DE69330506D1 - Eintopfverfahren zur Herstellung von Pergolid - Google Patents
Eintopfverfahren zur Herstellung von PergolidInfo
- Publication number
- DE69330506D1 DE69330506D1 DE69330506T DE69330506T DE69330506D1 DE 69330506 D1 DE69330506 D1 DE 69330506D1 DE 69330506 T DE69330506 T DE 69330506T DE 69330506 T DE69330506 T DE 69330506T DE 69330506 D1 DE69330506 D1 DE 69330506D1
- Authority
- DE
- Germany
- Prior art keywords
- pergolide
- production
- pot process
- pot
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000005580 one pot reaction Methods 0.000 title 1
- YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 title 1
- 229960004851 pergolide Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/886,800 US5463060A (en) | 1992-05-21 | 1992-05-21 | One-pot process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69330506D1 true DE69330506D1 (de) | 2001-09-06 |
| DE69330506T2 DE69330506T2 (de) | 2002-04-11 |
Family
ID=25389802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69330506T Expired - Fee Related DE69330506T2 (de) | 1992-05-21 | 1993-05-19 | Eintopfverfahren zur Herstellung von Pergolid |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5463060A (de) |
| EP (1) | EP0571202B1 (de) |
| JP (1) | JP3580565B2 (de) |
| KR (1) | KR100285971B1 (de) |
| CN (1) | CN1040438C (de) |
| AR (1) | AR248023A1 (de) |
| AT (1) | ATE203750T1 (de) |
| AU (1) | AU656075B2 (de) |
| BR (1) | BR9302016A (de) |
| CA (1) | CA2095593C (de) |
| CZ (1) | CZ283997B6 (de) |
| DE (1) | DE69330506T2 (de) |
| DK (1) | DK0571202T3 (de) |
| ES (1) | ES2160587T3 (de) |
| FI (1) | FI114476B (de) |
| GR (1) | GR3037000T3 (de) |
| HU (1) | HU210324B (de) |
| IL (1) | IL105695A (de) |
| MX (1) | MX9302883A (de) |
| MY (1) | MY108884A (de) |
| NO (1) | NO302416B1 (de) |
| NZ (1) | NZ247545A (de) |
| PH (1) | PH30663A (de) |
| PL (1) | PL173522B1 (de) |
| PT (1) | PT571202E (de) |
| RU (1) | RU2108333C1 (de) |
| TW (1) | TW215438B (de) |
| YU (1) | YU49022B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1307934B1 (it) * | 1999-01-27 | 2001-11-29 | Poli Ind Chimica Spa | Processo per la preparazione di derivati alchimercaptometilergolinici. |
| US6388079B1 (en) | 2000-08-29 | 2002-05-14 | Scinopharm Singapore Pte Ltd. | Process for preparing pergolide |
| KR20040047880A (ko) * | 2001-10-02 | 2004-06-05 | 닛뽕소다 가부시키가이샤 | 에텐 유도체의 제조 방법 |
| DE60324776D1 (de) * | 2002-03-15 | 2009-01-02 | Antibioticos Spa | Verfahren zur synthese von pergolid |
| CN110330495A (zh) * | 2019-08-08 | 2019-10-15 | 重庆大学 | 一种合成麦角碱的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166182A (en) * | 1978-02-08 | 1979-08-28 | Eli Lilly And Company | 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
| US4782152A (en) * | 1985-08-16 | 1988-11-01 | Eli Lilly And Company | Decyanation of pergolide intermediate |
-
1992
- 1992-05-21 US US07/886,800 patent/US5463060A/en not_active Expired - Lifetime
-
1993
- 1993-05-04 NZ NZ247545A patent/NZ247545A/en not_active IP Right Cessation
- 1993-05-05 TW TW082103515A patent/TW215438B/zh active
- 1993-05-05 CA CA002095593A patent/CA2095593C/en not_active Expired - Fee Related
- 1993-05-10 AU AU38476/93A patent/AU656075B2/en not_active Ceased
- 1993-05-13 IL IL10569593A patent/IL105695A/xx not_active IP Right Cessation
- 1993-05-18 MY MYPI93000916A patent/MY108884A/en unknown
- 1993-05-18 AR AR93324957A patent/AR248023A1/es active
- 1993-05-18 CZ CZ93937A patent/CZ283997B6/cs not_active IP Right Cessation
- 1993-05-18 MX MX9302883A patent/MX9302883A/es not_active IP Right Cessation
- 1993-05-19 HU HU9301460A patent/HU210324B/hu not_active IP Right Cessation
- 1993-05-19 YU YU34593A patent/YU49022B/sh unknown
- 1993-05-19 PT PT93303895T patent/PT571202E/pt unknown
- 1993-05-19 DE DE69330506T patent/DE69330506T2/de not_active Expired - Fee Related
- 1993-05-19 FI FI932281A patent/FI114476B/fi active IP Right Grant
- 1993-05-19 NO NO931839A patent/NO302416B1/no unknown
- 1993-05-19 AT AT93303895T patent/ATE203750T1/de not_active IP Right Cessation
- 1993-05-19 EP EP93303895A patent/EP0571202B1/de not_active Expired - Lifetime
- 1993-05-19 DK DK93303895T patent/DK0571202T3/da active
- 1993-05-19 ES ES93303895T patent/ES2160587T3/es not_active Expired - Lifetime
- 1993-05-20 PH PH46211A patent/PH30663A/en unknown
- 1993-05-20 CN CN93106151A patent/CN1040438C/zh not_active Expired - Fee Related
- 1993-05-20 JP JP11822693A patent/JP3580565B2/ja not_active Expired - Fee Related
- 1993-05-20 KR KR1019930008679A patent/KR100285971B1/ko not_active IP Right Cessation
- 1993-05-20 RU RU93005369A patent/RU2108333C1/ru not_active IP Right Cessation
- 1993-05-20 PL PL93299010A patent/PL173522B1/pl not_active IP Right Cessation
- 1993-05-20 BR BR9302016A patent/BR9302016A/pt not_active Application Discontinuation
-
2001
- 2001-10-24 GR GR20010401873T patent/GR3037000T3/el not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |