ATE138380T1 - Bicyclische pyrimidinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische präparate - Google Patents
Bicyclische pyrimidinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische präparateInfo
- Publication number
- ATE138380T1 ATE138380T1 AT94902003T AT94902003T ATE138380T1 AT E138380 T1 ATE138380 T1 AT E138380T1 AT 94902003 T AT94902003 T AT 94902003T AT 94902003 T AT94902003 T AT 94902003T AT E138380 T1 ATE138380 T1 AT E138380T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- production
- pharmaceutical preparations
- bicyclic pyrimidine
- preparations containing
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940034982 antineoplastic agent Drugs 0.000 abstract 1
- -1 bicyclic pyrimidine compounds Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9214913A FR2699176B1 (fr) | 1992-12-11 | 1992-12-11 | Nouveaux composés bicycliques de pyrimidine, leur procédé de préparation et les compositions pharmaceutiques les renfermant. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE138380T1 true ATE138380T1 (de) | 1996-06-15 |
Family
ID=9436453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94902003T ATE138380T1 (de) | 1992-12-11 | 1993-12-09 | Bicyclische pyrimidinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische präparate |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5508277A (de) |
| EP (1) | EP0673376B1 (de) |
| JP (1) | JPH08504426A (de) |
| AT (1) | ATE138380T1 (de) |
| AU (1) | AU666422B2 (de) |
| CA (1) | CA2117462A1 (de) |
| DE (1) | DE69302829T2 (de) |
| DK (1) | DK0673376T3 (de) |
| ES (1) | ES2091126T3 (de) |
| FR (1) | FR2699176B1 (de) |
| GR (1) | GR3020330T3 (de) |
| NZ (1) | NZ258595A (de) |
| WO (1) | WO1994013668A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE9110772U1 (de) * | 1991-08-30 | 1991-11-14 | Wolf - Geräte GmbH Vertriebsgesellschaft KG, 5240 Betzdorf | Gartenschere |
| FR2699176B1 (fr) * | 1992-12-11 | 1995-03-03 | Adir | Nouveaux composés bicycliques de pyrimidine, leur procédé de préparation et les compositions pharmaceutiques les renfermant. |
| US6794390B2 (en) * | 1996-08-02 | 2004-09-21 | Cv Therapeutics, Inc. | Purine inhibitors of cyclin dependent kinase 2 & ikappabalpha |
| US5866702A (en) * | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
| JP4202250B2 (ja) | 2001-07-25 | 2008-12-24 | バイオマリン ファーマシューティカル インコーポレイテッド | 血液脳関門輸送を調節するための組成物および方法 |
| CA2789262C (en) | 2005-04-28 | 2016-10-04 | Proteus Digital Health, Inc. | Pharma-informatics system |
| JP2009502801A (ja) | 2005-07-22 | 2009-01-29 | サネシス ファーマシューティカルズ, インコーポレイテッド | Auroraキナーゼインヒビターとして有用なピラゾロピリミジン |
| US8795627B2 (en) | 2007-03-21 | 2014-08-05 | Raptor Pharmaceuticals Inc. | Treatment of liver disorders by administration of RAP conjugates |
| ES2919563T3 (es) | 2009-02-20 | 2022-07-27 | Enhanx Biopharm Inc | Sistema de administración de medicamentos a base de glutatión |
| WO2010114894A1 (en) | 2009-03-31 | 2010-10-07 | Arqule, Inc. | Substituted heterocyclic compounds |
| CN110075069A (zh) | 2009-05-06 | 2019-08-02 | 实验室护肤股份有限公司 | 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| US20250213546A1 (en) * | 2022-04-01 | 2025-07-03 | Drexel University | Treating cancer with small molecules that inhibit acss-2 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1544419A (en) * | 1975-11-19 | 1979-04-19 | Science Union & Cie | Purines and pyrazolo-pyrimidines a process for their preparation and pharmaceutical compositions containing them |
