ATE302272T1 - Neutrokin alpha - Google Patents
Neutrokin alphaInfo
- Publication number
- ATE302272T1 ATE302272T1 AT96939612T AT96939612T ATE302272T1 AT E302272 T1 ATE302272 T1 AT E302272T1 AT 96939612 T AT96939612 T AT 96939612T AT 96939612 T AT96939612 T AT 96939612T AT E302272 T1 ATE302272 T1 AT E302272T1
- Authority
- AT
- Austria
- Prior art keywords
- neutrokine alpha
- methods
- immune system
- related disorders
- alpha
- Prior art date
Links
- 230000006303 immediate early viral mRNA transcription Effects 0.000 abstract 2
- 210000000987 immune system Anatomy 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Physics & Mathematics (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1996/017957 WO1998018921A1 (en) | 1996-10-25 | 1996-10-25 | NEUTROKINE $g(a) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE302272T1 true ATE302272T1 (de) | 2005-09-15 |
Family
ID=22256104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96939612T ATE302272T1 (de) | 1996-10-25 | 1996-10-25 | Neutrokin alpha |
Country Status (14)
| Country | Link |
|---|---|
| EP (3) | EP0939804B2 (de) |
| JP (1) | JP2001503263A (de) |
| KR (2) | KR20050004269A (de) |
| CN (1) | CN1539970A (de) |
| AT (1) | ATE302272T1 (de) |
| AU (1) | AU731553B2 (de) |
| BR (1) | BR9612752A (de) |
| CA (2) | CA2266439C (de) |
| DE (1) | DE69635088T3 (de) |
| DK (1) | DK0939804T4 (de) |
| ES (1) | ES2248823T5 (de) |
| NZ (1) | NZ334309A (de) |
| PT (1) | PT939804E (de) |
| WO (1) | WO1998018921A1 (de) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7597886B2 (en) | 1994-11-07 | 2009-10-06 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
| US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
| US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
| WO1997033904A1 (en) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US7357927B2 (en) | 1996-03-12 | 2008-04-15 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US6713061B1 (en) | 1996-03-12 | 2004-03-30 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US7964190B2 (en) | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
| US6635743B1 (en) | 1996-03-22 | 2003-10-21 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II and methods of use |
| US6812327B1 (en) | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
| US8212004B2 (en) | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
| US6689579B1 (en) | 1996-10-25 | 2004-02-10 | Human Genome Sciences, Inc. | Polynucleotides encoding neutrokine-α |
| AU5705898A (en) * | 1996-12-17 | 1998-07-15 | Schering Corporation | Mammalian cell surface antigens; related reagents |
| CA2232743A1 (en) * | 1997-04-02 | 1998-10-02 | Smithkline Beecham Corporation | A tnf homologue, tl5 |
| EP0991759A1 (de) * | 1997-06-06 | 2000-04-12 | Regeneron Pharmaceuticals, Inc. | Ntn-2, mitglied von tnf-ligand-familie |
| WO1998055620A1 (en) * | 1997-06-06 | 1998-12-10 | Regeneron Pharmaceuticals, Inc. | Ntn-2 member of tnf ligand family |
| AU9376498A (en) * | 1997-09-05 | 1999-03-22 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
| HUP0004034A3 (en) * | 1997-09-12 | 2002-08-28 | Apotech R & D Sa | Kay - a novel immune system protein |
| CA2310987A1 (en) * | 1997-11-26 | 1999-06-03 | Eli Lilly And Company | Tnf ligand family gene |
| WO1999033980A2 (en) * | 1997-12-30 | 1999-07-08 | Chiron Corporation | Members of tnf and tnfr families |
| US6297367B1 (en) | 1997-12-30 | 2001-10-02 | Chiron Corporation | Polynucleotide encoding TNFL1 |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| GB9828628D0 (en) * | 1998-12-23 | 1999-02-17 | Glaxo Group Ltd | Novel ligand |
| CN1342202A (zh) | 1999-01-07 | 2002-03-27 | 津莫吉尼蒂克斯公司 | 可溶性受体br43×2和应用方法 |
| US7833529B1 (en) | 1999-01-07 | 2010-11-16 | Zymogenetics, Inc. | Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor |
| ES2204528T3 (es) | 1999-01-25 | 2004-05-01 | Biogen, Inc. | Baff, sus inhibidores y su uso en la modulacion de la respuesta de las celulas b. |
| US20030095967A1 (en) | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
| US6475986B1 (en) * | 1999-02-02 | 2002-11-05 | Research Development Foundation | Uses of THANK, a TNF homologue that activates apoptosis |
| CN100439499C (zh) * | 1999-02-23 | 2008-12-03 | 人体基因组科学有限公司 | Neutrokine-α和Neutrokine-α剪接变体 |
| AU777536B2 (en) * | 1999-02-23 | 2004-10-21 | Human Genome Sciences, Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
| JP2002537769A (ja) | 1999-02-26 | 2002-11-12 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | ヒトエンドカインαおよび使用方法 |
| JP4716578B2 (ja) | 1999-04-12 | 2011-07-06 | ジェネンテック, インコーポレイテッド | 腫瘍壊死因子相同体及びそれをコードする核酸 |
| US20030022233A1 (en) | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction |
| US6475987B1 (en) | 1999-05-06 | 2002-11-05 | National Jewish Medical And Research Center | Tall-1 receptor homologues |
| IL147029A0 (en) | 1999-06-28 | 2002-08-14 | Genentech Inc | Method for making apo-2 ligand using divalent metal ions |
| JP4787439B2 (ja) | 1999-08-17 | 2011-10-05 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 免疫調節因子であるbaffレセプター(bcma) |
| UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
| AU3495301A (en) | 2000-02-11 | 2001-08-20 | Biogen Inc | Heterologous polypeptide of the tnf family |
| IL150755A0 (en) | 2000-02-16 | 2003-02-12 | Genentech Inc | Uses of agonists and antagonists to modulate activity of tnf-related molecules |
| US6969519B2 (en) | 2000-03-10 | 2005-11-29 | Human Genome Sciences, Inc. | Methods of using an agonistic antibody human tumor necrosis factor receptor (TR17) |
| MXPA02010011A (es) | 2000-04-11 | 2003-04-25 | Genentech Inc | Anticuerpos multivalentes y usos para los mismos. |
| EP2275557A1 (de) | 2000-04-12 | 2011-01-19 | Human Genome Sciences, Inc. | Albuminfusionsproteine |
| AU2001263114A1 (en) | 2000-05-12 | 2001-11-26 | Amgen Inc | Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci |
| CA2413160A1 (en) | 2000-06-15 | 2001-12-20 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
| US7879328B2 (en) | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
| US7220840B2 (en) | 2000-06-16 | 2007-05-22 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator protein |
| MXPA02012434A (es) | 2000-06-16 | 2004-09-06 | Cambridge Antibody Tech | Anticuerpos que se unen inmunoespecificamente a estimulador de linfocitos ii. |
| WO2002009755A2 (en) | 2000-07-27 | 2002-02-07 | Genentech, Inc. | Apo-2l receptor agonist and cpt-11 synergism |
| AU2001288260A1 (en) * | 2000-08-15 | 2002-03-13 | Human Genome Sciences, Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
