ES2132201T3 - Inhibidores de la hiv proteasa utiles en el tratamiento del sida. - Google Patents
Inhibidores de la hiv proteasa utiles en el tratamiento del sida.Info
- Publication number
- ES2132201T3 ES2132201T3 ES93310359T ES93310359T ES2132201T3 ES 2132201 T3 ES2132201 T3 ES 2132201T3 ES 93310359 T ES93310359 T ES 93310359T ES 93310359 T ES93310359 T ES 93310359T ES 2132201 T3 ES2132201 T3 ES 2132201T3
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- aids
- protease inhibitors
- hiv protease
- useful hiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000030507 AIDS Diseases 0.000 title abstract 2
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99525692A | 1992-12-22 | 1992-12-22 | |
| US08/134,329 US5733906A (en) | 1993-10-12 | 1993-10-12 | Inhibitors of HIV Protease useful for the treatment of Aids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2132201T3 true ES2132201T3 (es) | 1999-08-16 |
Family
ID=26832220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93310359T Expired - Lifetime ES2132201T3 (es) | 1992-12-22 | 1993-12-20 | Inhibidores de la hiv proteasa utiles en el tratamiento del sida. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5905077A (enExample) |
| EP (1) | EP0604185B1 (enExample) |
| JP (1) | JPH06271534A (enExample) |
| KR (1) | KR940014337A (enExample) |
| CN (1) | CN1044117C (enExample) |
| AT (1) | ATE178055T1 (enExample) |
| AU (1) | AU667146B2 (enExample) |
| BR (1) | BR9305162A (enExample) |
| CA (1) | CA2112042A1 (enExample) |
| CZ (1) | CZ281493A3 (enExample) |
| DE (1) | DE69324120T2 (enExample) |
| ES (1) | ES2132201T3 (enExample) |
| FI (1) | FI935778A7 (enExample) |
| HU (1) | HUT69693A (enExample) |
| IL (1) | IL108092A (enExample) |
| MX (1) | MX9308016A (enExample) |
| MY (1) | MY131388A (enExample) |
| NO (1) | NO934719L (enExample) |
| NZ (1) | NZ250491A (enExample) |
| PL (1) | PL301581A1 (enExample) |
| TW (1) | TW262468B (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USH1649H (en) | 1987-07-31 | 1997-05-06 | Barrish; Joel C. | HIV protease inhibitor combinations |
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| JPH07504654A (ja) | 1992-03-11 | 1995-05-25 | ナルヘックス リミテッド | オキソ及びヒドロキシ置換炭化水素のアミン誘導体 |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| US5484926A (en) | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US5461154A (en) * | 1994-02-02 | 1995-10-24 | Eli Lilly And Company | Intermediate and process for making |
| TW472047B (en) * | 1994-02-04 | 2002-01-11 | Merck & Co Inc | Process for making HIV protease inhibitors |
| EP0710652B1 (en) * | 1994-11-04 | 1998-03-04 | Yamakawa Chemical Industry Co., Ltd. | Process for preparing optically active piperazine derivatives and intermediates for preparation |
| DE69616446T2 (de) * | 1995-02-03 | 2002-05-16 | Kaneka Corp., Osaka | Verfahren zur herstellung von alpha-haloketonen, alpha-halohydrinen und epoxiden |
| US5618937A (en) * | 1995-03-15 | 1997-04-08 | Merck & Co., Inc. | Process to make HIV protease inhibitor from (2S)-4-picolyl-2-piperazine-t-butylcarboxamide |
| CA2179935C (en) * | 1995-06-30 | 2010-09-07 | Ryohei Kato | Novel dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof |
| US6222043B1 (en) | 1995-06-30 | 2001-04-24 | Japan Energy Corporation | Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof |
| JP3611332B2 (ja) * | 1995-09-26 | 2005-01-19 | 日本たばこ産業株式会社 | アミド誘導体の製造方法及び中間体化合物 |
| ATE288891T1 (de) | 1995-09-26 | 2005-02-15 | Japan Tobacco Inc | Verfahren zur herstellung von amid-derivaten und ihren zwischenverbindungen |
| ATE377006T1 (de) * | 1995-11-28 | 2007-11-15 | Cephalon Inc | Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer |
| US5962725A (en) | 1996-09-05 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir |
| EP0900566A4 (en) | 1996-12-27 | 2001-04-25 | Japan Energy Corp | NEW TRIPEPTIDE COMPOUNDS AND MEDICINES AGAINST AIDS |
| JP4006058B2 (ja) | 1997-03-11 | 2007-11-14 | 第一三共株式会社 | 多臓器不全予防及び／又は治療剤 |
| ES2274567T3 (es) | 1997-03-14 | 2007-05-16 | Daiichi Pharmaceutical Co., Ltd. | Utilizacion de tcf-ii para el tratamiento de la perdida de peso corporal, la anemia y la elevacion de tnf causadas por el cancer. |
| EP1095022A1 (en) * | 1998-07-08 | 2001-05-02 | G.D. Searle & Co. | Retroviral protease inhibitors |
| NZ525513A (en) | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
| HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| WO2000038618A2 (en) * | 1998-12-24 | 2000-07-06 | Du Pont Pharmaceuticals Company | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
| US6960576B2 (en) * | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
| EP1222176A1 (en) | 1999-10-08 | 2002-07-17 | Bristol-Myers Squibb Pharma Company | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION |
| CA2395862A1 (en) | 2000-02-17 | 2001-08-23 | Hong Liu | Succinoylamino carbocycles and heterocycles as inhibitors of a.beta. protein production |
| US6495540B2 (en) | 2000-03-28 | 2002-12-17 | Bristol - Myers Squibb Pharma Company | Lactams as inhibitors of A-β protein production |
| EP1268434A1 (en) | 2000-04-03 | 2003-01-02 | Bristol-Myers Squibb Pharma Company | Cyclic lactams as inhibitors of a-beta protein production |
| CN1436175A (zh) | 2000-04-03 | 2003-08-13 | 布里斯托尔-迈尔斯斯奎布药品公司 | 作为Aβ－蛋白生产抑制剂的环状内酰胺 |
| US20100009966A1 (en) * | 2001-04-11 | 2010-01-14 | Bristol-Myers Squibb Pharma Company | Substituted lactams as inhibitors of abeta protein production |
| WO2001077086A1 (en) * | 2000-04-11 | 2001-10-18 | Dupont Pharmaceuticals Company | SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| US6878363B2 (en) * | 2000-05-17 | 2005-04-12 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
| CN1386118A (zh) | 2000-06-01 | 2002-12-18 | 布里斯托尔-迈尔斯斯奎布药品公司 | 作为Aβ蛋白产生抑制剂的被环状琥珀酸酯取代的内酰胺类化合物 |
| GB0028483D0 (en) * | 2000-11-22 | 2001-01-10 | Hoffmann La Roche | Hydroxyethylamine HIV protease inhibitors |
| JPWO2002064553A1 (ja) * | 2001-02-14 | 2004-06-10 | 呉羽化学工業株式会社 | ハロゲノアルコール誘導体の製造方法 |
| US20090062256A1 (en) * | 2001-06-01 | 2009-03-05 | Bristol-Myers Squibb Pharma Company | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION |
| GB0123467D0 (en) | 2001-09-28 | 2001-11-21 | Hoffmann La Roche | Carbocyclic HIV Protease inhibitors |
| KR101155335B1 (ko) * | 2005-01-07 | 2012-06-11 | 엘지전자 주식회사 | 이동통신 단말기의 멀티미디어 메시지 동작방법 |
| EP1910317B1 (en) | 2005-07-20 | 2013-07-03 | Eli Lilly And Company | 1-amino linked compounds |
| CN101508664B (zh) * | 2009-02-25 | 2012-08-22 | 江阴希迪医药科技有限公司 | N-苄氧羰基-3-氨基-1-氯-4-苯硫基-2-丁醇合成方法 |
| MX2012015097A (es) | 2010-07-02 | 2013-05-28 | Gilead Sciences Inc | Derivados de acido naft-2-ilacetico para tratar sida. |
| EP2588455B1 (en) | 2010-07-02 | 2018-04-04 | Gilead Sciences, Inc. | 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds |
| UA111841C2 (uk) | 2011-04-21 | 2016-06-24 | Гіліад Сайєнсіз, Інк. | Сполуки бензотіазолу та їх фармацевтичне застосування |
| US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| UY34750A (es) | 2012-04-20 | 2013-11-29 | Gilead Sciences Inc | ?compuestos para el tratamiento del hiv, composiciones,métodos de preparación, intermediarios y métodos terapéuticos?. |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| IL89900A0 (en) * | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
| CA1340588C (en) | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| EP0361341A3 (en) * | 1988-09-28 | 1991-07-03 | Miles Inc. | Therapeutics for aids based on inhibitors of hiv protease |
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| WO1992008701A1 (en) | 1990-11-19 | 1992-05-29 | Monsanto Company | Retroviral protease inhibitors |
| CA2060844A1 (en) * | 1991-02-08 | 1992-08-09 | Yabe Yuichiro | Beta-amino-alpha-hydroxycarboxylic acids and their use |
| US5430041A (en) * | 1991-05-10 | 1995-07-04 | Hoffmann-La Roche Inc. | Amino acid derivatives having antiviral activity |
| CN1071930A (zh) * | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
| ZA929869B (en) | 1991-12-20 | 1994-06-20 | Syntex Inc | Hiv protease inhibitors |
| US5312820A (en) * | 1992-07-17 | 1994-05-17 | Merck & Co., Inc. | Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines |
-
1993
- 1993-12-15 MX MX9308016A patent/MX9308016A/es not_active IP Right Cessation
- 1993-12-17 CZ CZ932814A patent/CZ281493A3/cs unknown
- 1993-12-17 NZ NZ250491A patent/NZ250491A/en unknown
- 1993-12-17 MY MYPI93002745A patent/MY131388A/en unknown
- 1993-12-20 NO NO934719A patent/NO934719L/no unknown
- 1993-12-20 DE DE69324120T patent/DE69324120T2/de not_active Expired - Fee Related
- 1993-12-20 IL IL108092A patent/IL108092A/en active IP Right Grant
- 1993-12-20 HU HU9303679A patent/HUT69693A/hu unknown
- 1993-12-20 AT AT93310359T patent/ATE178055T1/de not_active IP Right Cessation
- 1993-12-20 AU AU52528/93A patent/AU667146B2/en not_active Ceased
- 1993-12-20 ES ES93310359T patent/ES2132201T3/es not_active Expired - Lifetime
- 1993-12-20 EP EP93310359A patent/EP0604185B1/en not_active Expired - Lifetime
- 1993-12-20 PL PL93301581A patent/PL301581A1/xx unknown
- 1993-12-21 CN CN93112962A patent/CN1044117C/zh not_active Expired - Fee Related
- 1993-12-21 JP JP5322750A patent/JPH06271534A/ja active Pending
- 1993-12-21 BR BR9305162A patent/BR9305162A/pt not_active Application Discontinuation
- 1993-12-21 FI FI935778A patent/FI935778A7/fi not_active Application Discontinuation
- 1993-12-21 CA CA002112042A patent/CA2112042A1/en not_active Abandoned
- 1993-12-22 TW TW082110893A patent/TW262468B/zh active
- 1993-12-22 KR KR1019930029121A patent/KR940014337A/ko not_active Abandoned
-
1997
- 1997-11-19 US US08/974,430 patent/US5905077A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CZ281493A3 (en) | 1994-07-13 |
| ATE178055T1 (de) | 1999-04-15 |
| HUT69693A (en) | 1995-09-28 |
| MX9308016A (es) | 1994-08-31 |
| NO934719L (no) | 1994-06-23 |
| IL108092A (en) | 1998-06-15 |
| CN1044117C (zh) | 1999-07-14 |
| FI935778A0 (fi) | 1993-12-21 |
| JPH06271534A (ja) | 1994-09-27 |
| DE69324120T2 (de) | 1999-11-25 |
| NZ250491A (en) | 1995-08-28 |
| BR9305162A (pt) | 1994-11-01 |
| TW262468B (enExample) | 1995-11-11 |
| MY131388A (en) | 2007-08-30 |
| CN1094399A (zh) | 1994-11-02 |
| AU667146B2 (en) | 1996-03-07 |
| AU5252893A (en) | 1994-07-07 |
| EP0604185A1 (en) | 1994-06-29 |
| CA2112042A1 (en) | 1994-06-23 |
| PL301581A1 (en) | 1994-06-27 |
| FI935778A7 (fi) | 1994-06-23 |
| DE69324120D1 (de) | 1999-04-29 |
| IL108092A0 (en) | 1994-04-12 |
| US5905077A (en) | 1999-05-18 |
| NO934719D0 (no) | 1993-12-20 |
| EP0604185B1 (en) | 1999-03-24 |
| KR940014337A (ko) | 1994-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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