ES2132063T3 - Procedimiento para la captura y recuperacion de celulas. - Google Patents
Procedimiento para la captura y recuperacion de celulas.Info
- Publication number
- ES2132063T3 ES2132063T3 ES90307080T ES90307080T ES2132063T3 ES 2132063 T3 ES2132063 T3 ES 2132063T3 ES 90307080 T ES90307080 T ES 90307080T ES 90307080 T ES90307080 T ES 90307080T ES 2132063 T3 ES2132063 T3 ES 2132063T3
- Authority
- ES
- Spain
- Prior art keywords
- cells
- separation
- suspensions
- interest
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000011084 recovery Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 8
- 238000000926 separation method Methods 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 239000003124 biologic agent Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 210000005087 mononuclear cell Anatomy 0.000 abstract 1
- 210000005259 peripheral blood Anatomy 0.000 abstract 1
- 239000011886 peripheral blood Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46434—Antigens related to induction of tolerance to non-self
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/464838—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
- C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/545—Synthetic resin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16051—Methods of production or purification of viral material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/824—Immunological separation techniques
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Developmental Biology & Embryology (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
SE PRESENTAN DISPOSITIVO, PROCESO Y COMPOSICIONES PARA LA SEPARACION EFECTIVA DE CELULAS DE UNA MEZCLA DE CELULAS, EN EL CUAL PUEDE EMPLEARSE UNA SELECCION POSITIVA PARA SUMINISTRAR UNA POBLACION CELULAR DE INTERES. DE PARTICULAR UTILIDAD ES LA SEPARACION DE LAS CELULAS DE LAS CELULAS MONONUCLEARES DE LA SANGRE PERIFERICA, EN LA CUAL LOS MIEMBROS DE LAS LINEAS LINFOIDES O MIELOIDES PUEDEN AISLARSE Y USARSE PARA LA BUSQUEDA, LA DIAGNOSIS O LA TERAPIA. TAMBIEN ES DE INTERES LA SEPARACION CELULAR DE LA MEDULA DEL HUESO, DE LAS SUSPENSIONES TUMOLARES, DE LAS SUSPENSIONES DE TEJIDOS NINFOIDES, DONDE LAS CELULAS PUEDEN AISLARSE Y USARSE PARA UNA VARIEDAD DE PROPOSITOS. LAS CELULAS SEPARADAS PUEDEN SER HOMOGENEAS LIBRES DE AGENTES BIOLOGICOS EXOGENOS, CAPACES DE REPRODUCIRSE Y DE EXHIBIR SU COMPLETA ACTIVIDAD BIOLOGICA. FENOTIPOS MULTIPLES PUEDEN CAPTURARSE DE MANERA SIMULTANEA. LAS CELULAS CAPTURADAS PUEDEN ACTIVARSE ESPECIFICAMENTE CON CITOQUINAS Y ANTIGENOS PARA SUMINISTRAR CELULAS QUE TENGAN UN MHC RESTRINGIDO Y PRESENTEN FUNCIONES ESPECIFICAS DE ANTIGENO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37409189A | 1989-06-29 | 1989-06-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2132063T3 true ES2132063T3 (es) | 1999-08-16 |
Family
ID=23475243
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90307080T Expired - Lifetime ES2132063T3 (es) | 1989-06-29 | 1990-06-28 | Procedimiento para la captura y recuperacion de celulas. |
ES95118035T Expired - Lifetime ES2173142T3 (es) | 1989-06-29 | 1990-06-28 | Dispositivo y procedimiento para la captura y recuperacion de celulas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95118035T Expired - Lifetime ES2173142T3 (es) | 1989-06-29 | 1990-06-28 | Dispositivo y procedimiento para la captura y recuperacion de celulas. |
Country Status (9)
Country | Link |
---|---|
US (1) | US6432653B1 (es) |
EP (2) | EP0701130B1 (es) |
JP (1) | JP2656988B2 (es) |
AT (2) | ATE179751T1 (es) |
CA (2) | CA1340565C (es) |
DE (2) | DE69033963T2 (es) |
DK (2) | DK0701130T3 (es) |
ES (2) | ES2132063T3 (es) |
GR (1) | GR3030533T3 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5725855A (en) * | 1991-04-05 | 1998-03-10 | The United States Of America As Represented By The Department Of Health And Human Services | Method of treating tumors with CD8+ -depleted or CD4+ T cell subpopulations |