| WO2002016411A2 (en) | 2000-08-18 | 2002-02-28 | Human Genome Sciences, Inc. | Binding polypeptides and methods based thereon |
| UA83458C2 (uk) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
| US20030012783A1 (en) | 2001-02-20 | 2003-01-16 | Wayne Kindsvogel | Antibodies that bind both BCMA and TACI |
| EP2845864A3 (de) | 2001-05-11 | 2015-06-10 | Amgen, Inc | Peptide und verwandte Moleküle, die zu Groß - 1 binden |
| ATE446771T1 (de) | 2001-05-24 | 2009-11-15 | Zymogenetics Inc | Taci-immunoglobulin-fusionsproteine |
| ES2437992T3 (es) | 2001-05-25 | 2014-01-15 | Human Genome Sciences, Inc. | Anticuerpos que se unen inmunoespecíficamente a los receptores de TRAIL |
| CA2451680C (en) | 2001-07-03 | 2011-04-19 | Genentech, Inc. | Human dr4 antibodies and uses thereof |
| AR035119A1 (es) * | 2001-08-16 | 2004-04-14 | Lilly Co Eli | Anticuerpos humanos antagonistas anti-htnfsf13b |
| JP2005508162A (ja) | 2001-10-02 | 2005-03-31 | ジェネンテック・インコーポレーテッド | Apo−2リガンド変異体とその使用法 |
| WO2003033658A2 (en) * | 2001-10-17 | 2003-04-24 | Human Genome Sciences, Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
| IL161812A0 (en) | 2001-11-13 | 2005-11-20 | Genentech Inc | Apo2 ligand/trail formulations |
| US7741285B2 (en) | 2001-11-13 | 2010-06-22 | Genentech, Inc. | APO-2 ligand/trail formulations |
| US7842668B1 (en) | 2001-11-13 | 2010-11-30 | Genentech, Inc. | Apo-2 ligand/trail formulations |
| EP2990417A1 (de) | 2001-12-21 | 2016-03-02 | Human Genome Sciences, Inc. | Albumin-insulin-fusionsprotein |
| EP1556076A4 (de) | 2002-06-24 | 2009-07-08 | Genentech Inc | Apo-2 ligand/trail-varianten und ihre verwendungszwecke |
| US20050249671A9 (en) * | 2002-12-23 | 2005-11-10 | David Parmelee | Neutrokine-alpha conjugate, neutrokine-alpha complex, and uses thereof |
| NZ543174A (en) | 2003-03-28 | 2008-09-26 | Biogen Idec Inc | Truncated BAFF receptors |
| PT1631313E (pt) | 2003-06-05 | 2015-07-02 | Genentech Inc | Terapêutica de combinação para distúrbios de células b |
| US20050255560A1 (en) * | 2003-11-21 | 2005-11-17 | Zeren Gao | Ztnf11, a tumor necrosis factor |
| JP2008505607A (ja) * | 2004-01-29 | 2008-02-28 | ジェネンテック・インコーポレーテッド | Bcmaの細胞外ドメインの変異体とその使用法 |
| EP1773866B1 (de) | 2004-07-02 | 2013-06-19 | Bio-Layer Pty Limited | Verwendung von metallkomplexen |
| MX2007001468A (es) | 2004-08-06 | 2007-03-26 | Genentech Inc | Ensayos y metodos que utilizan biomarcadores. |
| AU2005271601A1 (en) | 2004-08-06 | 2006-02-16 | Genentech, Inc. | Assays and methods using biomarkers |
| US7846662B2 (en) | 2004-09-15 | 2010-12-07 | Kowa Company, Ltd. | Method of screening Baff suppressor or inhibitor |
| CA2580271A1 (en) | 2004-10-05 | 2006-04-20 | Genentech, Inc. | Method for treating vasculitis |
| NZ583905A (en) * | 2004-10-13 | 2011-12-22 | Univ Washington | Use of BAFF to Treat Sepsis |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| JP2008525002A (ja) | 2004-12-23 | 2008-07-17 | ラボラトワール セローノ ソシエテ アノニム | Bcmaポリペプチド及びその使用 |
| US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
| CA2618765A1 (en) | 2005-08-09 | 2007-02-15 | Zymogenetics, Inc. | Methods for treating b-cell malignancies using taci-ig fusion molecule |
| US8808696B2 (en) | 2005-08-09 | 2014-08-19 | Ares Trading S.A. | Methods for the treatment and prevention of abnormal cell proliferation using TACI-fusion molecules |
