ES2150039T3 - Benzonitrilos como 5-ht agonistas y antagonistas. - Google Patents

Benzonitrilos como 5-ht agonistas y antagonistas.

Info

Publication number
ES2150039T3
ES2150039T3 ES96104955T ES96104955T ES2150039T3 ES 2150039 T3 ES2150039 T3 ES 2150039T3 ES 96104955 T ES96104955 T ES 96104955T ES 96104955 T ES96104955 T ES 96104955T ES 2150039 T3 ES2150039 T3 ES 2150039T3
Authority
ES
Spain
Prior art keywords
benzonitrils
agonists
antagonists
salts
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96104955T
Other languages
English (en)
Spanish (es)
Inventor
Henning Dr Bottcher
Karl Ulrich Dr Buhring
Hartmut Dr Greiner
Gerd Bartoszyk
Christoph Dr Seyfried
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2150039T3 publication Critical patent/ES2150039T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
ES96104955T 1995-04-05 1996-03-28 Benzonitrilos como 5-ht agonistas y antagonistas. Expired - Lifetime ES2150039T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19512639A DE19512639A1 (de) 1995-04-05 1995-04-05 Benzonitrile und -fluoride

Publications (1)

Publication Number Publication Date
ES2150039T3 true ES2150039T3 (es) 2000-11-16

Family

ID=7758788

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96104955T Expired - Lifetime ES2150039T3 (es) 1995-04-05 1996-03-28 Benzonitrilos como 5-ht agonistas y antagonistas.

Country Status (28)

Country Link
US (1) US6310068B1 (enExample)
EP (1) EP0736525B1 (enExample)
JP (1) JP3834098B2 (enExample)
KR (1) KR100437751B1 (enExample)
CN (1) CN1072209C (enExample)
AR (1) AR002982A1 (enExample)
AT (1) ATE194595T1 (enExample)
AU (1) AU709708B2 (enExample)
BR (1) BR9601275A (enExample)
CA (1) CA2173418C (enExample)
CO (1) CO4700469A1 (enExample)
CY (1) CY2242B1 (enExample)
CZ (1) CZ289449B6 (enExample)
DE (2) DE19512639A1 (enExample)
DK (1) DK0736525T3 (enExample)
ES (1) ES2150039T3 (enExample)
GR (1) GR3034514T3 (enExample)
HU (1) HUP9600876A3 (enExample)
NO (1) NO305903B1 (enExample)
PL (1) PL183147B1 (enExample)
PT (1) PT736525E (enExample)
RU (1) RU2168508C2 (enExample)
SI (1) SI0736525T1 (enExample)
SK (1) SK281457B6 (enExample)
TR (1) TR199600286A2 (enExample)
TW (1) TW323279B (enExample)
UA (1) UA45325C2 (enExample)
ZA (1) ZA962768B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR004229A1 (es) * 1995-11-06 1998-11-04 Wyeth Corp Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
WO2000040554A1 (en) * 1999-01-07 2000-07-13 American Home Products Corporation Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
EP2298311B1 (en) * 1999-01-13 2012-05-09 Bayer HealthCare LLC w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
US7351834B1 (en) 1999-01-13 2008-04-01 Bayer Pharmaceuticals Corporation ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1140840B1 (en) * 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
SK287337B6 (sk) * 2000-11-14 2010-07-07 Merck Patent Gmbh Použitie zlúčenín, ktoré sú kombinovanými selektívnymi inhibítormi (SSRI) reabsorpcie serotonínu (5-HT) a agonistami receptora 5-HT1A na výrobu liečiva
UA76130C2 (en) 2000-11-20 2006-07-17 Merck Patent Gmbh Use of compounds combining properties of selective inhibitors of serotonin re-uptake and agonists of 5-ht1a receptor for treatment of irritable bowel syndrome
AR035521A1 (es) * 2000-12-22 2004-06-02 Lundbeck & Co As H Derivados de 3-indolina y composicion farmaceutica que los comprende
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
EP2305255B1 (en) * 2001-12-03 2012-08-22 Bayer HealthCare LLC Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers
US20030207872A1 (en) * 2002-01-11 2003-11-06 Bayer Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
WO2003068229A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
DK1478358T3 (da) 2002-02-11 2013-10-07 Bayer Healthcare Llc Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese
UY28213A1 (es) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
EP1636585B2 (en) 2003-05-20 2012-06-13 Bayer HealthCare LLC Diaryl ureas with kinase inhibiting activity
PL1663978T3 (pl) 2003-07-23 2008-04-30 Bayer Healthcare Llc Fluoropodstawiony omega-karboksyarylodifenylomocznik do leczenia i profilaktyki chorób i stanów
TWI367098B (en) * 2004-12-23 2012-07-01 Kowa Co Treating agent for glaucoma
CN102875538A (zh) * 2012-10-16 2013-01-16 北京诚创思达医药科技有限公司 维拉唑酮或其盐酸盐的制备方法
WO2015014256A1 (en) 2013-07-29 2015-02-05 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
EP3083589B1 (en) 2013-12-20 2019-12-18 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use thereof
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
US11285153B2 (en) 2017-09-29 2022-03-29 Sunshine Lake Pharma Co., Ltd. Substituted pyrimidine piperazine compound and use thereof
CN118834152B (zh) * 2023-04-23 2025-09-23 复旦大学附属肿瘤医院 一种维拉佐酮衍生物v02及其合成方法和在制备抗肿瘤药物中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1075156A (en) 1963-08-27 1967-07-12 Luso Farmaco Inst Substituted piperazines
US3468882A (en) 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
DE2138865A1 (de) 1970-08-15 1973-02-22 Sumitomo Chemical Co 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel
GB8830312D0 (en) 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
DE3923045A1 (de) * 1989-07-13 1991-01-17 Merck Patent Gmbh Indolderivate
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
CA2092112A1 (en) * 1992-03-23 1993-09-24 Nobuyoshi Iwata Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use

Also Published As

Publication number Publication date
NO961346D0 (no) 1996-04-02
DE19512639A1 (de) 1996-10-10
GR3034514T3 (en) 2000-12-29
CZ96496A3 (en) 1996-10-16
NO961346L (no) 1996-10-07
CZ289449B6 (cs) 2002-01-16
EP0736525B1 (de) 2000-07-12
AU709708B2 (en) 1999-09-02
JP3834098B2 (ja) 2006-10-18
HU9600876D0 (en) 1996-05-28
ZA962768B (en) 1996-11-13
JPH09151174A (ja) 1997-06-10
PL313632A1 (en) 1996-10-14
PL183147B1 (pl) 2002-05-31
SI0736525T1 (en) 2001-02-28
KR960037675A (ko) 1996-11-19
DE59605568D1 (de) 2000-08-17
UA45325C2 (uk) 2002-04-15
CN1072209C (zh) 2001-10-03
NO305903B1 (no) 1999-08-16
TW323279B (enExample) 1997-12-21
US6310068B1 (en) 2001-10-30
BR9601275A (pt) 1998-01-13
KR100437751B1 (ko) 2004-08-25
HUP9600876A3 (en) 2000-04-28
TR199600286A2 (tr) 1997-03-21
SK40396A3 (en) 1996-11-06
RU2168508C2 (ru) 2001-06-10
CO4700469A1 (es) 1998-12-29
EP0736525A1 (de) 1996-10-09
AR002982A1 (es) 1998-05-27
HUP9600876A2 (hu) 1998-09-28
DK0736525T3 (da) 2000-10-30
CN1137036A (zh) 1996-12-04
CA2173418A1 (en) 1996-10-06
PT736525E (pt) 2000-12-29
SK281457B6 (sk) 2001-03-12
CY2242B1 (en) 2003-07-04
ATE194595T1 (de) 2000-07-15
AU5040896A (en) 1996-10-17
CA2173418C (en) 2007-06-12

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