ES2126573T3 - Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado. - Google Patents

Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado.

Info

Publication number
ES2126573T3
ES2126573T3 ES91913666T ES91913666T ES2126573T3 ES 2126573 T3 ES2126573 T3 ES 2126573T3 ES 91913666 T ES91913666 T ES 91913666T ES 91913666 T ES91913666 T ES 91913666T ES 2126573 T3 ES2126573 T3 ES 2126573T3
Authority
ES
Spain
Prior art keywords
lower alkyl
substituted
hydroxy
phenyl
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91913666T
Other languages
English (en)
Spanish (es)
Inventor
Makoto Inoue
Kinji Hashimoto
Toshiko Kuwahara
Yukio Sugimoto
Takuji Uesako
Toshiaki Funato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd, Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2126573T3 publication Critical patent/ES2126573T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES91913666T 1991-04-22 1991-08-06 Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado. Expired - Lifetime ES2126573T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9070791 1991-04-22

Publications (1)

Publication Number Publication Date
ES2126573T3 true ES2126573T3 (es) 1999-04-01

Family

ID=14006001

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91913666T Expired - Lifetime ES2126573T3 (es) 1991-04-22 1991-08-06 Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado.

Country Status (12)

Country Link
US (1) US5688949A (cg-RX-API-DMAC10.html)
EP (1) EP0591528B1 (cg-RX-API-DMAC10.html)
JP (1) JPH0570353A (cg-RX-API-DMAC10.html)
KR (1) KR100191774B1 (cg-RX-API-DMAC10.html)
AT (1) ATE174917T1 (cg-RX-API-DMAC10.html)
AU (1) AU651986B2 (cg-RX-API-DMAC10.html)
CA (1) CA2107479C (cg-RX-API-DMAC10.html)
DE (1) DE69130683T2 (cg-RX-API-DMAC10.html)
DK (1) DK0591528T3 (cg-RX-API-DMAC10.html)
ES (1) ES2126573T3 (cg-RX-API-DMAC10.html)
TW (1) TW221434B (cg-RX-API-DMAC10.html)
WO (1) WO1992018504A1 (cg-RX-API-DMAC10.html)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0628559B1 (en) * 1993-06-10 2002-04-03 Beiersdorf-Lilly GmbH Pyrimidine compounds and their use as pharmaceuticals
EP0714898B1 (en) * 1994-06-21 2001-11-14 Otsuka Pharmaceutical Factory, Inc. PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE
RU2147584C1 (ru) * 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US6664261B2 (en) * 1996-02-07 2003-12-16 Neurocrine Biosciences, Inc. Pyrazolopyrimidines as CRF receptor antagonists
WO1997046560A1 (en) * 1996-06-06 1997-12-11 Otsuka Pharmaceutical Factory, Inc. Amide derivatives
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
PT915880E (pt) * 1996-07-24 2007-12-31 Bristol Myers Squibb Pharma Co Azol triazinas e pirimidinas
CA2259583C (en) * 1996-07-24 2009-11-17 Du Pont Pharmaceuticals Company Azolo triazines and pyrimidines
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
HUP9603001A3 (en) * 1996-10-30 1999-07-28 Richter Gedeon Vegyeszet Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
WO2000059907A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
WO2000059908A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
US20020061897A1 (en) * 2000-03-30 2002-05-23 Elliott Richard L. Neuropeptide Y antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
DE60216083T2 (de) * 2001-03-27 2007-06-28 Neurogen Corp., Branford (OXOPYRAZOLOi1,5AöPYRIMIDIN-2-YL) ALKYLCARBONSÄUREAMIDE
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP1511751B1 (en) * 2002-06-04 2008-03-19 Neogenesis Pharmaceuticals, Inc. Pyrazolo[1,5-a]pyrimidine compounds as antiviral agents
PL224879B1 (pl) 2002-09-04 2017-02-28 Pharmacopeia Drug Discovery Inc Pirazolo [1,5-a] pirymidynowy związek, jego zastosowanie do wytwarzania leku oraz zawierająca go farmaceutyczna kompozycja
US7205308B2 (en) * 2002-09-04 2007-04-17 Schering Corporation Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
KR20050057072A (ko) * 2002-09-04 2005-06-16 쉐링 코포레이션 사이클린 의존성 키나제 억제제로서의 피라졸로피리미딘
