ES2212340T3 - Secuencias de peptidos como regiones bisagra en fragmentos de inmunoglobulina similares a proteinas y su uso en medicina. - Google Patents
Secuencias de peptidos como regiones bisagra en fragmentos de inmunoglobulina similares a proteinas y su uso en medicina.Info
- Publication number
- ES2212340T3 ES2212340T3 ES98944070T ES98944070T ES2212340T3 ES 2212340 T3 ES2212340 T3 ES 2212340T3 ES 98944070 T ES98944070 T ES 98944070T ES 98944070 T ES98944070 T ES 98944070T ES 2212340 T3 ES2212340 T3 ES 2212340T3
- Authority
- ES
- Spain
- Prior art keywords
- hinge
- fab
- protein
- proteins
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/867—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody produced via recombinant dna technology
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
- Jellies, Jams, And Syrups (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9720054.7A GB9720054D0 (en) | 1997-09-19 | 1997-09-19 | Biological products |
| GB9720054 | 1997-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2212340T3 true ES2212340T3 (es) | 2004-07-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ES98944070T Expired - Lifetime ES2212340T3 (es) | 1997-09-19 | 1998-09-21 | Secuencias de peptidos como regiones bisagra en fragmentos de inmunoglobulina similares a proteinas y su uso en medicina. |
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| EP (1) | EP1015495B1 (enExample) |
| JP (1) | JP4257030B2 (enExample) |
| AT (1) | ATE257160T1 (enExample) |
| AU (1) | AU9174398A (enExample) |
| DE (1) | DE69820885T2 (enExample) |
| ES (1) | ES2212340T3 (enExample) |
| GB (1) | GB9720054D0 (enExample) |
| WO (1) | WO1999015549A2 (enExample) |
Families Citing this family (78)
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| GB0013810D0 (en) * | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
| AU2002337920A1 (en) * | 2001-10-19 | 2003-04-28 | Zymogenetics, Inc. | Dimerized growth factor and materials and methods for producing it |
| GB0303337D0 (en) | 2003-02-13 | 2003-03-19 | Celltech R&D Ltd | Biological products |
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| GB0315450D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
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| JP4833850B2 (ja) | 2003-11-21 | 2011-12-07 | ユセベ ファルマ ソシエテ アノニム | Ｉｌ−１７活性阻害による多発性硬化症を治療するための方法 |
| US7381794B2 (en) * | 2004-03-08 | 2008-06-03 | Zymogenetics, Inc. | Dimeric fusion proteins and materials and methods for producing them |
| WO2006074399A2 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
| KR20070100346A (ko) | 2005-01-05 | 2007-10-10 | 바이오겐 아이덱 엠에이 인코포레이티드 | 크립토 결합 분자 |
| JP5255435B2 (ja) | 2005-04-26 | 2013-08-07 | メディミューン，エルエルシー | ヒンジドメイン操作による抗体エフェクター機能の調節 |
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| GB0614780D0 (en) | 2006-07-25 | 2006-09-06 | Ucb Sa | Biological products |
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| GB0920127D0 (en) | 2009-11-17 | 2009-12-30 | Ucb Pharma Sa | Antibodies |
| GB0920324D0 (en) | 2009-11-19 | 2010-01-06 | Ucb Pharma Sa | Antibodies |
| GB201000467D0 (en) | 2010-01-12 | 2010-02-24 | Ucb Pharma Sa | Antibodies |
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| WO2025255480A1 (en) | 2024-06-07 | 2025-12-11 | Regeneron Pharmaceuticals, Inc. | Tetravalent multispecific binding molecules and methods of use thereof |
| WO2025255452A2 (en) | 2024-06-07 | 2025-12-11 | Regeneron Pharmaceuticals, Inc. | Antigen-binding molecules that bind to aav particles and uses thereof |
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Family Cites Families (2)
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|---|---|---|---|---|
| EP0284898A3 (de) | 1987-04-02 | 1990-06-27 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Hinge-Peptid, Verfahren zu seiner Herstellung und seine Verwendung zur Herstellung synthetischer Immunogene |
| ATE225801T1 (de) * | 1992-07-13 | 2002-10-15 | Bionebraska Inc | Verfahren zur modifizierung rekombinanter polypeptide |
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1997
- 1997-09-19 GB GBGB9720054.7A patent/GB9720054D0/en not_active Ceased
-
1998
- 1998-09-21 DE DE69820885T patent/DE69820885T2/de not_active Expired - Fee Related
- 1998-09-21 JP JP2000512854A patent/JP4257030B2/ja not_active Expired - Fee Related
- 1998-09-21 ES ES98944070T patent/ES2212340T3/es not_active Expired - Lifetime
- 1998-09-21 EP EP98944070A patent/EP1015495B1/en not_active Expired - Lifetime
- 1998-09-21 AU AU91743/98A patent/AU9174398A/en not_active Abandoned
- 1998-09-21 US US09/508,930 patent/US6642356B1/en not_active Expired - Fee Related
- 1998-09-21 WO PCT/GB1998/002851 patent/WO1999015549A2/en not_active Ceased
- 1998-09-21 AT AT98944070T patent/ATE257160T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB9720054D0 (en) | 1997-11-19 |
| WO1999015549A3 (en) | 1999-06-17 |
| EP1015495A2 (en) | 2000-07-05 |
| JP2001517423A (ja) | 2001-10-09 |
| JP4257030B2 (ja) | 2009-04-22 |
| DE69820885D1 (de) | 2004-02-05 |
| WO1999015549A2 (en) | 1999-04-01 |
| ATE257160T1 (de) | 2004-01-15 |
| DE69820885T2 (de) | 2004-12-16 |
| AU9174398A (en) | 1999-04-12 |
| EP1015495B1 (en) | 2004-01-02 |
| US6642356B1 (en) | 2003-11-04 |
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