| PT1915626E (pt) | 2005-08-16 | 2012-02-03 | Genentech Inc | Sensibilidade da apoptose a apo2l/trail por ensaio de expressão de galnac-t14 em células/tecidos |
| US9168286B2 (en) | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
| AU2006344395B2 (en) | 2005-10-13 | 2013-05-02 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive diseases |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| AU2006318539B2 (en) | 2005-11-23 | 2012-09-13 | Genentech, Inc. | Methods and compositions related to B cell assays |
| US8211649B2 (en) | 2006-03-31 | 2012-07-03 | Human Genome Sciences, Inc. | Methods of diagnosing and prognosing hodgkin's lymphoma |
| AR060935A1 (es) | 2006-05-15 | 2008-07-23 | Ares Trading Sa | Metodos para tratar enfermedades autoinmunes utilizando una molecula de fusion taci- ig |
| CN102227503B (zh) | 2008-09-26 | 2015-10-21 | 托卡根公司 | 重组载体 |
| US8501178B2 (en) | 2008-11-25 | 2013-08-06 | Biogen Idec Ma Inc. | Use of DR6 and p75 antagonists to promote survival of cells of the nervous system |
| WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| MX2012002766A (es) | 2009-09-03 | 2012-04-02 | Genentech Inc | Metodos para el tratamiento, diagnosis y monitoreo de artritis reumatoide. |
| CA2818548A1 (en) | 2010-11-19 | 2012-05-24 | Toshio Imai | Neutralizing anti-ccl20 antibodies |
| CA2827859A1 (en) | 2011-02-28 | 2012-09-07 | Genentech, Inc. | Biological markers and methods for predicting response to b-cell antagonists |
| BR112014018471A2 (pt) | 2012-01-31 | 2017-07-04 | Genentech Inc | anticorpos anti-ige m1' e métodos para o seu uso |
| CN103421113B (zh) * | 2012-05-22 | 2018-01-19 | 武汉华鑫康源生物医药有限公司 | 抗BLyS抗体 |
| WO2014066700A1 (en) | 2012-10-25 | 2014-05-01 | Tocagen Inc. | Retroviral vector with mini-promoter cassette |
| US9458246B2 (en) | 2013-03-13 | 2016-10-04 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
| PH12022550138A1 (en) | 2013-03-13 | 2023-03-06 | Amgen Inc | Proteins specific for baff and b7rp1 and uses thereof |
| DE102014018663A1 (de) | 2014-12-13 | 2015-03-05 | Heinz Kiefer | Nachweis von vermehrungsfähigen Zellen zur Überprüfung von Arzneimittel-Wirkstoffangaben bei Zulassungsverfahren |
| AR104368A1 (es) | 2015-04-03 | 2017-07-19 | Lilly Co Eli | Anticuerpos biespecíficos anti-cd20- / anti-baff |
| PE20230494A1 (es) | 2020-05-08 | 2023-03-23 | Alpine Immune Sciences Inc | Proteinas inmunomoduladoras inhibidoras de april y baff y metodos de uso de las mismas |
| IL308336A (en) | 2021-05-07 | 2024-01-01 | Alpine Immune Sciences Inc | Methods of dosing and treatment with TACI-FC modulatory fusion protein |
| CN113238061B (zh) * | 2021-07-09 | 2021-10-01 | 中南大学湘雅医院 | 以cd180阴性b细胞指示重症肌无力病情的试剂盒及应用 |
| JP2025535041A (ja) | 2022-10-04 | 2025-10-22 | アルパイン イミューン サイエンシズ インコーポレイテッド | 自己抗体介在疾患の治療における使用のための変異taci-fc融合タンパク質 |
| CN119799684A (zh) * | 2024-12-27 | 2025-04-11 | 深圳先进技术研究院 | 一种靶向无害梭菌的抗菌蛋白及其制备方法与应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| ATE12348T1 (de) | 1980-11-10 | 1985-04-15 | Gersonde Klaus Prof Dr | Verfahren zur herstellung von lipid-vesikeln durch ultraschallbehandlung, anwendung des verfahrens und vorrichtung zur durchfuehrung des verfahrens. |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4433092A (en) | 1981-03-09 | 1984-02-21 | Champion Spark Plug Company | Green ceramic of lead-free glass, conductive carbon, silicone resin and AlPO4, useful, after firing, as an electrical resistor |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| JPS58118008A (ja) | 1982-01-06 | 1983-07-13 | Nec Corp | デ−タ処理装置 |
| EP0088046B1 (de) | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipide in wässriger Phase |
| DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
| EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| DE3486459D1 (de) | 1983-09-26 | 1997-12-11 | Udo Dr Med Ehrenfeld | Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr |
| EP0143949B1 (de) | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Pharmazeutische Zusammensetzung mit Gehalt an Urokinase |
| EP0190205B1 (de) | 1984-07-24 | 1992-10-21 | Coselco Mimotopes Pty. Ltd. | Verfahren zur bestimmung von mimotopen |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (de) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimäre Rezeptoren durch Verbindung und Expression von DNS |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
| WO1987001130A1 (en) | 1985-08-15 | 1987-02-26 | Stauffer Chemical Company | Tryptophan producing microorganism |
| DE3650150T2 (de) | 1985-08-16 | 1995-04-27 | The Rockefeller University, New York, N.Y. | Modulator der anabolischen Aktivität und seine Verwendungen. |
| US4870163A (en) | 1985-08-29 | 1989-09-26 | New York Blood Center, Inc. | Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor |
| JPS63501765A (ja) | 1985-11-01 | 1988-07-21 | インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド | 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途 |
| US5075236A (en) | 1987-04-24 | 1991-12-24 | Teijin Limited | Method of detecting kawasaki disease using anti-tumor necrosis antibody |
| EP0394827A1 (de) | 1989-04-26 | 1990-10-31 | F. Hoffmann-La Roche Ag | Chimärische CD4-Immunoglobulin-Polypeptide |
| DE59109269D1 (de) | 1990-06-28 | 2005-12-15 | Hoechst Ag | Fusionsproteine mit Immunglobulinanteilen, ihre Herstellung und Verwendung |
| US5480971A (en) | 1993-06-17 | 1996-01-02 | Houghten Pharmaceuticals, Inc. | Peralkylated oligopeptide mixtures |
-
1996
- 1996-10-25 EP EP96939612A patent/EP0939804B2/de not_active Expired - Lifetime
- 1996-10-25 KR KR10-2004-7019418A patent/KR20050004269A/ko not_active Ceased
- 1996-10-25 AT AT96939612T patent/ATE302272T1/de active
- 1996-10-25 EP EP05012261A patent/EP1577391A1/de not_active Withdrawn
- 1996-10-25 NZ NZ334309A patent/NZ334309A/en not_active IP Right Cessation
- 1996-10-25 JP JP52041198A patent/JP2001503263A/ja not_active Withdrawn
- 1996-10-25 AU AU76745/96A patent/AU731553B2/en not_active Expired
- 1996-10-25 CN CNA2004100055320A patent/CN1539970A/zh active Pending
- 1996-10-25 WO PCT/US1996/017957 patent/WO1998018921A1/en not_active Ceased
- 1996-10-25 KR KR1019990703614A patent/KR20000052796A/ko not_active Ceased
- 1996-10-25 CA CA002266439A patent/CA2266439C/en not_active Expired - Lifetime
- 1996-10-25 PT PT96939612T patent/PT939804E/pt unknown
- 1996-10-25 ES ES96939612T patent/ES2248823T5/es not_active Expired - Lifetime
- 1996-10-25 EP EP10156941A patent/EP2230307A1/de not_active Withdrawn
- 1996-10-25 BR BR9612752-0A patent/BR9612752A/pt not_active Application Discontinuation
- 1996-10-25 DK DK96939612.6T patent/DK0939804T4/da active
- 1996-10-25 CA CA002665133A patent/CA2665133A1/en not_active Abandoned
- 1996-10-25 DE DE69635088T patent/DE69635088T3/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000052796A (ko) | 2000-08-25 |
| CN1539970A (zh) | 2004-10-27 |
| ES2248823T3 (es) | 2006-03-16 |
| NZ334309A (en) | 2000-08-25 |
| EP0939804A1 (de) | 1999-09-08 |
| KR20050004269A (ko) | 2005-01-12 |
| JP2001503263A (ja) | 2001-03-13 |
| WO1998018921A1 (en) | 1998-05-07 |
| EP1577391A1 (de) | 2005-09-21 |
| EP0939804B1 (de) | 2005-08-17 |
| DK0939804T3 (da) | 2005-12-19 |
| AU731553B2 (en) | 2001-04-05 |
| EP0939804B2 (de) | 2011-06-15 |
| DE69635088D1 (de) | 2005-09-22 |
| BR9612752A (pt) | 2000-01-18 |
| ES2248823T5 (es) | 2011-11-03 |
| AU7674596A (en) | 1998-05-22 |
| CA2266439A1 (en) | 1998-05-07 |
| EP2230307A1 (de) | 2010-09-22 |
| DE69635088T2 (de) | 2006-06-14 |
| PT939804E (pt) | 2005-11-30 |
| CA2266439C (en) | 2009-06-16 |
| CA2665133A1 (en) | 1998-05-07 |
| DE69635088T3 (de) | 2012-01-26 |
| DK0939804T4 (da) | 2011-07-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69635088D1 (de) | NEUTROKIN alpha | |
| ATE365796T1 (de) | Tumornekrosefaktor-rezeptoren 6 alpha& 6 beta | |
| DE69841140D1 (de) | Interleukin-17 rezeptor-ähnliches protein | |
| WO1998031806A3 (en) | Fc receptors and polypeptides | |
| WO1998031818A3 (en) | Tace-like and matrilysin-like polypeptides | |
| WO1998033920A3 (en) | Tissue factor pathway inhibitor-3 | |
| NZ510367A (en) | Interleukin 17-like receptor protein nucleic acid sequence encoding the interleukin receptor protein and method of expressing protein in recombinant vector | |
| DE69836956D1 (de) | Rezeptor 5, der eine für den zelltod verantwortliche domäne enthält | |
| DE68929043D1 (de) | Für androgen-rezeptor-protein kodierende dna | |
| ATE354638T1 (de) | Menschlicher gewebsinhibitor von metalloproteinase-4 | |
| ATE472599T1 (de) | Chemokin alpha-5 | |
| HK1042498A1 (zh) | 肿瘤坏死因子受体6α及6β | |
| ATE300554T1 (de) | Bindegewebe-wachstumsfaktor 3. | |
| WO2003027231A3 (en) | Polynucleotide encoding adapter protein, pmn29 | |
| WO2001032128A3 (en) | Human chemokine beta-13 | |
| WO2000039136A3 (en) | Human brainiac-5 | |
| DE60120507D1 (de) | Menschliches leucinereiche wiederholungen enthaltendes protein, vorwiegend im dünndarm exprimiert, hlrrsi1 | |
| WO2003031566A3 (en) | Keratinocyte derived interferon | |
| WO2002018622A3 (en) | TUMOR NECROSIS FACTOR RECEPTORS 6α AND 6$g(b) | |
| EP1187842A4 (de) | Der tr10 rezeptor des menschlichen tumor-nekrose-faktors | |
| EP1712631A3 (de) | Fc Rezeptoren | |
| MXPA03004334A (es) | Receptor novedoso acoplado a proteina g humana, hgprbmy11, expresado altamente en corazon y variantes del mismo. | |
| WO2002074959A3 (en) | Human leucine-rich repeat containing protein expressed predominately in nervous system tissues, hlrrns1 | |
| MXPA03005564A (es) | Nueva proteina que contiene repeticiones ricas en leucina de humano que es expresada predominantemente en medula osea, hlrrbm1. | |
| MX9801603A (es) | Alteraciones geneticas relacionadas con la enfermedad de alzheimer hereditaria. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0939804 Country of ref document: EP |
|
| UEP | Publication of translation of european patent specification |
Ref document number: 0939804 Country of ref document: EP |