ES2253754T3 - Celulas encapsuladas que producen particulas viricas. - Google Patents
Celulas encapsuladas que producen particulas viricas.Info
- Publication number
- ES2253754T3 ES2253754T3 ES96923905T ES96923905T ES2253754T3 ES 2253754 T3 ES2253754 T3 ES 2253754T3 ES 96923905 T ES96923905 T ES 96923905T ES 96923905 T ES96923905 T ES 96923905T ES 2253754 T3 ES2253754 T3 ES 2253754T3
- Authority
- ES
- Spain
- Prior art keywords
- cells
- capsule
- sulfate
- genes
- capsule according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 1
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- 229910052697 platinum Inorganic materials 0.000 description 1
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- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- FHHPUSMSKHSNKW-SMOYURAASA-M sodium deoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 FHHPUSMSKHSNKW-SMOYURAASA-M 0.000 description 1
- JJICLMJFIKGAAU-UHFFFAOYSA-M sodium;2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)purin-6-olate Chemical compound [Na+].NC1=NC([O-])=C2N=CN(COC(CO)CO)C2=N1 JJICLMJFIKGAAU-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK74095 | 1995-06-27 | ||
| DK740/95 | 1995-06-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2253754T3 true ES2253754T3 (es) | 2006-06-01 |
Family
ID=8097001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96923905T Expired - Lifetime ES2253754T3 (es) | 1995-06-27 | 1996-06-24 | Celulas encapsuladas que producen particulas viricas. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6776985B1 (ja) |
| EP (1) | EP0835137B1 (ja) |
| JP (2) | JP4119952B2 (ja) |
| KR (1) | KR100484883B1 (ja) |
| CN (1) | CN1187095C (ja) |
| AT (1) | ATE309000T1 (ja) |
| AU (1) | AU708273B2 (ja) |
| CA (1) | CA2222559A1 (ja) |
| CZ (1) | CZ286979B6 (ja) |
| DE (1) | DE69633180D1 (ja) |
| DK (1) | DK0835137T3 (ja) |
| ES (1) | ES2253754T3 (ja) |
| HK (1) | HK1010139A1 (ja) |
| IL (1) | IL122119A (ja) |
| NO (1) | NO321427B1 (ja) |
| NZ (1) | NZ312671A (ja) |
| PL (1) | PL185338B1 (ja) |
| PT (1) | PT835137E (ja) |
| RU (1) | RU2187301C2 (ja) |
| SI (1) | SI0835137T1 (ja) |
| UA (1) | UA65525C2 (ja) |
| WO (1) | WO1997001357A1 (ja) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0817858B1 (en) | 1995-03-09 | 2003-04-23 | Austrian Nordic Biotherapeutics AG | Vectors carrying therapeutic genes encoding antimicrobial peptides for gene therapy |
| CN1187095C (zh) | 1995-06-27 | 2005-02-02 | 巴法里安诺迪克有限公司 | 可生产病毒颗粒的被囊化细胞 |
| US6540995B1 (en) | 1996-03-27 | 2003-04-01 | Bavarian Nordic Research Institute Gmbh | Encapsulated cells producing cytochrome P450 |
| SI0892852T1 (sl) | 1996-03-27 | 2006-04-30 | Bavarian Nordic As | Inkapsulirane celice, ki eksprimirajo citokrom P450 za aktiviranje predzdravila |
| CN1266362A (zh) | 1998-05-05 | 2000-09-13 | 皇家菲利浦电子有限公司 | 包括具有刷毛区和齿间刷毛区的毛刷件的牙刷 |
| NZ550542A (en) | 2004-03-30 | 2009-03-31 | Nsgene As | Therapeutic use of a growth factor, NsG33 |
| JP2008540347A (ja) * | 2005-05-03 | 2008-11-20 | フェテリネールメディツィニシュ ウニベルジテート ウィーン | 浸透性カプセル |
| CN101903049B (zh) | 2007-12-20 | 2014-08-13 | 伊西康公司 | 包囊的肾组织 |
| KR101250925B1 (ko) * | 2011-10-28 | 2013-04-04 | 한화케미칼 주식회사 | 캡슐 세포용 구조체 |
| GB201408233D0 (en) | 2014-05-09 | 2014-06-25 | Austrianova Singapore Pte Ltd | Use of polyanionic composition |
| CA3006288A1 (en) * | 2015-11-24 | 2017-06-01 | Glaxosmithkline Intellectual Property Development Limited | Stable cell lines for retroviral production |
| RU2749717C2 (ru) * | 2015-11-24 | 2021-06-16 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Способ временной трансфекции для продуцирования ретровируса |
| CA3023473A1 (en) * | 2016-05-25 | 2017-11-30 | Lonza Houston Inc. | Methods for isolating adeno-associated virus using a polydiallyldialkylammonium salt |
| RU2688383C2 (ru) * | 2017-07-10 | 2019-05-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский национальный исследовательский государственный университет имени Н.Г. Чернышевского" | Способ синтеза белка в культуре бактериальных клеток |
| CN110615667B (zh) * | 2018-06-19 | 2022-02-15 | 华北理工大学 | 基于铁尾矿和碱渣的核壳结构陶粒及其制备方法 |
| CA3220736A1 (en) * | 2021-05-21 | 2022-11-24 | Bionaut Labs Ltd. | Systems and methods for microbot-mediated therapeutic delivery |
| CN115820683B (zh) * | 2022-09-28 | 2024-04-05 | 西南大学 | 家蚕Cyp9a20基因及其应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4391909A (en) * | 1979-03-28 | 1983-07-05 | Damon Corporation | Microcapsules containing viable tissue cells |
| DD160393A3 (de) * | 1980-11-14 | 1983-07-27 | Horst Dautzenberg | Mikrokapseln und verfahren zu ihrer herstellung |
| US4686098A (en) * | 1984-05-14 | 1987-08-11 | Merck & Co., Inc. | Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo |
| US4680174A (en) * | 1984-05-24 | 1987-07-14 | Damon Biotech, Inc. | Induction of immune response by immunization with encapsulated antigen-producing cells |
| EP0199362A3 (en) * | 1985-04-26 | 1987-10-07 | Massachusetts Institute Of Technology | System and apparatus for delayed and pulsed release of biologically active substances |
| CA1310924C (en) * | 1986-04-24 | 1992-12-01 | Francis P. Mccormick | Infective drug delivery system |
| ATE142268T1 (de) | 1988-05-17 | 1996-09-15 | Sloan Kettering Inst Cancer | Retroviraler vektor |
| US5328470A (en) * | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| DE4021050A1 (de) * | 1990-06-29 | 1992-01-02 | Akad Wissenschaften Ddr | Verfahren zur herstellung von mikrokapseln |
| CA2051288C (en) * | 1990-09-14 | 2002-02-05 | Robert L. Martuza | Viral targeted destruction of neoplastic cells |
| JPH06500927A (ja) * | 1990-12-13 | 1994-01-27 | アメリカ合衆国 | 高力価の組換えウイルスベクターおよび遺伝子療法に用いられる形質導入標的細胞の持続的及び連続的生産 |
| WO1994029437A1 (en) | 1993-06-07 | 1994-12-22 | University Of Medicine & Dentistry Of New Jersey | Highly-efficient, self-inactivating, recombination-free, u3-free retroviral vectors |
| US5688773A (en) | 1994-08-17 | 1997-11-18 | The General Hospital Corporation | Method of selectively destroying neoplastic cells |
| AU688590B2 (en) | 1994-09-02 | 1998-03-12 | Gsf - Forschungszentrum Fur Umwelt Und Gesundheit Gmbh | Non self-inactivating, expression targeted retroviral vectors |
| CN1187095C (zh) | 1995-06-27 | 2005-02-02 | 巴法里安诺迪克有限公司 | 可生产病毒颗粒的被囊化细胞 |
| EP0848757B1 (en) | 1995-09-06 | 2002-03-06 | Austrian Nordic Biotherapeutics AG | The use of the wap of mmtv regulatory sequences for targeted expression of linked heterologous genes in human mammary cells, including human mammary carcinoma cells |
