MXPA03004334A - Receptor novedoso acoplado a proteina g humana, hgprbmy11, expresado altamente en corazon y variantes del mismo. - Google Patents

Receptor novedoso acoplado a proteina g humana, hgprbmy11, expresado altamente en corazon y variantes del mismo.

Info

Publication number
MXPA03004334A
MXPA03004334A MXPA03004334A MXPA03004334A MXPA03004334A MX PA03004334 A MXPA03004334 A MX PA03004334A MX PA03004334 A MXPA03004334 A MX PA03004334A MX PA03004334 A MXPA03004334 A MX PA03004334A MX PA03004334 A MXPA03004334 A MX PA03004334A
Authority
MX
Mexico
Prior art keywords
hgprbmy11
polypeptides
variants
heart
human
Prior art date
Application number
MXPA03004334A
Other languages
English (en)
Inventor
Ramanathan Chandra
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MXPA03004334A publication Critical patent/MXPA03004334A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4719—G-proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invencion proporciona polinucleotidos novedosos que codifican a los polipeptidos HGPRBMY11, fragmentos, y homologos de los mismos. La presente invencion tambien proporciona polinucleotidos que codifican variantes del polipeptido HGPRBMY11, HGPRBMY11v1 y HGPRBMY11v2. Tambien se proporcionan vectores, celulas hospedadoras, anticuerpos y metodos sinteticos y recombinantes para producir los polipeptidos. La invencion se refiere ademas a metodos terapeuticos y de diagnostico para aplicar estos polipeptidos novedosos HGPRBMY11, HGPRBMY11v1, y/o HGPRBMY11v2 al diagnostico, tratamiento, y/o prevencion de diversas enfermedades y/o trastornos relacionados con estos polipeptidos, particularmente enfermedades y/o trastornos cardiovasculares. La invencion se refiere ademas a metodos de separacion por exclusion para identificar agonistas y antagonistas de los polinucleotidos y polipeptidos de la presente invencion.
MXPA03004334A 2000-11-17 2001-11-16 Receptor novedoso acoplado a proteina g humana, hgprbmy11, expresado altamente en corazon y variantes del mismo. MXPA03004334A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24961300P 2000-11-17 2000-11-17
US25761100P 2000-12-21 2000-12-21
US30581801P 2001-07-16 2001-07-16
PCT/US2001/044019 WO2002086123A2 (en) 2000-11-17 2001-11-16 A human g-protein coupled receptor, hgprbmy11, expressed highly in heart and variants thereof

Publications (1)

Publication Number Publication Date
MXPA03004334A true MXPA03004334A (es) 2004-05-04

Family

ID=27400227

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03004334A MXPA03004334A (es) 2000-11-17 2001-11-16 Receptor novedoso acoplado a proteina g humana, hgprbmy11, expresado altamente en corazon y variantes del mismo.

Country Status (7)

Country Link
US (1) US20030153063A1 (es)
EP (1) EP1349928A2 (es)
JP (1) JP2005504510A (es)
CA (1) CA2429351A1 (es)
IL (1) IL155569A0 (es)
MX (1) MXPA03004334A (es)
WO (1) WO2002086123A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020117752A1 (en) * 2018-12-04 2020-06-11 The University Of North Carolina At Chapel Hill G protein-coupled receptor screening systems
CN113999873B (zh) * 2021-12-31 2022-05-20 北京市疾病预防控制中心 一种基因修饰的非人动物的构建方法及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005274A1 (en) * 1997-07-23 1999-02-04 Smithkline Beecham Corporation Method of identifying novel g-protein receptors and their functions

Also Published As

Publication number Publication date
JP2005504510A (ja) 2005-02-17
WO2002086123A3 (en) 2003-07-31
IL155569A0 (en) 2003-11-23
EP1349928A2 (en) 2003-10-08
CA2429351A1 (en) 2002-10-31
WO2002086123A2 (en) 2002-10-31
US20030153063A1 (en) 2003-08-14

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Legal Events

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