scale Technologies, Llc Reagent storage in an assay device
EP2633289B1 (en) 2010-10-25 2016-04-20 Roche Diagniostics GmbH Use of signal enhancing compounds in electrochemiluminescence detection
US9777338B2 (en) 2011-11-11 2017-10-03 Meso Scale Technologies, Llc. Co-binder assisted assay methods
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
JP6416785B2 (ja) 2013-01-04 2018-10-31 メソ スケール テクノロジーズ エルエルシー マルチウェルプレートおよびコンタクトプラットフォームを利用した電気化学発光分析用計器
CA2904020C (en) 2013-03-11 2022-06-14 Meso Scale Technologies, Llc. Improved methods for conducting multiplexed assays
US9618510B2 (en) 2013-03-13 2017-04-11 Meso Scale Technologies, Llc. Assay methods
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
EP2970631B1 (en) 2013-03-15 2017-05-03 Lubrizol Advanced Materials, Inc. Heavy metal free cpvc compositions
IL229525A0 (en) 2013-11-20 2014-01-30 Yeda Res & Dev Metal complexes of tris-bipyridyl and their uses in electrochromic applications
CA3229509A1 (en) 2014-05-09 2015-11-12 Meso Scale Technologies, Llc. Graphene-modified electrodes
KR102497054B1 (ko) 2014-05-15 2023-02-06 메소 스케일 테크놀러지즈, 엘엘시 개선된 분석 방법
WO2016091755A1 (en) 2014-12-08 2016-06-16 F. Hoffmann-La Roche Ag Method for measurement of vitamin d
CN117491623A (zh) 2015-08-20 2024-02-02 豪夫迈·罗氏有限公司 使用聚乙二醇化分析物特异性结合剂的基于颗粒的免疫测定法
JP7065781B2 (ja) 2016-03-07 2022-05-12 エフ．ホフマン－ラ ロシュ アーゲー 抗ｐ５３抗体の検出
EP3426398B1 (en) 2016-03-11 2024-01-24 Roche Diagnostics GmbH Branched-chain amines in electrochemiluminescence detection
WO2018141768A1 (en) 2017-02-02 2018-08-09 Roche Diagnostics Gmbh Immunoassay using at least two pegylated analyte-specific binding agents
WO2019164180A1 (ko) * 2018-02-21 2019-08-29 고려대학교 세종산학협력단 유기전계발광소자용 조성물, 이로부터 제조된 정공주입층 재료 및 정공주입층을 포함하는 유기전계발광소자
EP3756009B1 (en) 2018-02-23 2023-09-06 Meso Scale Technologies, LLC Methods of screening antigen-binding molecules by normalizing for the concentration of antigen-binding molecule
EP3781600A1 (en) 2018-04-18 2021-02-24 F. Hoffmann-La Roche AG Novel anti-thymidine kinase antibodies
JP7577647B2 (ja) 2018-08-31 2024-11-05 エフ． ホフマン－ラ ロシュ アーゲー Ｄｌｂｃｌについての予後指標におけるチミジンキナーゼ（ｔｋ－１）
CN113366313A (zh) 2019-01-03 2021-09-07 中尺度技术有限责任公司 实施分析测量的组合物及方法
CA3132154A1 (en) 2019-03-01 2020-09-10 Meso Scale Technologies, Llc. Electrochemiluminescent labeled probes for use in immunoassay methods, methods using such and kits comprising same
CN120665985A (zh) 2019-06-07 2025-09-19 豪夫迈·罗氏有限公司 杂交全lna寡核苷酸
JP7379653B2 (ja) 2019-07-16 2023-11-14 メソ スケール テクノロジーズ エルエルシー アッセイ装置、方法、および試薬
EP4004555A1 (en) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG S100a6 as blood biomarker for the non-invasive diagnosis of endometriosis
CN114144674A (zh) 2019-07-22 2022-03-04 豪夫迈·罗氏有限公司 P物质作为用于子宫内膜异位症的非侵入性诊断的血液生物标志物
KR20220016210A (ko) 2019-07-22 2022-02-08 에프. 호프만-라 로슈 아게 자궁내막증의 비-침습적 진단용 혈액 생물표지자로써 s100a9
WO2021013784A1 (en) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag S100a8 as blood biomarker for the non-invasive diagnosis of endometriosis
BR112022001140A2 (pt) 2019-07-22 2022-03-15 Hoffmann La Roche Métodos para avaliar se um paciente tem endometriose ou está em risco de desenvolver endometriose, selecionar um paciente para terapia e monitorar um paciente que sofre de endometriose ou que está sendo tratado para endometriose
EP4058459A1 (en) 2019-11-15 2022-09-21 F. Hoffmann-La Roche AG Derivatization of beta-lactam antibiotics for massspec measurements in patient samples
EP4154008A1 (en) 2020-05-19 2023-03-29 Meso Scale Technologies, LLC Methods, compositions, and kits for nucleic acid detection
WO2022006236A1 (en) 2020-07-01 2022-01-06 Meso Scale Technologies, Llc. Compositions and methods for assay measurements
EP4200597A2 (en) 2020-08-21 2023-06-28 Meso Scale Technologies, LLC Electrochemical cells with auxiliary electrodes having a defined interface potential and methods of using them
JP2023547505A (ja) 2020-11-02 2023-11-10 エフ． ホフマン－ラ ロシュ アーゲー ＳＡＲＳ－ＣｏＶ－２ヌクレオカプシド抗体
CN116635083A (zh) 2020-12-22 2023-08-22 豪夫迈·罗氏有限公司 用于检测样品中的目标分析物的方法
WO2022207628A1 (en) 2021-03-30 2022-10-06 F. Hoffmann-La Roche Ag Scf as blood biomarker for the non-invasive diagnosis of endometriosis
WO2022207685A1 (en) 2021-04-01 2022-10-06 F. Hoffmann-La Roche Ag Psp94 as blood biomarker for the non-invasive diagnosis of endometriosis
JP7727015B2 (ja) 2021-05-17 2025-08-20 エフ． ホフマン－ラ ロシュ アーゲー 腺筋症の非侵襲的診断のための血液バイオマーカーとしてのｓＦＲＰ４
EP4384813A1 (en) 2021-08-13 2024-06-19 Meso Scale Technologies, LLC. Electrochemical cell devices and methods of manufacturing
WO2023072904A1 (en) 2021-10-26 2023-05-04 F. Hoffmann-La Roche Ag Monoclonal antibodies specific for sars-cov-2 rbd
KR20240146115A (ko) 2021-12-30 2024-10-07 메소 스케일 테크놀러지즈, 엘엘시 전기화학발광 검출 방법
CN118541217A (zh) 2022-01-04 2024-08-23 中尺度技术有限责任公司 电化学电池装置和制造方法
WO2023131594A1 (en) 2022-01-05 2023-07-13 F. Hoffmann-La Roche Ag Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm)
JP2025506652A (ja) 2022-02-18 2025-03-13 エフ． ホフマン－ラ ロシュ アーゲー 試料中の目的の分析物を検出するための方法
CN119404103A (zh) 2022-06-23 2025-02-07 豪夫迈·罗氏有限公司 用于诊断子宫内膜异位症及用于对子宫内膜异位症的分期进行分类的方法
WO2024017985A1 (en) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
EP4558825A1 (en) 2022-07-22 2025-05-28 F. Hoffmann-La Roche AG Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
CN119604768A (zh) 2022-07-22 2025-03-11 豪夫迈·罗氏有限公司 白三烯a4水解酶(lta4h)作为（血液）生物标志物用于诊断多囊卵巢综合征
WO2024173575A1 (en) 2023-02-15 2024-08-22 Meso Scale Technologies, Llc. Electrochemical cell devices and methods of manufacturing
WO2025017135A1 (en) 2023-07-20 2025-01-23 F. Hoffmann-La Roche Ag Screening methods for antibody compositions
WO2025026908A1 (en) 2023-07-28 2025-02-06 Roche Diagnostics Gmbh Serum epha1 as biomarker for endometriosis

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3905871A (en) * 1971-05-14 1975-09-16 Syva Co Lactam conjugates to enzymes
US4238195A (en) * 1979-01-18 1980-12-09 Miles Laboratories, Inc. Fluorescer-labeled specific binding assays
US4372745A (en) * 1979-12-19 1983-02-08 Electro-Nucleonics, Inc. Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer
EP0050965A1 (en) * 1980-10-23 1982-05-05 Takeda Chemical Industries, Ltd. Beta-lactamase inhibitory composition
US4396579A (en) * 1981-08-06 1983-08-02 Miles Laboratories, Inc. Luminescence detection device
US4713328A (en) * 1981-09-30 1987-12-15 Yolken Robert H Microbial Enzyme assays
JPS60200167A (ja) * 1984-03-24 1985-10-09 Toyobo Co Ltd 化学発光法による過酸化水素の定量法
US5310687A (en) * 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US5221605A (en) * 1984-10-31 1993-06-22 Igen, Inc. Luminescent metal chelate labels and means for detection
US4764462A (en) * 1985-08-23 1988-08-16 Georgetown University Detectably labeled cephalosporin assay for beta-lactamase
DE3784610T2 (de) * 1986-09-22 1993-09-23 Nippon Kayaku Kk Verfahren zur bestimmung von 1,5-anhydroglucitol und ausruestung dafuer.
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
JPH0630628B2 (ja) * 1987-12-16 1994-04-27 キング醸造株式会社 生細胞数及び活力の測定方法
US5321143A (en) * 1988-05-26 1994-06-14 Massachusetts Institute Of Technology Ruthenium-catalyzed production of cyclic sulfates
US5238610A (en) * 1988-10-06 1993-08-24 The United States Of America As Represented By The Secretary Of The Navy Method of detecting oxidizing agents in aqueous media through the use of chemiluminescent microemulsions
US5264346A (en) * 1991-06-03 1993-11-23 Chen Kirk C S Colorimetric method for beta-lactamase assay and its applications
US5321243A (en) * 1992-02-18 1994-06-14 International Verifact Inc. Card reader apparatus with read head mounting structure and card guide

Also Published As

Publication number Publication date
EP0836651B1 (en) 2006-02-15
DE69635822T2 (de) 2006-10-19
JP2007176939A (ja) 2007-07-12
CA2222926C (en) 2008-09-16
JP3997436B2 (ja) 2007-10-24
EP0836651A1 (en) 1998-04-22
JPH11507533A (ja) 1999-07-06
DE69635822D1 (de) 2006-04-20
EP0836651A4 (en) 2004-07-14
ES2258777T3 (es) 2006-09-01
US6165708A (en) 2000-12-26
CA2222926A1 (en) 1996-12-19
WO1996040978A1 (en) 1996-12-19
AU708865B2 (en) 1999-08-12
US5643713A (en) 1997-07-01
AU6381796A (en) 1996-12-30

Similar Documents

Publication Publication Date Title
ATE317913T1 (de) Beobachtung von verbindungen mittels elektrochemilumineszenz
EA199700219A1 (ru) Мультиматричное мультиспецифическое электрохемилюминесцентное испытание
ATE199263T1 (de) Für den chemilumineszenz-nachweis verwendbare aryl-n-alkylacridanthiocarboxylat-derivate
DE59409999D1 (de) Vorrichtung zur Signalanalyse des elektrischen Potentialverlaufes der Herzerregung
NL930144I2 (nl) Door fosfinylalkanoyl gesubstitueerde prolinen.
DE68909345D1 (de) Verfahren und Kompositionen zur Erzeugung verstärkter Chemilumineszenz von 1,2-Dioxetanen.
DE69122357D1 (de) Diagnostisches Verfahren zur Überwachung von Gas
ATE148788T1 (de) Verfahren zur aktivierung von polyanionischen,fluoreszierenden farbstoffen in schwach dielektrischen medien mit quaternären oniumverbindungen
ES2067945T3 (es) Derivados de hidroxiurea hipoglicemica.
DE69842134D1 (de) Elektronische verfahren und vorrichtung zum nachweis von analyten
DE69942068D1 (de) Erzeugen eines nichtlinearen modells und erzeugen tzung desselben
DE69939269D1 (de) Verfahren zur bestimmung der suzeptibilität zur sepsisentwicklung und arzneimittel zur behandlung von sepsis
ES2185218T3 (es) Un plasma sanguineo aplicable universalmente.
TR199800773T2 (xx) Trombin inhibit�rleri.
ES2048109B1 (es) Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
DE69108733D1 (de) Bisphosphonsäurederivate als antiarthritische mittel.
MX9302931A (es) Nuevas 4-aza-5&-colestan-onas 7b-substituidas como inhibidores de 5&-reductasa.
DE69022255D1 (de) Beta-Lactamasetests mit Gebrauch von chromogenen Niederschlag bildenden Substraten.
PT88887A (pt) Metodo para a deteccao de beta-lactamase de origem microbiana
FR2664702B1 (fr) Procede de reduction d'interferences dans un dosage par fluorescence.
DE68919597D1 (de) Spektrofluorometrisches verfahren und für dieses verfahren wertvolle verbindungen.
ATE226649T1 (de) System und verfahren zur elektrochemischen spaltung von verbindungen
NO972346D0 (no) Aminoguanidinkarboksylater for behandling av ikke-insulinavhengig diabetes millitus
DE3860525D1 (de) Vorrichtung zur erschliessung von muelldeponiegasquellen und zur erkundung und sanierung von altlasten und verunreinigten boeden.
DE69428552D1 (de) Verfahren zum Nachweis von seltenen Ereignissen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties