ES2257881T3 - Procedimiento para preparar particulas de farmaco revestidas y formulaciones farmaceuticas de las mismas. - Google Patents

Procedimiento para preparar particulas de farmaco revestidas y formulaciones farmaceuticas de las mismas.

Info

Publication number
ES2257881T3
ES2257881T3 ES99967110T ES99967110T ES2257881T3 ES 2257881 T3 ES2257881 T3 ES 2257881T3 ES 99967110 T ES99967110 T ES 99967110T ES 99967110 T ES99967110 T ES 99967110T ES 2257881 T3 ES2257881 T3 ES 2257881T3
Authority
ES
Spain
Prior art keywords
drug particles
particles
procedure
same
pharmaceutical formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99967110T
Other languages
English (en)
Inventor
James D Talton
Guenther Hochhaus
Rajiv K Singh
James M Navy Resea Fitz-Gerald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
Original Assignee
University of Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida filed Critical University of Florida
Application granted granted Critical
Publication of ES2257881T3 publication Critical patent/ES2257881T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/22—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
    • C23C14/223—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating specially adapted for coating particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/22—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
    • C23C14/24—Vacuum evaporation
    • C23C14/28—Vacuum evaporation by wave energy or particle radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]

Abstract

Un medicamento que comprende una pluralidad de partículas de fármaco revestidas, conteniendo cada una un tamaño de partícula medio de menos de 500 m de diámetro, comprendiendo la superficie de dichas partículas al menos una primera capa de partículas de revestimiento poliméricas biodegradables y biocompatibles, en las que el grosor medio de dicha capa de revestimiento está entre 1 y 500 nm, pudiendo obtenerse las partículas de fármaco revestidas a través de un proceso que comprende depositar dichas partículas de revestimiento poliméricas sobre la superficie de partículas de fármaco huésped por un proceso que comprende una ablación por láser por pulsos.
ES99967110T 1998-11-18 1999-11-18 Procedimiento para preparar particulas de farmaco revestidas y formulaciones farmaceuticas de las mismas. Expired - Lifetime ES2257881T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10884798P 1998-11-18 1998-11-18
US11029198P 1998-11-30 1998-11-30

Publications (1)

Publication Number Publication Date
ES2257881T3 true ES2257881T3 (es) 2006-08-01

Family

ID=26806343

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99967110T Expired - Lifetime ES2257881T3 (es) 1998-11-18 1999-11-18 Procedimiento para preparar particulas de farmaco revestidas y formulaciones farmaceuticas de las mismas.

Country Status (19)

