MX9801603A - Alteraciones geneticas relacionadas con la enfermedad de alzheimer hereditaria. - Google Patents
Alteraciones geneticas relacionadas con la enfermedad de alzheimer hereditaria.Info
- Publication number
- MX9801603A MX9801603A MX9801603A MX9801603A MX9801603A MX 9801603 A MX9801603 A MX 9801603A MX 9801603 A MX9801603 A MX 9801603A MX 9801603 A MX9801603 A MX 9801603A MX 9801603 A MX9801603 A MX 9801603A
- Authority
- MX
- Mexico
- Prior art keywords
- disease
- methods
- genetic alterations
- familial alzheimer
- same
- Prior art date
Links
- 208000025688 early-onset autosomal dominant Alzheimer disease Diseases 0.000 title 1
- 208000015756 familial Alzheimer disease Diseases 0.000 title 1
- 230000004077 genetic alteration Effects 0.000 title 1
- 231100000118 genetic alteration Toxicity 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 101100192145 Homo sapiens PSEN1 gene Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proporcionan moléculas aisladas de ácidos nucleicos que codifican productos de genes PS1 humanos. Los polipéptidos mutantes de PS1 también se proporcionan así como los vectores, células huéspedes y métodos recombinantes para producir los mismos. La invencion además se relaciona con métodos de examen para identificar agonistas y antagonistas de la actividad del polipéptido PS1 y mutantes del mismo. También se proporcionan métodos de diagnosticos para detectar la enfermedad de Alzheimer y métodos terapéuticos para el tratamiento de la misma.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US305495P | 1995-08-31 | 1995-08-31 | |
| US003054 | 1995-08-31 | ||
| US08/706,344 US6248555B1 (en) | 1995-08-31 | 1996-08-30 | Genetic alterations related to familial alzheimer's disease |
| US08706344 | 1996-08-30 | ||
| PCT/US1996/014114 WO1997008319A1 (en) | 1995-08-31 | 1996-09-03 | Genetic alterations related to familial alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9801603A true MX9801603A (es) | 1998-08-30 |
| MXPA98001603A MXPA98001603A (es) | 1998-11-12 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| US20010012626A1 (en) | 2001-08-09 |
| EP0851921A1 (en) | 1998-07-08 |
| JPH11512929A (ja) | 1999-11-09 |
| CA2230654A1 (en) | 1997-03-06 |
| WO1997008319A1 (en) | 1997-03-06 |
| US6248555B1 (en) | 2001-06-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |