DE69820885T2 - Peptidsquenzen als Gelenkregionen in Proteinen wie Immunglobulinfragmenten und ihre Verwendung in der Medizin - Google Patents

Peptidsquenzen als Gelenkregionen in Proteinen wie Immunglobulinfragmenten und ihre Verwendung in der Medizin Download PDF

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Publication number
DE69820885T2
DE69820885T2 DE69820885T DE69820885T DE69820885T2 DE 69820885 T2 DE69820885 T2 DE 69820885T2 DE 69820885 T DE69820885 T DE 69820885T DE 69820885 T DE69820885 T DE 69820885T DE 69820885 T2 DE69820885 T2 DE 69820885T2
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DE
Germany
Prior art keywords
joint
fab
protein
proteins
amino acid
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69820885T
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German (de)
English (en)
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DE69820885D1 (de
Inventor
Paul David Humphreys
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Celltech R&D Ltd
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Celltech Therapeutics Ltd
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Publication of DE69820885D1 publication Critical patent/DE69820885D1/de
Publication of DE69820885T2 publication Critical patent/DE69820885T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007Carcino-embryonic Antigens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/53Hinge
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54F(ab')2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/866Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/867Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody produced via recombinant dna technology

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Jellies, Jams, And Syrups (AREA)
DE69820885T 1997-09-19 1998-09-21 Peptidsquenzen als Gelenkregionen in Proteinen wie Immunglobulinfragmenten und ihre Verwendung in der Medizin Expired - Fee Related DE69820885T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9720054 1997-09-19
GBGB9720054.7A GB9720054D0 (en) 1997-09-19 1997-09-19 Biological products
PCT/GB1998/002851 WO1999015549A2 (en) 1997-09-19 1998-09-21 Peptide sequences as hinge regions in proteins like immunoglobulin fragments and their use in medicine

Publications (2)

Publication Number Publication Date
DE69820885D1 DE69820885D1 (de) 2004-02-05
DE69820885T2 true DE69820885T2 (de) 2004-12-16

Family

ID=10819407

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69820885T Expired - Fee Related DE69820885T2 (de) 1997-09-19 1998-09-21 Peptidsquenzen als Gelenkregionen in Proteinen wie Immunglobulinfragmenten und ihre Verwendung in der Medizin

Country Status (9)

Country Link
US (1) US6642356B1 (enExample)
EP (1) EP1015495B1 (enExample)
JP (1) JP4257030B2 (enExample)
AT (1) ATE257160T1 (enExample)
AU (1) AU9174398A (enExample)
DE (1) DE69820885T2 (enExample)
ES (1) ES2212340T3 (enExample)
GB (1) GB9720054D0 (enExample)
WO (1) WO1999015549A2 (enExample)

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Also Published As

Publication number Publication date
US6642356B1 (en) 2003-11-04
EP1015495A2 (en) 2000-07-05
GB9720054D0 (en) 1997-11-19
EP1015495B1 (en) 2004-01-02
ES2212340T3 (es) 2004-07-16
WO1999015549A2 (en) 1999-04-01
ATE257160T1 (de) 2004-01-15
JP4257030B2 (ja) 2009-04-22
DE69820885D1 (de) 2004-02-05
AU9174398A (en) 1999-04-12
WO1999015549A3 (en) 1999-06-17
JP2001517423A (ja) 2001-10-09

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