ES2121925T3 - Derivados de 1,5-benzodiacepina y su uso en medicina. - Google Patents
Derivados de 1,5-benzodiacepina y su uso en medicina.Info
- Publication number
- ES2121925T3 ES2121925T3 ES93200097T ES93200097T ES2121925T3 ES 2121925 T3 ES2121925 T3 ES 2121925T3 ES 93200097 T ES93200097 T ES 93200097T ES 93200097 T ES93200097 T ES 93200097T ES 2121925 T3 ES2121925 T3 ES 2121925T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- phenyl
- 4alkyl
- substituted
- bridgedcycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 108010089448 Cholecystokinin B Receptor Proteins 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 102000052874 Gastrin receptors Human genes 0.000 abstract 1
- 102100036016 Gastrin/cholecystokinin type B receptor Human genes 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- -1 hydroxy, phenyl Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE PRESENTAN COMPUESTOS DE LA FORMULA GENERAL (I) EN LA QUE R1 REPRESENTA UN GRUPO DE FENIL, DE CICLOALQUIL C3-C7, DE CICLOALQUIL PUENTEADO C7-C11 O DE ALQUIL C1-C6 DICHO GRUPO DE ALQUIL PUEDE ESTAR SUSTITUIDO POR UN GRUPO DE HIDROXIDO, FENIL, ALCOXICARBONIL C1-C3, CICLOALQUIL C3-C7 O CICLOALQUIL PUENTEADO C7-C11; R2 REPRESENTA UN GRUPO DE FENIL SUBSTITUIDO O INSUBSTITUIDO (EN EL QUE LOS SUSTITUYENTES PUEDEN SER 1 O 2 ENTRE HALO, ALQUIL C1C4, NITRO, CIANO, TRIFLUOROMETIL, TRIFLUOROMETOXIDO, ALQUILTIO C1-C4 O (CH2)N R4 EN DONDE R4 ES HIDROXIDO, ALCOXIDO C1-C3, CO2R5 O NR6R7. R3 ES FENIL OPCIONALMENTE SUSTITUIDO POR UNO O DOS ATOMOS DE HALOGENO; R5 REPRESENTA HIDROGENO O UN GRUPO ALQUIL C1-C4; R6 Y R7 REPRESENTAN INDEPENDIENTEMENTE HIDROGENO O UN GRUPO DE ALQUIL C1-C4. R8 REPRESENTA HIDROGENO O UN ATOMO DE HALOGENO; M ES 0, 1 O 2; N ES 0 O 1; LOS COMPUESTOS SON ANTAGONISTAS DE LA GASTRINA Y RECEPTORES DE CCK-B.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929201180A GB9201180D0 (en) | 1992-01-21 | 1992-01-21 | Chemical compounds |
| GB929221847A GB9221847D0 (en) | 1992-10-17 | 1992-10-17 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2121925T3 true ES2121925T3 (es) | 1998-12-16 |
Family
ID=26300183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93200097T Expired - Lifetime ES2121925T3 (es) | 1992-01-21 | 1993-01-15 | Derivados de 1,5-benzodiacepina y su uso en medicina. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0558104B1 (es) |
| AT (1) | ATE169007T1 (es) |
| DE (1) | DE69319945T2 (es) |
| DK (1) | DK0558104T3 (es) |
| ES (1) | ES2121925T3 (es) |
| SG (1) | SG52655A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1073089C (zh) * | 1993-12-28 | 2001-10-17 | 盐野义制药株式会社 | 苯并二氮杂噁衍生物、其组合物及其在药物制备中的用途 |
| ATE210447T1 (de) * | 1994-10-14 | 2001-12-15 | Glaxo Wellcome Spa | Verwendung von cck-b rezeptor antagonisten zur behandlung von schlafstörungen |
| GB9511220D0 (en) * | 1995-06-02 | 1995-07-26 | Glaxo Group Ltd | Solid dispersions |
| CU20090172A6 (es) | 2009-10-09 | 2011-10-05 | Facultad De Quimica Universidad De La Habana | Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2641280B1 (fr) * | 1988-12-29 | 1994-01-21 | Roussel Uclaf | Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments |
-
1993
- 1993-01-15 DE DE69319945T patent/DE69319945T2/de not_active Expired - Fee Related
- 1993-01-15 SG SG1996007401A patent/SG52655A1/en unknown
- 1993-01-15 DK DK93200097T patent/DK0558104T3/da active
- 1993-01-15 ES ES93200097T patent/ES2121925T3/es not_active Expired - Lifetime
- 1993-01-15 AT AT93200097T patent/ATE169007T1/de not_active IP Right Cessation
- 1993-01-15 EP EP93200097A patent/EP0558104B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69319945D1 (de) | 1998-09-03 |
| ATE169007T1 (de) | 1998-08-15 |
| DK0558104T3 (da) | 1999-04-26 |
| EP0558104B1 (en) | 1998-07-29 |
| SG52655A1 (en) | 1998-09-28 |
| EP0558104A1 (en) | 1993-09-01 |
| DE69319945T2 (de) | 1999-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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