ES2184758T3 - Compuestos hipolipidemicos. - Google Patents

Compuestos hipolipidemicos.

Info

Publication number
ES2184758T3
ES2184758T3 ES94906338T ES94906338T ES2184758T3 ES 2184758 T3 ES2184758 T3 ES 2184758T3 ES 94906338 T ES94906338 T ES 94906338T ES 94906338 T ES94906338 T ES 94906338T ES 2184758 T3 ES2184758 T3 ES 2184758T3
Authority
ES
Spain
Prior art keywords
pct
date aug
sec
compounds
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94906338T
Other languages
English (en)
Inventor
Lawrence Edward Brieaddy
Gordon Lewis Hodgson Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939303013A external-priority patent/GB9303013D0/en
Priority claimed from GB939315155A external-priority patent/GB9315155D0/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2184758T3 publication Critical patent/ES2184758T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

EL INVENTO PROPORCIONA UN COMPUESTO DE LA FORMULA (I), EN LA QUE 1 ES UN ENTERO DE 0 A 4; N ES UN ENTERO DE 0 A 2; X ES UN SISTEMA DE ANILLO MONOCICLICO O BICICLICO AROMATICO O NO AROMATICO QUE TIENE DE 5 A 10 ATOMOS DE CARBONO (INCLUYENDO LOS DOS ATOMOS DE CARBONO QUE FORMAN PARTE DEL ANILLO DE TIACEPINA) EN EL QUE OPCIONALMENTE UNO O MAS DE LOS ATOMOS DE CARBONO ES/SON REEMPLAZADO POR HETEROATOMO(S) INDEPENDIENTEMENTE SELECCIONADOS ENTRE NITROGENO, OXIGENO Y SULFURO; CON LA CONDICION DE QUE AL MENOS UNO DE R, R{SUP,2}, R{SUP,4} Y R{SUP,5} SEA HIDROXI O UN GRUPO QUE CONTENGA HIDROXI; Y SALES, SOLVATOS Y DERIVADOS FUNCIONALES FISIOLOGICAMENTE DE LOS MISMOS, FORMULACIONES FARMACEUTICAS QUE CONTIENEN DICHOS COMPUESTOS, PROCESO PARA SU PREPARACION Y SU USO REDUCIENDO LA RECEPCION DE ACIDO BILIAR Y POR LO TANTO COMO AGENTES HIPOLIPIDAEMICOS.
ES94906338T 1993-02-15 1994-02-15 Compuestos hipolipidemicos. Expired - Lifetime ES2184758T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939303013A GB9303013D0 (en) 1993-02-15 1993-02-15 Hypolipidaemic compounds
GB939315155A GB9315155D0 (en) 1993-07-22 1993-07-22 Hypolipidaemic compounds

Publications (1)

Publication Number Publication Date
ES2184758T3 true ES2184758T3 (es) 2003-04-16

Family

ID=26302465

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94906338T Expired - Lifetime ES2184758T3 (es) 1993-02-15 1994-02-15 Compuestos hipolipidemicos.

Country Status (16)

Country Link
US (1) US5723458A (es)
EP (1) EP0683774B1 (es)
JP (1) JP2886341B2 (es)
AT (1) ATE225778T1 (es)
AU (1) AU6008894A (es)
CA (1) CA2156183A1 (es)
DE (1) DE69431517T2 (es)
DK (1) DK0683774T3 (es)
ES (1) ES2184758T3 (es)
HK (1) HK1003939A1 (es)
HU (1) HUT71610A (es)
IL (1) IL108633A (es)
PT (1) PT683774E (es)
TW (1) TW275064B (es)
WO (1) WO1994018184A1 (es)
ZA (1) ZA941003B (es)

Families Citing this family (115)

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KR20230106651A (ko) 2020-11-12 2023-07-13 알비레오 에이비 진행성 가족성 간내 담즙정체증(pfic)을 치료하기 위한 오데빅시바트
CN116583504A (zh) 2020-12-04 2023-08-11 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
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US20240067617A1 (en) 2022-07-05 2024-02-29 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
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AU6008894A (en) 1994-08-29
HU9501818D0 (en) 1995-08-28
WO1994018184A1 (en) 1994-08-18
US5723458A (en) 1998-03-03
DE69431517D1 (de) 2002-11-14
TW275064B (es) 1996-05-01
EP0683774B1 (en) 2002-10-09
ATE225778T1 (de) 2002-10-15
ZA941003B (en) 1995-08-14
JPH08506576A (ja) 1996-07-16
DK0683774T3 (da) 2003-02-10
DE69431517T2 (de) 2003-06-12
IL108633A (en) 1998-07-15
PT683774E (pt) 2003-02-28
HK1003939A1 (en) 1998-11-13
HUT71610A (en) 1996-01-29
CA2156183A1 (en) 1994-08-18
IL108633A0 (en) 1994-05-30
EP0683774A1 (en) 1995-11-29
JP2886341B2 (ja) 1999-04-26

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