BR9915462A - Processos para preparação de partìculas dedroga revestidas e as suas formulaçõesfarmacêuticas - Google Patents

Processos para preparação de partìculas dedroga revestidas e as suas formulaçõesfarmacêuticas

Info

Publication number
BR9915462A
BR9915462A BR9915462-5A BR9915462A BR9915462A BR 9915462 A BR9915462 A BR 9915462A BR 9915462 A BR9915462 A BR 9915462A BR 9915462 A BR9915462 A BR 9915462A
Authority
BR
Brazil
Prior art keywords
coated
particles
drug
processes
preparation
Prior art date
Application number
BR9915462-5A
Other languages
English (en)
Inventor
James D Talton
Guenther Hochhaus
Rajiv K Singh
James M Fitz-Gerald
Original Assignee
Univ Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida filed Critical Univ Florida
Publication of BR9915462A publication Critical patent/BR9915462A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/22—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
    • C23C14/223—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating specially adapted for coating particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/22—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
    • C23C14/24—Vacuum evaporation
    • C23C14/28—Vacuum evaporation by wave energy or particle radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Metallurgy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: "PROCESSOS PARA A PREPARAçãO DEPARTìCULAS DE DROGA REVESTIDAS E SUASFORMULAçõES FARMACêUTICAS". São descritos métodosusando ablação a laser pulsante para preparar partículas de drogarevestidas de tamanho e espessura uniformes. As partículas dedroga revestidas variaram em tamanho de vários nanómetros avários milímetros no tamanho do diâmetro, e foram revestidas compartículas poliméricas orgânicas tendo tamanhos de diâmetromédios de cerca de 1 a 50 nm. Nas concretizações ilustrativas, aspartículas de droga revestidas ou as partículas de liberação dedroga são descritas, que compreendem um revestimento poliméricobiodegradável ou biocompatível tendo espessura controlada ouuma uniformidade de revestimento controlada, que oferecempropriedades farmacêuticas superiores para uma liberaçãocontrolada e uma maior biodisponibilidade.
BR9915462-5A 1998-11-18 1999-11-18 Processos para preparação de partìculas dedroga revestidas e as suas formulaçõesfarmacêuticas BR9915462A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10884798P 1998-11-18 1998-11-18
US11029198P 1998-11-30 1998-11-30
PCT/US1999/027401 WO2000028969A2 (en) 1998-11-18 1999-11-18 Methods for preparing coated drug particles and pharmaceutical formulations thereof

Publications (1)

Publication Number Publication Date
BR9915462A true BR9915462A (pt) 2001-12-11

Family

ID=26806343

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915462-5A BR9915462A (pt) 1998-11-18 1999-11-18 Processos para preparação de partìculas dedroga revestidas e as suas formulaçõesfarmacêuticas

Country Status (19)

