ES2121192T3 - Emulsiones vacunizables fluidas, agua en aceite, conteniendo un aceite metabolizable. - Google Patents

Emulsiones vacunizables fluidas, agua en aceite, conteniendo un aceite metabolizable.

Info

Publication number
ES2121192T3
ES2121192T3 ES94909151T ES94909151T ES2121192T3 ES 2121192 T3 ES2121192 T3 ES 2121192T3 ES 94909151 T ES94909151 T ES 94909151T ES 94909151 T ES94909151 T ES 94909151T ES 2121192 T3 ES2121192 T3 ES 2121192T3
Authority
ES
Spain
Prior art keywords
oil
metabolizable
water
vaccinizable
emulsions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94909151T
Other languages
English (en)
Inventor
Michel Emile Albert Riviere
Claude Roulet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Animal Health France SAS
Original Assignee
Merial SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9302661A external-priority patent/FR2702374B1/fr
Application filed by Merial SAS filed Critical Merial SAS
Application granted granted Critical
Publication of ES2121192T3 publication Critical patent/ES2121192T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Colloid Chemistry (AREA)
  • Edible Oils And Fats (AREA)
  • Lubricants (AREA)

Abstract

EL PRESENTE INVENTO SE REFIERE A EMULSIONES VACCINICAS AGUA EN EITE METABOLIZABLE. CONTIENEN: 5 A 50% V/V DE FASE ACUOSA QUE CONTIENE LOS ANTIGENES, PREFERENTEMENTE DE 12 A 25% V/V, DE 50 A 94% V/V DE FASE ACEITOSA QUE CONTIENE TOTALMENTE O PARCIALMENTE UN ACEITE METABOLIZABLE (ACEITE VEGETAL O ESTERES DE ACIDOS GRASOS Y DE POLIOLES O DE ALCOHOLES), DE 0,2 A 20% P/V DE TENSIOACTIVOS, PREFERENTEMENTE DE 3 A 8% P/V, SIENDO ESTOS EN SU TOTALIDAD O PARCIALMENTE O EN MEZCLA BIEN ESTERES POLIGLICEROL, SIENDO PREFERENTEMENTE DICHOS ESTERES DE POLIGLICEROL (POLI)RICINOLEATOS DE POLIGLICEROL, O BIEN ACEITES DE RICINO DE POLIOXIETILENO O INCLUSO ACEITES DE RICINO HIDROGENADOS DE POLIOXIETILENO.
ES94909151T 1993-03-08 1994-03-04 Emulsiones vacunizables fluidas, agua en aceite, conteniendo un aceite metabolizable. Expired - Lifetime ES2121192T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9302661A FR2702374B1 (fr) 1993-03-08 1993-03-08 Emulsions vaccinales fluides eau-dans-l'huile contenant une huile métabolisable.
FR9314651A FR2702373B1 (fr) 1993-03-08 1993-12-07 Emulsions vaccinales fluides eau-dans-l'huile contenant une huile métabolisable.

Publications (1)

Publication Number Publication Date
ES2121192T3 true ES2121192T3 (es) 1998-11-16

Family

ID=26230149

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94909151T Expired - Lifetime ES2121192T3 (es) 1993-03-08 1994-03-04 Emulsiones vacunizables fluidas, agua en aceite, conteniendo un aceite metabolizable.

Country Status (13)

Country Link
US (1) US6235282B1 (es)
EP (1) EP0639071B1 (es)
JP (1) JP4045310B2 (es)
KR (1) KR100328009B1 (es)
AT (1) ATE169496T1 (es)
AU (1) AU679212B2 (es)
CA (1) CA2135192C (es)
DE (1) DE69412391T2 (es)
DK (1) DK0639071T3 (es)
ES (1) ES2121192T3 (es)
FR (1) FR2702373B1 (es)
NZ (1) NZ262429A (es)
WO (1) WO1994020071A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0781559T3 (da) * 1995-11-30 2007-02-26 Chemo Sero Therapeut Res Inst Olieadjuvansvaccine og fremgangsmåde til fremstilling af samme
UA78180C2 (uk) 1997-10-03 2007-03-15 Меріаль Кільцевий вірус свині типу ii, вакцини та діагностичні реагенти
BR0207698A (pt) * 2001-02-28 2004-04-20 Akzo Nobel Nv Adjuvante para uso em formulação de vacina, vacina, e, uso de um emulsificante polimérico
FR2822834B1 (fr) * 2001-04-02 2005-02-25 Flamel Tech Sa Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation
FR2823222B1 (fr) 2001-04-06 2004-02-06 Merial Sas Vaccin contre le virus de la fievre du nil
HU228690B1 (en) 2001-07-27 2013-05-28 Wyeth Corp West nile vaccine
US7914801B1 (en) 2002-03-21 2011-03-29 The United States Of America As Represented By The Secretary Of Agriculture Metabolizable oil emulsion adjuvants and vaccines for enhancing immuno-properties of antibodies and their subpopulations
FR2840614B1 (fr) 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2843117B1 (fr) * 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
EP1550453B1 (en) * 2002-09-12 2015-05-27 International Institute of Cancer Immunology, Inc. Cancer antigen peptide preparation
FR2855521B1 (fr) * 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
JP2005075752A (ja) * 2003-08-29 2005-03-24 Nippon Inst For Biological Science 豚繁殖・呼吸障害症候群用ワクチン製剤
FR2860516B1 (fr) * 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2862536B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
WO2006078059A1 (ja) 2005-01-19 2006-07-27 Dainippon Sumitomo Pharma Co., Ltd. 希釈用乳化組成物および癌ワクチン組成物
ATE531389T1 (de) * 2005-01-28 2011-11-15 Univ Northwest Lipid- und distickstoffoxidverbindung als hilfsmittel zur erhöhung der impfstoffeffizienz
US7862821B2 (en) 2006-06-01 2011-01-04 Merial Limited Recombinant vaccine against bluetongue virus
FR2910318B1 (fr) * 2006-12-20 2009-07-03 Flamel Technologies Sa Dispersion de polyaminoacides dans une phase lipidique continue.
JP5135852B2 (ja) * 2007-03-30 2013-02-06 日油株式会社 可溶化用組成物
WO2010025469A1 (en) * 2008-08-29 2010-03-04 Boehringer Ingelheim Vetmedica, Inc. West nile virus vaccine
US8394384B2 (en) 2008-11-28 2013-03-12 Merial Limited Recombinant avian influenza vaccine and uses thereof
JP4598864B2 (ja) 2009-01-29 2010-12-15 ファナック株式会社 パラレルロボット
US8893578B2 (en) 2009-02-13 2014-11-25 Fanuc Corporation Parallel robot provided with wrist section having three degrees of freedom
JP4659098B2 (ja) 2009-02-13 2011-03-30 ファナック株式会社 ３自由度を有する姿勢変更機構を備えたパラレルリンクロボット
EP2686012B1 (en) 2011-03-14 2020-12-02 Boehringer Ingelheim Animal Health USA Inc. Equine rhinitis vaccine
US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes
MX2015000237A (es) 2012-06-27 2015-08-14 Orban Biotech Llc Proteinas de fusion ctla4 para el tratamiento de la diabetes.
EP2821082A1 (en) 2013-07-05 2015-01-07 Laboratoire Biodim Method of producing an inactivated lentivirus, especially HIV, vaccine, kit and method of use
FR3011850B1 (fr) 2013-10-15 2018-04-06 Cfl Biotech Vaccin therapeutique contre le cancer a base de proteines de stress rendues immunogenes
GB2523399B (en) 2014-02-25 2019-03-13 Orban Tihamer A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence
CN116421560A (zh) * 2023-05-26 2023-07-14 山东中牧兽药有限公司 一种阿苯达唑伊维菌素的微乳剂及其制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL292949A (es) *
NL269002A (es) * 1960-09-06
AT257043B (de) * 1963-05-21 1967-09-25 Philips Nv Verfahren zur Herstellung einer Vakzineflüssigkeit von Brucella Abortus-Bakterien
GB1128325A (en) * 1964-11-11 1968-09-25 Wellcome Found Improvements in water-in-oil emulsion vaccines
US3983228A (en) * 1973-08-28 1976-09-28 Merck & Co., Inc. Water-in-oil adjuvant composition
US3966632A (en) * 1974-06-06 1976-06-29 G. D. Searle & Co. Vegetable oil emulsion
FR2466247A1 (fr) * 1979-10-03 1981-04-10 Decroix Guy Preparation immuno-stimulante et application
US4606918A (en) * 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4770874A (en) * 1983-08-22 1988-09-13 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
JPS60174377A (ja) * 1984-02-17 1985-09-07 松下電器産業株式会社 揺動式三輪自転車
JPS60199833A (ja) * 1984-03-26 1985-10-09 Meiji Milk Prod Co Ltd 医薬品、化粧品等用ｗ／ｏ／ｗ型複合エマルジヨンの製造法
JPS61289026A (ja) * 1985-06-18 1986-12-19 Nippon Oil & Fats Co Ltd 静脈注射用脂肪乳剤
US4806352A (en) * 1986-04-15 1989-02-21 Ribi Immunochem Research Inc. Immunological lipid emulsion adjuvant
FR2597346B1 (fr) * 1986-04-22 1989-08-18 Oreal Procede pour faciliter la formation de niosomes en dispersion dans une phase aqueuse et pour ameliorer leur stabilite et leur taux d'encapsulation, et dispersions correspondantes.
FR2649012B1 (fr) * 1989-07-03 1991-10-25 Seppic Sa Emulsions multiphasiques injectables
FR2649013B1 (fr) * 1989-07-03 1991-10-25 Seppic Sa Vaccins et vecteurs de principes actifs fluides contenant une huile metabolisable
JPH05255112A (ja) * 1992-03-14 1993-10-05 Kanebo Ltd アジュバント組成物

Also Published As

Publication number Publication date
FR2702373B1 (fr) 1996-06-07
DK0639071T3 (da) 1999-05-10
ATE169496T1 (de) 1998-08-15
FR2702373A1 (fr) 1994-09-16
AU679212B2 (en) 1997-06-26
US6235282B1 (en) 2001-05-22
JP4045310B2 (ja) 2008-02-13
JPH07509733A (ja) 1995-10-26
CA2135192A1 (en) 1994-09-15
DE69412391T2 (de) 1999-01-14
EP0639071B1 (fr) 1998-08-12
AU6210094A (en) 1994-09-26
KR100328009B1 (ko) 2002-10-25
CA2135192C (en) 2004-06-29
KR950701213A (ko) 1995-03-23
WO1994020071A1 (fr) 1994-09-15
EP0639071A1 (fr) 1995-02-22
NZ262429A (en) 1997-03-24
DE69412391D1 (de) 1998-09-17

Similar Documents

Publication Publication Date Title
ES2121192T3 (es) Emulsiones vacunizables fluidas, agua en aceite, conteniendo un aceite metabolizable.
ES2061055T3 (es) Vacunas y vectores de principios activos fluidos que contienen un aceite metabolizable.
ES2041959T3 (es) Un cosmetico en emulsion del tipo agua-en-aceite.
SE9301347D0 (sv) An emulsion type defoaming agent composition and a method of defoaming utilizing it
ATE152604T1 (de) Wasser-in-öl emulsionen mit einer fluorkohlenwasserstoff enthaltenden kontinuierlichen phase und die verwendung von gewissen silikon tenziden für ihre herstellung
ES2087974T3 (es) Agente antiemulsion/antiespuma para uso en aceites.
SE8000441L (sv) Sprengemneskomposition
ES476562A1 (es) Procedimiento de preparacion de una composicion cosmetica - para la limpieza de la piel.
GB1242518A (en) Defoaming emulsion
FI955962A0 (fi) Stabiilit vesi-öljyemulsiot
ATE65447T1 (de) Konservierungszusammensetzungen.
ATE361738T1 (de) Mehrphasen emulsionen mit niedrigen emulgiermittel
ES2068704T3 (es) Desemulsionamiento de aceites.
MX9202400A (es) Emulsion de agua en aceite que contiene hidroxilamina y metodo para su preparacion.
ATE245018T1 (de) Wasser-in-öl emulsionzusammensetzung mit verlaufsveränderlicher schergeschwindigkeit
DE3785323T2 (de) Kosmetische zusammensetzung.
MY130536A (en) Stable water-in-oil emulsions
FR2702374B1 (fr) Emulsions vaccinales fluides eau-dans-l'huile contenant une huile métabolisable.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 639071

Country of ref document: ES