JPH06506465A (ja) * | 1991-04-05 | 1994-07-21 | リージエンツ・オブ・ザ・ユニバーシテイ・オブ・ミネソタ | 細胞サブセットの欠落/陽性選択による免疫細胞の免疫療法活性の増強方法 |
FR2709309B1 (fr) * | 1993-08-25 | 1995-11-10 | Centre Nat Rech Scient | Compositions cellulaires, préparation et utilisations thérapeutiques. |
CA2227327A1 (en) * | 1995-07-25 | 1997-02-13 | Celltherapy, Inc. | Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease |
AU9374198A (en) * | 1997-09-08 | 1999-03-29 | Idec Pharmaceuticals Corporation | Methods for producing human antibodies in scid mice using dendritic cells |
MXPA01011279A (es) | 1999-05-07 | 2002-07-02 | Genentech Inc | Tratamiento de enfermedades autoinmunes con antagonistas que se unene a los marcadores de superficie, de celulas b. |
AU5967100A (en) * | 1999-07-21 | 2001-02-13 | Britta Christensen | A novel method for the improved isolation of a target cell population |
DE10014708A1 (de) * | 2000-03-24 | 2001-10-31 | Walter Schubert | Verfahren zur Identifizierung und Anreicherung von zellspezifischen Zielstrukturen |
DE10014685B4 (de) * | 2000-03-24 | 2004-07-01 | Schubert, Walter, Dr. | Verfahren zur Identifizierung von zellspezifischen Zielstrukturen |
US20070276352A1 (en) * | 2002-06-04 | 2007-11-29 | Stemcor Systems, Inc. | Removable device and method for tissue disruption |
AU2003240512B2 (en) * | 2002-06-04 | 2009-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Device and method for rapid aspiration and collection of body tissue from within an enclosed body space |
WO2004029221A2 (en) | 2002-09-27 | 2004-04-08 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
WO2004042019A2 (en) * | 2002-10-30 | 2004-05-21 | Pointilliste, Inc. | Systems for capture and analysis of biological particles and methods using the systems |
DE10311981A1 (de) * | 2003-03-12 | 2004-09-23 | Oligene Gmbh | Vorrichtung und Verfahren für den vivo-Zelltransfer |
WO2005014801A1 (en) * | 2003-08-04 | 2005-02-17 | University Court Of The University Of Edinburgh | Improvements in cell culture productivity |
US7996825B2 (en) * | 2003-10-31 | 2011-08-09 | Hewlett-Packard Development Company, L.P. | Cross-file inlining by using summaries and global worklist |
US20060018911A1 (en) * | 2004-01-12 | 2006-01-26 | Dana Ault-Riche | Design of therapeutics and therapeutics |
JP2005336080A (ja) * | 2004-05-26 | 2005-12-08 | Asahi Kasei Medical Co Ltd | 血管新生療法用細胞の分離回収方法および分離回収システム |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
EP2029779A4 (en) | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
US8691568B2 (en) * | 2006-11-22 | 2014-04-08 | Hua Liu | Method for preparing cell populations with anti-tumor immune response activity |
PT2562268T (pt) | 2008-09-20 | 2017-03-29 | Univ Leland Stanford Junior | Diagnóstico não invasivo de aneuploidia fetal por sequenciação |
EP2625263B1 (en) | 2010-10-08 | 2020-03-11 | Terumo BCT, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
JP6633522B2 (ja) | 2013-11-16 | 2020-01-22 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
JP6830059B2 (ja) | 2014-09-26 | 2021-02-17 | テルモ ビーシーティー、インコーポレーテッド | スケジュール化された細胞フィーディング |
US20160178490A1 (en) * | 2014-12-22 | 2016-06-23 | Saint-Gobain Performance Plastics Corporation | Capture system of cells and methods |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
EP3397172A4 (en) | 2016-02-01 | 2019-03-06 | Regenmed Systems, Inc. | CANNULA FOR TISSUE BREAKAGE |
EP3464565A4 (en) | 2016-05-25 | 2020-01-01 | Terumo BCT, Inc. | CELL EXPANSION |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
CN117247899A (zh) | 2017-03-31 | 2023-12-19 | 泰尔茂比司特公司 | 细胞扩增 |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1676579A (en) | 1927-02-14 | 1928-07-10 | Daniel Laurence | Light-treatment process |
US3016336A (en) | 1957-09-30 | 1962-01-09 | Fermco Lab Inc | Deoxygenating method and product |
US3645849A (en) | 1969-04-17 | 1972-02-29 | Gray Ind Inc | Stability of enzymes |
US3956219A (en) | 1973-02-01 | 1976-05-11 | Eli Lilly And Company | Crosslinked polystyrene and substituted polystyrene compositions |
IL43366A (en) | 1973-10-04 | 1976-09-30 | Yeda Res & Dev | Production of organic reagents for the acylation of organic compounds |
US4250139A (en) | 1979-02-01 | 1981-02-10 | Collagen Corporation | Microwave sterilization of dry protein |
US4497796A (en) * | 1980-03-26 | 1985-02-05 | The Regents Of The University Of California | Gene transfer in intact mammals |
US4464165A (en) | 1980-11-24 | 1984-08-07 | American Hoechst Corporation | Material and method for removing immunoglobulins from whole blood |
US4438198A (en) | 1981-09-30 | 1984-03-20 | Trimedyne, Inc. | Biochemically active matrix for use in a bio-artificial organ |
US4699877A (en) | 1982-11-04 | 1987-10-13 | The Regents Of The University Of California | Methods and compositions for detecting human tumors |
US4460445A (en) | 1983-02-28 | 1984-07-17 | Milliken Research Corporation | Radiation-stable polyolefin compositions containing benzaldehyde acetals |
DE3311889A1 (de) | 1983-03-31 | 1984-10-11 | Byk-Mallinckrodt Chemische Produkte Gmbh, 6057 Dietzenbach | Verfahren zur irreversiblen bindung von protein an polystyroloberflaechen unter erhaltung der biologischen aktivitaet, so erhaltene polystyroloberflaechen und ihre verwendung |
US4727027A (en) | 1983-05-02 | 1988-02-23 | Diamond Scientific Co. | Photochemical decontamination treatment of whole blood or blood components |
JPS6035263A (ja) * | 1983-08-05 | 1985-02-23 | Wako Pure Chem Ind Ltd | 不溶性担体に固定化された免疫活性物質の安定化法及び該物質を構成単位として含む生理活性物質測定用試薬 |
US4620908A (en) | 1983-10-03 | 1986-11-04 | Biocell Laboratories, Inc. | Method for destroying microbial contamination in protein materials |
US4714680B1 (en) | 1984-02-06 | 1995-06-27 | Univ Johns Hopkins | Human stem cells |
US4614513A (en) | 1984-08-13 | 1986-09-30 | Fred Hutchinson Cancer Research Center | Method and apparatus for treatment to remove immunoreactive substances from blood |
FR2582815B1 (fr) | 1985-05-31 | 1989-04-07 | Commissariat Energie Atomique | Procede de separation des anticorps antifacteur viii : c, utilisable notamment pour l'epuration du plasma sanguin d'un hemophile de type a |
US4690915A (en) * | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
US5081029A (en) | 1985-09-25 | 1992-01-14 | Oncogen | Methods of adoptive immunotherapy for treatment of aids |
WO1987004628A1 (en) * | 1986-01-30 | 1987-08-13 | Fred Hutchinson Cancer Research Center | Immunoselection method |
SE459008B (sv) * | 1986-09-04 | 1989-05-29 | Bioinvent Int Ab | Saett att framsstaella humana monoklonala antikroppar |
US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
US5241012A (en) | 1987-05-19 | 1993-08-31 | Applied Immune Sciences, Inc. | Activated and conjugated polystyrene substrate |
US5215926A (en) * | 1988-06-03 | 1993-06-01 | Cellpro, Inc. | Procedure for designing efficient affinity cell separation processes |
JP2639834B2 (ja) | 1988-11-30 | 1997-08-13 | 有限会社ジオリサーチ | 免疫記憶細胞懸濁液およびその調製方法 |
US4933410A (en) | 1989-03-29 | 1990-06-12 | Applied Immunesciences, Inc. | Covalent attachment of macromolecules on substrate surfaces |
US5081030A (en) * | 1989-04-25 | 1992-01-14 | The Johns Hopkins University | Release of cells from affinity matrices |
US5126132A (en) | 1989-08-21 | 1992-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor infiltrating lymphocytes as a treatment modality for human cancer |
-
1989
- 1989-09-28 CA CA000613945A patent/CA1340565C/en not_active Expired - Fee Related
-
1990
- 1990-02-22 JP JP2039890A patent/JP2656988B2/ja not_active Expired - Fee Related
- 1990-06-28 AT AT90307080T patent/ATE179751T1/de not_active IP Right Cessation
- 1990-06-28 EP EP95118035A patent/EP0701130B1/en not_active Expired - Lifetime
- 1990-06-28 DE DE69033963T patent/DE69033963T2/de not_active Expired - Fee Related
- 1990-06-28 AT AT95118035T patent/ATE217974T1/de not_active IP Right Cessation
- 1990-06-28 DE DE69033083T patent/DE69033083T2/de not_active Expired - Fee Related
- 1990-06-28 DK DK95118035T patent/DK0701130T3/da active
- 1990-06-28 EP EP90307080A patent/EP0405972B1/en not_active Expired - Lifetime
- 1990-06-28 DK DK90307080T patent/DK0405972T3/da active
- 1990-06-28 ES ES90307080T patent/ES2132063T3/es not_active Expired - Lifetime
- 1990-06-28 ES ES95118035T patent/ES2173142T3/es not_active Expired - Lifetime
-
1994
- 1994-07-28 CA CA000616896A patent/CA1337644C/en not_active Expired - Fee Related
- 1994-08-17 US US08/291,335 patent/US6432653B1/en not_active Expired - Fee Related
-
1999
- 1999-06-16 GR GR990401610T patent/GR3030533T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69033963T2 (de) | 2002-09-05 |
JP2656988B2 (ja) | 1997-09-24 |
ATE179751T1 (de) | 1999-05-15 |
EP0701130A3 (en) | 1996-03-20 |
CA1337644C (en) | 1995-11-28 |
EP0701130B1 (en) | 2002-05-22 |
DK0405972T3 (da) | 1999-11-01 |
EP0701130A2 (en) | 1996-03-13 |
EP0405972A1 (en) | 1991-01-02 |
ATE217974T1 (de) | 2002-06-15 |
CA1340565C (en) | 1999-05-25 |
EP0405972B1 (en) | 1999-05-06 |
ES2173142T3 (es) | 2002-10-16 |
US6432653B1 (en) | 2002-08-13 |
DK0701130T3 (da) | 2002-06-17 |
DE69033083T2 (de) | 1999-08-26 |
GR3030533T3 (en) | 1999-10-29 |
DE69033963D1 (de) | 2002-06-27 |
JPH0339088A (ja) | 1991-02-20 |
DE69033083D1 (de) | 1999-06-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2132063T3 (es) | Procedimiento para la captura y recuperacion de celulas. | |
Jamieson et al. | Generation of functional thymocytes in the human adult | |
Wright et al. | Studies on the mechanism of natural killer cytotoxicity. II. coculture of human PBL with NK-sensitive or resistant cell lines stimulates release of natural killer cytotoxic factors (NKCF) selectively cytotoxic to NK-sensitive target cells. | |
ATE449837T1 (de) | Abstammungs-spezifische zellen und vorläuferzellen | |
Stern et al. | Isolation and characterization of inflammatory cells from the human periapical granuloma | |
AU637702B2 (en) | T-lymphocyte progenitor cell assay | |
FI92258B (fi) | Onkostatiini-A:n käyttö diagnostisessa menetelmässä | |
CA2259984A1 (en) | Precise efficacy assay methods for active agents including chemotherapeutic agents | |
PT633930E (pt) | Geracao in vitro de celulas dendriticas humanas e utilizacoes destas | |
ATE231912T1 (de) | Zell/gewebekultursystem und -verfahren | |
ATE253112T1 (de) | Menschliche hematopoietische stammzellen | |
ES2147720T3 (es) | Factor de celulas madre. | |
ES2151607T3 (es) | Factor 12 de crecimiento y de diferenciacion. | |
Glaser et al. | In vitro generation of secondary cell-mediated cytotoxic response against a syngeneic Gross virus-induced lymphoma in rats | |
Altman et al. | Natural cell-mediated cytotoxicity in guinea pigs: properties and specificity of natural killer cells | |
ES8402346A1 (es) | Procedimiento para la obtencion de lineas de celulas animales y humanas cultivables permanentemente. | |
Hirschberg et al. | Stimulation of human lymphocytes by allogeneic endothelial cells in vitro | |
Bagnasco et al. | Clonal analysis of T lymphocytes infiltrating the thyroid gland in Hashimoto’s thyroiditis | |
Green et al. | Phylogeny of immunocompetent cells: III. Mitogen response characteristics of lymphocyte subpopulations from normal and thymectomized frogs (Xenopus laevis) | |
Gibofsky et al. | The identification of HL-A antigens on fresh and cultured human endothelial cells | |
SE8801426D0 (sv) | Forfarande och medel for blodbehandling | |
Debout et al. | Natural killer activity of Kurloff cells: a direct demonstration on purified Kurloff cell suspensions | |
Patel et al. | Enrichment of mouse splenic natural killer cells using discontinuous polyvinylpyrrolidone silica (Percoll) gradients. | |
ATE73665T1 (de) | Blutzellentrennung. | |
Lundgren et al. | In vitro cytotoxicity by human lymphocytes from individuals immunized against histocompatibility antigens. II. Relation to HL-A incompatibility between effector and target cells |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 405972 Country of ref document: ES |