Country Link
EP (1) EP1131054B1 (pt)
JP (1) JP2003516926A (pt)
KR (1) KR20010082309A (pt)
CN (1) CN1200693C (pt)
AT (1) ATE317687T1 (pt)
AU (1) AU757121B2 (pt)
BR (1) BR9915462A (pt)
CA (1) CA2350894C (pt)
CZ (1) CZ300323B6 (pt)
DE (1) DE69929904T2 (pt)
ES (1) ES2257881T3 (pt)
HK (1) HK1043548B (pt)
HU (1) HUP0104687A3 (pt)
IL (2) IL143234A0 (pt)
NO (1) NO20012395L (pt)
NZ (1) NZ511689A (pt)
PL (1) PL349953A1 (pt)
TR (1) TR200101401T2 (pt)
WO (1) WO2000028969A2 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984404B1 (en) 1998-11-18 2006-01-10 University Of Florida Research Foundation, Inc. Methods for preparing coated drug particles and pharmaceutical formulations thereof
HUP0201645A2 (hu) * 1999-06-07 2002-12-28 Nanosphere, Inc. Eljárás szemcsék bevonására és az eljárással gyártott szemcsék
AU2005201757B2 (en) * 1999-06-07 2007-04-26 Nanotherapeutics, Inc. Methods for coating particles and particles produced thereby
US6406745B1 (en) 1999-06-07 2002-06-18 Nanosphere, Inc. Methods for coating particles and particles produced thereby
WO2001090260A2 (en) * 2000-05-19 2001-11-29 Ppg Industries Ohio, Inc. Coating compositions comprised of a geometrically ordered array of unfused polymeric particles, composition exhibiting bragg diffraction, and a method for inhibiting sound transmission
EP1920763B2 (en) 2000-11-30 2022-06-15 Vectura Limited Pharmaceutical compositions for inhalation
EP2168571B1 (en) 2000-11-30 2018-08-22 Vectura Limited Particles for use in a Pharmaceutical Composition
EP1343480B2 (en) * 2000-12-21 2016-02-17 Alrise Biosystems GmbH Induced phase transition method for the production of microparticles containing hydrophobic active agents
JP2003342196A (ja) * 2002-05-31 2003-12-03 Mukku:Kk 静脈注射用組成物、その製造法およびその製剤
CN101862456B (zh) * 2002-08-27 2012-11-28 寺田弘 治疗药
ATE371436T1 (de) 2003-05-19 2007-09-15 Euro Celtique Sa Trockene liposomale pvp-jod zubereitungen
US20060251584A1 (en) * 2003-06-11 2006-11-09 Nara Machinery Co., Ltd. Drug nano-particle, method and apparatus for preparing pharmaceutical preparation using the particle
JP2006218346A (ja) * 2005-02-08 2006-08-24 Honda Motor Co Ltd 水素吸着材及びその製造方法
EP2133097B1 (en) * 2007-03-30 2017-01-25 Hirofumi Takeuchi Transpulmonary liposome for controlling drug arrival
US20090004231A1 (en) 2007-06-30 2009-01-01 Popp Shane M Pharmaceutical dosage forms fabricated with nanomaterials for quality monitoring
EP2211841A4 (en) * 2007-10-15 2013-03-13 Cooperative Res Ct For Asthma PROPHYLAXIS METHOD AND AGENTS FOR USE IN THIS METHOD
EP2279283A1 (de) * 2008-03-27 2011-02-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur herstellung eines mehrkomponentigen, polymer- und metallhaltigen schichtsystems, vorrichtung und beschichteter gegenstand
US20110104282A1 (en) * 2008-04-25 2011-05-05 Karolinska Institutet Innovations Ab New Therapy of Treatment of the Irritable Bowel Syndrome
GB0814302D0 (en) 2008-08-05 2008-10-01 Coretherapix Slu Compounds and methods
WO2010044089A1 (en) * 2008-10-15 2010-04-22 Lifecare, Innovations Pvt. Ltd Drug delivery system for econazole, moxifloxacin, and rifampicin
JPWO2010058840A1 (ja) * 2008-11-20 2012-04-19 テルモ株式会社 リポソームからの薬物放出手段および放出性評価法
SE535381C2 (sv) * 2010-02-24 2012-07-17 Plasmadvance Ab Plasmasputtringsprocess för att producera partiklar
MX351421B (es) * 2011-10-14 2017-10-13 Dsm Ip Assets Bv Nuevo sistema de recubrimiento.
JP6334214B2 (ja) * 2013-03-08 2018-05-30 学校法人慶應義塾 レーザーを用いた薬剤放出方法
US20210290543A1 (en) * 2020-02-19 2021-09-23 Nano Pharmasolutions, Inc. Therapeutic agent nanoparticles and methods of preparation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200669A (en) * 1978-11-22 1980-04-29 The United States Of America As Represented By The Secretary Of The Navy Laser spraying
US4623588A (en) * 1984-02-06 1986-11-18 Biotek, Inc. Controlled release composite core coated microparticles
DE3541999A1 (de) * 1985-11-28 1987-06-04 Bbc Brown Boveri & Cie Verfahren und vorrichtung zur beschichtung von flaechen
WO1990002546A1 (en) * 1988-09-09 1990-03-22 The Ronald T. Dodge Company Pharmaceuticals microencapsulated by vapor deposited polymers and method
DE4239244A1 (de) * 1992-11-21 1994-05-26 Basf Ag Retard-Form für pharmazeutische Wirkstoffe
US6025036A (en) * 1997-05-28 2000-02-15 The United States Of America As Represented By The Secretary Of The Navy Method of producing a film coating by matrix assisted pulsed laser deposition
WO1999047726A1 (en) * 1998-03-19 1999-09-23 The University Of Florida Process for depositing atomic to nanometer particle coatings on host particles

Also Published As

Publication number Publication date
CZ300323B6 (cs) 2009-04-22
HUP0104687A2 (en) 2002-06-29
CZ20011747A3 (cs) 2001-10-17
NZ511689A (en) 2003-03-28
ATE317687T1 (de) 2006-03-15
AU757121B2 (en) 2003-02-06
PL349953A1 (en) 2002-10-21
ES2257881T3 (es) 2006-08-01
HK1043548B (zh) 2006-01-06
WO2000028969A2 (en) 2000-05-25
WO2000028969A3 (en) 2000-11-09
AU2345700A (en) 2000-06-05
IL143234A0 (en) 2002-04-21
DE69929904D1 (de) 2006-04-20
HK1043548A1 (en) 2002-09-20
KR20010082309A (ko) 2001-08-29
EP1131054A2 (en) 2001-09-12
DE69929904T2 (de) 2006-08-31
CN1348361A (zh) 2002-05-08
JP2003516926A (ja) 2003-05-20
CA2350894A1 (en) 2000-05-25
EP1131054B1 (en) 2006-02-15
IL143234A (en) 2007-05-15
CA2350894C (en) 2009-01-27
NO20012395L (no) 2001-07-16
HUP0104687A3 (en) 2006-07-28
NO20012395D0 (no) 2001-05-15
CN1200693C (zh) 2005-05-11
TR200101401T2 (tr) 2001-11-21

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements