ES2248823T5 - Neutroquina alfa. - Google Patents
Neutroquina alfa. Download PDFInfo
- Publication number
- ES2248823T5 ES2248823T5 ES96939612T ES96939612T ES2248823T5 ES 2248823 T5 ES2248823 T5 ES 2248823T5 ES 96939612 T ES96939612 T ES 96939612T ES 96939612 T ES96939612 T ES 96939612T ES 2248823 T5 ES2248823 T5 ES 2248823T5
- Authority
- ES
- Spain
- Prior art keywords
- neutroquina
- polypeptide
- amino acid
- protein
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Physics & Mathematics (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1996/017957 WO1998018921A1 (en) | 1996-10-25 | 1996-10-25 | NEUTROKINE $g(a) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2248823T3 ES2248823T3 (es) | 2006-03-16 |
| ES2248823T5 true ES2248823T5 (es) | 2011-11-03 |
Family
ID=22256104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96939612T Expired - Lifetime ES2248823T5 (es) | 1996-10-25 | 1996-10-25 | Neutroquina alfa. |
Country Status (14)
| Country | Link |
|---|---|
| EP (3) | EP2230307A1 (https=) |
| JP (1) | JP2001503263A (https=) |
| KR (2) | KR20050004269A (https=) |
| CN (1) | CN1539970A (https=) |
| AT (1) | ATE302272T1 (https=) |
| AU (1) | AU731553B2 (https=) |
| BR (1) | BR9612752A (https=) |
| CA (2) | CA2665133A1 (https=) |
| DE (1) | DE69635088T3 (https=) |
| DK (1) | DK0939804T4 (https=) |
| ES (1) | ES2248823T5 (https=) |
| NZ (1) | NZ334309A (https=) |
| PT (1) | PT939804E (https=) |
| WO (1) | WO1998018921A1 (https=) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7597886B2 (en) | 1994-11-07 | 2009-10-06 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
| US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
| US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
| WO1997033904A1 (en) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US6713061B1 (en) | 1996-03-12 | 2004-03-30 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US7357927B2 (en) | 1996-03-12 | 2008-04-15 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US6635743B1 (en) | 1996-03-22 | 2003-10-21 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II and methods of use |
| US7964190B2 (en) | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
| US8212004B2 (en) | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
| US6689579B1 (en) | 1996-10-25 | 2004-02-10 | Human Genome Sciences, Inc. | Polynucleotides encoding neutrokine-α |
| US6812327B1 (en) | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
| WO1998027114A2 (en) * | 1996-12-17 | 1998-06-25 | Schering Corporation | Mammalian cell surface antigens; related reagents |
| CA2232743A1 (en) * | 1997-04-02 | 1998-10-02 | Smithkline Beecham Corporation | A tnf homologue, tl5 |
| AU7608898A (en) * | 1997-06-06 | 1998-12-21 | Regeneron Pharmaceuticals, Inc. | Ntn-2 member of tnf ligand family |
| JP2002504818A (ja) * | 1997-06-06 | 2002-02-12 | リジェネロン ファーマシューティカルズ,インコーポレイテッド | リガンドファミリーのntn−2メンバー |
| WO1999011791A2 (en) * | 1997-09-05 | 1999-03-11 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
| EP1012270A2 (en) * | 1997-09-12 | 2000-06-28 | Apotech R&D S.A. | Kay - a novel immune system protein |
| CA2310987A1 (en) * | 1997-11-26 | 1999-06-03 | Eli Lilly And Company | Tnf ligand family gene |