Country Link
EP (1) EP1131054B1 (es)
JP (1) JP2003516926A (es)
KR (1) KR20010082309A (es)
CN (1) CN1200693C (es)
AT (1) ATE317687T1 (es)
AU (1) AU757121B2 (es)
BR (1) BR9915462A (es)
CA (1) CA2350894C (es)
CZ (1) CZ300323B6 (es)
DE (1) DE69929904T2 (es)
ES (1) ES2257881T3 (es)
HK (1) HK1043548B (es)
HU (1) HUP0104687A3 (es)
IL (2) IL143234A0 (es)
NO (1) NO20012395L (es)
NZ (1) NZ511689A (es)
PL (1) PL349953A1 (es)
TR (1) TR200101401T2 (es)
WO (1) WO2000028969A2 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984404B1 (en) 1998-11-18 2006-01-10 University Of Florida Research Foundation, Inc. Methods for preparing coated drug particles and pharmaceutical formulations thereof
US6406745B1 (en) 1999-06-07 2002-06-18 Nanosphere, Inc. Methods for coating particles and particles produced thereby
IL146808A0 (en) * 1999-06-07 2002-07-25 Nanosphere Inc Methods for coating particles and particles produced thereby
AU2005201757B2 (en) * 1999-06-07 2007-04-26 Nanotherapeutics, Inc. Methods for coating particles and particles produced thereby
WO2001090260A2 (en) * 2000-05-19 2001-11-29 Ppg Industries Ohio, Inc. Coating compositions comprised of a geometrically ordered array of unfused polymeric particles, composition exhibiting bragg diffraction, and a method for inhibiting sound transmission
EP2283818B1 (en) 2000-11-30 2017-08-02 Vectura Limited Method of making particles for use in a pharmaceutical composition
ES2334642T5 (es) 2000-11-30 2016-03-07 Vectura Limited Partículas para usar en una composición farmacéutica
DK1343480T4 (en) * 2000-12-21 2016-04-18 Alrise Biosystems Gmbh Induced phase transition method for the preparation of microparticles containing hydrophobic active agents.
JP2003342196A (ja) * 2002-05-31 2003-12-03 Mukku:Kk 静脈注射用組成物、その製造法およびその製剤
EP1547615B1 (en) 2002-08-27 2016-04-13 Hiroshi Terada Remedy
DK1479379T3 (da) 2003-05-19 2008-01-02 Euro Celtique Sa Törre, liposomale PVP-iod-sammensætninger
JPWO2004110405A1 (ja) * 2003-06-11 2006-08-17 株式会社奈良機械製作所 薬物ナノ粒子、その粒子を使用した薬剤の製造方法および薬剤の製造装置
JP2006218346A (ja) * 2005-02-08 2006-08-24 Honda Motor Co Ltd 水素吸着材及びその製造方法
AR065865A1 (es) * 2007-03-30 2009-07-08 Hirofumi Takeuchi Liposoma para la administracion pulmonar para controlar el suministro de la droga
US20090004231A1 (en) 2007-06-30 2009-01-01 Popp Shane M Pharmaceutical dosage forms fabricated with nanomaterials for quality monitoring
AU2008314500A1 (en) * 2007-10-15 2009-04-23 Cooperative Research Centre For Asthma A method of prophylaxis and agents for use therein
WO2009118034A1 (de) * 2008-03-27 2009-10-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur herstellung eines mehrkomponentigen, polymer- und metallhaltigen schichtsystems, vorrichtung und beschichteter gegenstand
US20110104282A1 (en) * 2008-04-25 2011-05-05 Karolinska Institutet Innovations Ab New Therapy of Treatment of the Irritable Bowel Syndrome
GB0814302D0 (en) 2008-08-05 2008-10-01 Coretherapix Slu Compounds and methods
US8409619B2 (en) 2008-10-15 2013-04-02 Lifecare Innovations Pvt. Ltd. Oral drug delivery system for azole, moxifloxacin and rifampicin
US20110223675A1 (en) * 2008-11-20 2011-09-15 Terumo Kabushiki Kaisha Drug release means from liposomes and method for evaluating releasability
SE535381C2 (sv) 2010-02-24 2012-07-17 Plasmadvance Ab Plasmasputtringsprocess för att producera partiklar
JP6103258B2 (ja) * 2011-10-14 2017-03-29 ディーエスエム アイピー アセッツ ビー．ブイ． 新規コーティングシステム
JP6334214B2 (ja) * 2013-03-08 2018-05-30 学校法人慶應義塾 レーザーを用いた薬剤放出方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200669A (en) * 1978-11-22 1980-04-29 The United States Of America As Represented By The Secretary Of The Navy Laser spraying
US4623588A (en) * 1984-02-06 1986-11-18 Biotek, Inc. Controlled release composite core coated microparticles
DE3541999A1 (de) * 1985-11-28 1987-06-04 Bbc Brown Boveri & Cie Verfahren und vorrichtung zur beschichtung von flaechen
WO1990002546A1 (en) * 1988-09-09 1990-03-22 The Ronald T. Dodge Company Pharmaceuticals microencapsulated by vapor deposited polymers and method
DE4239244A1 (de) * 1992-11-21 1994-05-26 Basf Ag Retard-Form für pharmazeutische Wirkstoffe
US6025036A (en) * 1997-05-28 2000-02-15 The United States Of America As Represented By The Secretary Of The Navy Method of producing a film coating by matrix assisted pulsed laser deposition
WO1999047726A1 (en) * 1998-03-19 1999-09-23 The University Of Florida Process for depositing atomic to nanometer particle coatings on host particles

Also Published As

Publication number Publication date
HK1043548A1 (en) 2002-09-20
NO20012395L (no) 2001-07-16
IL143234A0 (en) 2002-04-21
BR9915462A (pt) 2001-12-11
HUP0104687A3 (en) 2006-07-28
AU757121B2 (en) 2003-02-06
ATE317687T1 (de) 2006-03-15
AU2345700A (en) 2000-06-05
CN1348361A (zh) 2002-05-08
PL349953A1 (en) 2002-10-21
TR200101401T2 (tr) 2001-11-21
DE69929904D1 (de) 2006-04-20
HK1043548B (zh) 2006-01-06
WO2000028969A3 (en) 2000-11-09
NZ511689A (en) 2003-03-28
CZ20011747A3 (cs) 2001-10-17
IL143234A (en) 2007-05-15
KR20010082309A (ko) 2001-08-29
JP2003516926A (ja) 2003-05-20
CZ300323B6 (cs) 2009-04-22
EP1131054A2 (en) 2001-09-12
DE69929904T2 (de) 2006-08-31
CA2350894C (en) 2009-01-27
NO20012395D0 (no) 2001-05-15
CN1200693C (zh) 2005-05-11
HUP0104687A2 (en) 2002-06-29
CA2350894A1 (en) 2000-05-25
WO2000028969A2 (en) 2000-05-25
EP1131054B1 (en) 2006-02-15

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