DE69033963D1 - Vorrichtung und Verfahren zur Fixierung und Rückgewinnung von Zellen - Google Patents
Vorrichtung und Verfahren zur Fixierung und Rückgewinnung von ZellenInfo
- Publication number
- DE69033963D1 DE69033963D1 DE69033963T DE69033963T DE69033963D1 DE 69033963 D1 DE69033963 D1 DE 69033963D1 DE 69033963 T DE69033963 T DE 69033963T DE 69033963 T DE69033963 T DE 69033963T DE 69033963 D1 DE69033963 D1 DE 69033963D1
- Authority
- DE
- Germany
- Prior art keywords
- fixing
- recovering cells
- cells
- recovering
- sterilizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229940088623 biologically active substance Drugs 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46434—Antigens related to induction of tolerance to non-self
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/464838—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
- C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/545—Synthetic resin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16051—Methods of production or purification of viral material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/824—Immunological separation techniques
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Developmental Biology & Embryology (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37409189A | 1989-06-29 | 1989-06-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69033963D1 true DE69033963D1 (de) | 2002-06-27 |
DE69033963T2 DE69033963T2 (de) | 2002-09-05 |
Family
ID=23475243
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69033963T Expired - Fee Related DE69033963T2 (de) | 1989-06-29 | 1990-06-28 | Vorrichtung und Verfahren zur Fixierung und Rückgewinnung von Zellen |
DE69033083T Expired - Fee Related DE69033083T2 (de) | 1989-06-29 | 1990-06-28 | Verfahren zur Fixierung und Rückgewinnung von Zellen |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69033083T Expired - Fee Related DE69033083T2 (de) | 1989-06-29 | 1990-06-28 | Verfahren zur Fixierung und Rückgewinnung von Zellen |
Country Status (9)
Country | Link |
---|---|
US (1) | US6432653B1 (de) |
EP (2) | EP0701130B1 (de) |
JP (1) | JP2656988B2 (de) |
AT (2) | ATE217974T1 (de) |
CA (2) | CA1340565C (de) |
DE (2) | DE69033963T2 (de) |
DK (2) | DK0405972T3 (de) |
ES (2) | ES2173142T3 (de) |
GR (1) | GR3030533T3 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0578740A4 (en) * | 1991-04-05 | 1995-12-20 | Univ Minnesota | Method of enhancing the immunotherapeutic activity of immune cells by depletion/positive selection of cell subsets |
US5725855A (en) * | 1991-04-05 | 1998-03-10 | The United States Of America As Represented By The Department Of Health And Human Services | Method of treating tumors with CD8+ -depleted or CD4+ T cell subpopulations |
FR2709309B1 (fr) * | 1993-08-25 | 1995-11-10 | Centre Nat Rech Scient | Compositions cellulaires, préparation et utilisations thérapeutiques. |
EP0852618A1 (de) * | 1995-07-25 | 1998-07-15 | Celltherapy Inc. | Autologe immunzellentherapie, zellzusammensetzungen, verfahren und verwendung zur behandlung menschlicher krankheiten |
WO1999012553A1 (en) * | 1997-09-08 | 1999-03-18 | Idec Pharmaceuticals Corporation | Methods for producing human antibodies in scid mice using dendritic cells |
AU777970C (en) | 1999-05-07 | 2006-08-17 | F. Hoffman-La Roche Ag | Treatment of autoimmune diseases with antagonists which bind to B cell surface markers |
AU5967100A (en) * | 1999-07-21 | 2001-02-13 | Britta Christensen | A novel method for the improved isolation of a target cell population |
DE10014708A1 (de) * | 2000-03-24 | 2001-10-31 | Walter Schubert | Verfahren zur Identifizierung und Anreicherung von zellspezifischen Zielstrukturen |
DE10014685B4 (de) * | 2000-03-24 | 2004-07-01 | Schubert, Walter, Dr. | Verfahren zur Identifizierung von zellspezifischen Zielstrukturen |
US7462181B2 (en) | 2002-06-04 | 2008-12-09 | Stanford Office Of Technology Licensing | Device and method for rapid aspiration and collection of body tissue from within an enclosed body space |
US20070276352A1 (en) * | 2002-06-04 | 2007-11-29 | Stemcor Systems, Inc. | Removable device and method for tissue disruption |
US8895298B2 (en) | 2002-09-27 | 2014-11-25 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
EP1576126A3 (de) * | 2002-10-30 | 2005-10-26 | Pointilliste, Inc. | Systeme zum einfangen und zur analyse biologischer partikel und verfahren unter verwendung dieser systeme |
DE10311981A1 (de) * | 2003-03-12 | 2004-09-23 | Oligene Gmbh | Vorrichtung und Verfahren für den vivo-Zelltransfer |
WO2005014801A1 (en) * | 2003-08-04 | 2005-02-17 | University Court Of The University Of Edinburgh | Improvements in cell culture productivity |
US7996825B2 (en) * | 2003-10-31 | 2011-08-09 | Hewlett-Packard Development Company, L.P. | Cross-file inlining by using summaries and global worklist |
US20060018911A1 (en) * | 2004-01-12 | 2006-01-26 | Dana Ault-Riche | Design of therapeutics and therapeutics |
JP2005336080A (ja) * | 2004-05-26 | 2005-12-08 | Asahi Kasei Medical Co Ltd | 血管新生療法用細胞の分離回収方法および分離回収システム |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
EP2589668A1 (de) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten |
EP2029779A4 (de) | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | Verwendung hoch paralleler snp-genotypisierung zur fötalen diagnose |
US8691568B2 (en) * | 2006-11-22 | 2014-04-08 | Hua Liu | Method for preparing cell populations with anti-tumor immune response activity |
PT2562268T (pt) | 2008-09-20 | 2017-03-29 | Univ Leland Stanford Junior | Diagnóstico não invasivo de aneuploidia fetal por sequenciação |
US8895291B2 (en) | 2010-10-08 | 2014-11-25 | Terumo Bct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
US9617506B2 (en) | 2013-11-16 | 2017-04-11 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
EP3613841B1 (de) | 2014-03-25 | 2022-04-20 | Terumo BCT, Inc. | Passives ersetzen von medien |
CN106715676A (zh) | 2014-09-26 | 2017-05-24 | 泰尔茂比司特公司 | 按计划供养 |
US20160178490A1 (en) * | 2014-12-22 | 2016-06-23 | Saint-Gobain Performance Plastics Corporation | Capture system of cells and methods |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
EP3397172A4 (de) | 2016-02-01 | 2019-03-06 | Regenmed Systems, Inc. | Kanüle für gewebedisruption |
US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11702634B2 (en) | 2017-03-31 | 2023-07-18 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1676579A (en) | 1927-02-14 | 1928-07-10 | Daniel Laurence | Light-treatment process |
US3016336A (en) | 1957-09-30 | 1962-01-09 | Fermco Lab Inc | Deoxygenating method and product |
US3645849A (en) | 1969-04-17 | 1972-02-29 | Gray Ind Inc | Stability of enzymes |
US3956219A (en) | 1973-02-01 | 1976-05-11 | Eli Lilly And Company | Crosslinked polystyrene and substituted polystyrene compositions |
IL43366A (en) | 1973-10-04 | 1976-09-30 | Yeda Res & Dev | Production of organic reagents for the acylation of organic compounds |
US4250139A (en) | 1979-02-01 | 1981-02-10 | Collagen Corporation | Microwave sterilization of dry protein |
US4497796A (en) * | 1980-03-26 | 1985-02-05 | The Regents Of The University Of California | Gene transfer in intact mammals |
US4464165A (en) | 1980-11-24 | 1984-08-07 | American Hoechst Corporation | Material and method for removing immunoglobulins from whole blood |
US4438198A (en) | 1981-09-30 | 1984-03-20 | Trimedyne, Inc. | Biochemically active matrix for use in a bio-artificial organ |
US4699877A (en) | 1982-11-04 | 1987-10-13 | The Regents Of The University Of California | Methods and compositions for detecting human tumors |
US4460445A (en) | 1983-02-28 | 1984-07-17 | Milliken Research Corporation | Radiation-stable polyolefin compositions containing benzaldehyde acetals |
DE3311889A1 (de) | 1983-03-31 | 1984-10-11 | Byk-Mallinckrodt Chemische Produkte Gmbh, 6057 Dietzenbach | Verfahren zur irreversiblen bindung von protein an polystyroloberflaechen unter erhaltung der biologischen aktivitaet, so erhaltene polystyroloberflaechen und ihre verwendung |