| SI0892852T1 (sl) | 1996-03-27 | 2006-04-30 | Bavarian Nordic As | Inkapsulirane celice, ki eksprimirajo citokrom P450 za aktiviranje predzdravila |
-
1996
- 1996-06-24 CN CNB961950501A patent/CN1187095C/zh not_active Expired - Fee Related
- 1996-06-24 AT AT96923905T patent/ATE309000T1/de not_active IP Right Cessation
- 1996-06-24 CA CA002222559A patent/CA2222559A1/en not_active Abandoned
- 1996-06-24 JP JP50416597A patent/JP4119952B2/ja not_active Expired - Lifetime
- 1996-06-24 PL PL96324289A patent/PL185338B1/pl not_active IP Right Cessation
- 1996-06-24 RU RU98101362/13A patent/RU2187301C2/ru not_active IP Right Cessation
- 1996-06-24 SI SI9630729T patent/SI0835137T1/sl unknown
- 1996-06-24 DE DE69633180T patent/DE69633180D1/de not_active Expired - Lifetime
- 1996-06-24 EP EP96923905A patent/EP0835137B1/en not_active Expired - Lifetime
- 1996-06-24 AU AU64154/96A patent/AU708273B2/en not_active Expired
- 1996-06-24 CZ CZ19974195A patent/CZ286979B6/cs not_active IP Right Cessation
- 1996-06-24 NZ NZ312671A patent/NZ312671A/xx not_active IP Right Cessation
- 1996-06-24 UA UA97126354A patent/UA65525C2/uk unknown
- 1996-06-24 DK DK96923905T patent/DK0835137T3/da active
- 1996-06-24 KR KR1019970709807A patent/KR100484883B1/ko not_active IP Right Cessation
- 1996-06-24 ES ES96923905T patent/ES2253754T3/es not_active Expired - Lifetime
- 1996-06-24 WO PCT/EP1996/002748 patent/WO1997001357A1/en active IP Right Grant
- 1996-06-24 PT PT96923905T patent/PT835137E/pt unknown
- 1996-06-24 IL IL12211996A patent/IL122119A/en not_active IP Right Cessation
-
1997
- 1997-12-10 NO NO19975813A patent/NO321427B1/no not_active IP Right Cessation
- 1997-12-23 US US08/996,460 patent/US6776985B1/en not_active Expired - Lifetime
-
1998
- 1998-09-26 HK HK98110992A patent/HK1010139A1/xx not_active IP Right Cessation
-
2007
- 2007-11-21 JP JP2007301109A patent/JP4848348B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| UA65525C2 (en) | 2004-04-15 |
| NO975813D0 (no) | 1997-12-10 |
| PT835137E (pt) | 2004-12-31 |
| NZ312671A (en) | 1999-10-28 |
| JP4119952B2 (ja) | 2008-07-16 |
| AU708273B2 (en) | 1999-07-29 |
| AU6415496A (en) | 1997-01-30 |
| CZ419597A3 (cs) | 1998-03-18 |
| HK1010139A1 (en) | 1999-06-17 |
| RU2187301C2 (ru) | 2002-08-20 |
| CN1187095C (zh) | 2005-02-02 |
| CN1189104A (zh) | 1998-07-29 |
| JP2008101011A (ja) | 2008-05-01 |
| US6776985B1 (en) | 2004-08-17 |
| IL122119A (en) | 2004-06-01 |
| WO1997001357A1 (en) | 1997-01-16 |
| CZ286979B6 (en) | 2000-08-16 |
| EP0835137A1 (en) | 1998-04-15 |
| DK0835137T3 (da) | 2006-03-06 |
| IL122119A0 (en) | 1998-04-05 |
| JPH11508768A (ja) | 1999-08-03 |
| PL324289A1 (en) | 1998-05-11 |
| JP4848348B2 (ja) | 2011-12-28 |
| KR19990028491A (ko) | 1999-04-15 |
| PL185338B1 (pl) | 2003-04-30 |
| CA2222559A1 (en) | 1997-01-16 |
| DE69633180D1 (de) | 2004-09-23 |
| SI0835137T1 (sl) | 2006-04-30 |
| KR100484883B1 (ko) | 2005-09-02 |
| NO975813L (no) | 1998-02-23 |
| NO321427B1 (no) | 2006-05-08 |
| ATE309000T1 (de) | 2005-11-15 |
| EP0835137B1 (en) | 2005-11-09 |
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