DK1354876T3 - Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og dennes estere og anvendelse heraf i syntesen af perindopril - Google Patents
Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og dennes estere og anvendelse heraf i syntesen af perindoprilInfo
- Publication number
- DK1354876T3 DK1354876T3 DK03291420T DK03291420T DK1354876T3 DK 1354876 T3 DK1354876 T3 DK 1354876T3 DK 03291420 T DK03291420 T DK 03291420T DK 03291420 T DK03291420 T DK 03291420T DK 1354876 T3 DK1354876 T3 DK 1354876T3
- Authority
- DK
- Denmark
- Prior art keywords
- synthesis
- perhydroindole
- perindopril
- esters
- carboxylic acid
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 2
- 238000003786 synthesis reaction Methods 0.000 title 2
- CQYBNXGHMBNGCG-FXQIFTODSA-N (2s,3as,7as)-2,3,3a,4,5,6,7,7a-octahydro-1h-indol-1-ium-2-carboxylate Chemical compound C1CCC[C@@H]2[NH2+][C@H](C(=O)[O-])C[C@@H]21 CQYBNXGHMBNGCG-FXQIFTODSA-N 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title 1
- 229960002582 perindopril Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03291420A EP1354876B1 (fr) | 2003-06-13 | 2003-06-13 | Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1354876T3 true DK1354876T3 (da) | 2005-08-15 |
Family
ID=28459642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03291420T DK1354876T3 (da) | 2003-06-13 | 2003-06-13 | Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og dennes estere og anvendelse heraf i syntesen af perindopril |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1354876B1 (https=) |
| AR (1) | AR044670A1 (https=) |
| AT (1) | ATE294161T1 (https=) |
| DE (1) | DE60300558T2 (https=) |
| DK (1) | DK1354876T3 (https=) |
| ES (1) | ES2240921T3 (https=) |
| MY (1) | MY142634A (https=) |
| PT (1) | PT1354876E (https=) |
| SI (1) | SI1354876T1 (https=) |
| WO (1) | WO2005003091A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100391945C (zh) * | 2005-05-31 | 2008-06-04 | 浙江大学 | 一种s-(-)-吲哚啉-2-羧酸的合成方法 |
| EP1792896A1 (en) * | 2005-12-01 | 2007-06-06 | KRKA, tovarna zdravil, d.d., Novo mesto | Process for the preparation of perindopril and salts thereof |
| US8558023B2 (en) | 2010-04-20 | 2013-10-15 | Chiral Quest, Inc. | Enantioselective process for cycloalkenyl β-substituted alanines |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE55867B1 (en) * | 1981-12-29 | 1991-02-14 | Hoechst Ag | New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation |
| FR2620703B1 (fr) * | 1987-09-17 | 1991-10-04 | Adir | Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides |
-
2003
- 2003-06-13 SI SI200330034T patent/SI1354876T1/xx unknown
- 2003-06-13 DK DK03291420T patent/DK1354876T3/da active
- 2003-06-13 AT AT03291420T patent/ATE294161T1/de active
- 2003-06-13 ES ES03291420T patent/ES2240921T3/es not_active Expired - Lifetime
- 2003-06-13 DE DE60300558T patent/DE60300558T2/de not_active Expired - Lifetime
- 2003-06-13 PT PT03291420T patent/PT1354876E/pt unknown
- 2003-06-13 EP EP03291420A patent/EP1354876B1/fr not_active Expired - Lifetime
-
2004
- 2004-06-09 WO PCT/FR2004/001427 patent/WO2005003091A1/fr not_active Ceased
- 2004-06-10 MY MYPI20042237A patent/MY142634A/en unknown
- 2004-06-11 AR ARP040102021A patent/AR044670A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60300558T2 (de) | 2006-02-23 |
| MY142634A (en) | 2010-12-15 |
| EP1354876B1 (fr) | 2005-04-27 |
| PT1354876E (pt) | 2005-06-30 |
| SI1354876T1 (https=) | 2005-08-31 |
| ES2240921T3 (es) | 2005-10-16 |
| EP1354876A1 (fr) | 2003-10-22 |
| DE60300558D1 (de) | 2005-06-02 |
| AR044670A1 (es) | 2005-09-21 |
| ATE294161T1 (de) | 2005-05-15 |
| WO2005003091A1 (fr) | 2005-01-13 |
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