ES2138605T3 - Hidrogenacion asimetrica. - Google Patents

Hidrogenacion asimetrica.

Info

Publication number
ES2138605T3
ES2138605T3 ES93109092T ES93109092T ES2138605T3 ES 2138605 T3 ES2138605 T3 ES 2138605T3 ES 93109092 T ES93109092 T ES 93109092T ES 93109092 T ES93109092 T ES 93109092T ES 2138605 T3 ES2138605 T3 ES 2138605T3
Authority
ES
Spain
Prior art keywords
compounds
general formula
preparation
image
asymmetric hydrogenation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93109092T
Other languages
English (en)
Inventor
Emil Albin Broger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2138605T3 publication Critical patent/ES2138605T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

UN PROCEDIMIENTO PARA LA HIDROGENACION ASIMETRICA DE 6,7-DIHIDROPIRIDO(1,2-A)INDOL-8METANOL O SUS DERIVADOS SUBSTITUIDOS AROMATICAMENTE DE FORMULA (II) DONDE R1, R2 Y R3 INDEPENDIENTE ENTRE SI HIDROGENO, HALOGENO, C1 -7-ALQUILO, C1-7-HALOGENOALQUILO, HIDROXI, C1-7-ALCOXI, C1-7-ALQUILTIO, C1-7-ALQUILSULFINULO, C1-7-ALQUILSULFONILO, NITRO, AMINO O ACILAMINO A COMPUESTOS (S)FICADO INDICADO Y SE CARACTERIZA POR UN CENTRO QUIRAL DE EFECTUA EMPLEANDO COMPLEJOS DIFOSFINA-RODIO OPTICAMENTE ACTIVOS COMO CATALIZADORES. SE DESCRIBE LA PRODUCCION DE NUEVOS COMPUESTOS DE FORMULA GENERAL (II) QUE FORMAN EL OBJETO POSTERIOR DE LA PRESENTE INVENCION. LOS COMPUESTOS (I) Y (II) SON PRODUCTOS INTERMEDIOS VALIOSOS PARA LA PRODUCCION DE SUBTANCIAS ACTIVAS FARMACOLOGICAS.
ES93109092T 1992-06-19 1993-06-07 Hidrogenacion asimetrica. Expired - Lifetime ES2138605T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH194492 1992-06-19
CH82693 1993-03-18

Publications (1)

Publication Number Publication Date
ES2138605T3 true ES2138605T3 (es) 2000-01-16

Family

ID=25685815

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93109092T Expired - Lifetime ES2138605T3 (es) 1992-06-19 1993-06-07 Hidrogenacion asimetrica.

Country Status (7)

Country Link
US (1) US5374727A (es)
EP (1) EP0574783B1 (es)
JP (1) JP2788841B2 (es)
AT (1) ATE185346T1 (es)
DE (1) DE59309812D1 (es)
DK (1) DK0574783T3 (es)
ES (1) ES2138605T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543559A (en) 1994-07-07 1996-08-06 Hoffman-La Roche Inc. Process for the enantioselective hydrogenation of ketosiophorone derivatives
DE19532320A1 (de) * 1995-09-01 1997-03-06 Bayer Ag Verfahren zur Herstellung von optisch aktiven ortho-substituierten 4-Aryl-Dihydropyridinen
MY195300A (en) * 2012-12-18 2023-01-12 Dsm Ip Assets Bv (6r,10r)-6,10,14-trimetylpentadecan-2-one prepared from 6,10-dimetylundec-5-en-2-one or 6,10-dimetylundeca-5,9-dien-2-one
WO2014096066A1 (en) * 2012-12-18 2014-06-26 Dsm Ip Assets B.V. (6r,10r)-6,10,14-trimetylpentadecan-2-one prepared from (r)-3,7-dimetyloct-6-enal
CN110229152B (zh) * 2019-06-14 2020-06-23 中国药科大学 一种2-位双取代吲哚啉-3-酮类化合物及其不对称合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4155247A (en) * 1977-05-02 1979-05-22 Westinghouse Electric Corp. Multi-part gas sampler
DE3018388A1 (de) * 1980-05-14 1981-11-19 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von optisch aktiven verbindungen und deren verwendung zur herstellung von vitamin e
DK350383A (da) * 1982-08-27 1984-02-28 Hoffmann La Roche Phosphorforbindelser
EP0158875B1 (de) * 1984-04-19 1989-12-13 F. Hoffmann-La Roche Ag Chirale Rhodium-diphosphinkomplexe für asymmetrische Hydrierungen
US4962242A (en) * 1986-08-27 1990-10-09 Takasago Perfumery Co., Ltd. Process for producing optically active alcohols
ATE128140T1 (de) * 1989-05-18 1995-10-15 Hoffmann La Roche Phosphorverbindungen.
ES2082104T3 (es) * 1990-12-21 1996-03-16 Ciba Geigy Ag Hidrogenacion asimetrica.
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides

Also Published As

Publication number Publication date
US5374727A (en) 1994-12-20
EP0574783A3 (en) 1994-06-08
DK0574783T3 (da) 2000-03-13
JPH0665240A (ja) 1994-03-08
EP0574783B1 (de) 1999-10-06
DE59309812D1 (de) 1999-11-11
EP0574783A2 (de) 1993-12-22
JP2788841B2 (ja) 1998-08-20
ATE185346T1 (de) 1999-10-15

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