ES2158493T3 - Agentes farmaceuticos que contienen complejos metalicos con un contenido de perfluoroalquilo y su utilizacion en la terapia de tumores y en la radiologia intervencional. - Google Patents

Agentes farmaceuticos que contienen complejos metalicos con un contenido de perfluoroalquilo y su utilizacion en la terapia de tumores y en la radiologia intervencional.

Info

Publication number
ES2158493T3
ES2158493T3 ES97903278T ES97903278T ES2158493T3 ES 2158493 T3 ES2158493 T3 ES 2158493T3 ES 97903278 T ES97903278 T ES 97903278T ES 97903278 T ES97903278 T ES 97903278T ES 2158493 T3 ES2158493 T3 ES 2158493T3
Authority
ES
Spain
Prior art keywords
tumor therapy
perfluoroalquilo
interventional radiology
content
pharmaceutical agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97903278T
Other languages
English (en)
Spanish (es)
Inventor
Johannes Platzek
Ulrich Niedballa
Bernd Raduchel
Wolfgang Schlecker
Hanns-Joachim Weinmann
Thomas Frenzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2158493T3 publication Critical patent/ES2158493T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/244—Lanthanides; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES97903278T 1996-02-23 1997-02-14 Agentes farmaceuticos que contienen complejos metalicos con un contenido de perfluoroalquilo y su utilizacion en la terapia de tumores y en la radiologia intervencional. Expired - Lifetime ES2158493T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19608278A DE19608278A1 (de) 1996-02-23 1996-02-23 Pharmazeutische Mittel enthaltend perfluoralkylhaltige Metallkomplexe, und ihre Verwendung in der Tumortherapie und interventioniellen Radiologie

Publications (1)

Publication Number Publication Date
ES2158493T3 true ES2158493T3 (es) 2001-09-01

Family

ID=7787153

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97903278T Expired - Lifetime ES2158493T3 (es) 1996-02-23 1997-02-14 Agentes farmaceuticos que contienen complejos metalicos con un contenido de perfluoroalquilo y su utilizacion en la terapia de tumores y en la radiologia intervencional.

Country Status (14)

Country Link
EP (1) EP0882010B1 (enExample)
JP (1) JP2000504736A (enExample)
AT (1) ATE200894T1 (enExample)
AU (1) AU1769297A (enExample)
CA (1) CA2247253A1 (enExample)
DE (2) DE19608278A1 (enExample)
DK (1) DK0882010T3 (enExample)
ES (1) ES2158493T3 (enExample)
GR (1) GR3036306T3 (enExample)
NO (1) NO323547B1 (enExample)
PT (1) PT882010E (enExample)
TW (1) TW477699B (enExample)
WO (1) WO1997030969A1 (enExample)
ZA (1) ZA971537B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919433A (en) * 1996-12-04 1999-07-06 Schering Aktiengesellschaft Macrocyclic metal complex carboxylic acids, their use as well as process for their production
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
DE19731591C2 (de) * 1997-07-17 1999-09-16 Schering Ag Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie
US6342598B1 (en) 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
US6461587B1 (en) 1999-03-22 2002-10-08 Schering Aktiengesellschaft Perfluoroalkylamides, their production and their use in diagnosis
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
US6676928B2 (en) 2000-08-11 2004-01-13 Schering Aktiengesellschaft Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use
DE10040858C2 (de) * 2000-08-11 2003-12-18 Schering Ag Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung
JP2005501082A (ja) * 2001-08-03 2005-01-13 グラクソ　グループ　リミテッド 界面活性剤化合物およびその使用
AU2003249999A1 (en) * 2002-07-10 2004-02-02 Hans Robert Kalbitzer 1,4,7,10-tetraazacyclododecanes as modulators of the guanine-binding protein for treating tumours
DE102005008309A1 (de) * 2005-02-17 2006-08-24 Schering Ag Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone
ITMI20131225A1 (it) * 2013-07-22 2015-01-23 Miteni Spa Nuovi composti organici fluorurati, procedimento per la loro preparazione e loro uso come intermedi di sintesi
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
EP3544964B1 (en) 2016-11-28 2020-06-17 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
IL321215B2 (en) 2018-11-23 2026-05-01 Bayer Ag Contrast media formulation and process for its preparation
JP2024020674A (ja) * 2021-01-06 2024-02-15 Ａｇｃ株式会社 ペプチド

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803869C2 (de) * 1978-01-30 1983-12-29 Ethicon, Inc., 08876 Somerville, N.J. Injizierbare Embolisations- und Okklusionslösung
JPS59130813A (ja) * 1983-01-14 1984-07-27 Green Cross Corp:The 癌化学療法補助剤
JPS59130812A (ja) * 1983-01-14 1984-07-27 Green Cross Corp:The 癌化学療法補助剤
JP2657393B2 (ja) * 1988-05-18 1997-09-24 日本化薬株式会社 化学塞栓療法剤
FR2682110B1 (fr) * 1991-10-02 1995-05-24 Atta Ligands amphiphiles perfluoroalkyles leurs complexes metalliques et leurs utilisations dans des preparations a usage therapeutique.
EP0673655A1 (en) * 1992-03-19 1995-09-27 Daikin Industries, Limited Mri contrast medium and diagnostic method
US5401493A (en) * 1993-03-26 1995-03-28 Molecular Biosystems, Inc. Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same

Also Published As

Publication number Publication date
CA2247253A1 (en) 1997-08-28
NO323547B1 (no) 2007-06-11
GR3036306T3 (en) 2001-10-31
DE59703468D1 (de) 2001-06-07
AU1769297A (en) 1997-09-10
WO1997030969A1 (de) 1997-08-28
DE19608278A1 (de) 1997-08-28
EP0882010A1 (de) 1998-12-09
JP2000504736A (ja) 2000-04-18
PT882010E (pt) 2001-10-30
NO983875L (no) 1998-10-22
NO983875D0 (no) 1998-08-21
ATE200894T1 (de) 2001-05-15
ZA971537B (en) 1997-10-30
DK0882010T3 (da) 2001-08-20
TW477699B (en) 2002-03-01
EP0882010B1 (de) 2001-05-02

Similar Documents

Publication Publication Date Title
DK0642334T3 (da) Farmaceutiske og andre doseringsformer
NO963499L (no) Hydroksaminsyre- og karboksylsyrederivater, fremgangsmåte for deres fremstilling og anvendelse derav
DE69616749D1 (de) Arylsubstituierte 5,5 verknüpfte aromatische nitroverbindungen als entzündungshemmende wirkstoffe
DE122006000010I1 (de) Benzocyclobutyl- oder Indanyl-Alkyl-Amino-Alkyl substituierte 3- Benzazepin-2-ones, verwendbar in der Behandlung von kardiovaskularen Krankheiten
ES2150664T3 (es) Nuevos derivados peptidos.
ES2109495T3 (es) Tioureas sustituidas utilizadas como agentes quelantes bifuncionales.
CY1110927T1 (el) Αμινο-καταληκτικως διακλαδισμενη rantεs ως ανταγωνιστης των χημοκινων
NO302366B1 (no) 4-merkaptoacetylamino-£2|benzazepinon(3)-derivater, og farmasöytisk preparat
EA200100524A1 (ru) Амиды антраниловой кислоты и их применение в качестве лекарственных средств
ES2170244T3 (es) Benzotriazoles microbicidas.
DK0396184T3 (da) Anvendelse af ketoconazol og et retinoid til behandling af acne vulgaris
PT1042291E (pt) Piridilalcano, alceno e alcino carboxamidas substituidas com arilo, uteis como agentes citostaticos e imunossupressores
DE69922131D1 (de) Medikament zur behandlung intraepithelialer prostataneoplasie
NO983875D0 (no) Farmas°ytiske midler inneholdende perfluoralkylholdige metallkomplekser, og deres anvendelse ved tumorterapi og intervensjonell radiologi
EA199700380A1 (ru) Бициклические ароматические соединения, фармацевтическая и косметическая композиции на их основе и применение косметической композиции
DE69518070D1 (de) Mehrfachkomponenten-inklusionskomplexe enthaltend einen sauren arzneistoff, ein zyklodextrin und eine base
DK0464298T3 (da) Echinacea-ekstrakter, fremgangsmåde til fremstilling deraf og formuleringer, der indeholder dem
NO990216L (no) Fargeblandinger omfattende et pyrogallolinneholdende middel, et jern(II)salt og en organisk syre
DK0658553T3 (da) Hidtil ukendte polycykliske aromatiske forbindelser, farmaceutiske præparater og kosmetiske sammensætninger indeholdende di
MX9102088A (es) Complejos que contienen acidos s(+) fenilalcanos y alfa-aminoacidos
HU9400685D0 (en) Veterinary composition of anesthetic activity
ES2094608T3 (es) Mezclas fungicidas.
FR2353297A1 (fr) Nouveaux complexes neutres et insolubles de la polyvinylpolypyrrolidone et des halogenes, leurs procedes d'obtention et leurs applications
ES2138668T3 (es) Nuevos derivados de peptidos terapeuticamente activos en la cadena de coagulacion sanguinea, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ATE179075T1 (de) Stabilisierte pharmazeutische zusammensetzungen enthaltend dobutamine

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 882010

Country of ref document: ES