AR248023A1 - Un procedimiento en un solo recipiente para preparar pergolida. - Google Patents

Un procedimiento en un solo recipiente para preparar pergolida.

Info

Publication number
AR248023A1
AR248023A1 AR93324957A AR32495793A AR248023A1 AR 248023 A1 AR248023 A1 AR 248023A1 AR 93324957 A AR93324957 A AR 93324957A AR 32495793 A AR32495793 A AR 32495793A AR 248023 A1 AR248023 A1 AR 248023A1
Authority
AR
Argentina
Prior art keywords
pergolide
mixture
prepare
gross
dilute
Prior art date
Application number
AR93324957A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of AR248023A1 publication Critical patent/AR248023A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D457/00Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN PROCESO EN UN SOLO RECIPIENTE PARA PREPARAR PERGOLIDA QUE COMPRENDE REACCIONAR 8, 9-DIHIDROELIMOCLAVINA CON 1-YODOPROPANO A ELEVADA TEMPERATURA EN PRESENCIA DE UN BICARBONATO O CARBONATO DE CALCIO, MAGNESIO ALCALINO METALICO Y UN DISOLVENTE COMO DE N-METILPIRROLIDINONA, HEXAMETILFOSFORAMIDA, DIMETILPROPILENOUREA Y DIMETILETILENOUREA HASTA QUE LA 8, 9-DIHIDROELIMOCLAVINA SE CONSUME SUBSTANCIALMENTE PARA PREPARAR UNA PRIMERA MEZCLA INTERMEDIA; DILUIR LA PRIMERA MEZCLA INTERMEDIA CON UN VOLUMEN GRANDE DE UN DISOLVENTE COMO PIRIDINA, PICOLINA Y LUTIDINA, ENFRIAR LA MEZCLA DILUIDA A UNA TEMPERATURA BAJA, COMBINARLA CON UN HALURO DE TOLUENO O DE ALCANOSULFONILO HASTA COMPLETAR LA REACCION PARA PREPARAR UNA SEGUNDA MEZCLA INTERMEDIA; COMBINAR ESTA CON UNA SOLUCION FRIA DE TIOMETOXIDO ALCALINO METALICO Y DEJAR QUE REACCIONE TOTALMENTE PARA PREPARAR UNA MEZCLA DE PERGOLIDA BRUTA; DILUIR LA MEZCLA DE PERGOLIDA BRUTA CON AGUA PARA OBTENER PERGOLIDA SOLIDA, Y LAVAR LA PERGOLIDA CON AGUA PA RA OBTENER PERGOLIDA DE AL MENOS 90% DE PUREZA.
AR93324957A 1992-05-21 1993-05-18 Un procedimiento en un solo recipiente para preparar pergolida. AR248023A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/886,800 US5463060A (en) 1992-05-21 1992-05-21 One-pot process

Publications (1)

Publication Number Publication Date
AR248023A1 true AR248023A1 (es) 1995-05-31

Family

ID=25389802

Family Applications (1)

Application Number Title Priority Date Filing Date
AR93324957A AR248023A1 (es) 1992-05-21 1993-05-18 Un procedimiento en un solo recipiente para preparar pergolida.

Country Status (28)

Country Link
US (1) US5463060A (es)
EP (1) EP0571202B1 (es)
JP (1) JP3580565B2 (es)
KR (1) KR100285971B1 (es)
CN (1) CN1040438C (es)
AR (1) AR248023A1 (es)
AT (1) ATE203750T1 (es)
AU (1) AU656075B2 (es)
BR (1) BR9302016A (es)
CA (1) CA2095593C (es)
CZ (1) CZ283997B6 (es)
DE (1) DE69330506T2 (es)
DK (1) DK0571202T3 (es)
ES (1) ES2160587T3 (es)
FI (1) FI114476B (es)
GR (1) GR3037000T3 (es)
HU (1) HU210324B (es)
IL (1) IL105695A (es)
MX (1) MX9302883A (es)
MY (1) MY108884A (es)
NO (1) NO302416B1 (es)
NZ (1) NZ247545A (es)
PH (1) PH30663A (es)
PL (1) PL173522B1 (es)
PT (1) PT571202E (es)
RU (1) RU2108333C1 (es)
TW (1) TW215438B (es)
YU (1) YU49022B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1307934B1 (it) * 1999-01-27 2001-11-29 Poli Ind Chimica Spa Processo per la preparazione di derivati alchimercaptometilergolinici.
US6388079B1 (en) 2000-08-29 2002-05-14 Scinopharm Singapore Pte Ltd. Process for preparing pergolide
US20040242933A1 (en) * 2001-10-02 2004-12-02 Nobuo Matsui Process for preparation of ethene derivatives
US7019140B2 (en) * 2002-03-15 2006-03-28 Antibioticos S.P.A. Process for the synthesis of pergolide
CN110330495A (zh) * 2019-08-08 2019-10-15 重庆大学 一种合成麦角碱的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4782152A (en) * 1985-08-16 1988-11-01 Eli Lilly And Company Decyanation of pergolide intermediate

Also Published As

Publication number Publication date
HU210324B (en) 1995-03-28
HUT64539A (en) 1994-01-28
ES2160587T3 (es) 2001-11-16
DK0571202T3 (da) 2001-10-08
PH30663A (en) 1997-09-16
CA2095593C (en) 2003-09-30
MY108884A (en) 1996-11-30
DE69330506D1 (de) 2001-09-06
FI932281A (fi) 1993-11-22
US5463060A (en) 1995-10-31
NO931839L (no) 1993-11-22
CN1082544A (zh) 1994-02-23
CN1040438C (zh) 1998-10-28
FI932281A0 (fi) 1993-05-19
IL105695A (en) 1997-08-14
ATE203750T1 (de) 2001-08-15
JP3580565B2 (ja) 2004-10-27
AU3847693A (en) 1993-11-25
NZ247545A (en) 1995-03-28
RU2108333C1 (ru) 1998-04-10
YU34593A (sh) 1996-05-20
AU656075B2 (en) 1995-01-19
GR3037000T3 (en) 2002-01-31
HU9301460D0 (en) 1993-09-28
JPH069630A (ja) 1994-01-18
PT571202E (pt) 2001-11-30
EP0571202B1 (en) 2001-08-01
TW215438B (en) 1993-11-01
CZ283997B6 (cs) 1998-07-15
PL173522B1 (pl) 1998-03-31
CA2095593A1 (en) 1993-11-22
NO931839D0 (no) 1993-05-19
IL105695A0 (en) 1993-09-22
MX9302883A (es) 1993-11-01
FI114476B (fi) 2004-10-29
DE69330506T2 (de) 2002-04-11
KR930023365A (ko) 1993-12-18
NO302416B1 (no) 1998-03-02
BR9302016A (pt) 1993-11-30
EP0571202A1 (en) 1993-11-24
CZ93793A3 (en) 1994-01-19
PL299010A1 (en) 1993-12-27
YU49022B (sh) 2003-07-07
KR100285971B1 (ko) 2001-05-02

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