ES2167566T3 - Metodo para obtener una dispersion solida de un farmaco poco soluble en agua. - Google Patents

Metodo para obtener una dispersion solida de un farmaco poco soluble en agua.

Info

Publication number
ES2167566T3
ES2167566T3 ES96917457T ES96917457T ES2167566T3 ES 2167566 T3 ES2167566 T3 ES 2167566T3 ES 96917457 T ES96917457 T ES 96917457T ES 96917457 T ES96917457 T ES 96917457T ES 2167566 T3 ES2167566 T3 ES 2167566T3
Authority
ES
Spain
Prior art keywords
pct
pharmaco
obtaining
water
solid dispersion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96917457T
Other languages
English (en)
Inventor
James Matthew Butler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icos Corp
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Application granted granted Critical
Publication of ES2167566T3 publication Critical patent/ES2167566T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Glass Compositions (AREA)

Abstract

SE DESCRIBEN DISPERSIONES SOLIDAS DE FARMACOS DE BAJA SOLUBILIDAD EN AGUA, PROCESOS PARA SU PREPARACION Y SU USO EN COMPOSICIONES FARMACEUTICAS. ESPECIFICAMENTE, SE DESCRIBEN DISPERSIONES SOLIDAS DE (6R,12AR) TIL 3,4-B]INDOL IN
ES96917457T 1995-06-02 1996-05-30 Metodo para obtener una dispersion solida de un farmaco poco soluble en agua. Expired - Lifetime ES2167566T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9511220.7A GB9511220D0 (en) 1995-06-02 1995-06-02 Solid dispersions

Publications (1)

Publication Number Publication Date
ES2167566T3 true ES2167566T3 (es) 2002-05-16

Family

ID=10775439

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96917457T Expired - Lifetime ES2167566T3 (es) 1995-06-02 1996-05-30 Metodo para obtener una dispersion solida de un farmaco poco soluble en agua.

Country Status (8)

Country Link
US (1) US5985326A (es)
EP (1) EP0828479B1 (es)
AT (1) ATE207344T1 (es)
AU (1) AU6002696A (es)
DE (1) DE69616313T2 (es)
ES (1) ES2167566T3 (es)
GB (1) GB9511220D0 (es)
WO (1) WO1996038131A1 (es)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143746A (en) * 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
AU756136B2 (en) 1997-06-23 2003-01-02 Queen's University At Kingston Microdose therapy
US6350786B1 (en) † 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
SA99191255B1 (ar) 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
HUP0001632A3 (en) * 1999-04-30 2001-12-28 Lilly Icos Llc Wilmington Pharmaceutical compositions comprising selective phosphodiestherase inhibitors
US6451807B1 (en) 1999-04-30 2002-09-17 Lilly Icos, Llc. Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor
US6821975B1 (en) 1999-08-03 2004-11-23 Lilly Icos Llc Beta-carboline drug products
EP1200090B1 (en) * 1999-08-03 2013-09-11 ICOS Corporation Pharmaceutical formulation comprising a beta-carboline and its use for treating sexual dysfunction
UA71629C2 (en) * 1999-08-03 2004-12-15 Lilli Icos Llc Composition containing free drug particulate form of ?-carboline (variants), method for its manufacture (variants), and method for treating sexual dysfunction
US20010053791A1 (en) * 2000-03-16 2001-12-20 Babcock Walter C. Glycogen phosphorylase inhibitor
EP1307183A2 (en) * 2000-08-11 2003-05-07 Pfizer Limited Treatment of the insulin resistance syndrome with selective cgmp pde5 inhibitors
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
MXPA04002446A (es) 2001-09-26 2004-07-23 Baxter Int Preparacion de nanoparticulas de tamano de submicras mediante dispersion y remocion de la fase liquida o solvente.
MXPA04007428A (es) * 2002-02-01 2004-10-11 Pfizer Prod Inc Formas de dosificacion de liberacion inmediata que contienen dispersiones de farmaco solido.
EP1650266A1 (en) * 2003-06-20 2006-04-26 Meiji Seika Kaisha Ltd. Product of coprecipitation of sparingly soluble substance and water-soluble polymer and process for producing the same
WO2005068464A2 (en) * 2003-12-15 2005-07-28 Cadila Healthcare Limited Process for preparing tadalafil and its intermediates
WO2006050458A2 (en) * 2004-11-02 2006-05-11 Teva Pharmaceutical Industries, Ltd. Tadalafil crystal forms and processes for preparing them
WO2006073973A2 (en) * 2004-12-31 2006-07-13 Reddy Us Therapeutics, Inc. Novel benzylamine derivatives as cetp inhibitors
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
WO2006091974A1 (en) * 2005-02-25 2006-08-31 Teva Pharmaceutical Industries Ltd. Tadalafil having a large particle size and a process for preparation thereof
EP1851223A1 (en) * 2005-02-25 2007-11-07 Teva Pharmaceutical Industries Ltd Process of purifying tadalafil
KR20070102719A (ko) * 2005-02-25 2007-10-19 테바 파마슈티컬 인더스트리즈 리미티드 타달라필의 합성 방법
MX2008016569A (es) * 2006-07-07 2009-01-30 Teva Pharma Composiciones solidas que contienen tadalafil y al menos un portador.
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US20090098211A1 (en) * 2007-04-25 2009-04-16 Ilan Zalit Solid dosage forms
CA2686756A1 (en) * 2007-05-11 2008-11-20 F. Hoffmann-La Roche Ag Pharmaceutical compositions for poorly soluble drugs
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
DE102007028869A1 (de) 2007-06-22 2008-12-24 Ratiopharm Gmbh Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil
WO2009012283A1 (en) 2007-07-17 2009-01-22 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
ES2552386T3 (es) * 2009-04-03 2015-11-27 F. Hoffmann-La Roche Ag Composiciones de {3-[5-(4-cloro-fenil)-1H-pirrol[2,3-b]piridin-3-carbonil]-2,4-difluoro-fenil}-amida del ácido propano-1-sulfónico y usos de las mismas
EP2238979A1 (en) 2009-04-06 2010-10-13 LEK Pharmaceuticals d.d. Active pharmaceutical ingredient adsorbed on solid support
DE102009033396A1 (de) 2009-07-16 2011-01-20 Ratiopharm Gmbh Wässrige Lösung und gelatinierte Zusammensetzung umfassend einen Phosphodiesterase-5-Inhibitor sowie diesbezügliche Verfahren und Verwendung
DE102009035211A1 (de) 2009-07-29 2011-02-17 Ratiopharm Gmbh Copräzipitate umfassend einen Phosphodiesterase-5-Inhibitor (PDE-5-Inhibitor) und einen pharmazeutisch verträglichen Trägerstoff, ihre Herstellung und Verwendung
JP2013510166A (ja) 2009-11-06 2013-03-21 プレキシコン インコーポレーテッド キナーゼ調節のための化合物、方法およびその適用
WO2012085927A2 (en) * 2010-12-02 2012-06-28 Mylan Laboratories, Limited Tadalafil compositions
WO2012095151A1 (en) 2010-12-23 2012-07-19 Zaklady Farmaceutyczne Polpharma Sa Solid pharmaceutical dosage forms comprising tadalafil and methods of preparation thereof
AU2012214762B2 (en) 2011-02-07 2015-08-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2012107092A1 (en) 2011-02-10 2012-08-16 Synthon Bv Pharmaceutical composition comprising tadalafil and a cyclodextrin
RU2013141446A (ru) 2011-02-10 2015-03-20 Синтон Бв Фармацевтическая композиция, содержащая тадалафил и циклодекстрин
WO2012107090A1 (en) 2011-02-10 2012-08-16 Synthon Bv Granulated composition comprising tadalafil and a disintegrant
KR20140006879A (ko) 2011-02-17 2014-01-16 에프. 호프만-라 로슈 아게 고온 용융 압출에 의해 활성 약학 성분을 과냉된 액체 상태로부터 제어되는 방식으로 결정화시키는 방법
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
EP2535049A1 (en) 2011-06-17 2012-12-19 Proyecto de Biomedicina Cima, S.L. Tadalafil for the treatment of dementia
CN103827105B (zh) 2011-08-18 2016-08-17 雷迪博士实验室有限公司 作为胆固醇酯转移蛋白(cetp)抑制剂的取代的杂环胺化合物
CN103958511A (zh) 2011-09-27 2014-07-30 雷迪博士实验室有限公司 作为胆固醇酯转移蛋白(CETP)抑制剂用于治疗动脉粥样硬化的5-苄基氨基甲基-6-氨基吡唑并[3,4-b]吡啶衍生物
US20140128431A1 (en) 2012-04-03 2014-05-08 Hoffmann-Laroche Inc. Pharmaceutical composition with improved bioavailability, safety and tolerability
EP2649989B1 (en) 2012-04-13 2017-10-18 King Saud University Method for preparing a solid dispersion, solid dispersion obtained thereby and use thereof
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
WO2014003678A1 (en) * 2012-06-28 2014-01-03 Xspray Microparticles Ab Pharmaceutical compositions comprising ambrisentan and solid dispersion particles containing tadalafil
WO2014003677A1 (en) * 2012-06-28 2014-01-03 Xspray Microparticles Ab Pharmaceutical compositions comprising solid dispersion particles containing tadalafil
CA2891502A1 (en) 2012-11-19 2014-05-22 Dr. Reddy's Laboratories Ltd. Pharmaceutical compositions of cetp inhibitors
EP2948141A1 (en) * 2013-01-22 2015-12-02 F. Hoffmann-La Roche AG Pharmaceutical composition with improved bioavailability
CA2953917C (en) 2013-07-01 2021-10-19 The Research Foundation For The State University Of New York Ship inhibition to combat obesity
US20160339074A1 (en) * 2014-02-05 2016-11-24 Merck Sharp & Dohme Corp. Pharmaceutical composition of selective hcv ns3/4a inhibitors
AU2015277194B2 (en) 2014-06-17 2020-10-22 The Research Foundation For The State University Of New York Ship inhibition to induce activation of natural killer cells
SI3466951T1 (sl) 2014-07-23 2022-05-31 Krka, D.D., Novo Mesto Proces za pripravo zaviralca CGMP-fosfodiesteraze in oralne farmacevtske formulacije, ki obsega koprecipitate tadalafila
TWI586379B (zh) * 2015-06-29 2017-06-11 永信藥品工業股份有限公司 一種製作難溶藥物固體劑型的方法
CN105384740A (zh) * 2015-12-18 2016-03-09 海南通用康力制药有限公司 一种制备他达拉非的中间体高纯度晶体及制备方法
CN107663210A (zh) * 2016-07-28 2018-02-06 常州爱诺新睿医药技术有限公司 一种新的制备无水他达拉非晶型i的方法
KR102265644B1 (ko) * 2016-12-15 2021-06-16 후아 메디슨 (상하이) 엘티디. 글루코키나아제 활성화제의 경구제제 및 이의 제조방법
ES2824818T3 (es) 2018-01-10 2021-05-13 Gap S A Cápsulas de gelatina blanda que comprenden una suspensión de tadalafilo
CN114028574A (zh) * 2018-05-31 2022-02-11 华领医药技术（上海）有限公司 含葡萄糖激酶激活剂和双胍类降糖药物的药物组合、组合物和复方制剂及其制备方法和用途
WO2023227185A1 (en) 2022-05-27 2023-11-30 Rontis Hellas S.A. Improved pharmaceutical composition containing tadalafil and nanomilling process for the preparation thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0297866A3 (en) * 1987-07-01 1989-12-13 The Boots Company PLC Therapeutic agents
US5194263A (en) * 1989-01-20 1993-03-16 Allied Colloids Limited Particulate materials, their production and use
ES2121925T3 (es) * 1992-01-21 1998-12-16 Glaxo Wellcome Spa Derivados de 1,5-benzodiacepina y su uso en medicina.
GB9401090D0 (en) * 1994-01-21 1994-03-16 Glaxo Lab Sa Chemical compounds
US5665331A (en) * 1995-01-10 1997-09-09 Nanosystems L.L.C. Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers

Also Published As

Publication number Publication date
GB9511220D0 (en) 1995-07-26
WO1996038131A1 (en) 1996-12-05
ATE207344T1 (de) 2001-11-15
DE69616313T2 (de) 2002-04-18
EP0828479B1 (en) 2001-10-24
US5985326A (en) 1999-11-16
EP0828479A1 (en) 1998-03-18
AU6002696A (en) 1996-12-18
DE69616313D1 (de) 2001-11-29

Similar Documents

Publication Publication Date Title
ES2167566T3 (es) Metodo para obtener una dispersion solida de un farmaco poco soluble en agua.
PT839040E (pt) Utilizacao de inibidores da cgmp-fosfodiesterase para tratar a impotencia
BG100946A (en) New amino acid derivatives, method for their preparation and pharmaceutical compositions containing them
DE69104723T2 (de) Hustenstillendes und schleimregulierendes mittel, verfahren zu seiner herstellung und dieses enthaltende pharmazeutische zusammensetzungen.
EA199800340A1 (ru) Производные пиримидина как антагонисты 5нт2с
NO993027D0 (no) Pyrrolo[3,4-D]pyrimidinonderivater og deres anvendelse som legemidler
BR0107749A (pt) Métodos de uso de uma composição de bebida
AU5764496A (en) Cyclohexyl dihydrobenzofuranes
CA2187409A1 (en) Stable Crystalline Tetrahydrofolic Acid Salts
GEP20063972B (en) Streptogramin derivatives, preparation and compositions containing them
ATE138380T1 (de) Bicyclische pyrimidinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische präparate
IL116526A0 (en) Piperazinediones their preparation and use
PL328123A1 (en) Derivatives of banzo[c]quinolysine and method of obtaining them
AU693241B2 (en) New 3-substituted 3h-2,3-benzodiazepine derivatives, their preparation and use as medicaments
DE69927997D1 (de) Neuartige pyrimidin-derivate und verfahren zu ihrer herstellung
PL311296A1 (en) Derivatives of benzo [f] quinoxalinodione, method of obtaining them and their application in therapeutic agents
NO974687L (no) Kondenserte <beta>-carboliner