ATE121739T1 - Discodermolideverbindungen, diese enthaltende zubereitungen, verfahren zu ihrer herstellung und deren verwendung. - Google Patents
Discodermolideverbindungen, diese enthaltende zubereitungen, verfahren zu ihrer herstellung und deren verwendung.Info
- Publication number
- ATE121739T1 ATE121739T1 AT90912243T AT90912243T ATE121739T1 AT E121739 T1 ATE121739 T1 AT E121739T1 AT 90912243 T AT90912243 T AT 90912243T AT 90912243 T AT90912243 T AT 90912243T AT E121739 T1 ATE121739 T1 AT E121739T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- production
- preparations containing
- coz
- coa
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- AADVCYNFEREWOS-OBRABYBLSA-N Discodermolide Chemical class C=C\C=C/[C@H](C)[C@H](OC(N)=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](C)\C=C/[C@@H](O)C[C@@H]1OC(=O)[C@H](C)[C@@H](O)[C@H]1C AADVCYNFEREWOS-OBRABYBLSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 lactone compounds Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
- 125000005023 xylyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/392,468 US4939168A (en) | 1989-08-11 | 1989-08-11 | Discodermolide compounds, compositions containing same and methods of preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE121739T1 true ATE121739T1 (de) | 1995-05-15 |
Family
ID=23550726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90912243T ATE121739T1 (de) | 1989-08-11 | 1990-08-09 | Discodermolideverbindungen, diese enthaltende zubereitungen, verfahren zu ihrer herstellung und deren verwendung. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4939168A (de) |
| EP (1) | EP0486565B1 (de) |
| JP (1) | JP3008985B2 (de) |
| AT (1) | ATE121739T1 (de) |
| CA (1) | CA2056412C (de) |
| DE (1) | DE69018991T2 (de) |
| DK (1) | DK0486565T3 (de) |
| ES (1) | ES2071826T3 (de) |
| WO (1) | WO1991001982A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1118325E (pt) | 1993-07-29 | 2006-05-31 | Us Health | Utilizacao de paclitaxel e seus derivados na preparacao de um medicamento para o tratamento de restenose |
| GB9315802D0 (en) * | 1993-07-30 | 1993-09-15 | Roussel Lab Ltd | Chemical compounds |
| US5684036A (en) * | 1994-02-18 | 1997-11-04 | Harbor Branch Oceanographic Institution, Inc. | Cytotoxic macrolides and methods of use |
| US5478861A (en) * | 1994-02-18 | 1995-12-26 | Harbor Branch Oceanographic Institution, Inc. | Cytotoxic macrolides and methods of use |
| US5681847A (en) * | 1995-12-05 | 1997-10-28 | Harbor Branch Oceanographic Institution, Inc. | Methods of using discodermolide compounds |
| US20050065353A1 (en) * | 1996-12-03 | 2005-03-24 | Smith Amos B. | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof |
| US5789605A (en) * | 1996-12-03 | 1998-08-04 | Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof |
| US6127406A (en) * | 1998-10-09 | 2000-10-03 | Harbor Branch Oceanographic Institution, Inc. | Discodermolide compounds and methods of use |
| US6384187B1 (en) | 1999-05-15 | 2002-05-07 | Harbor Branch Oceanographic Institution, Inc. | Antiproliferative activity of microsclerodermins |
| US6495594B2 (en) | 2000-03-01 | 2002-12-17 | Harbor Branch Oceanographic Institution, Inc. | Biologically active analogs of discodermolide |
| MY127609A (en) * | 2000-08-07 | 2006-12-29 | Novartis Ag | Process for preparing discodermolide and analogues thereof |
| US6541509B2 (en) | 2000-09-15 | 2003-04-01 | Albert Einstein College Of Medicine Of Yeshiva University | Method for treating neoplasia using combination chemotherapy |
| US6734177B2 (en) * | 2001-04-17 | 2004-05-11 | Novartis Ag | Certain salts of discodermolide acid, pharmaceutical compositions containing them and their use in treating tumors |
| WO2003014102A1 (en) * | 2001-08-06 | 2003-02-20 | Novartis Ag | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors |
| TW200408407A (en) * | 2001-11-30 | 2004-06-01 | Dana Farber Cancer Inst Inc | Methods and compositions for modulating the immune system and uses thereof |
| AU2003226717A1 (en) * | 2002-03-27 | 2003-10-08 | Novartis Ag | Intermediates for the synthesis of discodermolide and related analogues and methods for their preparation |
| US7348436B2 (en) * | 2004-03-02 | 2008-03-25 | Kosan Biosciences Incorporated | Compounds useful for the synthesis of (+)-discodermolide and methods thereof |
| US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| US7214708B2 (en) * | 2004-11-18 | 2007-05-08 | Kosan Biosciences Incorporated | Synthetic discodermolide analogs |
| EP1883627B1 (de) | 2005-05-18 | 2018-04-18 | Pharmascience Inc. | An die bir-domäne bindende verbindungen |
| KR20090007635A (ko) | 2006-05-09 | 2009-01-19 | 노파르티스 아게 | 철 킬레이터 및 항-신생물 약제를 포함하는 조합물 및 그의용도 |
| WO2007131366A1 (en) | 2006-05-16 | 2007-11-22 | Aegera Therapeutics Inc. | Iap bir domain binding compounds |
| WO2009049378A1 (en) * | 2007-10-17 | 2009-04-23 | Qbiotics Limited | Lactone derivatives |
| KR101806323B1 (ko) | 2009-11-13 | 2017-12-07 | 다이이치 산쿄 유럽 게엠베하 | Ｈｅｒ-３ 관련 질병을 치료하거나 예방하기 위한 물질 및 방법 |
| SG182724A1 (en) | 2010-02-12 | 2012-08-30 | Pharmascience Inc | Iap bir domain binding compounds |
| JP2013540694A (ja) | 2010-08-06 | 2013-11-07 | ウー３・フアルマ・ゲー・エム・ベー・ハー | Ｈｅｒ３結合剤の前立腺治療における使用 |
-
1989
- 1989-08-11 US US07/392,468 patent/US4939168A/en not_active Expired - Lifetime
-
1990
- 1990-08-09 ES ES90912243T patent/ES2071826T3/es not_active Expired - Lifetime
- 1990-08-09 DE DE69018991T patent/DE69018991T2/de not_active Expired - Lifetime
- 1990-08-09 AT AT90912243T patent/ATE121739T1/de not_active IP Right Cessation
- 1990-08-09 CA CA002056412A patent/CA2056412C/en not_active Expired - Lifetime
- 1990-08-09 DK DK90912243.4T patent/DK0486565T3/da active
- 1990-08-09 EP EP90912243A patent/EP0486565B1/de not_active Expired - Lifetime
- 1990-08-09 JP JP2511555A patent/JP3008985B2/ja not_active Expired - Lifetime
- 1990-08-09 WO PCT/US1990/004493 patent/WO1991001982A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2056412C (en) | 2001-04-10 |
| EP0486565A1 (de) | 1992-05-27 |
| DE69018991T2 (de) | 1995-08-24 |
| DK0486565T3 (da) | 1995-10-02 |
| DE69018991D1 (de) | 1995-06-01 |
| US4939168A (en) | 1990-07-03 |
| ES2071826T3 (es) | 1995-07-01 |
| JPH04507245A (ja) | 1992-12-17 |
| JP3008985B2 (ja) | 2000-02-14 |
| CA2056412A1 (en) | 1991-02-12 |
| EP0486565B1 (de) | 1995-04-26 |
| WO1991001982A1 (en) | 1991-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |