ES2240921T3 - Procedimiento de sintesis del acido (2s,3as,7as)-perhidroindol-2-carboxilico y sus esteres y su utilizacion en la sintesis de perindopril. - Google Patents

Procedimiento de sintesis del acido (2s,3as,7as)-perhidroindol-2-carboxilico y sus esteres y su utilizacion en la sintesis de perindopril.

Info

Publication number
ES2240921T3
ES2240921T3 ES03291420T ES03291420T ES2240921T3 ES 2240921 T3 ES2240921 T3 ES 2240921T3 ES 03291420 T ES03291420 T ES 03291420T ES 03291420 T ES03291420 T ES 03291420T ES 2240921 T3 ES2240921 T3 ES 2240921T3
Authority
ES
Spain
Prior art keywords
formula
compound
synthesis
lead
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03291420T
Other languages
English (en)
Spanish (es)
Inventor
Thierry Dubuffet
Pascal Langlois
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Application granted granted Critical
Publication of ES2240921T3 publication Critical patent/ES2240921T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES03291420T 2003-06-13 2003-06-13 Procedimiento de sintesis del acido (2s,3as,7as)-perhidroindol-2-carboxilico y sus esteres y su utilizacion en la sintesis de perindopril. Expired - Lifetime ES2240921T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03291420A EP1354876B1 (fr) 2003-06-13 2003-06-13 Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril

Publications (1)

Publication Number Publication Date
ES2240921T3 true ES2240921T3 (es) 2005-10-16

Family

ID=28459642

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03291420T Expired - Lifetime ES2240921T3 (es) 2003-06-13 2003-06-13 Procedimiento de sintesis del acido (2s,3as,7as)-perhidroindol-2-carboxilico y sus esteres y su utilizacion en la sintesis de perindopril.

Country Status (10)

Country Link
EP (1) EP1354876B1 (https=)
AR (1) AR044670A1 (https=)
AT (1) ATE294161T1 (https=)
DE (1) DE60300558T2 (https=)
DK (1) DK1354876T3 (https=)
ES (1) ES2240921T3 (https=)
MY (1) MY142634A (https=)
PT (1) PT1354876E (https=)
SI (1) SI1354876T1 (https=)
WO (1) WO2005003091A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100391945C (zh) * 2005-05-31 2008-06-04 浙江大学 一种s-(-)-吲哚啉-2-羧酸的合成方法
EP1792896A1 (en) * 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
US8558023B2 (en) 2010-04-20 2013-10-15 Chiral Quest, Inc. Enantioselective process for cycloalkenyl β-substituted alanines
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides

Also Published As

Publication number Publication date
DE60300558T2 (de) 2006-02-23
MY142634A (en) 2010-12-15
EP1354876B1 (fr) 2005-04-27
PT1354876E (pt) 2005-06-30
SI1354876T1 (https=) 2005-08-31
EP1354876A1 (fr) 2003-10-22
DE60300558D1 (de) 2005-06-02
AR044670A1 (es) 2005-09-21
ATE294161T1 (de) 2005-05-15
DK1354876T3 (da) 2005-08-15
WO2005003091A1 (fr) 2005-01-13

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