ES2140596T3 - 17-desoxi-corticoide-21-(esteres de acidos carboxilicos), procedimiento para su preparacion y medicamentos que los contienen. - Google Patents

17-desoxi-corticoide-21-(esteres de acidos carboxilicos), procedimiento para su preparacion y medicamentos que los contienen.

Info

Publication number
ES2140596T3
ES2140596T3 ES95114511T ES95114511T ES2140596T3 ES 2140596 T3 ES2140596 T3 ES 2140596T3 ES 95114511 T ES95114511 T ES 95114511T ES 95114511 T ES95114511 T ES 95114511T ES 2140596 T3 ES2140596 T3 ES 2140596T3
Authority
ES
Spain
Prior art keywords
opt
corticoide
desoxi
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95114511T
Other languages
English (en)
Inventor
Ulrich Dr Stache
Hans-Georg Dr Alpermann
Manfred Dr Bohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2140596T3 publication Critical patent/ES2140596T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBEN 17 - DESOXI - CORTICOIDE - 21 - ESTER DE ACIDO CARBOXILICO DE LA FORMULA I CON A IGUAL A CHOH Y CHCL, CH{SUB, 2}, C=O, 9(11) - DOBLE ENLACE; Y IGUAL H, F, CL; Z IGUAL H, F, CH{SUB, 3}; R(1) IGUAL ARILO, HETARILO; R(2) IGUAL H, METILO OBTENIENDO DE TAL MODO QUE SE TRANSFORMA UN COMPUESTO DE LA FORMULA II, EN DONDE R(4) ES IGUAL A OH, CON UN ACIDO CARBOXILICO ACTIVADO DE LA FORMULA III, LOS COMPUESTOS I SON ACTIVOS DE FORMA LOCAL Y TOPICA CON ACCION ANTIFLOGISTICA FUERTE Y SON APROPIADOS POR SU MUY BUENA RELACION DE ACCION LOCAL CON RESPECTO A EFECTO ANTIINFLAMATORIO SISTEMATICO, PORTANDO EN CONTRA DE LOS CORTICOIDES - 21 - ESTERES DIRIGIDOS DE FORMA ESTRUCTURAL, QUE NO PORTAN EN LA POSICION RESTO 21 - ESTER NINGUN GRUPO ALQUILO O HETARILO O SE DISPONEN CONTRA 17 - DESOXI - CORTICOIDES ANALOGOS CON GRUPOS ESTERIFICADOS, TAMBIEN GRUPOS 21 - HIDROXILO LIBRES, DE FORMA CLARA.
ES95114511T 1994-09-20 1995-09-15 17-desoxi-corticoide-21-(esteres de acidos carboxilicos), procedimiento para su preparacion y medicamentos que los contienen. Expired - Lifetime ES2140596T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4433374A DE4433374A1 (de) 1994-09-20 1994-09-20 17-Desoxi-corticosteroid-21-/O/-Carbonsäure- ester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
ES2140596T3 true ES2140596T3 (es) 2000-03-01

Family

ID=6528610

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95114511T Expired - Lifetime ES2140596T3 (es) 1994-09-20 1995-09-15 17-desoxi-corticoide-21-(esteres de acidos carboxilicos), procedimiento para su preparacion y medicamentos que los contienen.

Country Status (24)

Country Link
US (1) US5824670A (es)
EP (1) EP0708111B1 (es)
JP (1) JP3902255B2 (es)
KR (1) KR100406627B1 (es)
CN (1) CN1056151C (es)
AT (1) ATE188480T1 (es)
AU (1) AU695710B2 (es)
CA (1) CA2158610C (es)
CZ (1) CZ288297B6 (es)
DE (2) DE4433374A1 (es)
DK (1) DK0708111T3 (es)
ES (1) ES2140596T3 (es)
FI (1) FI114708B (es)
GR (1) GR3032688T3 (es)
HU (1) HU217438B (es)
IL (1) IL115331A (es)
NO (1) NO305210B1 (es)
NZ (1) NZ280038A (es)
PL (1) PL186071B1 (es)
PT (1) PT708111E (es)
RU (1) RU2161624C2 (es)
SI (1) SI9500295B (es)
TW (1) TW424094B (es)
ZA (1) ZA957877B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2805832A1 (en) 2010-07-20 2012-01-26 Taro Pharmaceutical Industries Ltd. Process for the preparation of 17-desoxy-corticosteroids

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2755292A (en) * 1952-01-21 1956-07-17 Organon Labor Ltd Phenyl propionate of testosterone
US2783226A (en) * 1955-02-03 1957-02-26 Schering Corp Esters of cortical hormones
ES229413A1 (es) * 1956-06-22 1956-11-01 Francisco Vismara S P A UN PROCEDIMIENTO PARA LA PREPARACIoN DE COMPUESTOS ESTEROIDALES QUE CONTENGAN UN GRUPO CEToLICO EN LA CADENA LATERAL
DE1131668B (de) * 1959-07-16 1962-06-20 Leo Ab Verfahren zur Herstellung von Estern von Corticosteroid-Hormonen
CH495969A (de) * 1965-11-09 1970-09-15 Schering Ag Verfahren zur Herstellung neuer 21-Ester von 16a-Methyl-21-hydroxy- 1,4-steroiden
DE2047105C3 (de) * 1970-09-18 1979-02-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen 17-Chlorsteroide und Verfahren zu ihrer Herstellung
US3956349A (en) * 1975-02-18 1976-05-11 Syntex (U.S.A.) Inc. Process for preparing 3-enol ethers of 11β-hydroxy-Δ4 -pregnene-3-ones and derivatives thereof
FR2342738A1 (fr) * 1976-03-02 1977-09-30 Roussel Uclaf Nouveaux derives halogenes de la serie du 16a-methyl pregnane
DE2617655C2 (de) * 1976-04-21 1984-11-08 F. Hoffmann-La Roche & Co Ag, Basel Kortikoide, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
DE2645104C2 (de) * 1976-10-04 1986-04-24 Schering AG, 1000 Berlin und 4709 Bergkamen 11β-Hydroxy-1,4,8-pregnatrien-3,20-dion-Derivate und Verfahren zu ihrer Herstellung
FR2381065A2 (fr) * 1977-02-22 1978-09-15 Roussel Uclaf Nouveaux derives halogenes de la serie du 16 a-methyl pregnane
US4086254A (en) * 1977-04-13 1978-04-25 The Upjohn Company Photocleavable steroids
LU77457A1 (es) * 1977-05-31 1979-01-19
US4377573A (en) * 1978-01-06 1983-03-22 Leveen Harry H Method of control of gastrointestinal bleeding
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung
DE2920726A1 (de) * 1979-05-18 1980-11-27 Schering Ag Neue kortikoide, ihre herstellung und verwendung
ATE8790T1 (de) * 1981-02-02 1984-08-15 Schering Corporation Aromatische heterocyclische steroidester, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
SE8303031D0 (sv) * 1983-05-30 1983-05-30 Leo Ab Improved steroid esters preparation
US4910191A (en) * 1988-06-28 1990-03-20 Merrell Dow Pharmaceuticals Inc. 19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors
US4920114A (en) * 1988-06-28 1990-04-24 Merrell Dow Pharmaceuticals Inc. 19-fluoro- or cyano-21-hydroxyprogesterone derivatives useful as 19-hydroxylase inhibitors
NZ237559A (en) * 1990-04-02 1993-04-28 Merrell Dow Pharma Halogenoethyl steroid derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
HUT72969A (en) 1996-06-28
CN1056151C (zh) 2000-09-06
CN1124250A (zh) 1996-06-12
US5824670A (en) 1998-10-20
JPH0899992A (ja) 1996-04-16
RU2161624C2 (ru) 2001-01-10
EP0708111A1 (de) 1996-04-24
KR960010681A (ko) 1996-04-20
TW424094B (en) 2001-03-01
ATE188480T1 (de) 2000-01-15
ZA957877B (en) 1996-04-03
IL115331A0 (en) 1995-12-31
HU9502735D0 (en) 1995-11-28
CA2158610A1 (en) 1996-03-21
GR3032688T3 (en) 2000-06-30
DE59507565D1 (de) 2000-02-10
IL115331A (en) 2002-07-25
AU3172895A (en) 1996-04-04
CZ288297B6 (en) 2001-05-16
DK0708111T3 (da) 2000-06-13
JP3902255B2 (ja) 2007-04-04
AU695710B2 (en) 1998-08-20
PT708111E (pt) 2000-04-28
FI954394A0 (fi) 1995-09-18
DE4433374A1 (de) 1996-03-21
SI9500295A (en) 1996-04-30
EP0708111B1 (de) 2000-01-05
NZ280038A (en) 1997-03-24
SI9500295B (en) 2001-12-31
HU217438B (hu) 2000-01-28
FI114708B (fi) 2004-12-15
CA2158610C (en) 2007-07-17
NO953695D0 (no) 1995-09-19
NO953695L (no) 1996-03-21
CZ242595A3 (en) 1996-04-17
KR100406627B1 (ko) 2004-02-19
PL310544A1 (en) 1996-04-01
FI954394A (fi) 1996-03-21
NO305210B1 (no) 1999-04-19
PL186071B1 (pl) 2003-10-31

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