ES2160587T3 - Procedimiento en un solo recipiente para preparar pergolida. - Google Patents

Procedimiento en un solo recipiente para preparar pergolida.

Info

Publication number
ES2160587T3
ES2160587T3 ES93303895T ES93303895T ES2160587T3 ES 2160587 T3 ES2160587 T3 ES 2160587T3 ES 93303895 T ES93303895 T ES 93303895T ES 93303895 T ES93303895 T ES 93303895T ES 2160587 T3 ES2160587 T3 ES 2160587T3
Authority
ES
Spain
Prior art keywords
single container
pergolide
prepare
procedure
yodopropane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93303895T
Other languages
English (en)
Inventor
Jerry Wayne Misner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2160587T3 publication Critical patent/ES2160587T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D457/00Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE PRODUCE PERGOLIDA A PARTIR DE 8.9-DIHIDROELIMOCLAVINA MEDIANTE UN PROCESO EN UN SOLO RECIPIENTE EN EL QUE SE SOMETE A REACCION SUCESIVAMENTE CON 1-YODOPROPANO, CON UN HALURO SULFONILO, Y CON METAL ALCALINO TIOMETOXIDO SIN EL AISLAMIENTO DE PRODUCTOS INTERMEDIOS.
ES93303895T 1992-05-21 1993-05-19 Procedimiento en un solo recipiente para preparar pergolida. Expired - Lifetime ES2160587T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/886,800 US5463060A (en) 1992-05-21 1992-05-21 One-pot process

Publications (1)

Publication Number Publication Date
ES2160587T3 true ES2160587T3 (es) 2001-11-16

Family

ID=25389802

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93303895T Expired - Lifetime ES2160587T3 (es) 1992-05-21 1993-05-19 Procedimiento en un solo recipiente para preparar pergolida.

Country Status (28)

Country Link
US (1) US5463060A (es)
EP (1) EP0571202B1 (es)
JP (1) JP3580565B2 (es)
KR (1) KR100285971B1 (es)
CN (1) CN1040438C (es)
AR (1) AR248023A1 (es)
AT (1) ATE203750T1 (es)
AU (1) AU656075B2 (es)
BR (1) BR9302016A (es)
CA (1) CA2095593C (es)
CZ (1) CZ283997B6 (es)
DE (1) DE69330506T2 (es)
DK (1) DK0571202T3 (es)
ES (1) ES2160587T3 (es)
FI (1) FI114476B (es)
GR (1) GR3037000T3 (es)
HU (1) HU210324B (es)
IL (1) IL105695A (es)
MX (1) MX9302883A (es)
MY (1) MY108884A (es)
NO (1) NO302416B1 (es)
NZ (1) NZ247545A (es)
PH (1) PH30663A (es)
PL (1) PL173522B1 (es)
PT (1) PT571202E (es)
RU (1) RU2108333C1 (es)
TW (1) TW215438B (es)
YU (1) YU49022B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1307934B1 (it) * 1999-01-27 2001-11-29 Poli Ind Chimica Spa Processo per la preparazione di derivati alchimercaptometilergolinici.
US6388079B1 (en) 2000-08-29 2002-05-14 Scinopharm Singapore Pte Ltd. Process for preparing pergolide
CN1561335A (zh) * 2001-10-02 2005-01-05 日本曹达株式会社 乙烯衍生物的制备方法
WO2003078432A2 (en) * 2002-03-15 2003-09-25 Antibioticos S.P.A. Process for the synthesis of pergolide
CN110330495A (zh) * 2019-08-08 2019-10-15 重庆大学 一种合成麦角碱的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4782152A (en) * 1985-08-16 1988-11-01 Eli Lilly And Company Decyanation of pergolide intermediate

Also Published As

Publication number Publication date
NO931839D0 (no) 1993-05-19
HUT64539A (en) 1994-01-28
EP0571202B1 (en) 2001-08-01
PL173522B1 (pl) 1998-03-31
MY108884A (en) 1996-11-30
EP0571202A1 (en) 1993-11-24
DK0571202T3 (da) 2001-10-08
IL105695A (en) 1997-08-14
YU49022B (sh) 2003-07-07
JPH069630A (ja) 1994-01-18
PT571202E (pt) 2001-11-30
PH30663A (en) 1997-09-16
HU9301460D0 (en) 1993-09-28
HU210324B (en) 1995-03-28
AU3847693A (en) 1993-11-25
NO931839L (no) 1993-11-22
FI114476B (fi) 2004-10-29
KR930023365A (ko) 1993-12-18
JP3580565B2 (ja) 2004-10-27
CN1082544A (zh) 1994-02-23
DE69330506T2 (de) 2002-04-11
CZ93793A3 (en) 1994-01-19
IL105695A0 (en) 1993-09-22
NZ247545A (en) 1995-03-28
RU2108333C1 (ru) 1998-04-10
CA2095593C (en) 2003-09-30
BR9302016A (pt) 1993-11-30
KR100285971B1 (ko) 2001-05-02
NO302416B1 (no) 1998-03-02
FI932281A (fi) 1993-11-22
PL299010A1 (en) 1993-12-27
YU34593A (sh) 1996-05-20
FI932281A0 (fi) 1993-05-19
CA2095593A1 (en) 1993-11-22
CZ283997B6 (cs) 1998-07-15
GR3037000T3 (en) 2002-01-31
DE69330506D1 (de) 2001-09-06
TW215438B (en) 1993-11-01
MX9302883A (es) 1993-11-01
ATE203750T1 (de) 2001-08-15
AU656075B2 (en) 1995-01-19
CN1040438C (zh) 1998-10-28
AR248023A1 (es) 1995-05-31
US5463060A (en) 1995-10-31

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