ES2186807T3 - Inhibidores de trombina. - Google Patents

Inhibidores de trombina.

Info

Publication number
ES2186807T3
ES2186807T3 ES96936804T ES96936804T ES2186807T3 ES 2186807 T3 ES2186807 T3 ES 2186807T3 ES 96936804 T ES96936804 T ES 96936804T ES 96936804 T ES96936804 T ES 96936804T ES 2186807 T3 ES2186807 T3 ES 2186807T3
Authority
ES
Spain
Prior art keywords
thrombin inhibitors
thrombin
inhibitors
compound
human thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96936804T
Other languages
English (en)
Inventor
William C Lumma
Thomas J Tucker
Keith M Witherup
Stephen F Brady
Willie L Whitter
Joseph P Vacca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605163.6A external-priority patent/GB9605163D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2186807T3 publication Critical patent/ES2186807T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

SE DESCRIBE UN COMPUESTO QUE INHIBE LA TROMBINA HUMANA Y QUE PRESENTA LA ESTRUCTURA (I), TAL COMO (II).
ES96936804T 1995-10-24 1996-10-21 Inhibidores de trombina. Expired - Lifetime ES2186807T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US607695P 1995-10-24 1995-10-24
GBGB9605163.6A GB9605163D0 (en) 1996-03-12 1996-03-12 Thrombin inhibitors
US2316496P 1996-08-05 1996-08-05

Publications (1)

Publication Number Publication Date
ES2186807T3 true ES2186807T3 (es) 2003-05-16

Family

ID=27268176

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96936804T Expired - Lifetime ES2186807T3 (es) 1995-10-24 1996-10-21 Inhibidores de trombina.

Country Status (8)

Country Link
EP (1) EP0858262B1 (es)
JP (1) JPH11514378A (es)
AT (1) ATE228760T1 (es)
AU (1) AU709088B2 (es)
CA (1) CA2233860A1 (es)
DE (1) DE69625230T2 (es)
ES (1) ES2186807T3 (es)
WO (1) WO1997015190A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
CA2431588A1 (en) * 2000-12-18 2002-06-27 Merck & Co., Inc. Benzylamine derivatives and their use as thrombin inhibitors
US7144899B2 (en) 2001-02-09 2006-12-05 Merck & Co., Inc. Thrombin inhibitors
US7084134B2 (en) 2002-05-02 2006-08-01 Merk & Co., Inc. Thrombin inhibitors
JP2006143667A (ja) * 2004-11-22 2006-06-08 Ube Ind Ltd ピペコリン酸アミド誘導体及び抗菌剤
CN102464701B (zh) 2010-11-08 2015-10-21 上海医药工业研究院 一类新型化合物、其制备方法及用途
US9133147B2 (en) 2012-03-28 2015-09-15 Merck Sharp & Dohme Corp. Thrombin inhibitors
WO2014028318A1 (en) * 2012-08-14 2014-02-20 Merck Sharp & Dohme Corp. Thrombin inhibitors
EP3668837B1 (en) 2017-08-17 2022-07-06 XWPharma Ltd. Preparation and uses of reactive oxygen species scavenger derivatives
CN115475229A (zh) 2017-09-04 2022-12-16 凯瑞康宁生物工程（武汉）有限公司 活性氧清除剂的制备及用途
GB201807014D0 (en) * 2018-04-30 2018-06-13 Univ Leeds Innovations Ltd Factor xlla inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58849B1 (en) * 1984-12-18 1993-11-17 Gruenenthal Chemie Use of dipeptide derivatives for the manufacture of medicaments for the treatment of patients with amyotrophic lateral sclerosis
US4804743A (en) * 1987-01-29 1989-02-14 Warner-Lambert Copmany Proline-containing renin inhibitors
ZA897515B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
IL112795A (en) * 1994-03-04 2001-01-28 Astrazeneca Ab Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
WO1997015190A1 (en) 1997-05-01
JPH11514378A (ja) 1999-12-07
DE69625230D1 (de) 2003-01-16
AU709088B2 (en) 1999-08-19
EP0858262B1 (en) 2002-12-04
DE69625230T2 (de) 2003-09-04
EP0858262A4 (en) 1998-12-02
AU7463496A (en) 1997-05-15
EP0858262A1 (en) 1998-08-19
ATE228760T1 (de) 2002-12-15
CA2233860A1 (en) 1997-05-01

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