| DE2804416A1 (de) * | 1978-02-02 | 1979-08-09 | Boehringer Mannheim Gmbh | Neue purin-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| US5204353A (en) * | 1987-04-07 | 1993-04-20 | Ciba-Geigy Corporation | 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith |
| US4999363A (en) * | 1988-06-09 | 1991-03-12 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds |
| EP0363320A3 (de) * | 1988-10-06 | 1991-11-21 | Ciba-Geigy Ag | Substituierte 9H-Purine |
| FR2643373B1 (fr) * | 1989-01-10 | 1993-12-31 | Adir Cie | Nouveaux derives des bisarylalcenes, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| US5256650A (en) * | 1989-03-29 | 1993-10-26 | Merrell Dow Pharmaceuticals Inc. | Selective adenosine receptor agents |
| EP0514540B1 (de) * | 1989-09-19 | 1996-07-17 | Teijin Limited | Pyrrolo[2,3-d]pyrimidinderivate, verfahren zur herstellung und arzneimittelzusammensetzungen die diese enthalten |
| ES2087916T3 (es) * | 1989-10-11 | 1996-08-01 | Teijin Ltd | Derivado de pirimidina biciclico, metodo para producir el mismo, y preparacion farmaceutica que contiene el mismo como ingrediente activo. |
| US5397782A (en) * | 1990-06-13 | 1995-03-14 | Janssen Pharmaceutica N.V. | Method of treating addiction to alcohol |
| US5217980A (en) * | 1990-07-19 | 1993-06-08 | Janssen Pharmaceutica N.V. | Oxazolyl and piperidinyl substituted benimidazolyl compounds |
| KR0168404B1 (ko) * | 1990-12-06 | 1999-03-20 | 오오가 노리오 | 피드백 클램프 회로 |
| FR2699176B1 (fr) * | 1992-12-11 | 1995-03-03 | Adir | Nouveaux composés bicycliques de pyrimidine, leur procédé de préparation et les compositions pharmaceutiques les renfermant. |
-
1992
- 1992-12-11 FR FR9214913A patent/FR2699176B1/fr not_active Expired - Fee Related
-
1993
- 1993-12-09 NZ NZ258595A patent/NZ258595A/en unknown
- 1993-12-09 CA CA002117462A patent/CA2117462A1/fr not_active Abandoned
- 1993-12-09 JP JP6513866A patent/JPH08504426A/ja active Pending
- 1993-12-09 DE DE69302829T patent/DE69302829T2/de not_active Expired - Fee Related
- 1993-12-09 US US08/284,689 patent/US5508277A/en not_active Expired - Fee Related
- 1993-12-09 WO PCT/FR1993/001211 patent/WO1994013668A1/fr not_active Ceased
- 1993-12-09 AT AT94902003T patent/ATE138380T1/de not_active IP Right Cessation
- 1993-12-09 ES ES94902003T patent/ES2091126T3/es not_active Expired - Lifetime
- 1993-12-09 EP EP94902003A patent/EP0673376B1/de not_active Expired - Lifetime
- 1993-12-09 AU AU56535/94A patent/AU666422B2/en not_active Ceased
- 1993-12-09 DK DK94902003.6T patent/DK0673376T3/da active
-
1996
- 1996-06-24 GR GR960401699T patent/GR3020330T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0673376B1 (de) | 1996-05-22 |
| CA2117462A1 (fr) | 1994-06-23 |
| AU5653594A (en) | 1994-07-04 |
| DK0673376T3 (da) | 1996-10-07 |
| GR3020330T3 (en) | 1996-09-30 |
| NZ258595A (en) | 1996-04-26 |
| EP0673376A1 (de) | 1995-09-27 |
| US5508277A (en) | 1996-04-16 |
| WO1994013668A1 (fr) | 1994-06-23 |
| DE69302829D1 (de) | 1996-06-27 |
| AU666422B2 (en) | 1996-02-08 |
| JPH08504426A (ja) | 1996-05-14 |
| DE69302829T2 (de) | 1996-11-28 |
| FR2699176A1 (fr) | 1994-06-17 |
| FR2699176B1 (fr) | 1995-03-03 |
| ES2091126T3 (es) | 1996-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |