YU34593A - Postupak sa jednim sudom za dobijanje pergolida - Google Patents

Postupak sa jednim sudom za dobijanje pergolida

Info

Publication number
YU34593A
YU34593A YU34593A YU34593A YU34593A YU 34593 A YU34593 A YU 34593A YU 34593 A YU34593 A YU 34593A YU 34593 A YU34593 A YU 34593A YU 34593 A YU34593 A YU 34593A
Authority
YU
Yugoslavia
Prior art keywords
pergolide
mixture
alkali metal
water
consumed
Prior art date
Application number
YU34593A
Other languages
English (en)
Other versions
YU49022B (sh
Inventor
J. Wayne Misner
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of YU34593A publication Critical patent/YU34593A/sh
Publication of YU49022B publication Critical patent/YU49022B/sh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D457/00Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

POSTUPAK SA JEDNIM SUDOM ZA DOBIJANJE PERGOLIDA, postupak sa jednim sudom za dobijanje pergolida koji obuhvata reakciju dihidrolizergola 8,9-dihidroelimoklavina sa 1-jodpropanom na povišenoj temperaturi u prisustvu kalcijuma, magnezijuma ili bikarbonata alkalnog metala ili karbonata i rastvarača izabranih iz N-metilpirolidinona, heksametilfosforamida, dimetilpropilenkarbamida i dimetiletilenkarbamida sve dok 8,9-dihidroelimoklavin ne bude znatno potrošen radi dobijanja smeše prvog intermedijara; razblaživanje smeše prvog intermedijara velikom zapreminom osnovnog rastvarača izabranog iz piridina, pikolina i lutidina, hladjenjem razblažene smeše do niske temperature, njenim spajanjem sa toluenom ili C1-C3 alkansulfonil halogenidom, i omogućavanjem nastavka reakcije na niskoj temperaturi sve dok pri intermedijar ne bude u osnovi potrošen da bi se dobila smeša drugog intermedijara; sjedinjavanjem hladne smeše drugog intermedijara sa hladnim rastvorom tiometoksida alkalnog metala, i omogućavanjem nastavka reakcije na povišenoj temperaturi sve dok drugi intermedijar ne bude u osnovi potrošen radi dobijanja sirove smeše pergolida; razblaživanjem sirove smeše pergolida vodom radi dobijanja smeše čvrstog pergolida sa vodom radi dobijanja čvrstog pergolida, i ispiranjem pergolida vodom radi dobijanja pergolida čistoće od najamanje 90%.
YU34593A 1992-05-21 1993-05-19 Postupak sa jednim sudom za dobijanje pergolida YU49022B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/886,800 US5463060A (en) 1992-05-21 1992-05-21 One-pot process

Publications (2)

Publication Number Publication Date
YU34593A true YU34593A (sh) 1996-05-20
YU49022B YU49022B (sh) 2003-07-07

Family

ID=25389802

Family Applications (1)

Application Number Title Priority Date Filing Date
YU34593A YU49022B (sh) 1992-05-21 1993-05-19 Postupak sa jednim sudom za dobijanje pergolida

Country Status (28)

Country Link
US (1) US5463060A (sh)
EP (1) EP0571202B1 (sh)
JP (1) JP3580565B2 (sh)
KR (1) KR100285971B1 (sh)
CN (1) CN1040438C (sh)
AR (1) AR248023A1 (sh)
AT (1) ATE203750T1 (sh)
AU (1) AU656075B2 (sh)
BR (1) BR9302016A (sh)
CA (1) CA2095593C (sh)
CZ (1) CZ283997B6 (sh)
DE (1) DE69330506T2 (sh)
DK (1) DK0571202T3 (sh)
ES (1) ES2160587T3 (sh)
FI (1) FI114476B (sh)
GR (1) GR3037000T3 (sh)
HU (1) HU210324B (sh)
IL (1) IL105695A (sh)
MX (1) MX9302883A (sh)
MY (1) MY108884A (sh)
NO (1) NO302416B1 (sh)
NZ (1) NZ247545A (sh)
PH (1) PH30663A (sh)
PL (1) PL173522B1 (sh)
PT (1) PT571202E (sh)
RU (1) RU2108333C1 (sh)
TW (1) TW215438B (sh)
YU (1) YU49022B (sh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1307934B1 (it) * 1999-01-27 2001-11-29 Poli Ind Chimica Spa Processo per la preparazione di derivati alchimercaptometilergolinici.
US6388079B1 (en) 2000-08-29 2002-05-14 Scinopharm Singapore Pte Ltd. Process for preparing pergolide
US20040242933A1 (en) * 2001-10-02 2004-12-02 Nobuo Matsui Process for preparation of ethene derivatives
US7019140B2 (en) * 2002-03-15 2006-03-28 Antibioticos S.P.A. Process for the synthesis of pergolide
CN110330495A (zh) * 2019-08-08 2019-10-15 重庆大学 一种合成麦角碱的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4782152A (en) * 1985-08-16 1988-11-01 Eli Lilly And Company Decyanation of pergolide intermediate

Also Published As

Publication number Publication date
HU210324B (en) 1995-03-28
HUT64539A (en) 1994-01-28
ES2160587T3 (es) 2001-11-16
DK0571202T3 (da) 2001-10-08
PH30663A (en) 1997-09-16
CA2095593C (en) 2003-09-30
MY108884A (en) 1996-11-30
DE69330506D1 (de) 2001-09-06
FI932281A (fi) 1993-11-22
US5463060A (en) 1995-10-31
NO931839L (no) 1993-11-22
CN1082544A (zh) 1994-02-23
CN1040438C (zh) 1998-10-28
FI932281A0 (fi) 1993-05-19
IL105695A (en) 1997-08-14
ATE203750T1 (de) 2001-08-15
JP3580565B2 (ja) 2004-10-27
AU3847693A (en) 1993-11-25
NZ247545A (en) 1995-03-28
RU2108333C1 (ru) 1998-04-10
AU656075B2 (en) 1995-01-19
GR3037000T3 (en) 2002-01-31
AR248023A1 (es) 1995-05-31
HU9301460D0 (en) 1993-09-28
JPH069630A (ja) 1994-01-18
PT571202E (pt) 2001-11-30
EP0571202B1 (en) 2001-08-01
TW215438B (en) 1993-11-01
CZ283997B6 (cs) 1998-07-15
PL173522B1 (pl) 1998-03-31
CA2095593A1 (en) 1993-11-22
NO931839D0 (no) 1993-05-19
IL105695A0 (en) 1993-09-22
MX9302883A (es) 1993-11-01
FI114476B (fi) 2004-10-29
DE69330506T2 (de) 2002-04-11
KR930023365A (ko) 1993-12-18
NO302416B1 (no) 1998-03-02
BR9302016A (pt) 1993-11-30
EP0571202A1 (en) 1993-11-24
CZ93793A3 (en) 1994-01-19
PL299010A1 (en) 1993-12-27
YU49022B (sh) 2003-07-07
KR100285971B1 (ko) 2001-05-02

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