ES2207590T3 - Benzopiranos y su uso como agentes terapeuticos. - Google Patents

Benzopiranos y su uso como agentes terapeuticos.

Info

Publication number
ES2207590T3
ES2207590T3 ES01200801T ES01200801T ES2207590T3 ES 2207590 T3 ES2207590 T3 ES 2207590T3 ES 01200801 T ES01200801 T ES 01200801T ES 01200801 T ES01200801 T ES 01200801T ES 2207590 T3 ES2207590 T3 ES 2207590T3
Authority
ES
Spain
Prior art keywords
pharmaceutically acceptable
compounds
disorders
trans
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01200801T
Other languages
English (en)
Spanish (es)
Inventor
Wai Ngor Glaxo Smith Kline Chan
Helen Kate Ann Glaxo Smith Kline Morgan
Mervyn Glaxo Smith Kline Thompson
John Morris Glaxo Smith Kline Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9411632A external-priority patent/GB9411632D0/en
Priority claimed from GB9411798A external-priority patent/GB9411798D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of ES2207590T3 publication Critical patent/ES2207590T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
ES01200801T 1994-06-10 1995-05-31 Benzopiranos y su uso como agentes terapeuticos. Expired - Lifetime ES2207590T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9411632A GB9411632D0 (en) 1994-06-10 1994-06-10 Novel treatment
GB9411632 1994-06-10
GB9411798A GB9411798D0 (en) 1994-06-13 1994-06-13 Novel treatment
GB9411798 1994-06-13

Publications (1)

Publication Number Publication Date
ES2207590T3 true ES2207590T3 (es) 2004-06-01

Family

ID=26305044

Family Applications (2)

Application Number Title Priority Date Filing Date
ES01200801T Expired - Lifetime ES2207590T3 (es) 1994-06-10 1995-05-31 Benzopiranos y su uso como agentes terapeuticos.
ES95921798T Expired - Lifetime ES2170798T3 (es) 1994-06-10 1995-05-31 Benzopiranos y su uso como agentes terapeuticos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES95921798T Expired - Lifetime ES2170798T3 (es) 1994-06-10 1995-05-31 Benzopiranos y su uso como agentes terapeuticos.

Country Status (29)

Country Link
US (1) US5760074A (cs)
EP (2) EP0764157B1 (cs)
JP (2) JP3575767B2 (cs)
KR (1) KR100397721B1 (cs)
CN (2) CN1234702C (cs)
AP (1) AP714A (cs)
AT (2) ATE250052T1 (cs)
AU (1) AU701060B2 (cs)
BG (1) BG63339B1 (cs)
BR (1) BR9507980A (cs)
CA (1) CA2192480C (cs)
CY (1) CY2508B1 (cs)
CZ (1) CZ286081B6 (cs)
DE (2) DE69531801T2 (cs)
DK (2) DK1114821T3 (cs)
ES (2) ES2207590T3 (cs)
FI (1) FI120686B (cs)
HK (1) HK1039115B (cs)
HU (1) HUT76136A (cs)
NO (1) NO315651B1 (cs)
NZ (1) NZ287872A (cs)
OA (1) OA10593A (cs)
PL (1) PL188134B1 (cs)
PT (2) PT764157E (cs)
RO (1) RO113463B1 (cs)
SG (1) SG67930A1 (cs)
SI (2) SI0764157T1 (cs)
SK (1) SK281456B6 (cs)
WO (1) WO1995034545A1 (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010021780A1 (en) * 1992-12-11 2001-09-13 Smithkline Beecham P.L.C. Pharmaceutical composition containing bicyclic type compounds
GB9411635D0 (en) * 1994-06-10 1994-08-03 Smithkline Beecham Plc Novel treatment
GB9619492D0 (en) * 1996-09-18 1996-10-30 Smithkline Beecham Plc Novel treatment
US6492415B2 (en) * 1996-09-18 2002-12-10 Smithkline Beecham P.L.C. Use of benzopyranols to treat neurological disorders
GB9726543D0 (en) * 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel compositions
GB9813949D0 (en) * 1998-06-29 1998-08-26 Smithkline Beecham Plc Novel compounds
GB0028697D0 (en) * 2000-11-23 2001-01-10 S P A Novel process
US20090042861A1 (en) * 2005-04-04 2009-02-12 Takeda Pharmaceutical Company Limited Prophylactic or Therapeutic Agent for Depression or Anxiety Disorder
EP2307004A1 (en) * 2008-06-05 2011-04-13 Minster Research Limited Novel treatments
JP2011522031A (ja) * 2008-06-05 2011-07-28 ミンスター・リサーチ・リミテッド 新規な治療
MX2012006352A (es) 2009-12-03 2012-06-27 Proximagen Ltd Tratamiento de alodinia e hiperalgesia.
RU2012124838A (ru) 2009-12-03 2014-01-10 Проксимэджен ЛТД Лечение инфекционных заболеваний
EP2870148A1 (en) 2012-07-03 2015-05-13 Proximagen Limited Pro-drug compounds
GB201304814D0 (en) * 2013-03-15 2013-05-01 Proximagen Ltd Pro-drug compounds
GB201322932D0 (en) * 2013-12-23 2014-02-12 Proximagen Ltd Pro-drug compounds
GB201322934D0 (en) 2013-12-23 2014-02-12 Proximagen Ltd Prodrug compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126311B1 (en) * 1983-05-18 1989-09-13 Beecham Group Plc Benzopyran derivatives.
GB9112721D0 (en) * 1991-06-13 1991-07-31 Smithkline Beecham Plc Novel treatment
WO1994013656A1 (en) * 1992-12-11 1994-06-23 Smithkline Beecham Plc Bicyclic compounds with pharmaceutical activity
NZ258611A (en) * 1992-12-11 1997-07-27 Smithkline Beecham Plc 4-benzoyl(or heteroarylcarbonyl)amino-3,4-dihydro- 3-hydroxy-2h-benzo[b]pyran derivatives;benzopyrano[4,3-d]oxazole intermediates
US5536718A (en) * 1995-01-17 1996-07-16 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists

Also Published As

Publication number Publication date
EP0764157A1 (en) 1997-03-26
WO1995034545A1 (en) 1995-12-21
PT1114821E (pt) 2004-02-27
AU701060B2 (en) 1999-01-21
AP714A (en) 1998-12-23
CZ361796A3 (en) 1997-08-13
CN1174975C (zh) 2004-11-10
HU9603415D0 (en) 1997-02-28
BR9507980A (pt) 1997-08-12
CN1234702C (zh) 2006-01-04
CA2192480A1 (en) 1995-12-21
US5760074A (en) 1998-06-02
ATE211469T1 (de) 2002-01-15
EP0764157B1 (en) 2002-01-02
HK1039115B (en) 2004-08-13
DK0764157T3 (da) 2002-04-22
SK281456B6 (sk) 2001-03-12
ES2170798T3 (es) 2002-08-16
HUT76136A (en) 1997-06-30
EP1114821B1 (en) 2003-09-17
BG63339B1 (bg) 2001-10-31
SK158796A3 (en) 1997-07-09
CA2192480C (en) 2007-07-24
FI964936A0 (fi) 1996-12-10
SG67930A1 (en) 1999-10-19
CN1336369A (zh) 2002-02-20
JPH10501251A (ja) 1998-02-03
DE69524871T2 (de) 2002-08-22
NZ287872A (en) 1998-05-27
PT764157E (pt) 2002-06-28
PL188134B1 (pl) 2004-12-31
RO113463B1 (ro) 1998-07-30
NO965260L (no) 1997-02-06
JP3575767B2 (ja) 2004-10-13
AU2672795A (en) 1996-01-05
EP1114821A1 (en) 2001-07-11
HK1001286A1 (en) 1998-06-12
DE69531801D1 (de) 2003-10-23
BG101040A (en) 1997-08-29
SI1114821T1 (en) 2004-02-29
HK1039115A1 (en) 2002-04-12
NO315651B1 (no) 2003-10-06
FI964936L (fi) 1997-02-06
KR100397721B1 (ko) 2004-04-28
DE69524871D1 (de) 2002-02-07
CY2508B1 (en) 2005-12-23
AP9600889A0 (en) 1997-01-31
JP2003238554A (ja) 2003-08-27
CN1154698A (zh) 1997-07-16
OA10593A (en) 2002-07-10
NO965260D0 (no) 1996-12-09
DK1114821T3 (da) 2004-02-02
ATE250052T1 (de) 2003-10-15
CZ286081B6 (cs) 2000-01-12
SI0764157T1 (en) 2002-06-30
FI120686B (fi) 2010-01-29
PL317579A1 (en) 1997-04-14
DE69531801T2 (de) 2004-07-01

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