MX9308016A - Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene. - Google Patents
Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene.Info
- Publication number
- MX9308016A MX9308016A MX9308016A MX9308016A MX9308016A MX 9308016 A MX9308016 A MX 9308016A MX 9308016 A MX9308016 A MX 9308016A MX 9308016 A MX9308016 A MX 9308016A MX 9308016 A MX9308016 A MX 9308016A
- Authority
- MX
- Mexico
- Prior art keywords
- procedure
- preparation
- pharmaceutical formulation
- immunodeficiency virus
- human immunodeficiency
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 241000725303 Human immunodeficiency virus Species 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 title 1
- 239000004365 Protease Substances 0.000 title 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 239000004030 hiv protease inhibitor Substances 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99525692A | 1992-12-22 | 1992-12-22 | |
| US08/134,329 US5733906A (en) | 1993-10-12 | 1993-10-12 | Inhibitors of HIV Protease useful for the treatment of Aids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9308016A true MX9308016A (es) | 1994-08-31 |
Family
ID=26832220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9308016A MX9308016A (es) | 1992-12-22 | 1993-12-15 | Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5905077A (enExample) |
| EP (1) | EP0604185B1 (enExample) |
| JP (1) | JPH06271534A (enExample) |
| KR (1) | KR940014337A (enExample) |
| CN (1) | CN1044117C (enExample) |
| AT (1) | ATE178055T1 (enExample) |
| AU (1) | AU667146B2 (enExample) |
| BR (1) | BR9305162A (enExample) |
| CA (1) | CA2112042A1 (enExample) |
| CZ (1) | CZ281493A3 (enExample) |
| DE (1) | DE69324120T2 (enExample) |
| ES (1) | ES2132201T3 (enExample) |
| FI (1) | FI935778A7 (enExample) |
| HU (1) | HUT69693A (enExample) |
| IL (1) | IL108092A (enExample) |
| MX (1) | MX9308016A (enExample) |
| MY (1) | MY131388A (enExample) |
| NO (1) | NO934719L (enExample) |
| NZ (1) | NZ250491A (enExample) |
| PL (1) | PL301581A1 (enExample) |
| TW (1) | TW262468B (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USH1649H (en) | 1987-07-31 | 1997-05-06 | Barrish; Joel C. | HIV protease inhibitor combinations |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| EP0633881B1 (en) | 1992-03-11 | 2003-10-29 | Narhex Limited | Amine derivatives of oxo- and hydroxy-substitued hydrocarbons |
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| US5484926A (en) | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US5461154A (en) * | 1994-02-02 | 1995-10-24 | Eli Lilly And Company | Intermediate and process for making |
| TW472047B (en) * | 1994-02-04 | 2002-01-11 | Merck & Co Inc | Process for making HIV protease inhibitors |
| US5792869A (en) * | 1994-11-04 | 1998-08-11 | Yamakawa Chemical Industry Co., Ltd | Process for preparing optically active piperazine derivatives and Intermediates for preparation |
| ES2167541T3 (es) * | 1995-02-03 | 2002-05-16 | Kaneka Corp | Procedimientos de produccion de alfa-halocetonas, de alfa-halohidrinas y de epoxidos. |
| US5618937A (en) * | 1995-03-15 | 1997-04-08 | Merck & Co., Inc. | Process to make HIV protease inhibitor from (2S)-4-picolyl-2-piperazine-t-butylcarboxamide |
| US6222043B1 (en) | 1995-06-30 | 2001-04-24 | Japan Energy Corporation | Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof |
| US5932550A (en) * | 1995-06-30 | 1999-08-03 | Japan Energy Corporation | Dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof |
| WO1997011937A1 (en) | 1995-09-26 | 1997-04-03 | Japan Tobacco Inc. | Process for producing amide derivatives and intermediates |
| ES2318852T3 (es) * | 1995-09-26 | 2009-05-01 | Japan Tobacco Inc. | Procedimiento para producir derivados de amida y compuestos intermedios. |
| EP0910564B1 (en) * | 1995-11-28 | 2007-10-31 | Cephalon, Inc. | D-amino acid derived inhibitors of cysteine and serine proteases |
| US5962725A (en) | 1996-09-05 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir |
| CA2249747A1 (en) | 1996-12-27 | 1998-07-09 | Tsutomu Mimoto | Novel tripeptide compounds and anti-aids drugs |
| JP4006058B2 (ja) | 1997-03-11 | 2007-11-14 | 第一三共株式会社 | 多臓器不全予防及び／又は治療剤 |
| DK0950416T3 (da) | 1997-03-14 | 2007-02-26 | Daiichi Seiyaku Co | Anvendelse af TCF-II til behandling af cancerrelateret tab af kropsvægt, anæmi og TNF-forhöjelse |
| US6538006B1 (en) * | 1998-07-08 | 2003-03-25 | Pharmacia Corporation | Retroviral protease inhibitors |
| HRP990246A2 (en) * | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| NZ525513A (en) | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
| WO2000038618A2 (en) * | 1998-12-24 | 2000-07-06 | Du Pont Pharmaceuticals Company | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
| US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
| AU7997700A (en) | 1999-10-08 | 2001-04-23 | Du Pont Pharmaceuticals Company | Amino lactam sulfonamides as inhibitors of abeta protein production |
| US6525044B2 (en) | 2000-02-17 | 2003-02-25 | Bristol-Myers Squibb Company | Succinoylamino carbocycles and heterocycles as inhibitors of a-β protein production |
| US6495540B2 (en) | 2000-03-28 | 2002-12-17 | Bristol - Myers Squibb Pharma Company | Lactams as inhibitors of A-β protein production |
| JP2003535046A (ja) * | 2000-04-03 | 2003-11-25 | デュポン ファーマシューティカルズ カンパニー | Ａβタンパク質産生の阻害剤としての環状ラクタム |
| BR0110051A (pt) | 2000-04-03 | 2004-12-07 | Bristol Myers Squibb Pharma Co | Composto, uso do composto, composição farmacêutica e método de tratamento do mal de alzheimer |
| US20100009966A1 (en) * | 2001-04-11 | 2010-01-14 | Bristol-Myers Squibb Pharma Company | Substituted lactams as inhibitors of abeta protein production |
| EP1289966A1 (en) * | 2000-04-11 | 2003-03-12 | Bristol-Myers Squibb Pharma Company | SUBSTITUTED LACTAMS AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION |
| US6878363B2 (en) * | 2000-05-17 | 2005-04-12 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
| MXPA02000862A (es) * | 2000-06-01 | 2003-07-14 | Bristol Myers Squibb Pharma Co | Lactamas substituidas por succinatos ciclicos como inhibidores de la produccion de proteina abeta. |
| GB0028483D0 (en) * | 2000-11-22 | 2001-01-10 | Hoffmann La Roche | Hydroxyethylamine HIV protease inhibitors |
| WO2002064553A1 (en) * | 2001-02-14 | 2002-08-22 | Kureha Chemical Industry Company, Limited | Process for preparation of halogenoalcohol derivatives |
| US20090062256A1 (en) * | 2001-06-01 | 2009-03-05 | Bristol-Myers Squibb Pharma Company | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION |
| GB0123467D0 (en) | 2001-09-28 | 2001-11-21 | Hoffmann La Roche | Carbocyclic HIV Protease inhibitors |
| KR101155335B1 (ko) * | 2005-01-07 | 2012-06-11 | 엘지전자 주식회사 | 이동통신 단말기의 멀티미디어 메시지 동작방법 |
| EP1910317B1 (en) | 2005-07-20 | 2013-07-03 | Eli Lilly And Company | 1-amino linked compounds |
| CN101508664B (zh) * | 2009-02-25 | 2012-08-22 | 江阴希迪医药科技有限公司 | N-苄氧羰基-3-氨基-1-氯-4-苯硫基-2-丁醇合成方法 |
| UY33479A (es) | 2010-07-02 | 2012-01-31 | Gilead Sciences Inc | Compuestos terapeuticos, composicion farmaceutica que lo comprende, metodo de tratamiento y su uso para la manufactura de un medicamento |
| WO2012003497A1 (en) | 2010-07-02 | 2012-01-05 | Gilead Sciences, Inc. | Napht- 2 -ylacetic acid derivatives to treat aids |
| ES2615734T3 (es) | 2011-04-21 | 2017-06-08 | Gilead Sciences, Inc. | Compuestos de benzotiazol y su uso farmacéutico |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
| PT3070081T (pt) | 2012-04-20 | 2018-05-21 | Gilead Sciences Inc | Derivados do ácido benzotiazol-6-ilacético e sua utilização para tratar uma infeção por vih |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| IL89900A0 (en) * | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
| CA1340588C (en) | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| EP0361341A3 (en) * | 1988-09-28 | 1991-07-03 | Miles Inc. | Therapeutics for aids based on inhibitors of hiv protease |
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| WO1992008701A1 (en) * | 1990-11-19 | 1992-05-29 | Monsanto Company | Retroviral protease inhibitors |
| CA2060844A1 (en) * | 1991-02-08 | 1992-08-09 | Yabe Yuichiro | Beta-amino-alpha-hydroxycarboxylic acids and their use |
| US5430041A (en) * | 1991-05-10 | 1995-07-04 | Hoffmann-La Roche Inc. | Amino acid derivatives having antiviral activity |
| CN1071930A (zh) * | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
| AU3278293A (en) | 1991-12-20 | 1993-07-28 | Syntex (U.S.A.) Inc. | Cyclic amides of 3-amino-2-hydroxy-carboxylic acids as hiv-protease inhibitors |
| US5312820A (en) * | 1992-07-17 | 1994-05-17 | Merck & Co., Inc. | Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines |
-
1993
- 1993-12-15 MX MX9308016A patent/MX9308016A/es not_active IP Right Cessation
- 1993-12-17 NZ NZ250491A patent/NZ250491A/en unknown
- 1993-12-17 CZ CZ932814A patent/CZ281493A3/cs unknown
- 1993-12-17 MY MYPI93002745A patent/MY131388A/en unknown
- 1993-12-20 NO NO934719A patent/NO934719L/no unknown
- 1993-12-20 EP EP93310359A patent/EP0604185B1/en not_active Expired - Lifetime
- 1993-12-20 AU AU52528/93A patent/AU667146B2/en not_active Ceased
- 1993-12-20 PL PL93301581A patent/PL301581A1/xx unknown
- 1993-12-20 HU HU9303679A patent/HUT69693A/hu unknown
- 1993-12-20 IL IL108092A patent/IL108092A/en active IP Right Grant
- 1993-12-20 DE DE69324120T patent/DE69324120T2/de not_active Expired - Fee Related
- 1993-12-20 ES ES93310359T patent/ES2132201T3/es not_active Expired - Lifetime
- 1993-12-20 AT AT93310359T patent/ATE178055T1/de not_active IP Right Cessation
- 1993-12-21 FI FI935778A patent/FI935778A7/fi not_active Application Discontinuation
- 1993-12-21 JP JP5322750A patent/JPH06271534A/ja active Pending
- 1993-12-21 CN CN93112962A patent/CN1044117C/zh not_active Expired - Fee Related
- 1993-12-21 CA CA002112042A patent/CA2112042A1/en not_active Abandoned
- 1993-12-21 BR BR9305162A patent/BR9305162A/pt not_active Application Discontinuation
- 1993-12-22 TW TW082110893A patent/TW262468B/zh active
- 1993-12-22 KR KR1019930029121A patent/KR940014337A/ko not_active Abandoned
-
1997
- 1997-11-19 US US08/974,430 patent/US5905077A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL108092A (en) | 1998-06-15 |
| NZ250491A (en) | 1995-08-28 |
| DE69324120T2 (de) | 1999-11-25 |
| CN1044117C (zh) | 1999-07-14 |
| ATE178055T1 (de) | 1999-04-15 |
| PL301581A1 (en) | 1994-06-27 |
| ES2132201T3 (es) | 1999-08-16 |
| NO934719L (no) | 1994-06-23 |
| NO934719D0 (no) | 1993-12-20 |
| US5905077A (en) | 1999-05-18 |
| FI935778A0 (fi) | 1993-12-21 |
| KR940014337A (ko) | 1994-07-18 |
| EP0604185A1 (en) | 1994-06-29 |
| FI935778A7 (fi) | 1994-06-23 |
| TW262468B (enExample) | 1995-11-11 |
| HUT69693A (en) | 1995-09-28 |
| IL108092A0 (en) | 1994-04-12 |
| JPH06271534A (ja) | 1994-09-27 |
| BR9305162A (pt) | 1994-11-01 |
| AU667146B2 (en) | 1996-03-07 |
| AU5252893A (en) | 1994-07-07 |
| MY131388A (en) | 2007-08-30 |
| DE69324120D1 (de) | 1999-04-29 |
| EP0604185B1 (en) | 1999-03-24 |
| CA2112042A1 (en) | 1994-06-23 |
| CN1094399A (zh) | 1994-11-02 |
| CZ281493A3 (en) | 1994-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |