ES2121404T3 - Procedimiento para la preparacion de trihidrato del (2r,3s)-3-terc-butoxicarbonilamino-2-hidroxi-3-fenilpropionato de 4-acetoxi-2alfa-benzoiloxi-5beta,20-epoxi-1,7beta,10beta-trihidroxi-9-oxo-tax-11-en-13alfa-ilo. - Google Patents

Procedimiento para la preparacion de trihidrato del (2r,3s)-3-terc-butoxicarbonilamino-2-hidroxi-3-fenilpropionato de 4-acetoxi-2alfa-benzoiloxi-5beta,20-epoxi-1,7beta,10beta-trihidroxi-9-oxo-tax-11-en-13alfa-ilo.

Info

Publication number
ES2121404T3
ES2121404T3 ES95925022T ES95925022T ES2121404T3 ES 2121404 T3 ES2121404 T3 ES 2121404T3 ES 95925022 T ES95925022 T ES 95925022T ES 95925022 T ES95925022 T ES 95925022T ES 2121404 T3 ES2121404 T3 ES 2121404T3
Authority
ES
Spain
Prior art keywords
ilo
tax
oxo
fenilpropionato
butoxicarbonilamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95925022T
Other languages
English (en)
Spanish (es)
Inventor
Jean-Rene Authelin
Jacques Doveze
Elie Fouque
Bernadette Mandard
Isabelle Taillepied
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2121404(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2121404T3 publication Critical patent/ES2121404T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
ES95925022T 1994-07-08 1995-07-07 Procedimiento para la preparacion de trihidrato del (2r,3s)-3-terc-butoxicarbonilamino-2-hidroxi-3-fenilpropionato de 4-acetoxi-2alfa-benzoiloxi-5beta,20-epoxi-1,7beta,10beta-trihidroxi-9-oxo-tax-11-en-13alfa-ilo. Expired - Lifetime ES2121404T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9408479A FR2722191B1 (fr) 1994-07-08 1994-07-08 Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle

Publications (1)

Publication Number Publication Date
ES2121404T3 true ES2121404T3 (es) 1998-11-16

Family

ID=9465183

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95925022T Expired - Lifetime ES2121404T3 (es) 1994-07-08 1995-07-07 Procedimiento para la preparacion de trihidrato del (2r,3s)-3-terc-butoxicarbonilamino-2-hidroxi-3-fenilpropionato de 4-acetoxi-2alfa-benzoiloxi-5beta,20-epoxi-1,7beta,10beta-trihidroxi-9-oxo-tax-11-en-13alfa-ilo.

Country Status (38)

Country Link
US (1) US6022985A (enEXAMPLES)
EP (1) EP0770070B1 (enEXAMPLES)
JP (1) JP3753155B2 (enEXAMPLES)
KR (1) KR100391753B1 (enEXAMPLES)
CN (1) CN1067996C (enEXAMPLES)
AT (1) ATE171702T1 (enEXAMPLES)
AU (1) AU706519B2 (enEXAMPLES)
BR (1) BR9508789A (enEXAMPLES)
CA (1) CA2193531C (enEXAMPLES)
CO (1) CO4410189A1 (enEXAMPLES)
CZ (1) CZ284695B6 (enEXAMPLES)
DE (1) DE69505128T2 (enEXAMPLES)
DK (1) DK0770070T3 (enEXAMPLES)
DZ (1) DZ1905A1 (enEXAMPLES)
ES (1) ES2121404T3 (enEXAMPLES)
FI (1) FI119246B (enEXAMPLES)
FR (1) FR2722191B1 (enEXAMPLES)
GR (1) GR3027558T3 (enEXAMPLES)
HU (1) HU220634B1 (enEXAMPLES)
IL (1) IL114274A (enEXAMPLES)
IN (1) IN183947B (enEXAMPLES)
IS (1) IS2032B (enEXAMPLES)
MA (1) MA23606A1 (enEXAMPLES)
MX (1) MX9700173A (enEXAMPLES)
MY (1) MY118481A (enEXAMPLES)
NO (1) NO314500B1 (enEXAMPLES)
NZ (1) NZ289455A (enEXAMPLES)
PE (1) PE8697A1 (enEXAMPLES)
PL (1) PL179876B1 (enEXAMPLES)
RU (1) RU2126397C1 (enEXAMPLES)
SI (1) SI0770070T1 (enEXAMPLES)
SK (1) SK280520B6 (enEXAMPLES)
TN (1) TNSN95071A1 (enEXAMPLES)
TW (1) TW419473B (enEXAMPLES)
UA (1) UA51624C2 (enEXAMPLES)
UY (1) UY23991A1 (enEXAMPLES)
WO (1) WO1996001815A1 (enEXAMPLES)
ZA (1) ZA955646B (enEXAMPLES)

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AU753781B2 (en) 1997-04-28 2002-10-31 Aventis Pharma S.A. Adenovirus-mediated intratumoral delivery of an angiogenesis antagonist for the treatment of tumors
SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
US6853921B2 (en) 1999-07-20 2005-02-08 Halliburton Energy Services, Inc. System and method for real time reservoir management
US6266619B1 (en) * 1999-07-20 2001-07-24 Halliburton Energy Services, Inc. System and method for real time reservoir management
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US7584165B2 (en) * 2003-01-30 2009-09-01 Landmark Graphics Corporation Support apparatus, method and system for real time operations and maintenance
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
PT1694660E (pt) 2003-12-12 2009-07-16 Quiral Quimica Do Brasil Processo de preparação de ingredientes farmacêuticos activos (api) anidros e hidratados; composições farmacêuticas estáveis preparadas a partir dos mesmos e utilizações das referidas composições
US7142986B2 (en) * 2005-02-01 2006-11-28 Smith International, Inc. System for optimizing drilling in real time
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
EP1928435B8 (en) * 2005-08-31 2019-03-20 Abraxis BioScience, LLC Compositions of poorly water soluble drugs with increased stability and methods for preparation thereof
ES2718323T3 (es) 2005-08-31 2019-07-01 Abraxis Bioscience Llc Composiciones que comprenden agentes farmacéuticos poco solubles en agua
EP1819688A2 (en) * 2005-10-12 2007-08-22 Sicor, Inc. Crystalline forms of docetaxel and processes for their preparation
KR100995390B1 (ko) 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
CA2636428C (en) * 2006-01-20 2013-12-24 Landmark Graphics Corporation Dynamic production system management
AU2007226937A1 (en) * 2006-03-21 2007-09-27 Dr. Reddy's Laboratories Ltd. Docetaxel polymorphs and processes
AU2007309534B2 (en) * 2006-10-20 2012-08-16 Scinopharm Singapore Pte, Ltd. Process for making crystalline anhydrous docetaxel
KR100868116B1 (ko) * 2007-04-09 2008-11-10 한미약품 주식회사 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법
KR100878455B1 (ko) * 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
EP2173732A4 (en) * 2007-07-04 2011-09-07 Reddys Lab Ltd Dr PROCESSES FOR THE PREPARATION OF DOCETAXEL AND POLYMORPHIC
EP2080763A1 (en) * 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
ES2389518T3 (es) * 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US8686165B2 (en) * 2009-11-04 2014-04-01 Emcure Pharmaceuticals Limited Process for preparation of taxane derivatives
AP3552A (en) 2010-05-03 2016-01-18 Teikoku Pharma Usa Inc Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
WO2012160568A1 (en) * 2011-05-23 2012-11-29 Shilpa Medicare Limited Process for preparing docetaxel trihydrate polymorph
EP2753355B1 (en) 2011-09-08 2018-10-24 New York University Oncolytic herpes simplex virus and therapeutic uses thereof
WO2013096455A1 (en) 2011-12-20 2013-06-27 Dana-Farber Cancer Institute, Inc. Methods for diagnosing and treating oncogenic kras-associated cancer
KR101809858B1 (ko) 2012-04-04 2017-12-15 할로자임, 아이엔씨 항-히알루로난 제제 및 종양-표적 탁산을 이용한 병용 치료
CA2874521A1 (en) 2012-05-24 2013-11-28 Dana-Farber Cancer Institute, Inc. Targeting the glutamine to pyruvate pathway for treatment of oncogenic kras-associated cancer
WO2014014518A1 (en) 2012-07-18 2014-01-23 Dana-Farber Cancer Institute, Inc. Methods for treating, preventing and predicting risk of developing breast cancer
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
US10238723B2 (en) 2013-03-14 2019-03-26 Icahn School Of Medicine At Mount Sinai Autologous tumor lysate-loaded dendritic cell vaccine for treatment of liver cancer
US10130590B2 (en) 2013-10-01 2018-11-20 Dana-Farber Cancer Institute, Inc. Methods of treating cancer with atovaquone-related compounds
WO2015149006A2 (en) 2014-03-27 2015-10-01 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating ncoa4-mediated autophagic targeting of ferritin
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
US10967015B2 (en) 2015-06-15 2021-04-06 New York University Method of treatment using oncolytic viruses
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

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Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Also Published As

Publication number Publication date
CZ3597A3 (en) 1997-04-16
RU2126397C1 (ru) 1999-02-20
PL179876B1 (pl) 2000-11-30
IS2032B (is) 2005-08-15
HUT76833A (en) 1997-11-28
ATE171702T1 (de) 1998-10-15
DK0770070T3 (da) 1999-03-01
TNSN95071A1 (fr) 1996-02-06
FR2722191A1 (fr) 1996-01-12
MY118481A (en) 2004-11-30
FR2722191B1 (fr) 1996-08-23
AU2930595A (en) 1996-02-09
SK697A3 (en) 1997-06-04
KR970704721A (ko) 1997-09-06
AU706519B2 (en) 1999-06-17
GR3027558T3 (en) 1998-11-30
DE69505128D1 (de) 1998-11-05
IN183947B (enEXAMPLES) 2000-05-20
FI119246B (fi) 2008-09-15
NO970007D0 (no) 1997-01-02
NZ289455A (en) 1997-12-19
IS4411A (is) 1997-01-07
JPH10502627A (ja) 1998-03-10
FI970069A0 (fi) 1997-01-07
IL114274A (en) 1999-04-11
HU9700041D0 (en) 1997-02-28
CA2193531C (fr) 2006-12-05
EP0770070A1 (fr) 1997-05-02
BR9508789A (pt) 1997-10-21
CZ284695B6 (cs) 1999-02-17
JP3753155B2 (ja) 2006-03-08
UA51624C2 (uk) 2002-12-16
DZ1905A1 (fr) 2002-02-17
CA2193531A1 (fr) 1996-01-25
SI0770070T1 (en) 1998-12-31
CO4410189A1 (es) 1997-01-09
HU220634B1 (hu) 2002-03-28
NO970007L (no) 1997-01-02
ZA955646B (en) 1996-02-21
MA23606A1 (fr) 1996-04-01
NO314500B1 (no) 2003-03-31
CN1151741A (zh) 1997-06-11
MX9700173A (es) 1997-04-30
PL318195A1 (en) 1997-05-26
TW419473B (en) 2001-01-21
SK280520B6 (sk) 2000-03-13
KR100391753B1 (ko) 2004-02-11
US6022985A (en) 2000-02-08
DE69505128T2 (de) 1999-04-01
UY23991A1 (es) 1995-09-20
CN1067996C (zh) 2001-07-04
PE8697A1 (es) 1997-03-26
FI970069L (fi) 1997-01-07
IL114274A0 (en) 1995-10-31
WO1996001815A1 (fr) 1996-01-25
EP0770070B1 (fr) 1998-09-30

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