US7161003B1 (en) * 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7074924B2 (en) * 2002-09-04 2006-07-11 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
ATE362474T1 (de) * 2002-09-04 2007-06-15 Schering Corp Pyrazolo(1,5-a)pyrimidine als hemmstoffe cyclin- abhängiger kinasen
US7119200B2 (en) 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US8673924B2 (en) 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
CN1310918C (zh) 2002-09-04 2007-04-18 先灵公司 作为细胞周期蛋白依赖激酶抑制剂的吡唑并嘧啶
US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
WO2004076458A1 (en) 2003-02-28 2004-09-10 Teijin Pharma Limited Pyrazolo[1,5-a]pyrimidine derivatives
WO2004087707A1 (en) * 2003-03-31 2004-10-14 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
US6949895B2 (en) * 2003-09-03 2005-09-27 Axcelis Technologies, Inc. Unipolar electrostatic quadrupole lens and switching methods for charged beam transport
AR049769A1 (es) * 2004-01-22 2006-09-06 Novartis Ag Derivados de pirazolo(1,5-a)pirimidin 7-il-amina para utilizarse en el tratamiento de enfermedades dependientes de la quinasa de proteina
CN101287411B (zh) 2005-04-28 2013-03-06 普罗秋斯生物医学公司 药物信息系统及其用途
ES2349476T3 (es) * 2005-09-09 2011-01-03 Schering Corporation Nuevos derivados de 4-ciano, 4-amino y 4-aminometilo de compuestos de pirazolo[1,5-a]piridinas, pirazolo[1,5-c]pirimidinas y 2h-indazol y derivados de 5-ciano, 5-amino y 5-aminometilo de compuestos de imidazo[1,2-a]piridinas e imidazo[1,5-a]pirazinas, como inhibidores de cinasa dependiente de ciclina.
AR055206A1 (es) * 2005-10-06 2007-08-08 Schering Corp Pirazolo[1, 5 - a]pirimidinas como inhibidoras de proteina quinasa, composiciones farmaceuticas y combinaciones con agentes citostaticos que las comprenden y su uso en la fabricacion de un medicamento para el tratamiento del cancer.
CN101321760A (zh) 2005-10-06 2008-12-10 先灵公司 作为蛋白激酶抑制剂的吡唑并嘧啶
GB0526419D0 (en) * 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
NZ597247A (en) * 2006-11-29 2013-06-28 Abbott Lab Inhibitors of diacylglycerol O-acylotransferase type 1 enzyme
JP5421925B2 (ja) * 2007-12-19 2014-02-19 ジェネンテック， インコーポレイテッド ５−アニリノイミダゾピリジン及び使用の方法
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
KR101483834B1 (ko) * 2009-12-23 2015-01-16 카트호리이케 유니버시타이트 로이펜 항바이러스 화합물
WO2012047570A1 (en) * 2010-09-28 2012-04-12 Schering Corporation Fused tricyclic inhibitors of mammalian target of rapamycin
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
EP2640705A2 (en) 2010-11-15 2013-09-25 Katholieke Universiteit Leuven Novel antiviral compounds
US8633198B1 (en) 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
AU2013407264B2 (en) * 2013-12-11 2016-09-29 Nant Holdings Ip, Llc Small molecule inhibitors of influenza a RNA-dependent RNA polymerase
RU2689788C2 (ru) * 2014-01-22 2019-05-29 Куровир Аб ПИРАЗОЛО[1,5-а]ПИРИМИДИНЫ В КАЧЕСТВЕ ПРОТИВОВИРУСНЫХ СОЕДИНЕНИЙ
GB201410817D0 (en) * 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R & D Therapeutic agents
CN111212839A (zh) * 2017-09-15 2020-05-29 艾杜罗生物科技公司 吡唑并嘧啶酮化合物及其用途
DE102018201598A1 (de) * 2018-02-02 2019-08-08 Beiersdorf Ag Stabile Wundheilsalbe
WO2022084741A1 (en) 2020-10-23 2022-04-28 Ildong Pharmaceutical Co., Ltd. Cftr modulator compounds, compositions, and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3925385A (en) * 1972-04-20 1975-12-09 Icn Pharmaceuticals 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
US4026893A (en) * 1975-11-07 1977-05-31 Squibb & Sons Inc Pyrazolo{8 1,5-a{9 pyrido{8 3,2-e{9 pyrimidine-7-carboxylic acid derivatives
DE3338292A1 (de) * 1983-10-21 1985-05-02 Basf Ag, 6700 Ludwigshafen 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide
JPS60100381A (ja) * 1983-11-04 1985-06-04 Yuasa Battery Co Ltd 密閉形鉛蓄電池
JPS60100581A (ja) * 1983-11-07 1985-06-04 S D S Baiotetsuku:Kk ピラゾロ〔１，５−ａ〕ピリミジン誘導体，それらを含有する農園芸用殺菌剤及びそれらの製造方法
JPS6157587A (ja) * 1984-08-29 1986-03-24 Shionogi & Co Ltd 縮合複素環誘導体および抗潰瘍剤
JP2585462B2 (ja) * 1989-10-25 1997-02-26 株式会社大塚製薬工場 ピラゾロ［１，５―ａ］ピリミジン誘導体
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids

Also Published As

Publication number Publication date
AU651986B2 (en) 1994-08-11
US5688949A (en) 1997-11-18
DE69130683T2 (de) 1999-05-06
AU8295891A (en) 1992-11-17
DE69130683D1 (de) 1999-02-04
JPH0570353A (ja) 1993-03-23
TW221434B (cg-RX-API-DMAC10.html) 1994-03-01
WO1992018504A1 (en) 1992-10-29
ATE174917T1 (de) 1999-01-15
EP0591528A4 (en) 1995-02-15
CA2107479C (en) 1997-12-16
EP0591528B1 (en) 1998-12-23
CA2107479A1 (en) 1992-10-23
KR100191774B1 (ko) 1999-06-15
DK0591528T3 (da) 1999-08-23
EP0591528A1 (en) 1994-04-13

Similar Documents

Publication Publication Date Title
ES2126573T3 (es) Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado.
EE03139B1 (et) Piperasiiniderivaadid, nende kasutamine ja farmatseutiline kompositsioon
ATE174596T1 (de) Imidazo (1,2-a)pyridine als bradykinin- antagonisten
ES2076827T3 (es) Azaindoles, procedimientos de preparacion y medicamentos que los contienen.
DE69428476D1 (de) Heterocyclische Verbindungen als Bradykinin Antagonisten
MY101208A (en) Phenyl-piperazine anti-arrhythmia agents.
CA2311742A1 (en) 6-amino-9-benzyl-8-hydroxypurine derivatives
CA2297326A1 (en) Heterocyclic compound and antitumor agent containing the same as active component
EP0638567A4 (en) ADENOSINE INHIBITORS.
DK367987D0 (da) 1,2,3,3a,8,8a-hexahydro-3a,8(og 1,3a,8)-di(og tri)methylpyrrolooe2,3-baaindoler, deres fremstilling og anvendelse som laegemidler
ATE153025T1 (de) Triazolopyrimidinderivate mit fungizider aktivität
NO905519L (no) Pyrimidinderivater.
DE69304057D1 (de) Indole fungizide
DE69232883D1 (de) Substituierte heterocyklische derivate, verwendbar als plättchenaggregationshemmstoffe
BG100069A (bg) Амидинови производни,съдържащи хетероциклични групи,получаване и приложението им
NZ330078A (en) Active oxygen carriers containing pterin derivatives and salts thereof for use as cosmetic agents and feed
NO307464B1 (no) Galantaminderivater, farmasøytisk sammensetning inneholdende samme samt deres anvendelse for fremstilling av medikamenter
FI935243A0 (fi) Pyridonkarboxylsyraderivat
DE69619259D1 (de) Amidin- und isothioharnstoffderivate als inhibitoren der stickstoffoxid-synthase
ATE173733T1 (de) Antimikrobielle carbapenem-derivate, ihre herstellung und ihre therapeutische verwendung
ES2069249T3 (es) Derivados de imidazol, su procedimiento de preparacion y los compuestos farmaceuticos que los contienen.
NZ196018A (en) 6-(phenyl or heteroaryl)-2,3-dihydroimidazo(1,2-b)-pyridazines
CA2053705A1 (en) Piperazine derivatives
IL101032A0 (en) 1,2,4-triazolo(1,5-a)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
MX9706123A (es) Derivados de pirazolil-benzoilo.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 591528

Country of ref document: ES