TR200101401T2 - Kaplanmış ilaç parçacıkları hazırlamak, bunların ispençiyari formulasyonu için metod - Google Patents

Kaplanmış ilaç parçacıkları hazırlamak, bunların ispençiyari formulasyonu için metod

Info

Publication number
TR200101401T2
TR200101401T2 TR2001/01401T TR200101401T TR200101401T2 TR 200101401 T2 TR200101401 T2 TR 200101401T2 TR 2001/01401 T TR2001/01401 T TR 2001/01401T TR 200101401 T TR200101401 T TR 200101401T TR 200101401 T2 TR200101401 T2 TR 200101401T2
Authority
TR
Turkey
Prior art keywords
coated drug
drug particles
particles
preparation
pharmaceutical formulations
Prior art date
Application number
TR2001/01401T
Other languages
English (en)
Inventor
D. Talton James
Hochhaus Guenther
K. Singh Rajiv
M. Fitz-Gerald James
Original Assignee
University Of Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Florida filed Critical University Of Florida
Publication of TR200101401T2 publication Critical patent/TR200101401T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/22—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
    • C23C14/223—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating specially adapted for coating particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/22—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
    • C23C14/24—Vacuum evaporation
    • C23C14/28—Vacuum evaporation by wave energy or particle radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]

Abstract

Üniform bir ebada ve kalinliga sahip olan kaplanmis ilaç partiküllerinin hazirlanmasi için palsli lazerle ablasyon kullanilan metodlar tarif edilmektedir.Kaplanmis ilaç partiküllerinin ebadi çap olarak birkaç nanometre ila birkaç milimetre mertebesindedir ve bunlar ortalama çaplari yaklasik 1 ila 50 nm olan organik polimer partikülleri ile kaplanir.Gösterme gayesi ile verilen tecessümlerde,kaplanmis ilaç partikülleri ya da ,ilaç uygulama partikülleri tarif edilmekte , ve bunlar kontrollu bir uygulama ve artan bir biyoelverislilik için üstün farmasötik özellikler sergileyen , ve kontrollu bir kalinliga ve kontrollu bir kaplama üniformitesine sahip olan, biyodegrasyona ugrayan ya d biyo-uyumlu olan bir polimer kaplama içermektedir.
TR2001/01401T 1998-11-18 1999-11-18 Kaplanmış ilaç parçacıkları hazırlamak, bunların ispençiyari formulasyonu için metod TR200101401T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10884798P 1998-11-18 1998-11-18
US11029198P 1998-11-30 1998-11-30

Publications (1)

Publication Number Publication Date
TR200101401T2 true TR200101401T2 (tr) 2001-11-21

Family

ID=26806343

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01401T TR200101401T2 (tr) 1998-11-18 1999-11-18 Kaplanmış ilaç parçacıkları hazırlamak, bunların ispençiyari formulasyonu için metod

Country Status (19)

Country Link
EP (1) EP1131054B1 (tr)
JP (1) JP2003516926A (tr)
KR (1) KR20010082309A (tr)
CN (1) CN1200693C (tr)
AT (1) ATE317687T1 (tr)
AU (1) AU757121B2 (tr)
BR (1) BR9915462A (tr)
CA (1) CA2350894C (tr)
CZ (1) CZ300323B6 (tr)
DE (1) DE69929904T2 (tr)
ES (1) ES2257881T3 (tr)
HK (1) HK1043548B (tr)
HU (1) HUP0104687A3 (tr)
IL (2) IL143234A0 (tr)
NO (1) NO20012395L (tr)
NZ (1) NZ511689A (tr)
PL (1) PL349953A1 (tr)
TR (1) TR200101401T2 (tr)
WO (1) WO2000028969A2 (tr)

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US6984404B1 (en) 1998-11-18 2006-01-10 University Of Florida Research Foundation, Inc. Methods for preparing coated drug particles and pharmaceutical formulations thereof
US6406745B1 (en) 1999-06-07 2002-06-18 Nanosphere, Inc. Methods for coating particles and particles produced thereby
EP1183018A1 (en) * 1999-06-07 2002-03-06 Nanosphere, Inc. Methods for coating particles and particles produced thereby
AU2005201757B2 (en) * 1999-06-07 2007-04-26 Nanotherapeutics, Inc. Methods for coating particles and particles produced thereby
US7217746B2 (en) 2000-05-19 2007-05-15 Ppg Industries Ohio, Inc. Coating compositions having a geometrically ordered array of polymeric particles and substrates coated therewith
ES2708961T3 (es) 2000-11-30 2019-04-12 Vectura Ltd Composiciones farmacéuticas para inhalación
DE60140268D1 (de) 2000-11-30 2009-12-03 Vectura Ltd Partikel zur verwendung in einer pharmazeutischen zusammensetzung
ATE361057T1 (de) * 2000-12-21 2007-05-15 Alrise Biosystems Gmbh Verfahren umfassend einen induzierten phasenübergang zur herstellung von hydrophobe wirkstoffe enthaltenden mikropartikeln
JP2003342196A (ja) * 2002-05-31 2003-12-03 Mukku:Kk 静脈注射用組成物、その製造法およびその製剤
UA84276C2 (uk) * 2002-08-27 2008-10-10 Хіроші Терада Лікарський засіб проти туберкульозу
EP1479379B1 (en) 2003-05-19 2007-08-29 Euro-Celtique S.A. Dry liposomal PVP-iodine compositions
EP1632225A4 (en) * 2003-06-11 2007-08-15 Nara Machinery Co Ltd DRUG NANOPARTICLE, PROCESS AND APPARATUS FOR PREPARING PHARMACEUTICAL PREPARATION THEREFROM
JP2006218346A (ja) * 2005-02-08 2006-08-24 Honda Motor Co Ltd 水素吸着材及びその製造方法
MX2009010479A (es) * 2007-03-30 2009-10-19 Otsuka Pharma Co Ltd Liposoma transpulmonar para controlar la llegada del farmaco.
US20090004231A1 (en) 2007-06-30 2009-01-01 Popp Shane M Pharmaceutical dosage forms fabricated with nanomaterials for quality monitoring
US20110014292A1 (en) * 2007-10-15 2011-01-20 Cooperative Research Centre For Asthma method of prophylaxis and agents for use therein
US20110111131A1 (en) * 2008-03-27 2011-05-12 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Method for producing a multicomponent, polymer- and metal-containing layer system, device and coated article
WO2009131537A1 (en) * 2008-04-25 2009-10-29 Karolinska Institutet Innovations Ab New therapy of treatment of the irritable bowel syndrome.
GB0814302D0 (en) 2008-08-05 2008-10-01 Coretherapix Slu Compounds and methods
CN101888836A (zh) * 2008-10-15 2010-11-17 莱富凯尔创新私人有限公司 用于益康唑、莫西沙星和利福平的基于聚dl-丙交酯-共-乙交酯(plg)纳米粒子的口服药物递送系统
US20110223675A1 (en) * 2008-11-20 2011-09-15 Terumo Kabushiki Kaisha Drug release means from liposomes and method for evaluating releasability
SE535381C2 (sv) 2010-02-24 2012-07-17 Plasmadvance Ab Plasmasputtringsprocess för att producera partiklar
WO2013053793A1 (en) * 2011-10-14 2013-04-18 Dsm Ip Assets B.V. Novel coating system
JP6334214B2 (ja) * 2013-03-08 2018-05-30 学校法人慶應義塾 レーザーを用いた薬剤放出方法
CA3166756A1 (en) * 2020-02-19 2021-08-26 Nano Pharmasolutions, Inc. Therapeutic agent nanoparticles and methods of preparation

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US4200669A (en) * 1978-11-22 1980-04-29 The United States Of America As Represented By The Secretary Of The Navy Laser spraying
US4623588A (en) * 1984-02-06 1986-11-18 Biotek, Inc. Controlled release composite core coated microparticles
DE3541999A1 (de) * 1985-11-28 1987-06-04 Bbc Brown Boveri & Cie Verfahren und vorrichtung zur beschichtung von flaechen
WO1990002546A1 (en) * 1988-09-09 1990-03-22 The Ronald T. Dodge Company Pharmaceuticals microencapsulated by vapor deposited polymers and method
DE4239244A1 (de) * 1992-11-21 1994-05-26 Basf Ag Retard-Form für pharmazeutische Wirkstoffe
US6025036A (en) * 1997-05-28 2000-02-15 The United States Of America As Represented By The Secretary Of The Navy Method of producing a film coating by matrix assisted pulsed laser deposition
WO1999047726A1 (en) * 1998-03-19 1999-09-23 The University Of Florida Process for depositing atomic to nanometer particle coatings on host particles

Also Published As

Publication number Publication date
CA2350894C (en) 2009-01-27
EP1131054B1 (en) 2006-02-15
JP2003516926A (ja) 2003-05-20
AU2345700A (en) 2000-06-05
NZ511689A (en) 2003-03-28
CN1200693C (zh) 2005-05-11
KR20010082309A (ko) 2001-08-29
PL349953A1 (en) 2002-10-21
HK1043548B (zh) 2006-01-06
CZ300323B6 (cs) 2009-04-22
IL143234A (en) 2007-05-15
HUP0104687A3 (en) 2006-07-28
IL143234A0 (en) 2002-04-21
NO20012395L (no) 2001-07-16
WO2000028969A3 (en) 2000-11-09
DE69929904T2 (de) 2006-08-31
HUP0104687A2 (en) 2002-06-29
CN1348361A (zh) 2002-05-08
AU757121B2 (en) 2003-02-06
BR9915462A (pt) 2001-12-11
HK1043548A1 (en) 2002-09-20
ATE317687T1 (de) 2006-03-15
ES2257881T3 (es) 2006-08-01
NO20012395D0 (no) 2001-05-15
CZ20011747A3 (cs) 2001-10-17
CA2350894A1 (en) 2000-05-25
WO2000028969A2 (en) 2000-05-25
DE69929904D1 (de) 2006-04-20
EP1131054A2 (en) 2001-09-12

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