ATE121739T1 - Discodermolideverbindungen, diese enthaltende zubereitungen, verfahren zu ihrer herstellung und deren verwendung. - Google Patents
Discodermolideverbindungen, diese enthaltende zubereitungen, verfahren zu ihrer herstellung und deren verwendung.Info
- Publication number
- ATE121739T1 ATE121739T1 AT90912243T AT90912243T ATE121739T1 AT E121739 T1 ATE121739 T1 AT E121739T1 AT 90912243 T AT90912243 T AT 90912243T AT 90912243 T AT90912243 T AT 90912243T AT E121739 T1 ATE121739 T1 AT E121739T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- production
- preparations containing
- coz
- coa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/392,468 US4939168A (en) | 1989-08-11 | 1989-08-11 | Discodermolide compounds, compositions containing same and methods of preparation and use |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE121739T1 true ATE121739T1 (de) | 1995-05-15 |
Family
ID=23550726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90912243T ATE121739T1 (de) | 1989-08-11 | 1990-08-09 | Discodermolideverbindungen, diese enthaltende zubereitungen, verfahren zu ihrer herstellung und deren verwendung. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4939168A (de) |
EP (1) | EP0486565B1 (de) |
JP (1) | JP3008985B2 (de) |
AT (1) | ATE121739T1 (de) |
CA (1) | CA2056412C (de) |
DE (1) | DE69018991T2 (de) |
DK (1) | DK0486565T3 (de) |
ES (1) | ES2071826T3 (de) |
WO (1) | WO1991001982A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE314845T1 (de) | 1993-07-29 | 2006-02-15 | Us Health | Verwendung von paclitaxel und seinen derivaten zur herstellung eines medikaments für die behandlung von restenose |
GB9315802D0 (en) * | 1993-07-30 | 1993-09-15 | Roussel Lab Ltd | Chemical compounds |
US5478861A (en) * | 1994-02-18 | 1995-12-26 | Harbor Branch Oceanographic Institution, Inc. | Cytotoxic macrolides and methods of use |
US5684036A (en) * | 1994-02-18 | 1997-11-04 | Harbor Branch Oceanographic Institution, Inc. | Cytotoxic macrolides and methods of use |
US5681847A (en) * | 1995-12-05 | 1997-10-28 | Harbor Branch Oceanographic Institution, Inc. | Methods of using discodermolide compounds |
US5789605A (en) * | 1996-12-03 | 1998-08-04 | Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof |
US20050065353A1 (en) * | 1996-12-03 | 2005-03-24 | Smith Amos B. | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof |
US6127406A (en) * | 1998-10-09 | 2000-10-03 | Harbor Branch Oceanographic Institution, Inc. | Discodermolide compounds and methods of use |
US6384187B1 (en) | 1999-05-15 | 2002-05-07 | Harbor Branch Oceanographic Institution, Inc. | Antiproliferative activity of microsclerodermins |
AU2001247241A1 (en) | 2000-03-01 | 2001-09-12 | Harbor Branch Oceanographic Institution, Inc. | Biologically active analogs of discodermolide |
MY127609A (en) * | 2000-08-07 | 2006-12-29 | Novartis Ag | Process for preparing discodermolide and analogues thereof |
US6541509B2 (en) | 2000-09-15 | 2003-04-01 | Albert Einstein College Of Medicine Of Yeshiva University | Method for treating neoplasia using combination chemotherapy |
US6734177B2 (en) * | 2001-04-17 | 2004-05-11 | Novartis Ag | Certain salts of discodermolide acid, pharmaceutical compositions containing them and their use in treating tumors |
CN100522956C (zh) * | 2001-08-06 | 2009-08-05 | 诺瓦提斯公司 | 取代的聚酮化合物,包含它们的药物组合物及其在治疗肿瘤中的用途 |
TW200408407A (en) * | 2001-11-30 | 2004-06-01 | Dana Farber Cancer Inst Inc | Methods and compositions for modulating the immune system and uses thereof |
AU2003226717A1 (en) * | 2002-03-27 | 2003-10-08 | Novartis Ag | Intermediates for the synthesis of discodermolide and related analogues and methods for their preparation |
WO2005084349A2 (en) * | 2004-03-02 | 2005-09-15 | Kosan Biosciences, Inc. | Compounds useful for the synthesis of (+)-discodermolide and methods therefor |
WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
US7214708B2 (en) * | 2004-11-18 | 2007-05-08 | Kosan Biosciences Incorporated | Synthetic discodermolide analogs |
JP4954983B2 (ja) | 2005-05-18 | 2012-06-20 | ファーマサイエンス・インコーポレイテッド | Birドメイン結合化合物 |
BRPI0711385A2 (pt) | 2006-05-09 | 2011-11-08 | Novartis Ag | combinação compreendendo um quelante de ferro e um agente anti-neoplástico e seu uso |
EP2024362A4 (de) | 2006-05-16 | 2012-01-25 | Pharmascience Inc | An die iap-bir-domäne bindende verbindungen |
WO2009049378A1 (en) * | 2007-10-17 | 2009-04-23 | Qbiotics Limited | Lactone derivatives |
RS56741B1 (sr) | 2009-11-13 | 2018-03-30 | Daiichi Sankyo Europe Gmbh | Materijal i postupci za lečenje ili prevenciju bolesti povezanih sa her-3 |
US9284350B2 (en) | 2010-02-12 | 2016-03-15 | Pharmascience Inc. | IAP BIR domain binding compounds |
AU2011286407A1 (en) | 2010-08-06 | 2013-02-21 | Amgen | Use of HER3 binding agents in prostate treatment |
-
1989
- 1989-08-11 US US07/392,468 patent/US4939168A/en not_active Expired - Lifetime
-
1990
- 1990-08-09 CA CA002056412A patent/CA2056412C/en not_active Expired - Lifetime
- 1990-08-09 AT AT90912243T patent/ATE121739T1/de not_active IP Right Cessation
- 1990-08-09 ES ES90912243T patent/ES2071826T3/es not_active Expired - Lifetime
- 1990-08-09 DK DK90912243.4T patent/DK0486565T3/da active
- 1990-08-09 EP EP90912243A patent/EP0486565B1/de not_active Expired - Lifetime
- 1990-08-09 DE DE69018991T patent/DE69018991T2/de not_active Expired - Lifetime
- 1990-08-09 WO PCT/US1990/004493 patent/WO1991001982A1/en active IP Right Grant
- 1990-08-09 JP JP2511555A patent/JP3008985B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69018991T2 (de) | 1995-08-24 |
JPH04507245A (ja) | 1992-12-17 |
US4939168A (en) | 1990-07-03 |
EP0486565A1 (de) | 1992-05-27 |
DE69018991D1 (de) | 1995-06-01 |
CA2056412A1 (en) | 1991-02-12 |
DK0486565T3 (da) | 1995-10-02 |
CA2056412C (en) | 2001-04-10 |
WO1991001982A1 (en) | 1991-02-21 |
ES2071826T3 (es) | 1995-07-01 |
EP0486565B1 (de) | 1995-04-26 |
JP3008985B2 (ja) | 2000-02-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |