HUT69693A - Inhibitors of hiv protease - Google Patents
Inhibitors of hiv proteaseInfo
- Publication number
- HUT69693A HUT69693A HU9303679A HU9303679A HUT69693A HU T69693 A HUT69693 A HU T69693A HU 9303679 A HU9303679 A HU 9303679A HU 9303679 A HU9303679 A HU 9303679A HU T69693 A HUT69693 A HU T69693A
- Authority
- HU
- Hungary
- Prior art keywords
- hiv protease
- inhibitors
- chem
- formula
- aids
- Prior art date
Links
- 108091005804 Peptidases Proteins 0.000 title 1
- 239000004365 Protease Substances 0.000 title 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000004030 hiv protease inhibitor Substances 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99525692A | 1992-12-22 | 1992-12-22 | |
| US08/134,329 US5733906A (en) | 1993-10-12 | 1993-10-12 | Inhibitors of HIV Protease useful for the treatment of Aids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUT69693A true HUT69693A (en) | 1995-09-28 |
Family
ID=26832220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9303679A HUT69693A (en) | 1992-12-22 | 1993-12-20 | Inhibitors of hiv protease |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5905077A (enExample) |
| EP (1) | EP0604185B1 (enExample) |
| JP (1) | JPH06271534A (enExample) |
| KR (1) | KR940014337A (enExample) |
| CN (1) | CN1044117C (enExample) |
| AT (1) | ATE178055T1 (enExample) |
| AU (1) | AU667146B2 (enExample) |
| BR (1) | BR9305162A (enExample) |
| CA (1) | CA2112042A1 (enExample) |
| CZ (1) | CZ281493A3 (enExample) |
| DE (1) | DE69324120T2 (enExample) |
| ES (1) | ES2132201T3 (enExample) |
| FI (1) | FI935778A7 (enExample) |
| HU (1) | HUT69693A (enExample) |
| IL (1) | IL108092A (enExample) |
| MX (1) | MX9308016A (enExample) |
| MY (1) | MY131388A (enExample) |
| NO (1) | NO934719L (enExample) |
| NZ (1) | NZ250491A (enExample) |
| PL (1) | PL301581A1 (enExample) |
| TW (1) | TW262468B (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USH1649H (en) | 1987-07-31 | 1997-05-06 | Barrish; Joel C. | HIV protease inhibitor combinations |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| JPH07504654A (ja) | 1992-03-11 | 1995-05-25 | ナルヘックス リミテッド | オキソ及びヒドロキシ置換炭化水素のアミン誘導体 |
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| US5484926A (en) | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US5461154A (en) * | 1994-02-02 | 1995-10-24 | Eli Lilly And Company | Intermediate and process for making |
| TW472047B (en) * | 1994-02-04 | 2002-01-11 | Merck & Co Inc | Process for making HIV protease inhibitors |
| EP0710652B1 (en) * | 1994-11-04 | 1998-03-04 | Yamakawa Chemical Industry Co., Ltd. | Process for preparing optically active piperazine derivatives and intermediates for preparation |
| US5929284A (en) * | 1995-02-03 | 1999-07-27 | Kaneka Corporation | Processes for producing α-halo ketones, α-halohydrins and epoxides |
| US5618937A (en) * | 1995-03-15 | 1997-04-08 | Merck & Co., Inc. | Process to make HIV protease inhibitor from (2S)-4-picolyl-2-piperazine-t-butylcarboxamide |
| CA2179935C (en) * | 1995-06-30 | 2010-09-07 | Ryohei Kato | Novel dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof |
| US6222043B1 (en) | 1995-06-30 | 2001-04-24 | Japan Energy Corporation | Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof |
| PT984000E (pt) * | 1995-09-26 | 2009-02-06 | Agouron Pharma | Processo para a produção de derivados amina e compostos intermediários |
| WO1997011937A1 (en) | 1995-09-26 | 1997-04-03 | Japan Tobacco Inc. | Process for producing amide derivatives and intermediates |
| ES2293651T3 (es) * | 1995-11-28 | 2008-03-16 | Cephalon, Inc. | Inhibidores de cisteina y serina proteasas derivados de aminoacidos d. |
| US5962725A (en) | 1996-09-05 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir |
| CA2249747A1 (en) | 1996-12-27 | 1998-07-09 | Tsutomu Mimoto | Novel tripeptide compounds and anti-aids drugs |
| JP4006058B2 (ja) | 1997-03-11 | 2007-11-14 | 第一三共株式会社 | 多臓器不全予防及び／又は治療剤 |
| DE69836315T2 (de) | 1997-03-14 | 2007-05-31 | Daiichi Pharmaceutical Co., Ltd. | Verwendung von TCF-II zur Behandlung von durch Krebs verursachtem Gewichtsverlust, Anaemie und TNF-Erhöhung |
| US6538006B1 (en) * | 1998-07-08 | 2003-03-25 | Pharmacia Corporation | Retroviral protease inhibitors |
| HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| NZ525513A (en) | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
| BR9917082A (pt) * | 1998-12-24 | 2001-11-06 | Du Pont Pharm Co | Compostos inibidores da produção de proteìnas a"beta", método de tratamento de disfunções neurológicas associadas com a produção de "beta"-amilóide, composição farmacêutica e, método de inibição da atividade de y-secretase |
| US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
| US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
| AU7997700A (en) | 1999-10-08 | 2001-04-23 | Du Pont Pharmaceuticals Company | Amino lactam sulfonamides as inhibitors of abeta protein production |
| JP2003523345A (ja) | 2000-02-17 | 2003-08-05 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | Ａβタンパク質産生の阻害剤としてのスクシノイルアミノ炭素環および複素環 |
| US6495540B2 (en) | 2000-03-28 | 2002-12-17 | Bristol - Myers Squibb Pharma Company | Lactams as inhibitors of A-β protein production |
| BR0107532A (pt) * | 2000-04-03 | 2004-11-03 | Bristol Myers Squibb Pharma Co | Composto, uso do composto, método para o tratamento de disfunções neurológicas associadas com a produção de b-amilóide, método de inibição da atividade de y-secretase e composição farmacêutica |
| EP1268434A1 (en) | 2000-04-03 | 2003-01-02 | Bristol-Myers Squibb Pharma Company | Cyclic lactams as inhibitors of a-beta protein production |
| US6632812B2 (en) * | 2000-04-11 | 2003-10-14 | Dupont Pharmaceuticals Company | Substituted lactams as inhibitors of Aβ protein production |
| US20100009966A1 (en) * | 2001-04-11 | 2010-01-14 | Bristol-Myers Squibb Pharma Company | Substituted lactams as inhibitors of abeta protein production |
| WO2001087354A2 (en) * | 2000-05-17 | 2001-11-22 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands for diagnostic imaging |
| MXPA02000862A (es) * | 2000-06-01 | 2003-07-14 | Bristol Myers Squibb Pharma Co | Lactamas substituidas por succinatos ciclicos como inhibidores de la produccion de proteina abeta. |
| GB0028483D0 (en) * | 2000-11-22 | 2001-01-10 | Hoffmann La Roche | Hydroxyethylamine HIV protease inhibitors |
| WO2002064553A1 (en) * | 2001-02-14 | 2002-08-22 | Kureha Chemical Industry Company, Limited | Process for preparation of halogenoalcohol derivatives |
| US20090062256A1 (en) * | 2001-06-01 | 2009-03-05 | Bristol-Myers Squibb Pharma Company | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION |
| GB0123467D0 (en) | 2001-09-28 | 2001-11-21 | Hoffmann La Roche | Carbocyclic HIV Protease inhibitors |
| KR101155335B1 (ko) * | 2005-01-07 | 2012-06-11 | 엘지전자 주식회사 | 이동통신 단말기의 멀티미디어 메시지 동작방법 |
| US8106090B2 (en) | 2005-07-20 | 2012-01-31 | Eli Lilly And Company | 1-amino linked compounds |
| CN101508664B (zh) * | 2009-02-25 | 2012-08-22 | 江阴希迪医药科技有限公司 | N-苄氧羰基-3-氨基-1-氯-4-苯硫基-2-丁醇合成方法 |
| US9102614B2 (en) * | 2010-07-02 | 2015-08-11 | Gilead Sciences, Inc. | Naphth-2-ylacetic acid derivatives to treat AIDS |
| WO2012003498A1 (en) | 2010-07-02 | 2012-01-05 | Gilead Sciences, Inc. | 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds |
| PE20141066A1 (es) | 2011-04-21 | 2014-09-05 | Gilead Sciences Inc | Compuestos de benzotiazol |
| WO2013103738A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Napthalene acetic acid derivatives against hiv infection |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| PH12014500842A1 (en) | 2012-04-20 | 2014-06-09 | Gilead Sciences Inc | Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| IL89900A0 (en) * | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
| CA1340588C (en) | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| EP0361341A3 (en) * | 1988-09-28 | 1991-07-03 | Miles Inc. | Therapeutics for aids based on inhibitors of hiv protease |
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| ES2243958T3 (es) * | 1990-11-19 | 2005-12-01 | Monsanto Company | Inhibidores de proteasas retrovirales. |
| CA2060844A1 (en) * | 1991-02-08 | 1992-08-09 | Yabe Yuichiro | Beta-amino-alpha-hydroxycarboxylic acids and their use |
| US5430041A (en) * | 1991-05-10 | 1995-07-04 | Hoffmann-La Roche Inc. | Amino acid derivatives having antiviral activity |
| CN1071930A (zh) | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
| AU3278293A (en) * | 1991-12-20 | 1993-07-28 | Syntex (U.S.A.) Inc. | Cyclic amides of 3-amino-2-hydroxy-carboxylic acids as hiv-protease inhibitors |
| US5312820A (en) * | 1992-07-17 | 1994-05-17 | Merck & Co., Inc. | Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines |
-
1993
- 1993-12-15 MX MX9308016A patent/MX9308016A/es not_active IP Right Cessation
- 1993-12-17 CZ CZ932814A patent/CZ281493A3/cs unknown
- 1993-12-17 NZ NZ250491A patent/NZ250491A/en unknown
- 1993-12-17 MY MYPI93002745A patent/MY131388A/en unknown
- 1993-12-20 PL PL93301581A patent/PL301581A1/xx unknown
- 1993-12-20 DE DE69324120T patent/DE69324120T2/de not_active Expired - Fee Related
- 1993-12-20 NO NO934719A patent/NO934719L/no unknown
- 1993-12-20 AU AU52528/93A patent/AU667146B2/en not_active Ceased
- 1993-12-20 IL IL108092A patent/IL108092A/en active IP Right Grant
- 1993-12-20 ES ES93310359T patent/ES2132201T3/es not_active Expired - Lifetime
- 1993-12-20 HU HU9303679A patent/HUT69693A/hu unknown
- 1993-12-20 EP EP93310359A patent/EP0604185B1/en not_active Expired - Lifetime
- 1993-12-20 AT AT93310359T patent/ATE178055T1/de not_active IP Right Cessation
- 1993-12-21 CA CA002112042A patent/CA2112042A1/en not_active Abandoned
- 1993-12-21 BR BR9305162A patent/BR9305162A/pt not_active Application Discontinuation
- 1993-12-21 FI FI935778A patent/FI935778A7/fi not_active Application Discontinuation
- 1993-12-21 CN CN93112962A patent/CN1044117C/zh not_active Expired - Fee Related
- 1993-12-21 JP JP5322750A patent/JPH06271534A/ja active Pending
- 1993-12-22 KR KR1019930029121A patent/KR940014337A/ko not_active Abandoned
- 1993-12-22 TW TW082110893A patent/TW262468B/zh active
-
1997
- 1997-11-19 US US08/974,430 patent/US5905077A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5905077A (en) | 1999-05-18 |
| AU5252893A (en) | 1994-07-07 |
| DE69324120D1 (de) | 1999-04-29 |
| ATE178055T1 (de) | 1999-04-15 |
| JPH06271534A (ja) | 1994-09-27 |
| MY131388A (en) | 2007-08-30 |
| BR9305162A (pt) | 1994-11-01 |
| FI935778A0 (fi) | 1993-12-21 |
| PL301581A1 (en) | 1994-06-27 |
| DE69324120T2 (de) | 1999-11-25 |
| CA2112042A1 (en) | 1994-06-23 |
| MX9308016A (es) | 1994-08-31 |
| EP0604185A1 (en) | 1994-06-29 |
| FI935778A7 (fi) | 1994-06-23 |
| ES2132201T3 (es) | 1999-08-16 |
| IL108092A (en) | 1998-06-15 |
| NZ250491A (en) | 1995-08-28 |
| IL108092A0 (en) | 1994-04-12 |
| NO934719L (no) | 1994-06-23 |
| KR940014337A (ko) | 1994-07-18 |
| AU667146B2 (en) | 1996-03-07 |
| CN1044117C (zh) | 1999-07-14 |
| CN1094399A (zh) | 1994-11-02 |
| TW262468B (enExample) | 1995-11-11 |
| EP0604185B1 (en) | 1999-03-24 |
| CZ281493A3 (en) | 1994-07-13 |
| NO934719D0 (no) | 1993-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DFC4 | Cancellation of temporary protection due to refusal |