| US6297367B1 (en) | 1997-12-30 | 2001-10-02 | Chiron Corporation | Polynucleotide encoding TNFL1 |
| AU2093499A (en) * | 1997-12-30 | 1999-07-19 | Chiron Corporation | Members of tnf and tnfr families |
| WO2001060397A1 (en) | 2000-02-16 | 2001-08-23 | Genentech, Inc. | Uses of agonists and antagonists to modulate activity of tnf-related molecules |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| GB9828628D0 (en) * | 1998-12-23 | 1999-02-17 | Glaxo Group Ltd | Novel ligand |
| US7833529B1 (en) | 1999-01-07 | 2010-11-16 | Zymogenetics, Inc. | Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor |
| SI1642972T1 (sl) * | 1999-01-07 | 2010-05-31 | Zymogenetics Inc | Terapevtske uporabe BR X topnih receptorjev |
| US20030095967A1 (en) | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
| IL144202A0 (en) * | 1999-01-25 | 2002-05-23 | Biogen Inc | Baff, related blocking agents and their use in the stimulation and inhibition of b-cells and immunoglobulins in immune responses |
| US6475986B1 (en) * | 1999-02-02 | 2002-11-05 | Research Development Foundation | Uses of THANK, a TNF homologue that activates apoptosis |
| CN100439499C (zh) * | 1999-02-23 | 2008-12-03 | 人体基因组科学有限公司 | Neutrokine-α和Neutrokine-α剪接变体 |
| CA2363112A1 (en) * | 1999-02-23 | 2000-08-31 | Craig A. Rosen | Neutrokine-alpha and neutrokine-alpha splice variant |
| AU3501700A (en) | 1999-02-26 | 2000-09-14 | Human Genome Sciences, Inc. | Human endokine alpha and methods of use |
| CA2365913C (en) | 1999-04-12 | 2015-03-03 | Genentech, Inc. | Tumor necrosis factor receptor homologs and nucleic acids encoding the same |
| US20030022233A1 (en) | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction |
| AU4986700A (en) | 1999-05-06 | 2000-11-21 | National Jewish Medical And Research Center | Tall-1 nucleic acid molecules, proteins, receptors and methods of use thereof |
| CN101633692A (zh) | 1999-06-28 | 2010-01-27 | 杰南技术公司 | 利用二价金属离子制备Apo-2配体的方法 |
| CN100447244C (zh) | 1999-08-17 | 2008-12-31 | 比奥根艾迪克Ma公司 | Baff受体(bcma),一种免疫调节剂 |
| UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
| CA2897626C (en) | 2000-02-11 | 2020-03-24 | Biogen Ma Inc. | Heterologous polypeptide of the tnf family |
| US6969519B2 (en) | 2000-03-10 | 2005-11-29 | Human Genome Sciences, Inc. | Methods of using an agonistic antibody human tumor necrosis factor receptor (TR17) |
| JP2003531588A (ja) | 2000-04-11 | 2003-10-28 | ジェネンテック・インコーポレーテッド | 多価抗体とその用途 |
| EP2213743A1 (en) | 2000-04-12 | 2010-08-04 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| WO2001087977A2 (en) | 2000-05-12 | 2001-11-22 | Amgen Inc. | Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci |
| EP2431054A3 (en) | 2000-06-15 | 2013-03-06 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
| US7879328B2 (en) | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
| US7220840B2 (en) | 2000-06-16 | 2007-05-22 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator protein |
| PT2281843T (pt) | 2000-06-16 | 2017-01-02 | Human Genome Sciences Inc | Anticorpos que se ligam imunoespecificamente a blys |
| DE60136816D1 (de) | 2000-07-27 | 2009-01-15 | Genentech Inc | Sequentielle verabreichung von cpt-11 und apo-2l polypeptid |
| WO2002018620A2 (en) * | 2000-08-15 | 2002-03-07 | Human Genome Sciences, Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
| AU2001288301A1 (en) | 2000-08-18 | 2002-03-04 | Human Genome Sciences, Inc. | Binding polypeptides and methods based thereon |
| UA83458C2 (uk) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
| WO2002066516A2 (en) | 2001-02-20 | 2002-08-29 | Zymogenetics, Inc. | Antibodies that bind both bcma and taci |
| DK1385882T3 (da) | 2001-05-11 | 2008-02-11 | Amgen Inc | Peptider og relaterede molekyler, der binder til TALL-1 |
| BRPI0209933B8 (pt) | 2001-05-24 | 2021-05-25 | Zymogenetics Inc | proteína de fusão, e, molécula de ácido nucleico |
| US7064189B2 (en) | 2001-05-25 | 2006-06-20 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
| EP1409544B1 (en) | 2001-07-03 | 2009-06-17 | Genentech, Inc. | Human dr4 antibodies and uses thereof |
| AR035119A1 (es) * | 2001-08-16 | 2004-04-14 | Lilly Co Eli | Anticuerpos humanos antagonistas anti-htnfsf13b |
| EP1501866A4 (en) | 2001-10-02 | 2006-02-08 | Genentech Inc | VARIANTS OF THE LIGAND APO-2 AND USES THEREOF |
| AU2002351495A1 (en) * | 2001-10-17 | 2003-04-28 | Human Genome Sciences, Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
| US7741285B2 (en) | 2001-11-13 | 2010-06-22 | Genentech, Inc. | APO-2 ligand/trail formulations |
| EP1450847B1 (en) | 2001-11-13 | 2010-09-29 | Genentech, Inc. | APO2 ligand/ TRAIL formulations and uses thereof |
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| AU2002364586A1 (en) | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| EP2500032A1 (en) | 2002-06-24 | 2012-09-19 | Genentech, Inc. | APO-2 ligand/trail variants and uses thereof |
| AU2003299819A1 (en) * | 2002-12-23 | 2004-07-22 | Human Genome Sciences, Inc. | Neutrokine-alpha conjugate, neutrokine-alpha complex, and uses thereof |
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| JP2007526220A (ja) | 2003-06-05 | 2007-09-13 | ジェネンテック・インコーポレーテッド | B細胞疾患の併用療法 |
| US20050255560A1 (en) * | 2003-11-21 | 2005-11-17 | Zeren Gao | Ztnf11, a tumor necrosis factor |
| US20070249530A1 (en) * | 2004-01-29 | 2007-10-25 | Genentech, Inc. | Bcma Polypeptides and Uses Thereof |
| WO2006002472A1 (en) | 2004-07-02 | 2006-01-12 | Bio-Layer Pty Ltd | Use of metal complexes |
| CN101061238B (zh) | 2004-08-06 | 2013-11-20 | 健泰科生物技术公司 | 使用生物标志的测定法和方法 |
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| JP4907353B2 (ja) | 2004-09-15 | 2012-03-28 | 興和株式会社 | Baff抑制剤又は阻害剤のスクリーニング方法 |
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| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| US7947805B2 (en) | 2004-12-23 | 2011-05-24 | Merck Serono S.A. | BCMA polypeptides and uses thereof |
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| US9168286B2 (en) | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
| WO2007142667A2 (en) | 2005-10-13 | 2007-12-13 | Human Genome Sciences, Inc. | Treatment of patients with autoantibody positive disease |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| ES2618543T3 (es) | 2005-11-23 | 2017-06-21 | Genentech, Inc. | Métodos y composiciones relacionados con ensayos de linfocitos B |
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| BRPI0711823A2 (pt) | 2006-05-15 | 2012-01-17 | Ares Trading Sa | métodos para tratamento de doenças auto-imunes com uma molécula de fusão taci-ig |
| CN102227503B (zh) | 2008-09-26 | 2015-10-21 | 托卡根公司 | 重组载体 |
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| JP5996429B2 (ja) | 2009-09-03 | 2016-09-21 | ジェネンテック, インコーポレイテッド | 関節リウマチの治療、診断及びモニターするための方法 |
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| EP4146684A2 (en) | 2020-05-08 | 2023-03-15 | Alpine Immune Sciences, Inc. | April and baff inhibitory immunomodulatory proteins with and without a t cell inhibitory protein and methods of use thereof |
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| CN113238061B (zh) * | 2021-07-09 | 2021-10-01 | 中南大学湘雅医院 | 以cd180阴性b细胞指示重症肌无力病情的试剂盒及应用 |
| KR20250099778A (ko) | 2022-10-04 | 2025-07-02 | 알파인 이뮨 사이언시즈, 인코포레이티드 | 자가항체-매개 질환의 치료에 사용하기 위한 돌연변이된 taci-fc 융합 단백질 |
| CN119799684B (zh) * | 2024-12-27 | 2026-02-03 | 杭州微新生物科技有限公司 | 一种靶向无害梭菌的抗菌蛋白及其制备方法与应用 |
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-
1996
- 1996-10-25 PT PT96939612T patent/PT939804E/pt unknown
- 1996-10-25 KR KR10-2004-7019418A patent/KR20050004269A/ko not_active Ceased
- 1996-10-25 NZ NZ334309A patent/NZ334309A/en not_active IP Right Cessation
- 1996-10-25 EP EP10156941A patent/EP2230307A1/en not_active Withdrawn
- 1996-10-25 KR KR1019990703614A patent/KR20000052796A/ko not_active Ceased
- 1996-10-25 ES ES96939612T patent/ES2248823T5/es not_active Expired - Lifetime
- 1996-10-25 BR BR9612752-0A patent/BR9612752A/pt not_active Application Discontinuation
- 1996-10-25 CN CNA2004100055320A patent/CN1539970A/zh active Pending
- 1996-10-25 EP EP96939612A patent/EP0939804B2/en not_active Expired - Lifetime
- 1996-10-25 JP JP52041198A patent/JP2001503263A/ja not_active Withdrawn
- 1996-10-25 AT AT96939612T patent/ATE302272T1/de active
- 1996-10-25 EP EP05012261A patent/EP1577391A1/en not_active Withdrawn
- 1996-10-25 AU AU76745/96A patent/AU731553B2/en not_active Expired
- 1996-10-25 DE DE69635088T patent/DE69635088T3/de not_active Expired - Lifetime
- 1996-10-25 CA CA002665133A patent/CA2665133A1/en not_active Abandoned
- 1996-10-25 DK DK96939612.6T patent/DK0939804T4/da active
- 1996-10-25 CA CA002266439A patent/CA2266439C/en not_active Expired - Lifetime
- 1996-10-25 WO PCT/US1996/017957 patent/WO1998018921A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ATE302272T1 (de) | 2005-09-15 |
| AU731553B2 (en) | 2001-04-05 |
| JP2001503263A (ja) | 2001-03-13 |
| DE69635088T3 (de) | 2012-01-26 |
| CN1539970A (zh) | 2004-10-27 |
| DK0939804T3 (da) | 2005-12-19 |
| EP2230307A1 (en) | 2010-09-22 |
| KR20050004269A (ko) | 2005-01-12 |
| BR9612752A (pt) | 2000-01-18 |
| DE69635088D1 (de) | 2005-09-22 |
| EP0939804B1 (en) | 2005-08-17 |
| ES2248823T3 (es) | 2006-03-16 |
| DE69635088T2 (de) | 2006-06-14 |
| EP0939804A1 (en) | 1999-09-08 |
| DK0939804T4 (da) | 2011-07-18 |
| EP1577391A1 (en) | 2005-09-21 |
| EP0939804B2 (en) | 2011-06-15 |
| WO1998018921A1 (en) | 1998-05-07 |
| PT939804E (pt) | 2005-11-30 |
| CA2665133A1 (en) | 1998-05-07 |
| KR20000052796A (ko) | 2000-08-25 |
| CA2266439A1 (en) | 1998-05-07 |
| CA2266439C (en) | 2009-06-16 |
| NZ334309A (en) | 2000-08-25 |
| AU7674596A (en) | 1998-05-22 |
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