US4727027A (en) | 1983-05-02 | 1988-02-23 | Diamond Scientific Co. | Photochemical decontamination treatment of whole blood or blood components |
JPS6035263A (ja) * | 1983-08-05 | 1985-02-23 | Wako Pure Chem Ind Ltd | 不溶性担体に固定化された免疫活性物質の安定化法及び該物質を構成単位として含む生理活性物質測定用試薬 |
US4620908A (en) | 1983-10-03 | 1986-11-04 | Biocell Laboratories, Inc. | Method for destroying microbial contamination in protein materials |
US4714680B1 (en) | 1984-02-06 | 1995-06-27 | Univ Johns Hopkins | Human stem cells |
US4614513A (en) | 1984-08-13 | 1986-09-30 | Fred Hutchinson Cancer Research Center | Method and apparatus for treatment to remove immunoreactive substances from blood |
FR2582815B1 (fr) | 1985-05-31 | 1989-04-07 | Commissariat Energie Atomique | Procede de separation des anticorps antifacteur viii : c, utilisable notamment pour l'epuration du plasma sanguin d'un hemophile de type a |
US4690915A (en) * | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
US5081029A (en) | 1985-09-25 | 1992-01-14 | Oncogen | Methods of adoptive immunotherapy for treatment of aids |
WO1987004628A1 (en) * | 1986-01-30 | 1987-08-13 | Fred Hutchinson Cancer Research Center | Immunoselection method |
SE459008B (sv) * | 1986-09-04 | 1989-05-29 | Bioinvent Int Ab | Saett att framsstaella humana monoklonala antikroppar |
US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
US5241012A (en) | 1987-05-19 | 1993-08-31 | Applied Immune Sciences, Inc. | Activated and conjugated polystyrene substrate |
US5215926A (en) * | 1988-06-03 | 1993-06-01 | Cellpro, Inc. | Procedure for designing efficient affinity cell separation processes |
JP2639834B2 (ja) | 1988-11-30 | 1997-08-13 | 有限会社ジオリサーチ | 免疫記憶細胞懸濁液およびその調製方法 |
US4933410A (en) | 1989-03-29 | 1990-06-12 | Applied Immunesciences, Inc. | Covalent attachment of macromolecules on substrate surfaces |
US5081030A (en) * | 1989-04-25 | 1992-01-14 | The Johns Hopkins University | Release of cells from affinity matrices |
US5126132A (en) | 1989-08-21 | 1992-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor infiltrating lymphocytes as a treatment modality for human cancer |
-
1989
- 1989-09-28 CA CA000613945A patent/CA1340565C/en not_active Expired - Fee Related
-
1990
- 1990-02-22 JP JP2039890A patent/JP2656988B2/ja not_active Expired - Fee Related
- 1990-06-28 DE DE69033963T patent/DE69033963T2/de not_active Expired - Fee Related
- 1990-06-28 AT AT95118035T patent/ATE217974T1/de not_active IP Right Cessation
- 1990-06-28 DK DK90307080T patent/DK0405972T3/da active
- 1990-06-28 DK DK95118035T patent/DK0701130T3/da active
- 1990-06-28 ES ES95118035T patent/ES2173142T3/es not_active Expired - Lifetime
- 1990-06-28 DE DE69033083T patent/DE69033083T2/de not_active Expired - Fee Related
- 1990-06-28 ES ES90307080T patent/ES2132063T3/es not_active Expired - Lifetime
- 1990-06-28 AT AT90307080T patent/ATE179751T1/de not_active IP Right Cessation
- 1990-06-28 EP EP95118035A patent/EP0701130B1/de not_active Expired - Lifetime
- 1990-06-28 EP EP90307080A patent/EP0405972B1/de not_active Expired - Lifetime
-
1994
- 1994-07-28 CA CA000616896A patent/CA1337644C/en not_active Expired - Fee Related
- 1994-08-17 US US08/291,335 patent/US6432653B1/en not_active Expired - Fee Related
-
1999
- 1999-06-16 GR GR990401610T patent/GR3030533T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0701130B1 (de) | 2002-05-22 |
ES2132063T3 (es) | 1999-08-16 |
DE69033083D1 (de) | 1999-06-10 |
JP2656988B2 (ja) | 1997-09-24 |
DK0405972T3 (da) | 1999-11-01 |
DE69033083T2 (de) | 1999-08-26 |
EP0701130A3 (de) | 1996-03-20 |
ATE217974T1 (de) | 2002-06-15 |
US6432653B1 (en) | 2002-08-13 |
GR3030533T3 (en) | 1999-10-29 |
JPH0339088A (ja) | 1991-02-20 |
CA1340565C (en) | 1999-05-25 |
CA1337644C (en) | 1995-11-28 |
EP0701130A2 (de) | 1996-03-13 |
ES2173142T3 (es) | 2002-10-16 |
EP0405972B1 (de) | 1999-05-06 |
EP0405972A1 (de) | 1991-01-02 |
ATE179751T1 (de) | 1999-05-15 |
DE69033963T2 (de) | 2002-09-05 |
DK0701130T3 (da) | 2002-06-17 |
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